Yoshida Kazuki 吉田一貴

Researcher Number	70803154
Other IDs
Affiliation (Current)	2025: 高崎健康福祉大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2025: 高崎健康福祉大学, 薬学部, 講師 2022 – 2023: 高崎健康福祉大学, 薬学部, 講師 2018 – 2021: 高崎健康福祉大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 47040:Pharmacology-related Except Principal Investigator Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator P2受容体 / 炎症性腸疾患 / ATP / 消化管粘膜 / P2X4受容体 / P2X受容体 / GPCR / 非受容体型チロシンキナーゼ / マスト細胞 Except Principal Investigator IgE … More / ヒトiPS細胞 / アレルギー疾患 / イオンチャネル / アレルギー反応 / ATP / EP3受容体 / プロスタグランジンE2 / P2X4受容体 / 炎症性サイトカイン / 脱顆粒反応 / プリン作動性シグナル / マスト細胞 Less

消化管粘膜防御におけるプリン受容体の機能解析Principal Investigator
- Principal Investigator
  
  吉田一貴
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Takasaki University of Health and Welfare
炎症性腸疾患におけるP2X4受容体の機能解析Principal Investigator
- Principal Investigator
  
  吉田一貴
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Takasaki University of Health and Welfare
Establishment of therapeutic basis for allergic diseases targeting P2X4 receptor of mast cells
- Principal Investigator
  
  Matsuoka Isao
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Takasaki University of Health and Welfare
The regulation mechanism of nRTKs activation by ionotropic receptorPrincipal Investigator
- Principal Investigator
  
  Yoshida Kazuki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Takasaki University of Health and Welfare

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Patent

[Journal Article] Amplification of poly(I:C)-induced interleukin-6 production in human bronchial epithelial cells by priming with interferon-γ2023
- Author(s)
  Okuma Norikazu、Ito Masa-aki、Shimizu Tomoyoshi、Hasegawa Atsuya、Ohmori Shin’ya、Yoshida Kazuki、Matsuoka Isao
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 21067-21067
- DOI
  10.1038/s41598-023-48422-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15282, KAKENHI-PROJECT-23K06169, KAKENHI-PROJECT-20K16010
[Journal Article] Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses2022
- Author(s)
  Matsuoka Isao、Yoshida Kazuki、Ito Masa-aki
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 150 Issue: 2 Pages: 94-99
- DOI
  10.1016/j.jphs.2022.07.005
- Data Source
  KAKENHI-PROJECT-22K15282
[Journal Article] Exploratory study of oxatomide derivatives with high P2X7 receptor inhibitory activity2022
- Author(s)
  Yamagiwa Noriyuki、Komine Mika、Hanaoka Fumi、Nobuta Tomoya、Yoshida Kazuki、Ito Masaaki、Matsuoka Isao
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 77 Pages: 129035-129035
- DOI
  10.1016/j.bmcl.2022.129035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16010, KAKENHI-PROJECT-22K15282
[Journal Article] Synergistic Cytokine Production by ATP and PGE2 via P2X4 and EP3 Receptors in Mouse Bone-Marrow-Derived Mast Cells2022
- Author(s)
  Obayashi Kosuke、Yoshida Kazuki、Ito Masa-aki、Mori Tetsuya、Yamamoto Kimiko、Imai Toshiyashu、Matsuoka Isao
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 4 Pages: 616-616
- DOI
  10.3390/cells11040616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07328, KAKENHI-PROJECT-18K14925, KAKENHI-PROJECT-21H03791, KAKENHI-PROJECT-20K16010
[Journal Article] P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice2022
- Author(s)
  Yoshida Kazuki、Tanihara Shota、Miyashita Yuki、Obayashi Kosuke、Ito Masa-aki、Yamamoto Kimiko、Imai Toshiyashu、Matsuoka Isao
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 18613-18613
- DOI
  10.1038/s41598-022-21667-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16010, KAKENHI-PROJECT-22K15282, KAKENHI-PROJECT-21H03791
[Journal Article] Differential Effects of Gq Protein-Coupled Uridine Receptor Stimulation on IL-8 Production in 1321N1 Human Astrocytoma Cells2022
- Author(s)
  Ito Masa-aki、Kojima Erika、Yanagihara Yu、Yoshida Kazuki、Matsuoka Isao
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 6 Pages: 691-697
- DOI
  10.1248/bpb.b21-01020
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16010, KAKENHI-PROJECT-22K15282
[Journal Article] Elucidation of Mast Cell Activation Mechanism Mediated by Purinergic Signaling2021
- Author(s)
  Yoshida Kazuki
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 9 Pages: 1057-1061
- DOI
  10.1248/yakushi.21-00113
- NAID
  130008081765
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-09-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07328, KAKENHI-PROJECT-18K14925
[Journal Article] ATP/P2X4受容体枢軸によるIgE依存性マスト細胞脱顆粒の増強反応2021
- Author(s)
  松岡　功、吉田一貴、伊藤正明
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 75 Pages: 369-376
- NAID
  40022504137
- Data Source
  KAKENHI-PROJECT-19K07328
[Journal Article] マスト細胞のP2X4受容体を介したアレルギー反応の増強2021
- Author(s)
  松岡　功、吉田一貴、伊藤正明
- Journal Title
  
  アレルギーの臨床
  
  Volume: 41 Pages: 176-180
- Data Source
  KAKENHI-PROJECT-19K07328
[Journal Article] Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation2020
- Author(s)
  Yoshida Kazuki、Ito Masa-aki、Sato Naoko、Obayashi Kosuke、Yamamoto Kimiko、Koizumi Schuichi、Tanaka Satoshi、Furuta Kazuyuki、Matsuoka Isao
- Journal Title
  
  The Journal of Immunology
  
  Volume: 204 Issue: 12 Pages: 3077-3085
- DOI
  10.4049/jimmunol.1900954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07328, KAKENHI-PROJECT-20K07040, KAKENHI-PROJECT-18K14925, KAKENHI-PROJECT-20K16010, KAKENHI-PUBLICLY-19H04746, KAKENHI-PUBLICLY-20H05060, KAKENHI-PROJECT-18H03510, KAKENHI-PROJECT-17K08273, KAKENHI-PROJECT-19K22952, KAKENHI-PROJECT-16H06276
[Journal Article] Co-Stimulation of Purinergic P2X4 and Prostanoid EP3 Receptors Triggers Synergistic Degranulation in Murine Mast Cells2019
- Author(s)
  Yoshida、Tajima、Nagano、Obayashi、Ito、Yamamoto、Matsuoka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 20 Pages: 5157-5157
- DOI
  10.3390/ijms20205157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07328, KAKENHI-PROJECT-18K14925
[Patent] 偽アレルギー反応に伴う症状の予防若しくは抑制又は治療用の医薬組成物2022
- Inventor(s)
  松岡功、伊藤政明、吉田一貴、今井利安
- Industrial Property Rights Holder
  松岡功、伊藤政明、吉田一貴、今井利安
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-060261
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-18K14925
[Presentation] マウスの大腸上皮細胞の遺伝子発現に対するP2X4受容体欠損の影響2024
- Author(s)
  吉田一貴、青木亮、萩原武蔵、伊藤政明、松岡功
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15282
[Presentation] GPCRによるマスト細胞活性化に対するP2X4受容体の促進作用2023
- Author(s)
  吉田一貴
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15282
[Presentation] ヒト神経膠芽腫A172細胞におけるATPによるインターロイキン６産生亢進作用の解析2022
- Author(s)
  青木楓佳, 伊藤政明, 吉田一貴, 松岡功
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] Purinergic regulation of mast cell function and allergic response via ionotropic P2X4 receptors2022
- Author(s)
  Kazuki yoshida
- Organizer
  日本薬理学会第96年会
- Data Source
  KAKENHI-PROJECT-22K15282
[Presentation] マスト細胞におけるATPとPGE2の共刺激による相乗的サイトカイン産生2022
- Author(s)
  大林昂右，吉田一貴，伊藤政明，松岡功
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] ヒト気道上皮NCl-H292細胞のサイトカイン産生における IFN-γとPoly(I:C)の相乗効果2022
- Author(s)
  大熊範和, 伊藤政明, 吉田一貴, 松岡功
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] P2X4 receptor signaling potentiate Mas-relate G protein-coupled receptor B2-induced mast cell degranulation2022
- Author(s)
  Kazuki Yoshida，Kousuke Obayashi，Syouta Tanihara，Yuuki Miyashita，Masa-aki Ito，Isao Matsuoka,
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K14925
[Presentation] P2X4受容体は偽アレルギー反応を増強する2022
- Author(s)
  吉田一貴，谷原祥太, 宮下友希, 大林晃右, 伊藤政明, 松岡功
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] P2X4 receptor signaling potentiate Mas-relate G protein-coupled receptor B2-induced mast cell degranulation2022
- Author(s)
  Kazuki Yoshida，Kousuke Obayashi，Syouta Tanihara，Yuuki Miyashita，Masa-aki Ito，Isao Matsuoka,
- Organizer
  第95回日本薬理学会年会,
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] IL-33 affects the expression of　purinergic receptors in bone marrow-derived mast cells.2021
- Author(s)
  Kazuki Yoshida，Yuu Ishida，Masaaki Ito，Isao Matsuoka
- Organizer
  第９４回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] マウス胸部大動脈器官培養による生理活性物質の血管機能に及ぼす影響の解析，2021
- Author(s)
  伊藤政明，中山睦子，吉田一貴，松岡功
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] Regulation by purinergic signal of glucose-induced insulin secretion from iGL insulinoma cells.2021
- Author(s)
  Masa-aki Ito，Chinatsu Machida，Kazuki Yoshida，Isao Matsuoka
- Organizer
  第９４回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] マスト細胞のサイトカイン産出に及ぼす細胞外ATPの作用2021
- Author(s)
  大林昂右，吉田一貴，伊藤政明，松岡功，
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] Upregulation of P2X7 receptor signaling by interleukin-33 in mouse bone marrow-derived mast cells2021
- Author(s)
  Kazuki Yoshida, Yuu Ishida, Masaaki Ito, Isao Matsuoka
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K14925
[Presentation] P2X4受容体が結合組織型マスト細胞の脱顆粒反応に及ぼす影響2021
- Author(s)
  吉田一貴、伊藤政明、松岡功
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K14925
[Presentation] オキサトミド誘導体のヒトP2X7受容体阻害作用2020
- Author(s)
  花岡芙美、宮本美希、福田康進、小峯美香、丹羽綾音、山際教之、吉田一貴、伊藤政明、松岡功
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] Effect of compound48/80 on antigen-dependent degranulation in BMMC2020
- Author(s)
  Yoshida　K，Takao　T，Ito　M， Matsuoka　I
- Organizer
  第93回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] 骨髄由来マスト細胞のプリン受容体発現に対するIL-33の効果2020
- Author(s)
  吉田一貴，石田悠，伊藤政明，松岡功
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K14925
[Presentation] 骨髄由来マスト細胞のプリン受容体発現に対するIL-33の効果2020
- Author(s)
  吉田一貴、石田悠、伊藤政明、松岡功
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] プリン受容体を解するマスト細胞活性化メカニズムの解明2020
- Author(s)
  吉田一貴
- Organizer
  第64回日本薬学会関東支部
- Data Source
  KAKENHI-PROJECT-18K14925
[Presentation] Role of purinergic P2X4 receptors in antigen-induced mast cell degranulation and allergic responses2020
- Author(s)
  Yoshida　K
- Organizer
  第49回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K14925
[Presentation] P2Y1受容体を介するIL-8産生に対するスタチンの抑制作用2020
- Author(s)
  伊藤政明、新井祥太、吉田一貴、松岡功
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] Changes of thoracic and mesenteric arterial vascular function in angiotensin II-induced hypertensive mice2020
- Author(s)
  Ito　M, Hayashi　T, Koyama　T,　Yoshida　K, Matsuoka I
- Organizer
  第93回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] Effect of compound48/80 on antigen-dependent degranulation in BMMC2020
- Author(s)
  Yoshida K，Takao T，Ito M，Matsuoka I
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K14925
[Presentation] Role of purinergic P2X4 receptors in antigen-induced mast cell degranulation and allergic responses2019
- Author(s)
  Yoshida　K
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07328
[Presentation] 粘膜型および組織型マスト細胞におけるP2X4 受容体を介する脱顆粒反応の調節2019
- Author(s)
  吉田一貴, 伊藤政明, 古田和幸, 田中智之, 松岡功
- Organizer
  日本薬学会第139年会、千葉
- Data Source
  KAKENHI-PROJECT-18K14925
[Presentation] Role of ionotropic P2X receptor signalling in regulation of mast cell function2018
- Author(s)
  Matsuoka I, Yoshida K, Hoshino Y, Ito M
- Organizer
  World Congress on Pharmacology and Toxicology, Rome
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14925
[Presentation] Synergistic effect of ATP and prostaglandin E2 on mast cell degranulation2018
- Author(s)
  Yoshida K, Ito M, Tajima M, Nagano T, Matsuoka I,
- Organizer
  The 18th WCP, Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14925

1. Matsuoka Isao (10145633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
2. 伊藤政明 (30438759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results

Yoshida Kazuki 吉田 一貴

Research Projects

Research Products

Co-Researchers

消化管粘膜防御におけるプリン受容体の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症性腸疾患におけるP2X4受容体の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of therapeutic basis for allergic diseases targeting P2X4 receptor of mast cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The regulation mechanism of nRTKs activation by ionotropic receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Amplification of poly(I:C)-induced interleukin-6 production in human bronchial epithelial cells by priming with interferon-γ2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploratory study of oxatomide derivatives with high P2X7 receptor inhibitory activity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synergistic Cytokine Production by ATP and PGE2 via P2X4 and EP3 Receptors in Mouse Bone-Marrow-Derived Mast Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential Effects of Gq Protein-Coupled Uridine Receptor Stimulation on IL-8 Production in 1321N1 Human Astrocytoma Cells2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Elucidation of Mast Cell Activation Mechanism Mediated by Purinergic Signaling2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] ATP/P2X4受容体枢軸によるIgE依存性マスト細胞脱顆粒の増強反応2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] マスト細胞のP2X4受容体を介したアレルギー反応の増強2021

Author(s)

Journal Title

Data Source

[Journal Article] Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation2020

Yoshida Kazuki 吉田一貴

[Presentation] マウスの大腸上皮細胞の遺伝子発現に対するP2X4受容体欠損の影響2024

[Presentation] IL-33 affects the expression of　purinergic receptors in bone marrow-derived mast cells.2021