Phng Li-Kun ＰｈｎｇＬｉＫｕｎ

… Alternative Names

Phng Li Kun Phng LiKun

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Researcher Number	70794098
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームディレクター
Affiliation (based on the past Project Information) *help	2019 – 2024: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Transformative Research Areas, Section (III) Except Principal Investigator Transformative Research Areas, Section (III)
Keywords	Principal Investigator Haemodynamic forces / Actin cytoskeleton / Mechanobiology / Morphogenesis / Blood vessels / Endothelial cell / morphogenesis / blood vessels / Blood vessel remodelling / Hemodynamic forces … More / hemodynamic forces / mechanobiology / actin cytoskeleton / endothelial cell / Blood vessel remodeling / 管腔メカニクス / 組織構築 / 管腔組織 / メカノケミカルフィードバック / Blood vessel / Angiogenesis / Blebbing / Tubulogenesis / Bleb / Marcksl1 / Actin / Lumen … More Except Principal Investigator 力学化学フィードバック / 力学計測解析 / 秩序化 / 細胞操作 / 生体計測 / 国際シンポジウム / 共同利用 / 共同研究 / 多細胞 / 自律的秩序化 / 力 / 発生 / 多細胞生物 / 多細胞システム / 細胞運命 / 自己組織化 / 形態形成 / 力作用 Less

Mechanical self-transformation of living systems
- Principal Investigator
  
  茂木文夫
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Hokkaido University
Mechanochemical feedback and emergence of tissue function in luminal tissuesPrincipal Investigator
- Principal Investigator
  
  Phng LiKun
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Institute of Physical and Chemical Research
Control of endothelial cell mechanics and blood vessel remodeling by blood flowPrincipal Investigator
- Principal Investigator
  
  Phng LiKun
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Institute of Physical and Chemical Research
Molecular regulation of blood vessel size by endothelial cells-the role of Marcksl1.Principal Investigator
- Principal Investigator
  
  Phng Li Kun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration2023
- Author(s)
  Maung Ye Swe Soe、Phng Li-Kun
- Journal Title
  
  PLOS Computational Biology
  
  Volume: 19 Issue: 12 Pages: 1-35
- DOI
  10.1371/journal.pcbi.1011665
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05168, KAKENHI-PROJECT-23K23887
[Journal Article] High-Throughput Imaging of Blood Flow Reveals Developmental Changes in Distribution Patterns of Hemodynamic Quantities in Developing Zebrafish2022
- Author(s)
  Maung Ye Swe Soe、Kim Jung Kyung、Carretero Nuria Taberner、Phng Li-Kun
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 13 Pages: 1-23
- DOI
  10.3389/fphys.2022.881929
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20190, KAKENHI-PLANNED-22H05168, KAKENHI-PROJECT-23K23887
[Journal Article] Endothelial cell mechanics and blood flow forces in vascular morphogenesis2021
- Author(s)
  Li-Kun Phng , Heinz-Georg Belting
- Journal Title
  
  Seminars in Cell and Developmental Biology
  
  Volume: 120 Pages: 32-43
- DOI
  10.1016/j.semcdb.2021.06.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06651
[Journal Article] Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size2020
- Author(s)
  Kondrychyn Igor、Kelly Douglas J.、Carretero N?ria Taberner、Nomori Akane、Kato Kagayaki、Chong Jeronica、Nakajima Hiroyuki、Okuda Satoru、Mochizuki Naoki、Phng Li-Kun
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 5476-5493
- DOI
  10.1038/s41467-020-19308-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06272, KAKENHI-PROJECT-19K06651, KAKENHI-PROJECT-19H01022
[Presentation] Regulation of endothelial cell behaviours by actin cytoskeleton and hydrostatic pressure during blood vessel morphogenesis2023
- Author(s)
  Li-Kun Phng
- Organizer
  A*Star Singapore
- Invited
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] A role of hydrostatic pressure in regulating endothelial cel migration during sprouting angiogenesis2023
- Author(s)
  Li-Kun Phng
- Organizer
  MBI Conference 2023, Mechanobiology in Health and Disease, Singapore
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] Mechanics of vascular tube formation and diameter regulation2023
- Author(s)
  Li-Kun Phng
- Organizer
  2023 Gordon Research Conference Angiogenesis
- Invited
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] Regulation of endothelial cell behaviours by actin cytoskeleton and hydrostatic pressure during blood vessel morphogenesis2023
- Author(s)
  Li-Kun Phng
- Organizer
  A*Star, Singapore
- Invited
- Data Source
  KAKENHI-PROJECT-23K23887
[Presentation] Mechanics of blood vessel lumenization and remodelling2023
- Author(s)
  Li-Kun Phng
- Organizer
  75th Annual Meeting of Japan Society of Cell Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23887
[Presentation] Mechanics of blood vessel lumenization and remodelling2023
- Author(s)
  Li-Kun Phng
- Organizer
  90th IRCMS Seminar-Symposium on New Horizons in Developmental Biology, Kumamoto University, Japan
- Invited
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] Mechanics of vascular tube formation and diameter regulation2023
- Author(s)
  Li-Kun Phng
- Organizer
  2023 GRC Angiogenesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23887
[Presentation] Mechanics of blood vessel lumenization and remodelling2023
- Author(s)
  Li-Kun Phng
- Organizer
  75th Annual Meeting of Japan Society of Cell Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] Mechanics of blood vessel lumenization and remodelling2022
- Author(s)
  Li-Kun Phng
- Organizer
  Biozentrum, University of Basel, Switzerland
- Invited
- Data Source
  KAKENHI-PROJECT-23K23887
[Presentation] Mechanics of blood vessel lumenization and remodelling2022
- Author(s)
  Li-Kun Phng
- Organizer
  Engineering Mechanics of Cell and Tissue Morphogenesis Symposium, Japan
- Invited
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] Mechanics of vascular tube formation and diameter regulation2022
- Author(s)
  Li-Kun Phng
- Organizer
  Molecular Biology Society of Japan Annual Meeting 2022
- Invited
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] Mechanics of blood vessel lumenization and remodelling2022
- Author(s)
  Li-Kun Phng
- Organizer
  Engineering Mechanics of Cell and Tissue Morphogenesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23887
[Presentation] Mechanics of vascular tube formation, maintenance and diameter regulation2022
- Author(s)
  Li-Kun Phng
- Organizer
  12th International Kloster Seeon Meeting “Angiogenesis”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23887
[Presentation] Mechanics of blood vessel lumenization and remodelling2022
- Author(s)
  Li-Kun Phng
- Organizer
  Australian Vascular Biology Meeting 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] Imaging blood flow and endothelial cell mechanics during zebrafish vascular morphogenesis2022
- Author(s)
  Li-Kun Phng
- Organizer
  Kick-off Symposium of Kento Imaging Support, Osaka, Japan
- Invited
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] Mechanics of vascular tube formation, maintenance and diameter regulation2022
- Author(s)
  Li-Kun Phng
- Organizer
  12th International Kloster Seeon Meeting “Angiogenesis”, Germany
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] Mechanics of blood vessel lumenization and remodelling2022
- Author(s)
  Li-Kun Phng
- Organizer
  Australian Vascular Biology Meeting 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23887
[Presentation] Mechanics of blood vessel lumenization and remodelling2022
- Author(s)
  Li-Kun Phng
- Organizer
  Biozentrum, University of Basel, Switzerland
- Invited
- Data Source
  KAKENHI-PLANNED-22H05168
[Presentation] Imaging blood flow and endothelial cell mechanics during zebrafish vascular morphogenesis2022
- Author(s)
  Li-Kun Phng
- Organizer
  Kick-off Symposium of Kento Imaging Support Center
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23887
[Presentation] Mechanics of vascular tube formation and diameter regulation2022
- Author(s)
  Li-Kun Phng
- Organizer
  Molecular Biology Society of Japan Annual Meeting 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23887
[Presentation] Endothelial cell mechanoresponse to haemodynamic forces during vascular lumenization2021
- Author(s)
  Li-Kun Phng
- Organizer
  Cell & Tissue Hydraulics Mini-symposium, Mechanobiology Institute, University of Singapore.
- Invited
- Data Source
  KAKENHI-PROJECT-19K06651
[Presentation] Endothelial cell mechanoresponse to haemodynamic forces during vascular tubulogenesis.2021
- Author(s)
  Li-Kun Phng
- Organizer
  Research Institute for Mathematical Sciences (RIMS) Workshop “Mathematical Mechanobiology”, Kyoto University, Japan.
- Invited
- Data Source
  KAKENHI-PROJECT-19K06651
[Presentation] Role of endothelial cell mechanoresponse to haemodynamic forces in the regulation of vessel morphology2021
- Author(s)
  Li-Kun Phng
- Organizer
  EMBO Workshop “Vascular Malformations: from fundamental biology to therapeutic opportunities”. Badalona, Spain.
- Data Source
  KAKENHI-PROJECT-19K06651
[Presentation] Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to regulate cell and vessel shape2021
- Author(s)
  Li-Kun Phng
- Organizer
  Annual Scientific Meeting of the Japanese Circulation Society, 2021. “Vascular biology”
- Invited
- Data Source
  KAKENHI-PROJECT-19K06651
[Presentation] Endothelial cell mechanoresponse to haemodynamic forces during vascular tubulogenesis2021
- Author(s)
  Li-Kun Phng
- Organizer
  Mathematical Mechanobiology, RIMS Workshop, University of Kyoto, Japan.
- Invited
- Data Source
  KAKENHI-PROJECT-19K06651
[Presentation] Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to regulate cell and vessel shape2020
- Author(s)
  Li-Kun Phng
- Organizer
  Annual Meeting of the Molecular Biology Society of Japan, 2020. “Decoding and Engineering Cell Shape”
- Invited
- Data Source
  KAKENHI-PROJECT-19K06651
[Presentation] Endothelial cell mechanoresponse to haemodynamic forces during vascular tubulogenesis.2020
- Author(s)
  Li-Kun Phng
- Organizer
  Mechanobiology Institute Conference, NUS, Singapore.
- Invited
- Data Source
  KAKENHI-PROJECT-19K06651
[Presentation] Shaping the vasculature - a balance of endothelial cell biomechanics and haemodynamic forces2019
- Author(s)
  Li-Kun Phng
- Organizer
  3rd Asia-Australia Vascular Biology Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06651
[Presentation] Shaping the vasculature - a balance of endothelial cell biomechanics and haemodynamic forces2019
- Author(s)
  Li-Kun Phng
- Organizer
  42nd Annual Meeting of the Molecular BIology Society of Japan.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06651
[Presentation] Marcksl1 modulates endothelial cell response to haemodynamic forces to control blood vessel shape and size2019
- Author(s)
  Li-Kun Phng
- Organizer
  Angiogenesis Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06651
[Presentation] Endothellial cell response to hemodynamic forces in developing blood vessels2019
- Author(s)
  Li-Kun Phng
- Organizer
  52nd Japan Society for Developmental Biology
- Invited
- Data Source
  KAKENHI-PROJECT-19K06651

1. 茂木文夫 (10360653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 柊卓志 (00512477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 見学美根子 (10303801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 柴田達夫 (10359888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 近藤武史 (60565084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 吉村成弘 (90346106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 進藤麻子 (60512118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤森俊彦 (80301274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 加藤輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Phng Li-Kun Ｐｈｎｇ ＬｉＫｕｎ

Phng Li Kun Phng LiKun

Research Projects

Research Products

Co-Researchers

Mechanical self-transformation of living systems

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanochemical feedback and emergence of tissue function in luminal tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of endothelial cell mechanics and blood vessel remodeling by blood flowPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular regulation of blood vessel size by endothelial cells-the role of Marcksl1.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A cell-and-plasma numerical model reveals hemodynamic stress and flow adaptation in zebrafish microvessels after morphological alteration2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High-Throughput Imaging of Blood Flow Reveals Developmental Changes in Distribution Patterns of Hemodynamic Quantities in Developing Zebrafish2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endothelial cell mechanics and blood flow forces in vascular morphogenesis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Regulation of endothelial cell behaviours by actin cytoskeleton and hydrostatic pressure during blood vessel morphogenesis2023

Author(s)

Organizer

Data Source

[Presentation] A role of hydrostatic pressure in regulating endothelial cel migration during sprouting angiogenesis2023

Author(s)

Organizer

Data Source

[Presentation] Mechanics of vascular tube formation and diameter regulation2023

Author(s)

Organizer

Data Source

[Presentation] Regulation of endothelial cell behaviours by actin cytoskeleton and hydrostatic pressure during blood vessel morphogenesis2023

Author(s)

Organizer

Data Source

[Presentation] Mechanics of blood vessel lumenization and remodelling2023

Author(s)

Organizer

Data Source

[Presentation] Mechanics of blood vessel lumenization and remodelling2023

Author(s)

Organizer

Data Source

[Presentation] Mechanics of vascular tube formation and diameter regulation2023

Author(s)

Organizer

Data Source

[Presentation] Mechanics of blood vessel lumenization and remodelling2023

Author(s)

Organizer

Phng Li-Kun ＰｈｎｇＬｉＫｕｎ