Hayama Tomonari 葉山智工

Researcher Number	70819903
Other IDs	https://orcid.org/0000-0002-8515-4134
Affiliation (Current)	2025: 横浜市立大学, 附属市民総合医療センター, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 横浜市立大学, 附属市民総合医療センター, 講師
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator 生殖細胞 / 卵巣胎児癌 / 卵巣悪性腫瘍 / モデル動物 / リプログラミング / 発癌 / 卵巣胚細胞性腫瘍 Except Principal Investigator 胚 / 生物学的マーカー / 着床 … More / バイオマーカー / 卵成熟 / 卵胞液 / 染色体モザイク胚 / 着床後経過 / ミトコンドリアDNA / ミトコンドリア / 着床前診断 / 染色体モザイク Less

着床期の胚・子宮内膜相互作用をコントロールする新規分子の解析
- Principal Investigator
  
  村瀬真理子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Yokohama City University
Why are healthy children born from mosaic embryos?
- Principal Investigator
  
  MIyakoshi Ai
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Yokohama City University
Inappropriate Reprogramming Induce Carcinogenesis of Ovarian Embryonal CarcinomaPrincipal Investigator
- Principal Investigator
  
  Hayama Tomonari
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Yokohama City University

All 2023 2022 2021 2020

All Journal Article Presentation Book Patent

[Book] 生殖医療フロントラインMOOK2、受精とその障害2022
- Author(s)
  葉山智工　上野寛枝
- Total Pages
  6
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20K18169
[Journal Article] Mitochondrial DNA mutations can influence the post-implantation development of human mosaic embryos2023
- Author(s)
  Ijuin Akifumi、Ueno Hiroe、Hayama Tomonari、Miyai Shunsuke、Miyakoshi Ai、Hamada Haru、Sueyoshi Sumiko、Tochihara Shiori、Saito Marina、Hamanoue Haruka、Takeshima Teppei、Yumura Yasushi、Miyagi Etsuko、Kurahashi Hiroki、Sakakibara Hideya、Murase Mariko
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 11 Pages: 1215626-1215626
- DOI
  10.3389/fcell.2023.1215626
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08855, KAKENHI-PROJECT-21K09474
[Journal Article] 【ミトコンドリア　疾患治療の新時代】生殖補助技術を用いた受精胚でのミトコンドリア病の根本治療戦略と展望2023
- Author(s)
  葉山智工
- Journal Title
  
  実験医学増刊号
  
  Volume: Vol.41 No.5 Pages: 180-187
- Data Source
  KAKENHI-PROJECT-20K18169
[Journal Article] Outcomes of the study of intracytoplasmic sperm injection (ICSI) and sperm motility with microdissection testicular sperm extraction2022
- Author(s)
  Murase Mariko、Arai Yuuka、Ueno Hiroe、Yamamoto Mizuki、Izumi Haruna、Takeshima Kazumi、Hayama Tomonari、Sakakibara Hideya、Yumura Yasushi、Miyagi Etsuko
- Journal Title
  
  Asian Journal of Andrology
  
  Volume: 24 Issue: 2 Pages: 221-221
- DOI
  10.4103/aja202152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18169
[Journal Article] The acceptance to germline gene therapy increased during <scp>COVID</scp> ‐19 pandemic among Japanese medical students2022
- Author(s)
  Ijuin Akifumi、Hayama Tomonari、Sakakibara Hideya
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 48 Issue: 6 Pages: 1495-1496
- DOI
  10.1111/jog.15246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18169
[Journal Article] 不妊治療の保険適用拡大の意義－薬局薬剤師への影響を含めて2022
- Author(s)
  葉山智工　倉澤健太郎
- Journal Title
  
  調剤と情報
  
  Volume: Vol28、No13 Pages: 2192-2197
- Data Source
  KAKENHI-PROJECT-20K18169
[Journal Article] 【特集　受精と胚発生をめぐる話題】ミトコンドリア遺伝子異常とその治療2022
- Author(s)
  葉山智工
- Journal Title
  
  HORMONE FRONTIER IN GYNECOLOGY
  
  Volume: 29（1） Pages: 37-42
- Data Source
  KAKENHI-PROJECT-20K18169
[Journal Article] Fertility preservation immediately after therapeutic abortion results in multiple normal follicular growth with the absence of mature oocytes due to early luteinization: a case report and literature review2021
- Author(s)
  Hamada Haru、Hayama Tomonari、Ijuin Akifumi、Miyakoshi Ai、Kasai Michi、Tochihara Shiori、Saito Marina、Nishi Mayuko、Ueno Hiroe、Yamamoto Mizuki、Komeya Mitsuru、Yumura Yasushi、Sakakibara Hideya、Miyagi Etsuko、Murase Mariko
- Journal Title
  
  Gynecological Endocrinology
  
  Volume: 37 Issue: 11 Pages: 1050-1053
- DOI
  10.1080/09513590.2021.1950135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18169
[Journal Article] Deleterious mtDNA Mutations are Common in Mature Oocytes.2020
- Author(s)
  Hayama T, Ma H, Van Dyken C, Darby H, Koski A, Lee Y, Gutierrez NM, Yamada S, Li Y, Andrews M, Ahmed R, Liang D, Gonmanee T, Kang E, Nasser M, Kempton B, Brigande J, McGill TJ, Terzic A, Amato P, Mitalipov S.
- Journal Title
  
  Biol Reprod.
  
  Volume: 102 Issue: 3 Pages: 607-619
- DOI
  10.1093/biolre/ioz202
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18169
[Patent] 妊孕性を判定するためのバイオマーカー及びそれを用いた判定方法2022
- Inventor(s)
  伊集院昌郁、葉山智工ら
- Industrial Property Rights Holder
  伊集院昌郁、葉山智工ら
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-169943
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20K18169
[Patent] 妊孕性を判定するためのバイオマーカー及びそれを用いた判定方法2021
- Inventor(s)
  宮城悦子、葉山智工ら
- Industrial Property Rights Holder
  宮城悦子、葉山智工ら
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20K18169
[Presentation] Mitochondrial DNA mutations can influence the post-implantation chromosomal purification and development in human embryos2023
- Author(s)
  Akifumi Ijuin, Tomonari Hayama, Ai Miyakoshi, Haru Hamada, Sumiko Sueyoshi, Haruka Hamanoue, Etsuko Miyagi, Hiroki Kurahashi, Hideya Sakakibara, Mariko Murase
- Organizer
  第75回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09474
[Presentation] Inappropriate Reprogramming Induce Carcinogenesis of Ovarian Embryonal Carcinoma in Rodent Ovary2023
- Author(s)
  Tomonari Hayama, Hideya Sakakibara, Etsuko Miyagi, Tomoyuki Yamaguchi
- Organizer
  第75回日本産科婦人科学会学術講演会、東京
- Data Source
  KAKENHI-PROJECT-20K18169
[Presentation] 卵胞液中に存在するタンパク質Aと妊娠の関係性2022
- Author(s)
  葉山智工，伊集院昌郁，上野寛枝，小堀宏樹，栃原しおり，末吉寿実鼓，濱田春，宮腰藍衣，齋藤満里奈，大池有紀，竹島徹平，榊原秀也，湯村寧，宮城悦子，村瀬真理子
- Organizer
  第67回日本生殖医学会学術講演会、横浜
- Data Source
  KAKENHI-PROJECT-20K18169
[Presentation] High spontaneous abortions in ICSI pregnancies using fertility-preserving frozen sperm in patients with testicular germ cell tumor (TGCT)2022
- Author(s)
  Haru Hamda, Tomonari Hayama, Akifumi Ijuin, Mizuki Yamamoto, Hiroe Ueno, Ai Miyakoshi, Mayuko Nishi, Marina Saito, Shiori Tochihara, Mitsuru Komeya, Teppei Takeshima, Shinnosuke Kuroda, Tomiki Saito, Miki Tanoshima, Kazumi Takeshima, Haruka Hamanoue, Hideya Sakakibara, Yasushi Yumura, Etsuko Miyagi & Mariko Murase
- Organizer
  ESHRE 2022 European Society of Human Reproduction and Embryology 38th annual meewting, Milan Italy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18169
[Presentation] Purifying selection for aneuploidy cells in mosaicism embryo at post-implantation stage.2021
- Author(s)
  Tomonari Hayama, Akifumi Ijuin, Hiroe Ueno, Haru Hamada, Ai Miyakoshi, Mayuko Nishi, Marina Saito, Haruka Hamanoue, Mitsuru Komeya, Teppei Takeshima, Shinnosuke Kuroda, Hideya Sakakibara, Yasushi Yumura, Etsuko Miyagi & Mariko Murase
- Organizer
  ESHRE 2021 European Society of Human Reproduction and Embryology 37th virtual annual meewting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18169
[Presentation] Purifying selection for aneuploidy cells in mosaicism embryo at post-implantation stage.2021
- Author(s)
  Tomonari Hayama, Akifumi Ijuin, Hiroe Ueno, Haru Hamada, Ai Miyakoshi, Mayuko Nishi, Marina Saito, Haruka Hamanoue, Mitsuru Komeya, Teppei Takeshima, Shinnosuke Kuroda, Hideya Sakakibara, Yasushi Yumura, Etsuko Miyagi, Mariko Murase
- Organizer
  37th Virtual Annual Meeting of the European Society of Human Reproduction and Embryology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09474
[Presentation] Inappropriate Reprogramming Factors Induce Sequential Ovarian Tumor Development in Rodent Ovary; Serous Cystadenoma- Benign Teratoma-Embryonal Carcinoma Sequence2020
- Author(s)
  Tomonari Hayama, Hideya Sakakibara, Etsuko Miyagi 第72回日本産科婦人科学会学術講演会、東京、2020年4月25
- Organizer
  第72回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K18169

1. 上野寛枝 (20425713)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 村瀬真理子 (80315796)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. MIyakoshi Ai (40866513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 浜之上はるか (90573759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 木村弥生 (80391936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 倉橋浩樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 工藤寛枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayama Tomonari 葉山 智工

Research Projects

Research Products

Co-Researchers

着床期の胚・子宮内膜相互作用をコントロールする新規分子の解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Why are healthy children born from mosaic embryos?

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inappropriate Reprogramming Induce Carcinogenesis of Ovarian Embryonal CarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 生殖医療フロントラインMOOK2、受精とその障害2022

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Mitochondrial DNA mutations can influence the post-implantation development of human mosaic embryos2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 【ミトコンドリア 疾患治療の新時代】生殖補助技術を用いた受精胚でのミトコンドリア病の根本治療戦略と展望2023

Author(s)

Journal Title

Data Source

[Journal Article] Outcomes of the study of intracytoplasmic sperm injection (ICSI) and sperm motility with microdissection testicular sperm extraction2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The acceptance to germline gene therapy increased during <scp>COVID</scp> ‐19 pandemic among Japanese medical students2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 不妊治療の保険適用拡大の意義－薬局薬剤師への影響を含めて2022

Author(s)

Journal Title

Data Source

[Journal Article] 【特集 受精と胚発生をめぐる話題】ミトコンドリア遺伝子異常とその治療2022

Author(s)

Journal Title

Data Source

[Journal Article] Fertility preservation immediately after therapeutic abortion results in multiple normal follicular growth with the absence of mature oocytes due to early luteinization: a case report and literature review2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deleterious mtDNA Mutations are Common in Mature Oocytes.2020

Author(s)

Journal Title

DOI

Data Source

[Patent] 妊孕性を判定するためのバイオマーカー及びそれを用いた判定方法2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] 妊孕性を判定するためのバイオマーカー及びそれを用いた判定方法2021

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Acquisition Date

Data Source

[Presentation] Mitochondrial DNA mutations can influence the post-implantation chromosomal purification and development in human embryos2023

Author(s)

Hayama Tomonari 葉山智工

[Journal Article] 【ミトコンドリア　疾患治療の新時代】生殖補助技術を用いた受精胚でのミトコンドリア病の根本治療戦略と展望2023

[Journal Article] 【特集　受精と胚発生をめぐる話題】ミトコンドリア遺伝子異常とその治療2022