Waddingham Mark ＷａｄｄｉｎｇｈａｍＭａｒｋ

… Alternative Names

WADDINGHAM MARK THOMAS ワディンガムマーク.トーマス

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Researcher Number	70822211
Other IDs	https://orcid.org/0000-0002-0058-9455
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2022 – 2023: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2021: 国立研究開発法人国立循環器病研究センター, 研究所, リサーチフェロー 2021: 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 2019 – 2020: 国立研究開発法人国立循環器病研究センター, 病院, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 48020:Physiology-related Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator Sarcomere / Myocardium / Heat Shock Proteins / Cardiomyocyte / Right Ventricle / Pulmonary Hypertension / Diastolic Dysunction / HCM / Microtubules / Myofilaments … More / Diastolic Dysfunction / SSRIs / Sympathetic Nervous Sys. / Heart Failure / Pressure-Volume Loop / X-ray Diffraction / Myofilament … More Except Principal Investigator sarcomere proteins / contractile dysfunction / heart failure / coronary dysfunction / cardiac hypertrophy Less

Investigating the mechanisms of regional hypercontractility and progression of hypertrophic cardiomyopathy and the efficacy of novel therapeutics
- Principal Investigator
  
  Pearson James
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Investigating Novel Mechanisms of Diastolic Dysfunction in Hypertrophic CardiomyopathyPrincipal Investigator
- Principal Investigator
  
  Waddingham Mark
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Cardiovascular Center Research Institute
The Pathophysiological Factors Driving Diastolic Dysfunction of the Right Heart in Pulmonary HypertensionPrincipal Investigator
- Principal Investigator
  
  Waddingham Mark
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Understanding the pathogenesis of right heart failure in pulmonary arterial hypertensionPrincipal Investigator
- Principal Investigator
  
  WADDINGHAM MARK THOMAS
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Cardiovascular Center Research Institute

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Using Synchrotron Radiation Imaging Techniques to Elucidate the Actions of Hexarelin in the Heart of Small Animal Models2022
- Author(s)
  Waddingham Mark T.、Tsuchimochi Hirotsugu、Sonobe Takashi、Asano Ryotaro、Jin Huiling、Ow Connie P. C.、Schwenke Daryl O.、Katare Rajesh、Aoyama Kohki、Umetani Keiji、Hoshino Masato、Uesugi Kentaro、Shirai Mikiyasu、Ogo Takeshi、Pearson James T.
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 12 Pages: 1-15
- DOI
  10.3389/fphys.2021.766818
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16498, KAKENHI-PROJECT-20K17137, KAKENHI-PROJECT-19H03405, KAKENHI-PROJECT-22K16121
[Presentation] Myofilament changes may drive right ventricular dysfunction ahead of pulmonary hypertension in a rat model of left ventricular diastolic dysfunction.2024
- Author(s)
  Mark T. Waddingham, Hirotsugu Tsuchimochi, Takeshi Ogo, James T. Pearson
- Organizer
  The 101st Annual Meeting of The Physiological Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-22K15368
[Presentation] Myofilament protein post-translational modifications may underlie right ventricular dysfunction in pulmonary hypertension2023
- Author(s)
  Waddingham MT, Tsuchimochi H, Ogo T, Pearson JT
- Organizer
  The 100th Anniversary Annual Meeting of The Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-22K15368
[Presentation] Myofilament changes may drive right ventricular dysfunction ahead of pulmonary hypertension in a rat model of left ventricular diastolic dysfunction.2023
- Author(s)
  Mark T. Waddingham, Hirotsugu Tsuchimochi, Takeshi Ogo, James T. Pearson
- Organizer
  The 7th JCS Council Forum on Basic Cardiovascular Research
- Data Source
  KAKENHI-PROJECT-22K15368
[Presentation] The Super Relaxed State of Myosin Contributes to the Pathogenesis of Right Ventricular Dysfunction in Pulmonary Hypertension2022
- Author(s)
  Waddingham MT, Tsuchimochi H, Asano R, Sonobe T, Higuchi T, Aoyama K, Shirai M, Pearson JT, Ogo T
- Organizer
  American Heart Association Scientific Sessions 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15368
[Presentation] Paroxetine improves right ventricular-pulmonary artery coupling in a rat model of pulmonary hypertension2022
- Author(s)
  Waddingham MT, Tsuchimochi H, Sonobe T, Pearson JT, Ogo T
- Organizer
  The 99th Annual Meeting of the Physiological Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16498
[Presentation] Myofilament protein post-translational modifications may underlie right ventricular dysfunction in pulmonary hypertension2022
- Author(s)
  Waddingham MT, Tsuchimochi H, Ogo T, Pearson JT
- Organizer
  The 6th JCS Council Forum on Basic CardioVascular Research (JCS Council-BCVR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15368
[Presentation] Paroxetine improves right ventricular-pulmonary artery coupling in a rat model of pulmonary hypertension2021
- Author(s)
  Waddingham MT, Tsuchimochi H, Sonobe T, Pearson JT, Ogo T
- Organizer
  The 5th JSC Council Forum on Basic Cardiovascular Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16498
[Presentation] Dysregulation of actin-myosin cross-bridges contribute to the pathogenesis of RV dysfunction in pulmonary hypertension2020
- Author(s)
  Waddingham MT, Tsuchimochi H, Asano R, Sonobe T, Shirai M, Pearson JT, Ogo T
- Organizer
  HFA Discoveries
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16498
[Presentation] A potential role for GRK2 in the development of right ventricular dysfunction in pulmonary arterial hypertension2019
- Author(s)
  Mark T Waddingham
- Organizer
  Japan Circulation Society Council Forum on Basic Cardiovascular Research
- Data Source
  KAKENHI-PROJECT-19K16498

1. Pearson James (30261390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 土持裕胤 (60379948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 森健二 (00416223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 岩田裕子 (80171908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Waddingham Mark Ｗａｄｄｉｎｇｈａｍ Ｍａｒｋ

WADDINGHAM MARK THOMAS ワディンガム マーク.トーマス

Research Projects

Research Products

Co-Researchers

Investigating the mechanisms of regional hypercontractility and progression of hypertrophic cardiomyopathy and the efficacy of novel therapeutics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating Novel Mechanisms of Diastolic Dysfunction in Hypertrophic CardiomyopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Pathophysiological Factors Driving Diastolic Dysfunction of the Right Heart in Pulmonary HypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the pathogenesis of right heart failure in pulmonary arterial hypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Using Synchrotron Radiation Imaging Techniques to Elucidate the Actions of Hexarelin in the Heart of Small Animal Models2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] Myofilament changes may drive right ventricular dysfunction ahead of pulmonary hypertension in a rat model of left ventricular diastolic dysfunction.2024

Author(s)

Organizer

Data Source

[Presentation] Myofilament protein post-translational modifications may underlie right ventricular dysfunction in pulmonary hypertension2023

Author(s)

Organizer

Data Source

[Presentation] Myofilament changes may drive right ventricular dysfunction ahead of pulmonary hypertension in a rat model of left ventricular diastolic dysfunction.2023

Author(s)

Organizer

Data Source

[Presentation] The Super Relaxed State of Myosin Contributes to the Pathogenesis of Right Ventricular Dysfunction in Pulmonary Hypertension2022

Author(s)

Organizer

Data Source

[Presentation] Paroxetine improves right ventricular-pulmonary artery coupling in a rat model of pulmonary hypertension2022

Author(s)

Organizer

Data Source

[Presentation] Myofilament protein post-translational modifications may underlie right ventricular dysfunction in pulmonary hypertension2022

Author(s)

Organizer

Data Source

[Presentation] Paroxetine improves right ventricular-pulmonary artery coupling in a rat model of pulmonary hypertension2021

Author(s)

Organizer

Data Source

[Presentation] Dysregulation of actin-myosin cross-bridges contribute to the pathogenesis of RV dysfunction in pulmonary hypertension2020

Author(s)

Organizer

Data Source

[Presentation] A potential role for GRK2 in the development of right ventricular dysfunction in pulmonary arterial hypertension2019

Author(s)

Organizer

Data Source

Waddingham Mark ＷａｄｄｉｎｇｈａｍＭａｒｋ

WADDINGHAM MARK THOMAS ワディンガムマーク.トーマス