Yamamoto Keita 山本圭太

Researcher Number	70899301
Other IDs
Affiliation (Current)	2026: 東京大学, 大学院新領域創成科学研究科, 助教
Affiliation (based on the past Project Information) *help	2026: 東京大学, 大学院新領域創成科学研究科, 助教 2022 – 2024: 東京大学, 大学院新領域創成科学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 膜の無い構造体 / CRISPR/Cas13 / 耐性化 / RNA蛋白質相互作用 / CRISPR／Cas13 / 薬剤耐性 / 白血病 / RNAー蛋白質相互作用 / split-TurboID / Split-TurboID / NanoBiT / BiFC / CRISPR／Cas１３ … More Except Principal Investigator … More 脂質ナノ粒子 / MECOM / 遺伝子治療 / 骨髄不全 / 造血幹細胞 / CRISPR-Cas13 / 白血病幹細胞 / 白血病融合遺伝子 / NEAT1 / 骨髄系腫瘍 / 核酸医薬 / CRISPR/Cas13 / 造血器腫瘍 / siRNA / lncRNA Less

Cas13を活用した反復配列の理解と治療応用Principal Investigator
- Principal Investigator
  
  山本圭太
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Development of In Vivo Gene Therapy for Bone Marrow Failure Syndrome
- Principal Investigator
  
  合山進
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
白血病治療抵抗性に関する研究：RNA-蛋白質相互作用に着目した新規メカニズムの解明Principal Investigator
- Principal Investigator
  
  山本圭太
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Analysis of protein-RNA interactions in membraneless organellesPrincipal Investigator
- Principal Investigator
  
  Yamamoto Keita
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Development of RNA-targeting drugs for hematopoietic neoplasms
- Principal Investigator
  
  合山進
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] NPM1-fusion proteins promote myeloid leukemogenesis through XPO1-dependent HOX activation2024
- Author(s)
  Shimosato Yuko、Yamamoto Keita、Jia Yuhan、Zhang Wenyu、Shiba Norio、Hayashi Yasuhide、Ito Shuichi、Kitamura Toshio、Goyama Susumu
- Journal Title
  
  Leukemia
  
  Volume: 39 Issue: 1 Pages: 75-86
- DOI
  10.1038/s41375-024-02438-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24360, KAKENHI-PROJECT-23K07847, KAKENHI-PROJECT-22KK0127
[Journal Article] HDAC7 is a potential therapeutic target in acute erythroid leukemia2024
- Author(s)
  Zhang Wenyu、Yamamoto Keita、Chang Yu-Hsuan、Yabushita Tomohiro、Hao Yangying、Shimura Ruka、Nakahara Jakushin、Shikata Shiori、Iida Kohei、Chen Qianyi、Zhang Xichen、Kitamura Toshio、Goyama Susumu
- Journal Title
  
  Leukemia
  
  Volume: 38 Issue: 12 Pages: 2614-2627
- DOI
  10.1038/s41375-024-02394-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24360, KAKENHI-PROJECT-22KK0127
[Journal Article] Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment.2023
- Author(s)
  Yabushita T, Chinen T, Nishiyama A, Asada S, Shimura R, Isobe T, Yamamoto K, Sato N, Enomoto Y, Tanaka Y, Fukuyama T, Satoh H, Kato K, Saitoh K, Ishikawa T, Soga T, Nannya Y, Fukagawa T, Nakanishi M, Kitagawa D, Kitamura T, Goyama S
- Journal Title
  
  Cell Rep.
  
  Volume: 42 Issue: 9 Pages: 113098-113098
- DOI
  10.1016/j.celrep.2023.113098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18113, KAKENHI-PROJECT-22KK0127, KAKENHI-PROJECT-22K19540, KAKENHI-ORGANIZER-19H05739, KAKENHI-PUBLICLY-22H04692, KAKENHI-PUBLICLY-23H04282, KAKENHI-PROJECT-22H00408, KAKENHI-PROJECT-23K24360
[Presentation] CRISPR/Cas9 Library Screens Identified Atp2a2 as an In Vivo Specific Tumor Suppressor in Myeloid Neoplasms2024
- Author(s)
  Ruka Shimura, Moe Tamura, Keita Yamamoto, Kohei Iida, Shuhei Asada, Emi Sugimoto, E. Christine Pietsch, Barbara A. Weir, Ramona Crescenzo, Glenn S. Cowley, Ricardo M. Attar, Ulrike Philippar, Satoshi Yamasaki, Taisei Hirouchi, Kaoru Uchimaru, Toshio Kitamura, Susumu Goyama.
- Organizer
  66th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance specifically in Monocytic AML2024
- Author(s)
  Yu-Hsuan Chang, Keita Yamamoto, Takeshi Fujino, Teh-Wei Wang, Emi Sugimoto, Wenyu Zhang, Tomohiro Yabushita, Ken Suzaki, E. Christine Pietsch, Barbara A. Weir, Ramona Crescenzo, Glenn S. Cowley, Ricardo Attar, Ulrike Philippar, Yutaka Enomoto, Yoich Imai, Toshio Kitamura, Susumu Goyama
- Organizer
  14th INTERNATIONAL WORKSHOP ON MOLECULAR ASPECTS OF MYELOID STEM CELL DEVELOPMENT AND LEUKEMIA
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] HDAC7 is a potential therapeutic target in Acute Erythroid Leukemia2024
- Author(s)
  張文宇、山本圭太、張育せん, 薮下知宏、北村俊雄、合山進
- Organizer
  第28回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] PCYT1A Is a Metabolic Vulnerability in Monocytic Acute Myeloid Leukemia2024
- Author(s)
  akushin Nakahara, Keita Yamamoto, Tomohiro Yabushita, Takumi Chinen, Kei Ito, Yutaka Takeda, Daiju Kitagawa, Toshio Kitamura, Susumu Goyama
- Organizer
  66th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] CRISPR/Cas13を用いたRNA-タンパク質相互作用解析ツールの開発と応用2024
- Author(s)
  山本圭太
- Organizer
  第29回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-24K19216
[Presentation] Machine learning-based modeling predicts efficacy of mTOR/TP53 co-targeted therapy in acute myeloid leukemia2024
- Author(s)
  ingmei Li, Emi Sugimoto, Keita Yamamoto, Yutong Dai, Sungjoon Park, Kenta Nakai, Toshio Kitamura, Susumu Goyama
- Organizer
  第８３回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] CRISPR/Cas13 を用いた RNA-タンパク質相互作用解析ツールの開発と応用2024
- Author(s)
  山本圭太、北村俊雄、合山進
- Organizer
  第29回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] NEAT1標的CRISPR/Cas13によるcollateral activityは抗白血病効果を示す2024
- Author(s)
  志村瑠香、山本圭太、藪下知宏、飯田孝平、張文宇、北村俊雄、合山進
- Organizer
  第８６回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] NPM1 融合蛋白質による白血病発症メカニズムの解明2024
- Author(s)
  下里侑子、山本圭太、賈宇涵、柴徳生、林泰秀、伊藤秀一、北村俊雄、合山進
- Organizer
  第29回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] カルシウム制御因子Atp2a2は骨髄系腫瘍においてin vivo特異的に増殖を抑制する2024
- Author(s)
  志村瑠香、田村萌、山本圭太、北村俊雄、合山進
- Organizer
  第28回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] MECOMはGATA2と拮抗することで白血病進展を促進し、マスト細胞への分化を抑制する2024
- Author(s)
  飯田孝平、中西繭子、中原若辰、山本圭太、浅田修平、藪下知宏、北村俊雄、合山進
- Organizer
  第８６回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-24K22128
[Presentation] Machine Learning-Based Predictive Modeling Maximizes the Efficacy of mTOR/TP53 Co-Targeting Therapy Against Acute Myeloid Leukemia2024
- Author(s)
  ingmei Li, Emi Sugimoto, Keita Yamamoto, Yutong Dai, Sung-Joon Park, Kenta Nakai, Toshio Kitamura, Susumu Goyama
- Organizer
  66th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] Group comparison based on genetic information reveals lineage-specific vulnerabilities in AML2024
- Author(s)
  Jakushin Nakahara, Keita Yamamoto, Tomohiro Yabushita, Daiju Kitagawa, Takumi Chinen, Kei Ito, Yutaka Takeda, Jakushin Nakahara
- Organizer
  第８３回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML2023
- Author(s)
  Yu-Hsuan Chang, Takeshi Fujino, Keita Yamamoto, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML2023
- Author(s)
  Chang YH, Fujino T, Yamamoto K, Enomoto Y, Kitamura T, Goyama S
- Organizer
  The 13th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] HDAC7 is a potential therapeutic target in acute erythroid leukemia2023
- Author(s)
  Wenyu Zhang, Keita Yamamoto, Yu Hsuan Chang, Tomohiro Yabushita, Yangying Hao, Jakushin Nakahara, Toshio Kitamura, Susumu Goyama
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] HDAC7 is a potential therapeutic target in acute erythroid leukemia2023
- Author(s)
  Zheng W, Yamamoto K, Chang YH, Yabushita T, Kitamura T, Goyama S
- Organizer
  The 13th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] SETDB1 Suppresses Interferon Responses and NK Cell-Mediated Immunosurveillance Specifically in Monocytic AML2023
- Author(s)
  Chang YH, Fujino T, Yamamoto K, Enomoto Y, Kitamura T, Goyama S.
- Organizer
  Annual meeting of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance in monocytic AML2023
- Author(s)
  Yu Hsuan Chang, Takeshi Fujino, Keita Yamamoto, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22KK0127
[Presentation] ASXL1 is involved in paraspeckle formation in hematopoietic cells2022
- Author(s)
  Keita Yamamoto
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K16319

1. 合山進 (80431849)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. 程久美子 (50213327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 深川竜郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamamoto Keita 山本 圭太

Research Projects

Research Products

Co-Researchers

Cas13を活用した反復配列の理解と治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of In Vivo Gene Therapy for Bone Marrow Failure Syndrome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

白血病治療抵抗性に関する研究：RNA-蛋白質相互作用に着目した新規メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of protein-RNA interactions in membraneless organellesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of RNA-targeting drugs for hematopoietic neoplasms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] NPM1-fusion proteins promote myeloid leukemogenesis through XPO1-dependent HOX activation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HDAC7 is a potential therapeutic target in acute erythroid leukemia2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment.2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] CRISPR/Cas9 Library Screens Identified Atp2a2 as an In Vivo Specific Tumor Suppressor in Myeloid Neoplasms2024

Author(s)

Organizer

Data Source

[Presentation] SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance specifically in Monocytic AML2024

Author(s)

Organizer

Data Source

[Presentation] HDAC7 is a potential therapeutic target in Acute Erythroid Leukemia2024

Author(s)

Organizer

Data Source

[Presentation] PCYT1A Is a Metabolic Vulnerability in Monocytic Acute Myeloid Leukemia2024

Author(s)

Organizer

Data Source

[Presentation] CRISPR/Cas13を用いたRNA-タンパク質相互作用解析ツールの開発と応用2024

Author(s)

Organizer

Data Source

[Presentation] Machine learning-based modeling predicts efficacy of mTOR/TP53 co-targeted therapy in acute myeloid leukemia2024

Author(s)

Organizer

Data Source

[Presentation] CRISPR/Cas13 を用いた RNA-タンパク質相互作用解析ツールの開発と応用2024

Author(s)

Organizer

Data Source

[Presentation] NEAT1標的CRISPR/Cas13によるcollateral activityは抗白血病効果を示す2024

Author(s)

Organizer

Yamamoto Keita 山本圭太