Takahashi go 高橋剛

… Alternative Names

TAKAHASHI Gou 高橋剛

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Researcher Number	70802817
Other IDs	https://orcid.org/0000-0003-2277-7657
Affiliation (Current)	2025: 東京農業大学, 農学部, 助教 2025: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 研究員
Affiliation (based on the past Project Information) *help	2024 – 2025: 東京農業大学, 農学部, 助教 2020 – 2023: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 研究員 2018 – 2019: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 44010:Cell biology-related / Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator iPS細胞 / ゲノム編集 / 欠失変異 / CRISPR-Cas12a / 筋ジストロフィー / 欠失導入 / CRISPR-Cas12s / Cas12a / デジタルPCR / ddPCR … More / Amplicon sequence / DMD / Exon skipping / Lentiviral Library / Amplicon Sequencing / CRISPR-Cpf1 / CRISPR/Cpf1 … More Except Principal Investigator iPS細胞 / 遺伝子交換 / 細胞融合 / 骨格筋細胞 / 肝細胞 / 心筋細胞 / 倍数性 / DNA組換え / 欠失導入 / HR / NHEJ / HDR / Cas12a / Cas9 / ゲノム編集 Less

Cas12の連続的編集による高効率な欠失導入法の確立Principal Investigator
- Principal Investigator
  
  高橋剛
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tokyo University of Agriculture
細胞種により異なる倍数性の意義をiPS細胞モデルにより追究する
- Principal Investigator
  
  宮岡佑一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
マウスの交配のように自在なヒトiPS細胞間の遺伝子交換手法の開発
- Principal Investigator
  
  宮岡佑一郎
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
医療応用可能なCRISPR-Cas12aによる欠失導入法の確立Principal Investigator
- Principal Investigator
  
  高橋剛
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Development of non-random genome editing technology for therapeutic applications
- Principal Investigator
  
  MIYAOKA Yuichiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Establishment of a precise deletion mutagenesis method using CRISPR/Cpf1 to enable gene therapyPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Gou
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Genome editing is induced in a binary manner in single human cells2022
- Author(s)
  Takahashi Gou、Kondo Daiki、Maeda Minato、Morishita Yuji、Miyaoka Yuichiro
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 12 Pages: 105619-105619
- DOI
  10.1016/j.isci.2022.105619
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03442
[Journal Article] Genome Editing Is Induced in a Binary Manner in Single Human Cells2022
- Author(s)
  Takahashi Gou、Kondo Daiki、Maeda Minato、Morishita Yuji、Miyaoka Yuichiro
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2022.03.04.482947
- Open Access
- Data Source
  KAKENHI-PROJECT-20K21409, KAKENHI-PROJECT-20H03442
[Journal Article] Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson’s disease-specific hepatocytes2022
- Author(s)
  Song Dan、Takahashi Gou、Zheng Yun-Wen、Matsuo-Takasaki Mami、Li Jingyue、Takami Miho、An Yuri、Hemmi Yasuko、Miharada Natsumi、Fujioka Tsuyoshi、Noguchi Michiya、Nakajima Takashi、Saito Megumu K、Nakamura Yukio、Oda Tatsuya、Miyaoka Yuichiro、Hayashi Yohei
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 31 Issue: 21 Pages: 3652-3671
- DOI
  10.1093/hmg/ddac080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03442
[Journal Article] Rapid, precise quantification of large DNA excisions and inversions by ddPCR2020
- Author(s)
  Watry Hannah L.、Feliciano Carissa M.、Gjoni Ketrin、Takahashi Gou、Miyaoka Yuichiro、Conklin Bruce R.、Judge Luke M.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 14896-14896
- DOI
  10.1038/s41598-020-71742-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21409, KAKENHI-PROJECT-20H03442
[Presentation] Genome editing is induced in a binary manner in single human cells.2022
- Author(s)
  Takahashi G, Kondo D, Maeda M, Morishita Y, Miyaoka Y
- Organizer
  Cold Spring Harbor Laboratory Meeting, GENOME ENGINEERING: CRISPR FRONTIERS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] ウィルソン病特異的iPS細胞由来肝細胞におけるセルロプラスミン分泌と酸化ストレスに対するレチノイン酸の効果2022
- Author(s)
  林　洋平、宋　丹、高橋　剛、宮岡　佑一郎
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] ヒト１細胞中でゲノム編集は同時多発的に誘導される2022
- Author(s)
  高橋　剛、近藤　大輝、前田　湊、森下　祐至、宮岡　佑一郎
- Organizer
  日本ゲノム編集学会第7回大会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] CRISPR-Cas9によるゲノム編集結果の１細胞レベル解析2021
- Author(s)
  近藤　大輝、高橋　剛、森下　祐至、前田　湊、宮岡　佑一郎
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] Adsマウスの優性白斑における責任遺伝子の同定2021
- Author(s)
  落合　弘光、高橋　剛、張　了了、福村　啓文、下井　岳、亀山　祐一、松島　芳文、和田　健太
- Organizer
  第68回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] On-chip SPiSによる１細胞レベルゲノム編集結果解析2021
- Author(s)
  近藤　大輝、高橋　剛、森下　祐至、宮岡　佑一郎
- Organizer
  日本ゲノム編集学会第6回大会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] 一細胞内で生じるCRISPR-Cas9によるゲノム編集結果の解析2021
- Author(s)
  近藤　大輝、高橋　剛、森下　祐至、宮岡　佑一郎
- Organizer
  日本ゲノム編集学会第6回大会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] Profiling of deletion mutagenesis by CRISPR-Cas12a dual cleavage2021
- Author(s)
  高橋　剛、森　秀人、石黒　宗、谷内江　望、宮岡　佑一郎
- Organizer
  日本ゲノム編集学会第6回大会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in steatosis models of Wilson’s disease-specific hepatocytes.2021
- Author(s)
  Dan Song, Gou Takahashi, Yun-Wen Zheng, Mami Matsuo-Takasaki, Jingyue Li, Miho Takami, Yuri An, Yasuko Hemmi, Natsumi Miharada, Tsuyoshi Fujioka, Michiya Noguchi, Takashi Nakajima, Megumu K Saito, Yukio Nakamura, Tatsuya Oda, Yuichiro Miyaoka, Yohei Hayashi
- Organizer
  Cold Spring Harbor-Asia, Liver Development, Metabolism, Disease & Cancer Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] Profiling of deletion mutagenesis by CRISPR-Cas12a dual cleavage2021
- Author(s)
  高橋　剛、森　秀人, 石黒　宗、谷内江　望、宮岡　佑一郎
- Organizer
  日本ゲノム編集学会第6回大会
- Data Source
  KAKENHI-PROJECT-18K15054
[Presentation] CRISPR-Cas9システムを基盤とした相同組換えによる修復(HDR)亢進因子の新規探索2021
- Author(s)
  加藤　朋子、高橋　剛、宮岡　佑一郎
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] CRISPR-Cas12aによる欠失変異導入のプロファイリング2021
- Author(s)
  高橋剛
- Organizer
  日本ゲノム編集学会第6回大会
- Data Source
  KAKENHI-PROJECT-18K15054
[Presentation] 雄優勢的長毛形質におけるFgf5の変異アレル効果2021
- Author(s)
  高橋　諒、高橋　剛、下井　岳、亀山　祐一、佐藤　正宏、大塚　正人、和田　健太
- Organizer
  第68回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] Genome editing outcomes induced by CRISPR/Cas9 in single cells2020
- Author(s)
  近藤大輝、高橋剛、森下祐至、宮岡佑一郎
- Organizer
  第43回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03442
[Presentation] CRISPR-Cas12aによる正確な欠失変異導入2019
- Author(s)
  高橋剛
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15054

1. MIYAOKA Yuichiro (20549521)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. 加藤朋子 (10638802)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results

Takahashi go 高橋 剛

TAKAHASHI Gou 高橋 剛

Research Projects

Research Products

Co-Researchers

Cas12の連続的編集による高効率な欠失導入法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞種により異なる倍数性の意義をiPS細胞モデルにより追究する

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マウスの交配のように自在なヒトiPS細胞間の遺伝子交換手法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

医療応用可能なCRISPR-Cas12aによる欠失導入法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of non-random genome editing technology for therapeutic applications

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a precise deletion mutagenesis method using CRISPR/Cpf1 to enable gene therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Genome editing is induced in a binary manner in single human cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome Editing Is Induced in a Binary Manner in Single Human Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson’s disease-specific hepatocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid, precise quantification of large DNA excisions and inversions by ddPCR2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Genome editing is induced in a binary manner in single human cells.2022

Author(s)

Organizer

Data Source

[Presentation] ウィルソン病特異的iPS細胞由来肝細胞におけるセルロプラスミン分泌と酸化ストレスに対するレチノイン酸の効果2022

Author(s)

Organizer

Data Source

[Presentation] ヒト１細胞中でゲノム編集は同時多発的に誘導される2022

Author(s)

Organizer

Data Source

[Presentation] CRISPR-Cas9によるゲノム編集結果の１細胞レベル解析2021

Author(s)

Organizer

Data Source

[Presentation] Adsマウスの優性白斑における責任遺伝子の同定2021

Author(s)

Organizer

Takahashi go 高橋剛

TAKAHASHI Gou 高橋剛