OHWADA WATARU 大和田渉

… Alternative Names

Ohwada Wataru 大和田渉

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Researcher Number	70896589
Other IDs
Affiliation (Current)	2026: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 札幌医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator アントラサイクリン / ミトコンドリア / オートファジー / ラパマイシン / MLKL / ドキソルビシン心筋症 / ネクロプトーシス / ドキソルビシン / フェロトーシス / アポトーシス

Elucidating the Mechanisms of Myocardial Injury in Doxorubicin-Induced Cardiomyopathy: A Focus on Necroptosis.Principal Investigator
- Principal Investigator
  
  大和田渉
- Project Period (FY)
  2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Sapporo Medical University
Elucidation of the cell death signal interconnections in doxorubicin-induced cardiomyopathy.Principal Investigator
- Principal Investigator
  
  Ohwada Wataru
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Sapporo Medical University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Contribution of MLKL to the development of doxorubicin-induced cardiomyopathy and its amelioration by rapamycin2024
- Author(s)
  Shimizu Masaki、Ohwada Wataru、Yano Toshiyuki、Kouzu Hidemichi、Sato Tatsuya、Ogawa Toshifumi、Osanami Arata、Toda Yuki、Nagahama Hiroshi、Tanno Masaya、Miura Tetsuji、Kuno Atsushi、Furuhashi Masato
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 156 Issue: 1 Pages: 9-18
- DOI
  10.1016/j.jphs.2024.06.005
- Data Source
  KAKENHI-PROJECT-23K15162
[Journal Article] Downregulation of Mitochondrial Fusion Protein Expression Affords Protection from Canonical Necroptosis in H9c2 Cardiomyoblasts2024
- Author(s)
  Toda Yuki、Ong Sang-Bing、Yano Toshiyuki、Kuno Atsushi、Kouzu Hidemichi、Sato Tatsuya、Ohwada Wataru、Tatekoshi Yuki、Ogawa Toshifumi、Shimizu Masaki、Tanno Masaya、Furuhashi Masato
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 5 Pages: 2905-2905
- DOI
  10.3390/ijms25052905
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15162, KAKENHI-PROJECT-22K08189
[Journal Article] Which came first: Sarcopenia or weight loss?2024
- Author(s)
  Ohori Katsuhiko、Yano Toshiyuki、Katano Satoshi、Nagaoka Ryohei、Numazawa Ryo、Yamano Kotaro、Fujisawa Yusuke、Kouzu Hidemichi、Nagano Nobutaka、Fujito Takefumi、Nishikawa Ryo、Ohwada Wataru、Furuhashi Masato
- Journal Title
  
  Geriatrics & Gerontology International
  
  Volume: - Issue: 6 Pages: 652-653
- DOI
  10.1111/ggi.14879
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11288, KAKENHI-PROJECT-23K15162, KAKENHI-PROJECT-20K19313
[Journal Article] Adverse plasma branched‐chain amino acid profile mirrors fatty muscle degeneration in diabetic heart failure patients2024
- Author(s)
  Kouzu Hidemichi、Yano Toshiyuki、Katano Satoshi、Kawaharata Wataru、Ogura Keishi、Numazawa Ryo、Nagaoka Ryohei、Ohori Katsuhiko、Nishikawa Ryo、Ohwada Wataru、Fujito Takefumi、Nagano Nobutaka、Furuhashi Masato
- Journal Title
  
  ESC Heart Failure
  
  Volume: 0 Issue: 5 Pages: 0-0
- DOI
  10.1002/ehf2.14872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15162, KAKENHI-PROJECT-22K08189, KAKENHI-PROJECT-20K19313, KAKENHI-PROJECT-23K07481
[Journal Article] Coexistence of sarcopenia and self‐reported weight loss is a powerful predictor of mortality in older patients with heart failure2023
- Author(s)
  Ohori Katsuhiko、Yano Toshiyuki、Katano Satoshi、Nagaoka Ryohei、Numazawa Ryo、Yamano Kotaro、Fujisawa Yusuke、Kouzu Hidemichi、Nagano Nobutaka、Fujito Takefumi、Nishikawa Ryo、Ohwada Wataru、Furuhashi Masato
- Journal Title
  
  Geriatrics & Gerontology International
  
  Volume: 24 Issue: 1 Pages: 95-101
- DOI
  10.1111/ggi.14778
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11288, KAKENHI-PROJECT-23K15162
[Journal Article] Circulating level of β-aminoisobutyric acid (BAIBA), a novel myokine-like molecule, is inversely associated with fat mass in patients with heart failure2023
- Author(s)
  Katano Satoshi、Yano Toshiyuki、Kouzu Hidemichi、Nagaoka Ryohei、Numazawa Ryo、Yamano Kotaro、Fujisawa Yusuke、Ohori Katsuhiko、Nagano Nobutaka、Fujito Takefumi、Nishikawa Ryo、Ohwada Wataru、Katayose Masaki、Sato Tatsuya、Kuno Atsushi、Furuhashi Masato
- Journal Title
  
  Heart and Vessels
  
  Volume: 39 Issue: 1 Pages: 35-47
- DOI
  10.1007/s00380-023-02308-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K19313, KAKENHI-PROJECT-22K11288, KAKENHI-PROJECT-23K15162
[Journal Article] Relationship between serum iron level and physical function in heart failure patients is lost by presence of diabetes2023
- Author(s)
  Ohori Katsuhiko、Yano Toshiyuki、Katano Satoshi、Nagaoka Ryohei、Numazawa Ryo、Yamano Kotaro、Fujisawa Yusuke、Kouzu Hidemichi、Nagano Nobutaka、Fujito Takefumi、Nishikawa Ryo、Ohwada Wataru、Sato Tatsuya、Furuhashi Masato
- Journal Title
  
  ESC Heart Failure
  
  Volume: 11 Issue: 1 Pages: 513-523
- DOI
  10.1002/ehf2.14610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11288, KAKENHI-PROJECT-23K15162
[Journal Article] Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study2023
- Author(s)
  Ohori Katsuhiko、Yano Toshiyuki、Katano Satoshi、Nagaoka Ryohei、Numazawa Ryo、Yamano Kotaro、Fujisawa Yusuke、Kouzu Hidemichi、Koyama Masayuki、Nagano Nobutaka、Fujito Takefumi、Nishikawa Ryo、Ohwada Wataru、Furuhashi Masato
- Journal Title
  
  Drugs & Aging
  
  Volume: 40 Issue: 8 Pages: 731-739
- DOI
  10.1007/s40266-023-01035-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08189, KAKENHI-PROJECT-22K11288, KAKENHI-PROJECT-23K15162
[Presentation] Contribution of MLKL to the development of doxorubicin-induced cardiomyopathy2024
- Author(s)
  Masaki Shimizu, Wataru Ohwada, Toshiyuki Yano, Hidemichi Kouzu, Tatsuya Sato, Arata Osanami, Toshifumi Ogawa, Yuki Toda, Atsushi Kuno, Masaya Tanno, Masato Furuhashi
- Organizer
  第88回　日本循環器学会
- Data Source
  KAKENHI-PROJECT-23K15162
[Presentation] Rapamycin ameliorates doxorubicin-induced cardiomyopathy through suppression of RIPK1-independent necroptosis.2023
- Author(s)
  Masaki Shimizu, Wataru Ohwada, Toshiyuki Yano, Hidemichi Kouzu, Tatsuya Sato, Arata Osanami, Toshifumi Ogawa, Yuki Toda, Atsushi Kuno, Masaya Tanno, Masato Furuhashi
- Organizer
  ESC Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15162
[Presentation] Rapamycin ameliorates doxorubicin-induced cardiomyopathy: potential role of necroptosis.2023
- Author(s)
  Masaki Shimizu, Wataru Ohwada, Toshiyuki Yano, Hidemichi Kouzu, Tatsuya Sato, Arata Osanami, Toshifumi Ogawa, Yuki Toda, Atsushi Kuno, Masaya Tanno, Masato Furuhashi
- Organizer
  第87回　日本循環器学会
- Data Source
  KAKENHI-PROJECT-21K16028
[Presentation] Nuclear accumulation of MLKL induces necroptosis in cardiomyocytes: potential implication in Doxorubicin-induced cardiotoxicity.2022
- Author(s)
  Masaki Shimizu, Wataru Ohwada, Hidemichi Kouzu, Tatsuya Sato, Arata Osanami, Toshifumi Ogawa, Shoya Ino, Yuki Toda, Atsushi Kuno, Masaya Tanno, Toshiyuki Yano
- Organizer
  ESC Congress 2022 Barcelona
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16028
[Presentation] MLKL, an executor of necroptosis, is involved in doxorubicin-induced cardiotoxicity.2022
- Author(s)
  Masaki Shimizu, Wataru Ohwada, Toshiyuki Yano, Hidemichi Kouzu, Tatsuya Sato, Arata Osanami, Toshifumi Ogawa, Shoya Ino, Yuki Toda, Atsushi Kuno, Masaya Tanno, Tetsuji Miura.
- Organizer
  第86回　日本循環器学会
- Data Source
  KAKENHI-PROJECT-21K16028
[Presentation] ネクロプトーシスはドキソルビシンによる心筋障害に寄与する2021
- Author(s)
  清水将輝、大和田渉、矢野俊之、神津英至、佐藤達也、長南新太、小川俊史、伊野祥哉、戸田悠貴、久野篤史、丹野雅也
- Organizer
  第4回　日本腫瘍循環器学会
- Data Source
  KAKENHI-PROJECT-21K16028

1. YANO Toshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
2. 片野唆敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 長岡凌平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHWADA WATARU 大和田 渉

Ohwada Wataru 大和田 渉

Research Projects

Research Products

Co-Researchers

Elucidating the Mechanisms of Myocardial Injury in Doxorubicin-Induced Cardiomyopathy: A Focus on Necroptosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the cell death signal interconnections in doxorubicin-induced cardiomyopathy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Contribution of MLKL to the development of doxorubicin-induced cardiomyopathy and its amelioration by rapamycin2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Downregulation of Mitochondrial Fusion Protein Expression Affords Protection from Canonical Necroptosis in H9c2 Cardiomyoblasts2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Which came first: Sarcopenia or weight loss?2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adverse plasma branched‐chain amino acid profile mirrors fatty muscle degeneration in diabetic heart failure patients2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Coexistence of sarcopenia and self‐reported weight loss is a powerful predictor of mortality in older patients with heart failure2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating level of β-aminoisobutyric acid (BAIBA), a novel myokine-like molecule, is inversely associated with fat mass in patients with heart failure2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship between serum iron level and physical function in heart failure patients is lost by presence of diabetes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] Contribution of MLKL to the development of doxorubicin-induced cardiomyopathy2024

Author(s)

Organizer

Data Source

[Presentation] Rapamycin ameliorates doxorubicin-induced cardiomyopathy through suppression of RIPK1-independent necroptosis.2023

Author(s)

Organizer

Data Source

[Presentation] Rapamycin ameliorates doxorubicin-induced cardiomyopathy: potential role of necroptosis.2023

Author(s)

Organizer

Data Source

[Presentation] Nuclear accumulation of MLKL induces necroptosis in cardiomyocytes: potential implication in Doxorubicin-induced cardiotoxicity.2022

Author(s)

Organizer

Data Source

[Presentation] MLKL, an executor of necroptosis, is involved in doxorubicin-induced cardiotoxicity.2022

Author(s)

Organizer

Data Source

[Presentation] ネクロプトーシスはドキソルビシンによる心筋障害に寄与する2021

Author(s)

Organizer

OHWADA WATARU 大和田渉

Ohwada Wataru 大和田渉