KUJIRAI TOMOYA 鯨井智也

… Alternative Names

Kujirai Tomoya 鯨井智也

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Researcher Number	70823566
Other IDs
Affiliation (Current)	2025: 東京大学, 定量生命科学研究所, 助教
Affiliation (based on the past Project Information) *help	2018 – 2024: 東京大学, 定量生命科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Broad Section G / Basic Section 43020:Structural biochemistry-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator ヌクレオソーム / クロマチン / クライオ電子顕微鏡 / 自然免疫 / cGAS / 遺伝子発現制御 / 転写 / RNAポリメラーゼII / DNA / ゲノムDNA … More / DNAセンサー / X線結晶構造解析 / エピジェネティクス / 癌 / DEK … More Except Principal Investigator 転写因子 / クライオ電子顕微鏡 / ヌクレオソーム / RNAポリメラーゼ / クロマチン / リボソーム / 転写 / 構造生物学 / Cryo-EM / クライオ電顕 / Rho / ncRNA / 転写終結因子 / ヒストンシャペロン / 転写伸長因子 Less

Structural basis of transcription in chromatin
- Principal Investigator
  
  関根俊一
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section G
- Research Institution
  Institute of Physical and Chemical Research
細胞内のクロマチンにおける多様な転写機構の構造基盤Principal Investigator
- Principal Investigator
  
  鯨井智也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
クロマチン構造における自然免疫制御機構の解明Principal Investigator
- Principal Investigator
  
  鯨井智也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  The University of Tokyo
Elucidation of recognition and regulation of chromatin by innate immune DNA sensor cGASPrincipal Investigator
- Principal Investigator
  
  Kujirai Tomoya
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  The University of Tokyo
Structural basis of higher-order complexes connecting transcription and its related functions
- Principal Investigator
  
  関根俊一
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section G
- Research Institution
  Institute of Physical and Chemical Research
RNAポリメラーゼを中心に形成される中核的複合体の構造基盤
- Principal Investigator
  
  関根俊一
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research
転写と共役したヌクレオソーム再構築の分子メカニズムの解明
- Principal Investigator
  
  江原晴彦
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Regulation of chromatin structure by DEKPrincipal Investigator
- Principal Investigator
  
  Kujirai Tomoya
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 生体の科学　転写伸長因子およびヒストンシャペロンFACTによるヌクレオソーム転写制御機構2023
- Author(s)
  畠澤卓, 鯨井智也, 胡桃坂仁志
- Total Pages
  6
- Publisher
  金原一郎記念医学医療振興財団
- Data Source
  KAKENHI-PROJECT-22K15033
[Book] 生体の科学転写伸長因子およびヒストンシャペロンFACTによるヌクレオソーム転写制御機構2023
- Author(s)
  畠澤卓, 鯨井智也, 胡桃坂仁志
- Total Pages
  6
- Publisher
  金原一郎記念医学医療振興財団
- Data Source
  KAKENHI-PROJECT-23K17392
[Book] クライオ電子顕微鏡ハンドブック2023
- Author(s)
  鯨井智也、胡桃坂仁志（難波啓一、加藤貴之、牧野文信編）
- Total Pages
  460
- Publisher
  エヌ・ティー・エス
- ISBN
  9784860438043
- Data Source
  KAKENHI-PROJECT-20H05690
[Book] セントラルドグマの新常識2022
- Author(s)
  鯨井智也、胡桃坂仁志（田口　英樹、小林　武彦、稲田　利文編）
- Total Pages
  264
- Publisher
  羊土社
- ISBN
  9784758104043
- Data Source
  KAKENHI-PROJECT-20H05690
[Book] エピゲノムで新たな解明が進む「先天性疾患」2021
- Author(s)
  大角健、鯨井智也、胡桃坂仁志　（副島英伸、秦健一郎編）
- Total Pages
  224
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-20H05690
[Book] イメージング時代の構造生命科学2020
- Author(s)
  鯨井智也, 滝沢由政, 胡桃坂仁志
- Total Pages
  5
- Publisher
  羊土社
- ISBN
  9784758103855
- Data Source
  KAKENHI-PROJECT-19K21177
[Book] 週刊医学のあゆみ　タンパク質代謝医学「クロマチンによるエピジェネティックな転写制御」2018
- Author(s)
  胡桃坂仁志、鯨井智也
- Total Pages
  7
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-19K21177
[Book] 実験医学別冊「あなたのタンパク質精製、大丈夫ですか？」2018
- Author(s)
  胡桃坂仁志，有村泰宏、鯨井智也、小山昌子、立和名博昭、野澤佳世、田口裕之、佐藤祥子、小林航、堀越直樹、飯倉ゆかり、町田晋一、加藤大貴、藤田理紗
- Total Pages
  18
- Publisher
  羊土社
- ISBN
  9784758122382
- Data Source
  KAKENHI-PROJECT-19K21177
[Journal Article] Structural perspectives on transcription in chromatin2024
- Author(s)
  Sekine Shun-ichi、Ehara Haruhiko、Kujirai Tomoya、Kurumizaka Hitoshi
- Journal Title
  
  Trends in Cell Biology
  
  Volume: 34 Issue: 3 Pages: 211-224
- DOI
  10.1016/j.tcb.2023.07.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475
[Journal Article] HMGA2 directly mediates chromatin condensation in association with neuronal fate regulation2023
- Author(s)
  Kuwayama Naohiro、Kujirai Tomoya、Kishi Yusuke、Hirano Rina、Echigoya Kenta、Fang Lingyan、Watanabe Sugiko、Nakao Mitsuyoshi、Suzuki Yutaka、Ishiguro Kei-ichiro、Kurumizaka Hitoshi、Gotoh Yukiko
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 6420-6420
- DOI
  10.1038/s41467-023-42094-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-22K19823, KAKENHI-PROJECT-20KK0185, KAKENHI-PUBLICLY-22H04687, KAKENHI-PUBLICLY-23H04214, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-22H00431, KAKENHI-PROJECT-21H02686
[Journal Article] Structural Transition of the Nucleosome during Transcription Elongation2023
- Author(s)
  Kujirai Tomoya、Ehara Haruhiko、Sekine Shun-ichi、Kurumizaka Hitoshi
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 10 Pages: 1388-1388
- DOI
  10.3390/cells12101388
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475
[Journal Article] 特集クロマチンによる転写制御機構の最前線 Ⅰ.分子レベル転写伸長因子およびヒストンシャペロンFACTによるヌクレオソーム転写制御機構2023
- Author(s)
  畠澤卓、鯨井智也、胡桃坂仁志
- Journal Title
  
  生体の科学
  
  Volume: 74 Issue: 3 Pages: 193-198
- DOI
  10.11477/mf.2425201674
- ISSN
  0370-9531, 1883-5503
- Year and Date
  2023-06-15
- Data Source
  KAKENHI-PROJECT-20H05690
[Journal Article] Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II2023
- Author(s)
  Oishi Takumi、Hatazawa Suguru、Kujirai Tomoya、Kato Junko、Kobayashi Yuki、Ogasawara Mitsuo、Akatsu Munetaka、Ehara Haruhiko、Sekine Shun-ichi、Hayashi Gosuke、Takizawa Yoshimasa、Kurumizaka Hitoshi
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 51 Issue: 19 Pages: 10364-10374
- DOI
  10.1093/nar/gkad754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23K20300
[Journal Article] Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.82023
- Author(s)
  Hirai Seiya、Kujirai Tomoya、Akatsu Munetaka、Ogasawara Mitsuo、Ehara Haruhiko、Sekine Shun-ichi、Ohkawa Yasuyuki、Takizawa Yoshimasa、Kurumizaka Hitoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 6 Pages: 549-559
- DOI
  10.1093/jb/mvad069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-22K19275, KAKENHI-PROJECT-22KJ0858, KAKENHI-PUBLICLY-22H04676, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23H00372, KAKENHI-PROJECT-23K20300
[Journal Article] Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA2023
- Author(s)
  Akatsu Munetaka、Ehara Haruhiko、Kujirai Tomoya、Fujita Risa、Ito Tomoko、Osumi Ken、Ogasawara Mitsuo、Takizawa Yoshimasa、Sekine Shun-ichi、Kurumizaka Hitoshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 299 Issue: 12 Pages: 105477-105477
- DOI
  10.1016/j.jbc.2023.105477
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23K20300
[Journal Article] Structural Basis of Damaged Nucleotide Recognition by Transcribing RNA Polymerase II in the Nucleosome2023
- Author(s)
  Osumi Ken、Kujirai Tomoya、Ehara Haruhiko、Ogasawara Mitsuo、Kinoshita Chiaki、Saotome Mika、Kagawa Wataru、Sekine Shun-ichi、Takizawa Yoshimasa、Kurumizaka Hitoshi
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 435 Issue: 13 Pages: 168130-168130
- DOI
  10.1016/j.jmb.2023.168130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15033, KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-23H05475, KAKENHI-PROJECT-23K20300, KAKENHI-PROJECT-23K24997
[Journal Article] Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT2022
- Author(s)
  Ehara Haruhiko、Kujirai Tomoya、Shirouzu Mikako、Kurumizaka Hitoshi、Sekine Shun-ichi
- Journal Title
  
  Science
  
  Volume: 377 Issue: 6611
- DOI
  10.1126/science.abp9466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-20H00449, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-23K20300
[Journal Article] Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H12022
- Author(s)
  Hirano Rina、Ehara Haruhiko、Kujirai Tomoya、Uejima Tamami、Takizawa Yoshimasa、Sekine Shun-ichi、Kurumizaka Hitoshi
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 7287-7287
- DOI
  10.1038/s41467-022-35003-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H05690, KAKENHI-PROJECT-20H00449, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-23K20300
[Journal Article] Structural and biochemical analyses of the nucleosome containing Komagataella pastoris histones2022
- Author(s)
  Fukushima Yutaro、Hatazawa Suguru、Hirai Seiya、Kujirai Tomoya、Ehara Haruhiko、Sekine Shun-ichi、Takizawa Yoshimasa、Kurumizaka Hitoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 172 Issue: 2 Pages: 79-88
- DOI
  10.1093/jb/mvac043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06098, KAKENHI-PROJECT-20H00449, KAKENHI-PROJECT-22KJ0858, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-23K20300
[Journal Article] Contributions of Histone Variants in Nucleosome Structure and Function2021
- Author(s)
  Kurumizaka Hitoshi、Kujirai Tomoya、Takizawa Yoshimasa
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 433 Issue: 6 Pages: 166678-166678
- DOI
  10.1016/j.jmb.2020.10.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15711, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-20H00449
[Journal Article] Inactivation Mechanism of an Innate Immune DNA Sensor cGAS by Self-chromatinized DNA2021
- Author(s)
  鯨井智也、胡桃坂仁志
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 61 Issue: 5 Pages: 324-326
- DOI
  10.2142/biophys.61.324
- NAID
  130008093151
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K15711
[Journal Article] クロマチンを形成したゲノムDNAが自然免疫DNAセンサーcGASの監視から逃れる仕組み2021
- Author(s)
  鯨井智也、胡桃坂仁志
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 75 Pages: 722-729
- NAID
  40022604517
- Data Source
  KAKENHI-PROJECT-20K15711
[Journal Article] Structural basis for the inhibition of cGAS by nucleosomes2020
- Author(s)
  Kujirai Tomoya、Zierhut Christian、Takizawa Yoshimasa、Kim Ryan、Negishi Lumi、Uruma Nobuki、Hirai Seiya、Funabiki Hironori、Kurumizaka Hitoshi
- Journal Title
  
  Science
  
  Volume: 370 Issue: 6515 Pages: 455-458
- DOI
  10.1126/science.abd0237
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06522, KAKENHI-PROJECT-20K15711, KAKENHI-PLANNED-18H05534
[Journal Article] Transcription through the nucleosome2020
- Author(s)
  Kujirai Tomoya、Kurumizaka Hitoshi
- Journal Title
  
  Current Opinion in Structural Biology
  
  Volume: 61 Pages: 42-49
- DOI
  10.1016/j.sbi.2019.10.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-19K21177
[Journal Article] Structure-based design of an H2A.Z.1 mutant stabilizing a nucleosome in vitro and in vivo2019
- Author(s)
  Horikoshi Naoki、Kujirai Tomoya、Sato Koichi、Kimura Hiroshi、Kurumizaka Hitoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 515 Issue: 4 Pages: 719-724
- DOI
  10.1016/j.bbrc.2019.06.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05527, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-19K21177
[Journal Article] Biochemical analysis of nucleosome targeting by Tn5 transposase2019
- Author(s)
  Sato S, Arimura Y, Kujirai T, Harada A, Maehara K, Nogami J, Ohkawa Y, Kurumizaka H.
- Journal Title
  
  Open Biol.
  
  Volume: 9 Issue: 8 Pages: 190116-190116
- DOI
  10.1098/rsob.190116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04802, KAKENHI-PUBLICLY-18H04904, KAKENHI-PLANNED-18H05534, KAKENHI-PUBLICLY-19H04970, KAKENHI-PUBLICLY-19H05244, KAKENHI-PUBLICLY-19H05425, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-17H03608, KAKENHI-PROJECT-19H03158, KAKENHI-PROJECT-19H03211, KAKENHI-PROJECT-18K19432, KAKENHI-PROJECT-19K21177, KAKENHI-PROJECT-19H03424
[Journal Article] Structure determination of the nucleosome core particle by selenium SAD phasing2019
- Author(s)
  Saotome Mika、Horikoshi Naoki、Urano Kazuki、Kujirai Tomoya、Yuzurihara Hidetaka、Kurumizaka Hitoshi、Kagawa Wataru
- Journal Title
  
  Acta Crystallographica Section D Structural Biology
  
  Volume: 75 Issue: 10 Pages: 930-936
- DOI
  10.1107/s2059798319012713
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-18J13707, KAKENHI-PROJECT-19K21177
[Journal Article] Structural insight into nucleosome transcription by RNA polymerase II with elongation factors2019
- Author(s)
  Ehara Haruhiko、Kujirai Tomoya、Fujino Yuka、Shirouzu Mikako、Kurumizaka Hitoshi、Sekine Shun-ichi
- Journal Title
  
  Science
  
  Volume: 363 Issue: 6428 Pages: 744-747
- DOI
  10.1126/science.aav8912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14643, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-15H04344, KAKENHI-PROJECT-19K21177
[Journal Article] Biochemical and structural analyses of the nucleosome containing human histone H2A.J2019
- Author(s)
  Tanaka Hiroki、Sato Shoko、Koyama Masako、Kujirai Tomoya、Kurumizaka Hitoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 167 Issue: 4 Pages: 419-427
- DOI
  10.1093/jb/mvz109
- NAID
  40022211009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06609, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-18J13668, KAKENHI-PROJECT-18K14677, KAKENHI-PROJECT-19K21177
[Journal Article] Biochemical characterization of the placeholder nucleosome for DNA hypomethylation maintenance2019
- Author(s)
  Hirano Rina、Kujirai Tomoya、Negishi Lumi、Kurumizaka Hitoshi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 18 Pages: 100634-100634
- DOI
  10.1016/j.bbrep.2019.100634
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21177, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-17H01408
[Journal Article] Methods for Preparing Nucleosomes Containing Histone Variants2018
- Author(s)
  Kujirai Tomoya、Arimura Yasuhiro、Fujita Risa、Horikoshi Naoki、Machida Shinichi、Kurumizaka Hitoshi
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1832 Pages: 3-20
- DOI
  10.1007/978-1-4939-8663-7_1
- ISBN
  9781493986620, 9781493986637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01408, KAKENHI-PROJECT-19K21177, KAKENHI-PROJECT-16J10043, KAKENHI-PROJECT-17K15043
[Journal Article] Structural basis of the nucleosome transition during RNA polymerase II passage2018
- Author(s)
  Kujirai Tomoya、Ehara Haruhiko、Fujino Yuka、Shirouzu Mikako、Sekine Shun-ichi、Kurumizaka Hitoshi
- Journal Title
  
  Science
  
  Volume: 362 Issue: 6414 Pages: 595-598
- DOI
  10.1126/science.aau9904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14643, KAKENHI-PLANNED-18H05534, KAKENHI-PROJECT-15H04344, KAKENHI-PROJECT-19K21177
[Presentation] 転写伸長におけるヌクレオソーム構造のダイナミクス2023
- Author(s)
  鯨井智也
- Organizer
  筑波大学開学50周年記念TARAシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K15033
[Presentation] 転写におけるヌクレオソームの崩壊と再構築の構造解析2023
- Author(s)
  3.鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第16回日本エピジェネティクス研究会年会　2023年6月
- Invited
- Data Source
  KAKENHI-PROJECT-22K15033
[Presentation] Cryo-EM structure of the DEK-nucleosome complex and its implications on gene regulation2023
- Author(s)
  Kujirai T, Echigoya K, Kishi Y, Takizawa Y, Saeki M, Ito T, Negishi L, Masumoto H, Kimura H, Gotoh Y, Kurumizaka H
- Organizer
  CSHL MECHANISMS OF EUKARYOTIC TRANSCRIPTION
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05690
[Presentation] Cryo-EM analysis on the nucleosome disassembly and reassembly during transcription elongation2023
- Author(s)
  Ehara H, Kujirai Y, Shirouzu M, Kurumizaka H, Sekine S
- Organizer
  CSHL MECHANISMS OF EUKARYOTIC TRANSCRIPTION
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05690
[Presentation] Cryo-EM structure of the DEK-nucleosome complex and its implications on gene regulation2023
- Author(s)
  1Kujirai T, Echigoya K, Kishi Y, Takizawa Y, Saeki M, Ito T, Negishi L, Masumoto H, Kimura H, Gotoh Y, Kurumizaka H
- Organizer
  Cold Spring Harbor Laboratory meeting, Mechanisms of Eukaryotic Transcription
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15033
[Presentation] 転写におけるヌクレオソームの崩壊と再構築の構造解析2023
- Author(s)
  鯨井　智也
- Organizer
  第16回日本エピジェネティクス研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K20300
[Presentation] Structural basis of nucleosome transcription by the RNAPII elongation complex2023
- Author(s)
  Sekine S, Ehara H, Kujirai Y, Kurumizaka H
- Organizer
  CSHL MECHANISMS OF EUKARYOTIC TRANSCRIPTION
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05690
[Presentation] 転写伸長におけるヌクレオソーム構造のダイナミクス2023
- Author(s)
  鯨井智也
- Organizer
  筑波大学開学50周年記念TARAシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K17392
[Presentation] Cryo-EM structure of the DEK-nucleosome complex and its implications on gene regulation2023
- Author(s)
  Kujirai T, Echigoya K, Kishi Y, Takizawa Y, Saeki M, Ito T, Negishi L, Masumoto H, Kimura H, Gotoh Y, Kurumizaka H
- Organizer
  , Cold Spring Harbor Laboratory meeting, Mechanisms of Eukaryotic Transcription
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K17392
[Presentation] クロマチン転写の構造生物学2023
- Author(s)
  江原晴彦、鯨井智也、白水美香子、胡桃坂仁志、関根俊一
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20H05690
[Presentation] 転写伸長におけるヌクレオソーム構造のダイナミクス2023
- Author(s)
  鯨井　智也
- Organizer
  筑波大学開学50周年記念TARAシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K20300
[Presentation] 転写におけるヌクレオソームの崩壊と再構築の構造解析2023
- Author(s)
  鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第16回日本エピジェネティクス研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H05690
[Presentation] 転写伸長におけるヌクレオソーム構造のダイナミクス2023
- Author(s)
  鯨井智也
- Organizer
  筑波大学開学50周年記念TARAシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20H05690
[Presentation] 転写におけるヌクレオソームの崩壊と再構築の構造解析2023
- Author(s)
  鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第16回日本エピジェネティクス研究会年会　2023年6月
- Invited
- Data Source
  KAKENHI-PROJECT-23K17392
[Presentation] 転写伸長におけるヌクレオソームの崩壊と再構築機構の構造生物学的解析2022
- Author(s)
  鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第40 回染色体ワークショップ・第21 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-22K15033
[Presentation] Cryo-EM structure of cGAS-nucleosome reveals the mechanism of innate immune inhibition2022
- Author(s)
  Tomoa Kujirai
- Organizer
  44th Indian Biophysical Society Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15711
[Presentation] 転写におけるヌクレオソーム構造変換のクライオEM構造解析2022
- Author(s)
  鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  生理研研究会「新世代のクライオ電子顕微鏡」
- Invited
- Data Source
  KAKENHI-PROJECT-22K15033
[Presentation] 転写伸長におけるヌクレオソームの崩壊と再構築機構の構造生物学的解析2022
- Author(s)
  鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第40 回染色体ワークショップ・第21 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-20H05690
[Presentation] 転写におけるヌクレオソーム構造のダイナミクス2022
- Author(s)
  鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-20H05690
[Presentation] 転写におけるヌクレオソーム構造変換のクライオEM構造解析2022
- Author(s)
  鯨井智也、江原晴彦、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  生理研研究会「新世代のクライオ電子顕微鏡」
- Invited
- Data Source
  KAKENHI-PROJECT-20H05690
[Presentation] クロマチン結合因子DEKの構造とクロマチン制御機構2022
- Author(s)
  鯨井智也、越後谷健太、岸雄介、滝沢由政、佐伯麻衣、増本博司、木村宏、後藤由季子、胡桃坂仁志
- Organizer
  第45回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15033
[Presentation] ヌクレオソームによる自然免疫DNAセンサーcGASの不活性化機構2021
- Author(s)
  鯨井智也, Christian Zierhut, 滝沢由政, Ryan Kim, 根岸瑠美, 粉間信樹, 平井誠也, 船引宏則, 胡桃坂仁志
- Organizer
  第38回染色体ワークショップ第19回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-20K15711
[Presentation] cGAS-ヌクレオソーム複合体構造から明らかになった自然免疫の不活化機構2021
- Author(s)
  鯨井智也, 滝沢由政, 根岸瑠美, 粉間信樹, 平井誠也, 胡桃坂仁志
- Organizer
  日本遺伝学会第93回大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K15711
[Presentation] 自然免疫DNAセンサーcGASとヌクレオソーム複合体のクライオEM構造解析2021
- Author(s)
  鯨井智也, 胡桃坂仁志
- Organizer
  日本顕微鏡学会第77回学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20K15711
[Presentation] クライオ電子顕微鏡解析から明らかになったヌクレオソームDNA転写のダイナミクス2020
- Author(s)
  鯨井智也
- Organizer
  令和2年度第2回量子線科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K15711
[Presentation] cGAS-ヌクレオソーム複合体構造から明らかになったヌクレオソームによるcGAS不活性化のメカニズム2020
- Author(s)
  鯨井智也, Christian Zierhut, 滝沢由政, Ryan Kim, 根岸瑠美, 粉間信樹, 平井誠也, 船引宏則, 胡桃坂仁志
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K15711
[Presentation] クライオ電子顕微鏡解析から明らかになったヌクレオソームDNA転写のダイナミクス2020
- Author(s)
  鯨井智也
- Organizer
  令和2年度第2回量子線科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20H05690
[Presentation] RNAポリメラーゼIIによるヌクレオソームDNA転写機構の構造生物学的解析2019
- Author(s)
  鯨井智也、江原晴彦、藤野優佳、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第36回染色体ワークショップ・第17回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19K21177
[Presentation] Structural transition of nucleosome during RNA polymerase II transcription revealed by cryo-EM2019
- Author(s)
  Tomoya Kujirai, Haruhiko Ehara, Yuka Fujino, Mikako Shirouzu, Shun-ichi Sekine, Hitoshi Kurumizaka
- Organizer
  第57回生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K21177
[Presentation] Structural study of transcription on chromatin2019
- Author(s)
  鯨井智也、江原晴彦、藤野優佳、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第13回日本エピジェネティクス研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K21177
[Presentation] 試験管内転写系によるクロマチン構造変換機構の生化学的、構造生物学的解析2019
- Author(s)
  鯨井智也、江原晴彦、藤野優佳、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第92回生化学会大会
- Data Source
  KAKENHI-PROJECT-19K21177
[Presentation] Structural insight into the nucleosomal DNA transcription by RNA polymerase II2019
- Author(s)
  Kujirai T, Ehara H, Fujino Y, Shirouzu M, Sekine S, Kurumizaka H.
- Organizer
  Cold Spring Harbor Laboratory meeting, Mechanisms of Eukaryotic Transcription
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21177
[Presentation] クロマチンによる転写制御の構造生物学的解析2019
- Author(s)
  鯨井智也、江原晴彦、藤野優佳、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第１９回日本蛋白質科学会年会第７１回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K21177
[Presentation] クロマチン構造における転写反応の構造基盤の解明2019
- Author(s)
  鯨井智也
- Organizer
  第92回生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K21177
[Presentation] Influence of nucleosome structure in transcription.2018
- Author(s)
  Kujirai T, Ehara H, Fujino Y, Nishimura M, Shirouzu M, Sekine S, Kurumizaka H.
- Organizer
  FASEB Science Research Conference, MACHINES ON GENES.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21177
[Presentation] ヌクレオソームによるRNAポリメラーゼIIの転写制御機構2018
- Author(s)
  鯨井智也、江原晴彦、藤野優佳、西村正宏、有村泰宏、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K21177
[Presentation] クロマチンにおける転写機構に関する解析2018
- Author(s)
  3.鯨井智也、江原晴彦、藤野優佳、西村正宏、有村泰宏、白水美香子、関根俊一、胡桃坂仁志
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K21177

1. 関根俊一 (50321774)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 江原晴彦 (80634766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. ITO YUMA

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. OHKAWA Yasuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 胡桃坂仁志

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 木村宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 滝沢由政

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
8. 佐藤祥子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUJIRAI TOMOYA 鯨井 智也

Kujirai Tomoya 鯨井 智也

Research Projects

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Co-Researchers

Structural basis of transcription in chromatin

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細胞内のクロマチンにおける多様な転写機構の構造基盤Principal Investigator

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クロマチン構造における自然免疫制御機構の解明Principal Investigator

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Elucidation of recognition and regulation of chromatin by innate immune DNA sensor cGASPrincipal Investigator

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Structural basis of higher-order complexes connecting transcription and its related functions

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RNAポリメラーゼを中心に形成される中核的複合体の構造基盤

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転写と共役したヌクレオソーム再構築の分子メカニズムの解明

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Regulation of chromatin structure by DEKPrincipal Investigator

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[Book] 生体の科学 転写伸長因子およびヒストンシャペロンFACTによるヌクレオソーム転写制御機構2023

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[Book] 生体の科学 転写伸長因子およびヒストンシャペロンFACTによるヌクレオソーム転写制御機構2023

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[Book] クライオ電子顕微鏡ハンドブック2023

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[Book] セントラルドグマの新常識2022

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[Book] エピゲノムで新たな解明が進む「先天性疾患」2021

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KUJIRAI TOMOYA 鯨井智也

Kujirai Tomoya 鯨井智也

[Book] 生体の科学　転写伸長因子およびヒストンシャペロンFACTによるヌクレオソーム転写制御機構2023

[Book] 生体の科学転写伸長因子およびヒストンシャペロンFACTによるヌクレオソーム転写制御機構2023

[Book] 週刊医学のあゆみ　タンパク質代謝医学「クロマチンによるエピジェネティックな転写制御」2018

[Book] 実験医学別冊「あなたのタンパク質精製、大丈夫ですか？」2018

[Journal Article] 特集クロマチンによる転写制御機構の最前線 Ⅰ.分子レベル転写伸長因子およびヒストンシャペロンFACTによるヌクレオソーム転写制御機構2023