Shiota Tomo 塩田智

Researcher Number	70837062
Other IDs
Affiliation (Current)	2025: 奈良県立医科大学, 医学部附属病院, 研究員
Affiliation (based on the past Project Information) *help	2025: 奈良県立医科大学, 医学部附属病院, 研究員 2021 – 2023: 奈良県立医科大学, 医学部附属病院, 研究員 2020: 奈良県立医科大学, 医学部附属病院, 医員 2019: 奈良県立医科大学, 医学部附属病院, 診療助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator 細胞骨格 / 難治性神経筋疾患 / 神経変性疾患 / ALS/FTD / オートファジー / 神経筋疾患 / 筋萎縮性側索硬化症 / 神経難病 / ALS Except Principal Investigator RAN翻訳 … More / リピート病 / オルガノイド / laser micro-irradiation / ポリペプチド / 脊髄小脳変性症 / 脳幹オルガノイド / DNA修復 / 核内封入体病 / ALS / RAN translation / C9orf72 / FUS / 脳オルガノイド / 筋萎縮性側索硬化症 / 非翻訳領域リピート病 / 神経変性疾患 Less

神経筋疾患におけるオートファジー機構破綻の機序解明Principal Investigator
- Principal Investigator
  
  塩田智
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nara Medical University
神経難病におけるリピート配列に起因する細胞骨格とオートファジー異常の解明Principal Investigator
- Principal Investigator
  
  塩田智
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nara Medical University
Pathophysiology of non-coding repeat expansion disordersPrincipal Investigator
- Principal Investigator
  
  Shiota Tomo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nara Medical University
Pathophysiological analysis of repeat disease causing neurodegenerative disease using human brain organoids.
- Principal Investigator
  
  Kiriyama Takao
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nara Medical University

All 2022 2021 2020

All Journal Article Presentation

[Journal Article] C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response2022
- Author(s)
  Shiota Tomo、Nagata Riko、Kikuchi Sotaro、Nanaura Hitoki、Matsubayashi Masaya、Nakanishi Mari、Kobashigawa Shinko、Isozumi Noriyoshi、Kiriyama Takao、Nagayama Kazuaki、Sugie Kazuma、Yamashiro Yoshito、Mori Eiichiro
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 10 Pages: 750829-750829
- DOI
  10.3389/fcell.2022.750829
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07978, KAKENHI-PROJECT-19K17043, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-21K15032, KAKENHI-PROJECT-22K07725, KAKENHI-PROJECT-21H03804, KAKENHI-PROJECT-19K08150, KAKENHI-PROJECT-23K21373, KAKENHI-PROJECT-21K19881
[Journal Article] C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers2021
- Author(s)
  Nanaura Hitoki、Aiba Yuichiro、Nakanishi Mari、Shiota Tomo、Hibino Masaki、Kikuchi Sotaro、Nagata Riko、Morikawa Naritaka、Iguchi Naohiko、Kiriyama Takao、Nagamori Shushi、Sugie Kazuma、Saio Tomohide、Yoshizawa Takuya、Mori Eiichiro et al.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5301-5301
- DOI
  10.1038/s41467-021-25560-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07978, KAKENHI-PROJECT-19K16060, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-18H03984, KAKENHI-PROJECT-18H05229, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-20K06493, KAKENHI-PROJECT-20K06527, KAKENHI-PROJECT-20K06569, KAKENHI-PROJECT-20K06579, KAKENHI-PROJECT-21K15032, KAKENHI-PROJECT-19KK0071, KAKENHI-PROJECT-22KJ0024, KAKENHI-PLANNED-20H05925, KAKENHI-PROJECT-19H05648
[Journal Article] Gene expression profiles of human cerebral organoids identify PPAR pathway and PKM2 as key markers for oxygen-glucose deprivation and reoxygenation2021
- Author(s)
  Naoki Iwasa, Takeshi K. Matsui, Naohiko Iguchi, Kaoru Kinugawa, Naritaka Morikawa, Yoshihiko M. Sakaguchi, Tomo Shiota, Shinko Kobashigawa et. al.
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: － Pages: 605030-605030
- DOI
  10.3389/fncel.2021.605030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K23952, KAKENHI-PROJECT-19K07978, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-21K06758, KAKENHI-PROJECT-21K18273, KAKENHI-PROJECT-20H03680, KAKENHI-PROJECT-19K08150
[Journal Article] Brainstem organoids from human pluripotent stem cells2020
- Author(s)
  Nobuyuki Eura, Takeshi K. Matsui, Joachim Luginbuhl, Masaya Matsubayashi, Hitoki Nanaura, Tomo Shiota, Kaoru Kinugawa, Naohiko Iguchi, Takao Kiriyama, Canbin Zheng, Tsukasa Kouno, Yan Jun Lan, Pornparn Kongpracha, Pattama Wiriyasermkul, Yoshihiko M. Sakaguchi, Riko Nagata, Tomoya Komeda, Naritaka Morikawa, et al.
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: - Pages: 00538-00538
- DOI
  10.3389/fnins.2020.00538
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23952, KAKENHI-PROJECT-19K21306, KAKENHI-PROJECT-19K07318, KAKENHI-PROJECT-19K07978, KAKENHI-PROJECT-19K08150, KAKENHI-PROJECT-20K16583, KAKENHI-PROJECT-20K16606, KAKENHI-PROJECT-20H03199, KAKENHI-PROJECT-18K06524, KAKENHI-PROJECT-19K16925, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H02770
[Journal Article] C9orf72- derived proline:arginine poly-dipeptides disturb cytoskeletal architecture2020
- Author(s)
  Tomo Shiota
- Journal Title
  
  BioRxiv
  
  Volume: -
- DOI
  10.1101/2020.10.14.338566
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17043, KAKENHI-PROJECT-20H03199
[Presentation] C9orf72-Derived Proline:Arginine Poly-Dipeptides Alter Cytoskeleton and Mechanical Stress Response2022
- Author(s)
  Tomo Shiota
- Organizer
  第６３回日本神経学会
- Data Source
  KAKENHI-PROJECT-19K17043
[Presentation] PR poly-dipeptides derived from the C9orf72 repeat expansion interfere with cytoskeletal architecture2021
- Author(s)
  Tomo Shiota
- Organizer
  第６２回日本神経学会
- Data Source
  KAKENHI-PROJECT-19K17043
[Presentation] C9orf72- derived proline:arginine poly-dipeptides interfere with cytoskeletal architecture2021
- Author(s)
  Tomo Shiota
- Organizer
  日本神経学会
- Data Source
  KAKENHI-PROJECT-19K17043

1. Kiriyama Takao (80571025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 杉江和馬 (60347549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 松井健 (90528605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 七浦仁紀 (00827909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 井口直彦 (50838232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 絹川薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Shiota Tomo 塩田 智

Research Projects

Research Products

Co-Researchers

神経筋疾患におけるオートファジー機構破綻の機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経難病におけるリピート配列に起因する細胞骨格とオートファジー異常の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiology of non-coding repeat expansion disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological analysis of repeat disease causing neurodegenerative disease using human brain organoids.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene expression profiles of human cerebral organoids identify PPAR pathway and PKM2 as key markers for oxygen-glucose deprivation and reoxygenation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Brainstem organoids from human pluripotent stem cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] C9orf72- derived proline:arginine poly-dipeptides disturb cytoskeletal architecture2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] C9orf72-Derived Proline:Arginine Poly-Dipeptides Alter Cytoskeleton and Mechanical Stress Response2022

Author(s)

Organizer

Data Source

[Presentation] PR poly-dipeptides derived from the C9orf72 repeat expansion interfere with cytoskeletal architecture2021

Author(s)

Organizer

Data Source

[Presentation] C9orf72- derived proline:arginine poly-dipeptides interfere with cytoskeletal architecture2021

Author(s)

Organizer

Data Source

Shiota Tomo 塩田智