Fujita Kenichi 藤田賢一

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fujita ken-ichi 藤田賢一

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Researcher Number	70816884
Other IDs
Affiliation (Current)	2025: 九州大学, 生体防御医学研究所, 特別研究員(PD)
Affiliation (based on the past Project Information) *help	2025: 九州大学, 生体防御医学研究所, 特別研究員(PD) 2023 – 2024: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2021 – 2023: 藤田医科大学, 医科学研究センター, 助教 2020: 藤田医科大学, 総合医科学研究所, 助教 2019: 京都大学, 生命科学研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 38060:Applied molecular and cellular biology-related Except Principal Investigator Broad Section F / Basic Section 38030:Applied biochemistry-related
Keywords	Principal Investigator エキシトロン / EJC / スプライシング / 再スプライシング現象 / がん抑制 / スプライシング完了機構 / EIF4A3 / mRNA再スプライシング / 癌 / EJC複合体 … More / がん / 再スプライシング / インフォマティクス解析 / 構造解析 / mRNA輸送体 / トランスクリプトーム解析 / 結晶構造解析 / 選択的mRNA輸送 … More Except Principal Investigator mRNA / タンパク質生産 / ネットワーク / 核外輸送経路 / NXF1 / ATREX / 核外輸送 / export / splicing / AREX / TREX Less

Toward an Integrated Understanding of Nuclear Key Effector Networks for mRNA Expression Optimization and a Use of Genetically Engineered mRNA Export Pathway for Protein Production.
- Principal Investigator
  
  増田誠司
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section F
- Research Institution
  Kindai University
新たなスプライシング様式「エキシトロン」から新展開するがん抑制への基盤研究Principal Investigator
- Principal Investigator
  
  藤田賢一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
ヒトにおける核内mRNA輸送経路の多様化とその生理的意義の解明
- Principal Investigator
  
  増田誠司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Kindai University
Elucidation of cancer-specific re-splicing regulatory mechanisms as a basis for new cancer suppression strategiesPrincipal Investigator
- Principal Investigator
  
  Fujita Kenichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cancer Center Japan
  Fujita Health University
Integrated analysis of selective mRNA export by mRNA export factors, UAP56 and URH49Principal Investigator
- Principal Investigator
  
  fujita ken-ichi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  Fujita Health University
  Kyoto University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 「mRNAの制御機構の解明と治療薬・ワクチンへの活用」中の「スプラシング制御１ mRNA転写・プロセシング・核外輸送・品質管理における相互連携の重要性」2023
- Author(s)
  藤田賢一、堀史人、鵜飼生望、前田明、増田誠司
- Total Pages
  411
- Publisher
  技術情報協会
- ISBN
  9784861049378
- Data Source
  KAKENHI-PROJECT-23K23531
[Journal Article] Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.2024
- Author(s)
  K-I. Fujita, M. Ito, M. Irie, K. Harada, N. Fujiwara, Y. Ikeda, H. Yoshioka, T. Yamazaki, M. Kojima, B. Mikami, A. Mayeda, S. Masuda
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 455-455
- DOI
  10.1038/s41467-023-44217-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06024, KAKENHI-PROJECT-21K19078, KAKENHI-PROJECT-21K15538, KAKENHI-PUBLICLY-23H04258, KAKENHI-PROJECT-23K23809
[Journal Article] MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus2022
- Author(s)
  Fujiwara Naoko、Shigemoto Maki、Hirayama Mizuki、Fujita Ken-ichi、Seno Shigeto、Matsuda Hideo、Nagahama Masami、Masuda Seiji
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 50 Issue: 15 Pages: 8779-8806
- DOI
  10.1093/nar/gkac559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19078, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K23531
[Journal Article] The exon junction complex core represses cancer-specific mature mRNA re-splicing: A potential key role in terminating splicing.2021
- Author(s)
  Y. Otani, K.-i. Fujita, T. Kameyama, A. Mayeda
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 22 Issue: 12 Pages: 6519-6519
- DOI
  10.3390/ijms22126519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06024, KAKENHI-PROJECT-21K15538
[Journal Article] URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway2020
- Author(s)
  Fujita Ken-ichi、Yamazaki Tomohiro、Harada Kotaro、Seno Shigeto、Matsuda Hideo、Masuda Seiji
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  
  Volume: 1863 Issue: 2 Pages: 194480-194480
- DOI
  10.1016/j.bbagrm.2020.194480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02884, KAKENHI-PROJECT-19K15807
[Journal Article] Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds2020
- Author(s)
  Fujita Ken-ichi、Ishizuka Takaki、Mitsukawa Mizuki、Kurata Masashi、Masuda Seiji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 6 Pages: 2026-2026
- DOI
  10.3390/ijms21062026
- NAID
  120006936384
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22280, KAKENHI-PROJECT-19H02884, KAKENHI-PROJECT-19K15807
[Journal Article] Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites2019
- Author(s)
  Kurata Masashi、Fujiwara Naoko、Fujita Ken-ichi、Yamanaka Yasutaka、Seno Shigeto、Kobayashi Hisato、Miyamae Yusaku、Takahashi Nobuyuki、Shibuya Yasuyuki、Masuda Seiji
- Journal Title
  
  iScience
  
  Volume: 22 Pages: 336-352
- DOI
  10.1016/j.isci.2019.11.033
- NAID
  120007132694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22280, KAKENHI-PROJECT-19K15807, KAKENHI-PROJECT-19H02884, KAKENHI-PROJECT-17K13264
[Presentation] Exon Junction Complex (EJC) triggers compacted mRNP structure that represses cancer-associated aberrant splicing in exitron (exonic intron)2023
- Author(s)
  Ken-ichi Fujita, Yuta Ohtani, Toshiki Kameyama, Peter Venhuizen, Kenkichi Masutomi, Maria Kalyna, Akila Mayeda
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15538
[Presentation] EJC CORE-TRIGGERED COMPACTED mRNP STRUCTURE REPRESSES CANCER-SPECIFIC SPLICING2023
- Author(s)
  Ken-ich Fujita, Yuta Otani, Toshiki Kameyama, Peter Venhuizen, Maria, Kalyna, Akila Mayeda
- Organizer
  EUKARYOTIC mRNA PROCESSING
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15538
[Presentation] Closely related RNA helicases, UAP56 and URH49, form distinct TREX and AREX complexes that promote specific pre-mRNA splicing followed by mRNA export2020
- Author(s)
  Ken-ichi Fujita, Yuya Ikeda, Hanae Yoshioka, Shigeto Seno, Yukio Kawahara, Bunzo Mikami, Masaki Kojima, Seiji Masuda, Akila Mayeda
- Organizer
  分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K15807
[Presentation] UAP56とURH49によるスプライシング制御を介した選択的mRNA輸送機構の解明2020
- Author(s)
  藤田賢一、池田宥哉、吉岡英恵、瀬尾茂人、増田誠司
- Organizer
  京都生体質量分析研究会シンポジウム
- Data Source
  KAKENHI-PROJECT-19K15807
[Presentation] UAP56とURH49によるスプライシング制御を介した選択的mRNA輸送機構の解明2019
- Author(s)
  藤田賢一、池田宥哉、吉岡英恵、増田誠司
- Organizer
  RNA学会
- Data Source
  KAKENHI-PROJECT-19K15807
[Presentation] UAP56とURH49によるスプライシング制御を介した選択的mRNA輸送機構の解明2019
- Author(s)
  藤田賢一、池田宥哉、吉岡英恵、瀬尾茂人、増田誠司
- Organizer
  分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K15807

1. 増田誠司 (20260614)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. 山崎智弘 (90732280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 瀬尾茂人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 前田明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Fujita Kenichi 藤田 賢一

fujita ken-ichi 藤田 賢一

Research Projects

Research Products

Co-Researchers

Toward an Integrated Understanding of Nuclear Key Effector Networks for mRNA Expression Optimization and a Use of Genetically Engineered mRNA Export Pathway for Protein Production.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新たなスプライシング様式「エキシトロン」から新展開するがん抑制への基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトにおける核内mRNA輸送経路の多様化とその生理的意義の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of cancer-specific re-splicing regulatory mechanisms as a basis for new cancer suppression strategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated analysis of selective mRNA export by mRNA export factors, UAP56 and URH49Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 「mRNAの制御機構の解明と治療薬・ワクチンへの活用」中の「スプラシング制御１ mRNA転写・プロセシング・核外輸送・品質管理における相互連携の重要性」2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The exon junction complex core represses cancer-specific mature mRNA re-splicing: A potential key role in terminating splicing.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Exon Junction Complex (EJC) triggers compacted mRNP structure that represses cancer-associated aberrant splicing in exitron (exonic intron)2023

Author(s)

Organizer

Data Source

[Presentation] EJC CORE-TRIGGERED COMPACTED mRNP STRUCTURE REPRESSES CANCER-SPECIFIC SPLICING2023

Author(s)

Organizer

Fujita Kenichi 藤田賢一

fujita ken-ichi 藤田賢一