Konno Sho 今野翔

Researcher Number	70882190
Other IDs
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator NRPS / 環状ペプチド / チオエステラーゼ / ペプチド環化酵素 / 非リボソームペプチド合成酵素 / Phosphonate inhibitor / Transition-state analog / Thioesterase / Macrocyclic peptide / 天然物 … More / 遷移状態アナログ / 環化酵素 / ハイブリッド合成 / 化学酵素合成 / 生合成 / PROTAC / COVID-19 / プロテインノックダウン / プロテアーゼ阻害剤 / SARS-CoV-2 / 3CLプロテアーゼ … More Except Principal Investigator ケミカルバイオロジー / 創薬 / ペプチドー薬物架橋体 / 抗ウイルス剤 / プロテアーゼ阻害剤 Less

Development of innovative drug discovery based on SARS-CoV-2 3CL protease inhibitor YH-53
- Principal Investigator
  
  林良雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of transition-state analogs for peptide macrocyclasesPrincipal Investigator
- Principal Investigator
  
  今野翔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Characterization of a tandem-macrocyclase in nonribosomal peptide synthetasesPrincipal Investigator
- Principal Investigator
  
  Konno Sho
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of a degrader for SARS-CoV-2 3CL proteasePrincipal Investigator
- Principal Investigator
  
  Konno Sho
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2023 2022 2021

All Journal Article Presentation

[Journal Article] Peptide mixed phosphonates for covalent complex formation with thioesterases in nonribosomal peptide synthetases2023
- Author(s)
  Konno Sho、Tanaka Miyu、Mizuguchi Tomoe、Toyokai Haruka、Taguchi Akihiro、Taniguchi Atsuhiko、Hayashi Yoshio
- Journal Title
  
  Journal of Peptide Science
  
  Volume: 30 Issue: 1
- DOI
  10.1002/psc.3532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14375
[Journal Article] Establishment of One-Pot Disulfide-Driven Cyclic Peptide Synthesis with a 3-Nitro-2-pyridinesulfenate2023
- Author(s)
  Shida, H., Taguchi, A., Konno, S., Takayama, K., Taniguchi, A., Hayashi, Y.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 6 Pages: 435-440
- DOI
  10.1248/cpb.c23-00087
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27305
[Journal Article] 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents2021
- Author(s)
  Konno S、Kobayashi K、Senda M、Funai Y、Seki Y、Tamai I、Schakel L、Sakata K、Pillaiyar T、Taguchi A、Taniguchi A、Gutschow M、Muller CE.、Takeuchi K、Hirohama M、Kawaguchi A、Kojima M、Senda T、Shirasaka Y、Kamitani W、Hayashi Y
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 65 Issue: 4 Pages: 2926-2939
- DOI
  10.1021/acs.jmedchem.1c00665
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07137, KAKENHI-PROJECT-20K22723, KAKENHI-PROJECT-19H03475, KAKENHI-PROJECT-21J12536, KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K07036
[Presentation] 環状ペプチドMA026の環化酵素の同定および基質許容性の解析2023
- Author(s)
  田中　美有、今野　翔、田口　晃弘、谷口　敦彦、林　良雄
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K14375
[Presentation] Substrate peptide-based mixed phosphonates as an irreversible inhibitor for thioesterase domain in nonribosomal peptide synthetases2023
- Author(s)
  Sho Konno, Miyu Tanaka, Tomoe Mizuguchi, Haruka Toyokai, Akihiro Taguchi, Atsuhiko Taniguchi and Yoshi Hayashi
- Organizer
  28th American peptide symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14375
[Presentation] MA026環化酵素を用いた化学酵素ハイブリッド合成法の開発2023
- Author(s)
  田中　美有、今野　翔、田口　晃弘、谷口　敦彦、林　良雄
- Organizer
  第67回日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-23K14375
[Presentation] Development of Peptide Phosphonate Inhibitors for Thioesterases in Nonribosomal Peptide Synthetases2023
- Author(s)
  今野翔、田中美有、水口友絵、田口晃弘、谷口敦彦、林良雄
- Organizer
  4th International Conference on NATURAL PRODUCT DISCOVERY and DEVELOPMENT in the Genetic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15285
[Presentation] Functional Characterization of Tandem Thioesterase in MA026 Biosynthesis2023
- Author(s)
  田中美有、今野翔、田口晃弘、谷口敦彦、林良雄
- Organizer
  4th International Conference on NATURAL PRODUCT DISCOVERY and DEVELOPMENT in the Genetic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15285
[Presentation] Characterization of Tandem Thioesterase Domains in MA026 Synthetase2022
- Author(s)
  田中美有、今野翔、田口晃弘、谷口敦彦、林良雄
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K15285
[Presentation] Peptide Phosphonates as a Transition State Analog for Thioesterases in Nonribosomal Peptide Synthetases2022
- Author(s)
  今野翔、田中美有、水口友絵、田口晃弘、谷口敦彦、林良雄
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K15285
[Presentation] 3CL protease inhibitor with an arylketone warhead group as anti-SARS-CoV-2 agents2021
- Author(s)
  Sho Konno at al.
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-20K22723

1. 林良雄 (10322562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 谷口敦彦 (30790125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 神谷亘 (60551421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAWAGUCHI Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Konno Sho 今野 翔

Research Projects

Research Products

Co-Researchers

Development of innovative drug discovery based on SARS-CoV-2 3CL protease inhibitor YH-53

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of transition-state analogs for peptide macrocyclasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of a tandem-macrocyclase in nonribosomal peptide synthetasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a degrader for SARS-CoV-2 3CL proteasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Peptide mixed phosphonates for covalent complex formation with thioesterases in nonribosomal peptide synthetases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of One-Pot Disulfide-Driven Cyclic Peptide Synthesis with a 3-Nitro-2-pyridinesulfenate2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 環状ペプチドMA026の環化酵素の同定および基質許容性の解析2023

Author(s)

Organizer

Data Source

[Presentation] Substrate peptide-based mixed phosphonates as an irreversible inhibitor for thioesterase domain in nonribosomal peptide synthetases2023

Author(s)

Organizer

Data Source

[Presentation] MA026環化酵素を用いた化学酵素ハイブリッド合成法の開発2023

Author(s)

Organizer

Data Source

[Presentation] Development of Peptide Phosphonate Inhibitors for Thioesterases in Nonribosomal Peptide Synthetases2023

Author(s)

Organizer

Data Source

[Presentation] Functional Characterization of Tandem Thioesterase in MA026 Biosynthesis2023

Author(s)

Organizer

Data Source

[Presentation] Characterization of Tandem Thioesterase Domains in MA026 Synthetase2022

Author(s)

Organizer

Data Source

[Presentation] Peptide Phosphonates as a Transition State Analog for Thioesterases in Nonribosomal Peptide Synthetases2022

Author(s)

Organizer

Data Source

[Presentation] 3CL protease inhibitor with an arylketone warhead group as anti-SARS-CoV-2 agents2021

Author(s)

Organizer

Data Source

Konno Sho 今野翔