URAKI RYUTA 浦木隆太

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Uraki Ryuta 浦木隆太

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Researcher Number	70843027
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療研究所, 主任研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立研究開発法人国立国際医療研究センター, 研究所, ウイルス感染動態研究部上級研究員 2021: 国立研究開発法人国立国際医療研究センター, 研究所ウイルス感染動態研究部, 上級研究員 2019 – 2020: 名古屋市立大学, 医薬学総合研究院(医学), 助教
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / 0803:Pathology, infection/immunology, and related fields Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator 制御性T細胞 / マウスモデル / SARS-CoV-2 / 免疫制御 / B型肝炎ウイルス / 免疫細胞 / ウイルス / 樹状細胞 / B型肝炎 Except Principal Investigator 樹状細胞 / 免疫担当細胞 / 自己免疫疾患 / 病巣感染

宿主免疫制御機構を用いたCOVID-19の予防・治療法の開発Principal Investigator
- Principal Investigator
  
  浦木隆太
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  National Center for Global Health and Medicine
Elucidation of the contribution of regulatory T cells to the pathogenesis of SARS-CoV-2 infection for novel therapeutics.Principal Investigator
- Principal Investigator
  
  URAKI Ryuta
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  National Center for Global Health and Medicine
Contribution of regulatory T cells in the establishment and maintenance of persistent hepatitis B virus infectionPrincipal Investigator
- Principal Investigator
  
  Uraki Ryuta
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  National Center for Global Health and Medicine
  Nagoya City University
Analysis of host immune systems in the onset of HBV-related chronic hepatitis / liver cancerPrincipal Investigator
- Principal Investigator
  
  Uraki Ryuta
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0803:Pathology, infection/immunology, and related fields
- Research Institution
  Nagoya City University
Mechanisms of autoimmune diseases triggered by infectious foci and treatment strategies
- Principal Investigator
  
  山崎小百合
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Nagoya City University

All 2024 2023 2021 2020 2019

All Journal Article Presentation

[Journal Article] Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens2021
- Author(s)
  Uraki Ryuta、Imai Masaki、Ito Mutsumi、Shime Hiroaki、Odanaka Mizuyu、Okuda Moe、Kawaoka Yoshihiro、Yamazaki Sayuri
- Journal Title
  
  PLOS Pathogens
  
  Volume: 17 Issue: 12 Pages: e1010085-e1010085
- DOI
  10.1371/journal.ppat.1010085
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07510, KAKENHI-PROJECT-20K16265, KAKENHI-PROJECT-20K09911, KAKENHI-PROJECT-19KK0202
[Journal Article] Reply to Slominski et al.: UVB irradiation induces proenkephalin+ regulatory T cells with a wound-healing function2021
- Author(s)
  Shime Hiroaki、Odanaka Mizuyu、Tsuiji Makoto、Matoba Takuma、Imai Masaki、Yasumizu Yoshiaki、Uraki Ryuta、Minohara Kiyoshi、Watanabe Maiko、Bonito Anthony John、Fukuyama Hidehiro、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi、Yamazaki Sayuri
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 3
- DOI
  10.1073/pnas.2021919118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07334, KAKENHI-PROJECT-19K07510, KAKENHI-PROJECT-20K09911, KAKENHI-PROJECT-19KK0202, KAKENHI-PUBLICLY-19H04812, KAKENHI-PROJECT-20H03469, KAKENHI-PROJECT-18K16158
[Journal Article] Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function2020
- Author(s)
  Shime Hiroaki、Odanaka Mizuyu、Tsuiji Makoto、Matoba Takuma、Imai Masaki、Yasumizu Yoshiaki、Uraki Ryuta、Minohara Kiyoshi、Watanabe Maiko、Bonito Anthony John、Fukuyama Hidehiro、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi、Yamazaki Sayuri
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 34 Pages: 20696-20705
- DOI
  10.1073/pnas.2000372117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07334, KAKENHI-PROJECT-19K07510, KAKENHI-PROJECT-20K09911, KAKENHI-PROJECT-19K18779, KAKENHI-PROJECT-19KK0202, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-19H04812, KAKENHI-PROJECT-20H03469, KAKENHI-PROJECT-18K16158, KAKENHI-PROJECT-20H03703, KAKENHI-PROJECT-20K16265, KAKENHI-PROJECT-19K23868
[Journal Article] TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes.2020
- Author(s)
  Yuchen Wang, Ryuta Uraki* (*corresponding), Jesse Hwang, Erol Fikrig.
- Journal Title
  
  Viruses
  
  Volume: 12 Issue: 5 Pages: 519-519
- DOI
  10.3390/v12050519
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0202, KAKENHI-PROJECT-20K16265, KAKENHI-PROJECT-19K23868
[Journal Article] Loss of the TAM Receptor Axl Ameliorates Severe Zika Virus Pathogenesis and Reduces Apoptosis in Microglia.2019
- Author(s)
  Hastings AK, Hastings K, Uraki R, Hwang J, Gaitsch H, Dhaliwal K, Williamson E, Fikrig E.
- Journal Title
  
  iScience.
  
  Volume: 13 Pages: 339-350
- DOI
  10.1016/j.isci.2019.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0202
[Journal Article] Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice2019
- Author(s)
  Uraki Ryuta、Hastings Andrew K.、Marin-Lopez Alejandro、Sumida Tomokazu、Takahashi Takehiro、Grover Jonathan R.、Iwasaki Akiko、Hafler David A.、Montgomery Ruth R.、Fikrig Erol
- Journal Title
  
  Nature Microbiology
  
  Volume: 4 Issue: 6 Pages: 948-955
- DOI
  10.1038/s41564-019-0385-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23868, KAKENHI-PROJECT-19KK0202
[Journal Article] Subclade 2.2.1-Specific Human Monoclonal Antibodies That Recognize an Epitope in Antigenic Site A of Influenza A(H5) Virus HA Detected between 2015 and 20182019
- Author(s)
  Okuda Moe、Yamayoshi Seiya、Uraki Ryuta、Ito Mutsumi、Hamabata Taiki、Kawaoka Yoshihiro
- Journal Title
  
  Viruses
  
  Volume: 11 Issue: 4 Pages: 321-321
- DOI
  10.3390/v11040321
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07141, KAKENHI-PROJECT-19K23868, KAKENHI-PROJECT-19KK0202, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-16H06434
[Journal Article] AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice2019
- Author(s)
  Uraki Ryuta、Hastings Andrew K.、Brackney Doug E.、Armstrong Philip M.、Fikrig Erol
- Journal Title
  
  npj Vaccines
  
  Volume: 4 Issue: 1
- DOI
  10.1038/s41541-019-0120-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23868, KAKENHI-PROJECT-19KK0202
[Journal Article] Aedes aegyptiNeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils2019
- Author(s)
  Hastings Andrew K.、Uraki Ryuta、Gaitsch Hallie、Dhaliwal Khushwant、Stanley Sydney、Sproch Hannah、Williamson Eric、MacNeil Tyler、Marin-Lopez Alejandro、Hwang Jesse、Wang Yuchen、Grover Jonathan R.、Fikrig Erol
- Journal Title
  
  Journal of Virology
  
  Volume: 93 Issue: 13
- DOI
  10.1128/jvi.00395-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23868, KAKENHI-PROJECT-19KK0202
[Presentation] 新興・再興ウイルス感染症に対するワクチンの効果を増強する方法の開発2024
- Author(s)
  浦木隆太
- Organizer
  第3回日本医学会連合Rising Star リトリート
- Invited
- Data Source
  KAKENHI-PROJECT-22K15482
[Presentation] RNAウイルスの病原性解析と新規予防法の開発2023
- Author(s)
  浦木隆太
- Organizer
  日本ウイルス学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15482
[Presentation] Skin regulatory T cells producing proenkephalin expand upon ultraviolet B exposure without ST2-IL33 axis and promote keratinocyte outgrowth.2021
- Author(s)
  Yamazaki S, Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A.
- Organizer
  第46回日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Skin regulatory T cells expanded by ultraviolet B exposure have a unique gene expression profile compared to other tissue Treg cells.2021
- Author(s)
  Odanaka M, Shime H, Tsuiji M, Imai M, Yasumizu Y, Uraki R, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, and Yamazaki S
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Proenkephalin+ regulatory T cells expanded by ultraviolet-B exposure maintain skin homeostasis with a healing function.2021
- Author(s)
  Shime H, Odanaka M, Tsuiji M, Imai M, Yasumizu Y, Uraki R, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, and Yamazaki S
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] 制御性T細胞を標的としたSARS-CoV-2に対する新規予防法の開発2021
- Author(s)
  浦木隆太、今井優樹、伊藤睦美、志馬寛明、河岡義裕、山崎小百合
- Organizer
  第68回日本ウルス学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16265
[Presentation] 制御性T細胞を標的としたSARS-CoV-2に対する新規予防法の開発2021
- Author(s)
  浦木隆太, 今井優樹, 伊藤睦美, 志馬寛明, 小田中瑞夕, 奥田萌, 河岡義裕, 山崎小百合
- Organizer
  第68回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Transient depletion of Treg cells induces adaptive immunity to SARS-CoV-2 antigens.2021
- Author(s)
  Ryuta Uraki, Masaki Imai, Hiroaki Shime, Yoshihiro Kawaoka, Sayuri Yamazaki
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16265
[Presentation] Transient depletion of Treg cells induces adaptive immunity to SARS-CoV-2 antigens.2021
- Author(s)
  Uraki R, Imai M, Shime H, Kawaoka Y, Yamazaki S
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Skin regulatory T cells possessing a healing function are expanded by ultraviolet-B exposure.2020
- Author(s)
  Yamazaki S, Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A.
- Organizer
  第45回日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] ネッタイシマカの唾液腺蛋白質AgBR1に対する抗体はフラビウイルスの蚊-哺乳類間伝播・感染を抑制する2020
- Author(s)
  浦木隆太
- Organizer
  新学術領域研究「ネオ・セルフの生成・機能・構造」第3回若手の会（第6回領域班会議）
- Data Source
  KAKENHI-PROJECT-19K23868
[Presentation] ジカウイルスの蚊－哺乳類間伝播モデルの確立とその応用研究2019
- Author(s)
  浦木隆太
- Organizer
  第8回実験動物科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] ネッタイシマカ AgBR1 蛋白質に対する抗体はジカウイルスの蚊-哺乳類間伝播・感染を抑制する.2019
- Author(s)
  Uraki Ryuta、Hastings Andrew K.、Marin-Lopez Alejandro、Sumida Tomokazu、Takahashi Takehiro、Grover Jonathan R.、Iwasaki Akiko、Hafler David A.、Montgomery Ruth R.、Fikrig Erol
- Organizer
  第190回日仏生物学会例会
- Data Source
  KAKENHI-PROJECT-19K23868
[Presentation] ネッタイシマカAgBR1蛋白質に対する抗体はジカウイルスの伝播・感染を抑制する2019
- Author(s)
  浦木隆太
- Organizer
  名古屋市立大学医学会総会
- Data Source
  KAKENHI-PROJECT-19K23868
[Presentation] Aedes aegypti salivary protein AgBR1 antibodies protects mice from mosquito-borne Zika virus infection by modulating local inflammatory responses2019
- Author(s)
  Uraki Ryuta、Hastings Andrew K.、Marin-Lopez Alejandro、Sumida Tomokazu、Takahashi Takehiro、Grover Jonathan R.、Iwasaki Akiko、Hafler David A.、Montgomery Ruth R.、Fikrig Erol
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K23868
[Presentation] Aedes aegypti salivary protein AgBR1 antibodies protects mice from mosquito-borne flavivirus infection by modulating local inflammatory responses2019
- Author(s)
  Uraki Ryuta、Hastings Andrew K.、Marin-Lopez Alejandro、Sumida Tomokazu、Takahashi Takehiro、Brackney Doug E.、Armstrong Philip M.、Grover Jonathan R.、Iwasaki Akiko、Hafler David A.、Montgomery Ruth R.、Fikrig Erol
- Organizer
  第67回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-19K23868
[Presentation] Aedes aegypti salivary protein AgBR1 antibodies protects mice from mosquito-borne flavivirus infection by modulating local inflammatory responses.2019
- Author(s)
  Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Brackney DE, Armstrong PM, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E.
- Organizer
  第67回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Aedes aegypti salivary protein AgBR1 antibodies protects mice from mosquito-borne Zika virus infection by modulating local inflammatory responses.2019
- Author(s)
  Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E.
- Organizer
  The 48 th Annual Meeting of the Japanese Society of Immunology
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] ネッタイシマカAgBR1蛋白質に対する抗体はジカウイルスの伝播・感染を抑制する2019
- Author(s)
  浦木隆太
- Organizer
  名古屋市立大学医学会総会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] ネッタイシマカ AgBR1 蛋白質に対する抗体はジカウイルスの蚊-哺乳類間伝播・感染を抑制する。2019
- Author(s)
  Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E.
- Organizer
  日仏生物学会第190回例会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] ジカウイルスの蚊－哺乳類間伝播モデルの確立とその応用研究2019
- Author(s)
  浦木隆太
- Organizer
  第8回　実験動物科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K23868

1. 山崎小百合 (70567255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. 今井優樹 (30440936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. 的場拓磨 (40790712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 志馬寛明 (70372133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. YAMAYOSHI Seiya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 小田中瑞夕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 築地信

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

URAKI RYUTA 浦木 隆太

Uraki Ryuta 浦木 隆太

Research Projects

Research Products

Co-Researchers

宿主免疫制御機構を用いたCOVID-19の予防・治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the contribution of regulatory T cells to the pathogenesis of SARS-CoV-2 infection for novel therapeutics.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Contribution of regulatory T cells in the establishment and maintenance of persistent hepatitis B virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of host immune systems in the onset of HBV-related chronic hepatitis / liver cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of autoimmune diseases triggered by infectious foci and treatment strategies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reply to Slominski et al.: UVB irradiation induces proenkephalin+ regulatory T cells with a wound-healing function2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of the TAM Receptor Axl Ameliorates Severe Zika Virus Pathogenesis and Reduces Apoptosis in Microglia.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Subclade 2.2.1-Specific Human Monoclonal Antibodies That Recognize an Epitope in Antigenic Site A of Influenza A(H5) Virus HA Detected between 2015 and 20182019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aedes aegyptiNeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils2019

Author(s)

Journal Title

DOI

Data Source

URAKI RYUTA 浦木隆太

Uraki Ryuta 浦木隆太