MIHARA TAIKI 三原大輝

… Alternative Names

Mihara Taiki 三原大輝

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Researcher Number	70908326
Other IDs	https://orcid.org/0009-0003-1611-8329
Affiliation (Current)	2026: 国立医薬品食品衛生研究所, 毒性部, 主任研究官
Affiliation (based on the past Project Information) *help	2026: 国立医薬品食品衛生研究所, 毒性部, 主任研究官 2021 – 2024: 東京大学, 大学院農学生命科学研究科(農学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related / 0605:Veterinary medical science, animal science, and related fields Except Principal Investigator Basic Section 42020:Veterinary medical science-related
Keywords	Principal Investigator 肝臓線維化 / 線維芽細胞増殖因子23 / 臓器連関 / 肝臓 / 線維化 / 細胞外小胞 / 代謝機能障害関連脂肪性肝炎 / 臓器連環 / 骨 / 骨異栄養症 / 骨粗鬆症 / マトリソーム / 肝硬変 … More Except Principal Investigator … More gastrointestine / smooth muscle / stromal cells / PDGFR alpha / ICC / 常在型マクロファージ / 平滑金細胞 / PDGFRα陽性間質前駆細胞 / カハール介在細胞 / 消化管 Less

代謝機能障害関連脂肪性肝疾患 (MASLD) における全身臓器連関の破綻メカニズムの解明Principal Investigator
- Principal Investigator
  
  三原大輝
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  National Institute of Health Sciences
線維芽細胞増殖因子23に着目した肝硬変および続発する合併症の増悪メカニズムの解明Principal Investigator
- Principal Investigator
  
  三原大輝
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  The University of Tokyo
Role of gastrointestinal stromal constituent cells in peristalsis and in the pathogenesis and repair of gastrointestinal diseases.
- Principal Investigator
  
  堀正敏
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  The University of Tokyo
A Novel Pathogenic Mechanism of Osteoporosis; Liver-Bone Organ Crosstalk Mediated by Fibroblast Growth Factor 23Principal Investigator
- Principal Investigator
  
  Mihara Taiki
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  The University of Tokyo
A novel therapeutic strategy for fibrosis targeting Fibroblast Growth Factor 23Principal Investigator
- Principal Investigator
  
  Mihara Taiki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0605:Veterinary medical science, animal science, and related fields
- Research Institution
  The University of Tokyo

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] Pemigatinib suppresses liver fibrosis and subsequent osteodystrophy in mice2025
- Author(s)
  Mihara Taiki、Tsuru Yoshiharu、Kurosawa Tamaki、Nonoshita Yuma、Yamakawa Yuki、Hori Masatoshi
- Journal Title
  
  Hepatology Communications
  
  Volume: 9 Issue: 1
- DOI
  10.1097/hc9.0000000000000610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15008
[Presentation] Liver-bone crosstalk mediated by fibroblast growth factor 23: Pemigatinib suppresses liver fibrosis and subsequent osteodystrophy2024
- Author(s)
  Taiki Mihara, Yoshiharu Tsuru, Tamaki Kurosawa, Yuma Nonoshita, Yuki Yamakawa, Masatoshi Hori
- Organizer
  The 1st Annual Meeting of the Japanese Cytokine Society
- Data Source
  KAKENHI-PROJECT-22K15008
[Presentation] Pemigatinib suppresses liver fibrosis and subsequent osteoporosis2023
- Author(s)
  Taiki Mihara, Yoshiharu Tsuru, Tamaki Kurosawa, Yuma Nonishita, Yuki Yamakawa, Masatoshi Hori
- Organizer
  第97回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K15008
[Presentation] Novel osteoporosis mechanism: liver-bone crosstalk mediated by fibroblast growth factor 232022
- Author(s)
  Taiki Mihara, Yoshiharu Tsuru, Masatoshi Hori
- Organizer
  The Cytokines & ILC4
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15008
[Presentation] Novel osteoporosis mechanism: liver-bone crosstalk mediated by fibroblast growth factor 232022
- Author(s)
  Taiki Mihara, Yoshiharu Tsuru, Masatoshi Hori
- Organizer
  JSICR MMCB Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15008
[Presentation] Novel osteoporosis mechanism: liver-bone crosstalk mediated by fibroblast growth factor 232022
- Author(s)
  Taiki Mihara, Yoshiharu Tsuru, Masatoshi Hori
- Organizer
  The Cytokines & ILC4
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20613
[Presentation] Novel osteoporosis mechanism: liver-bone crosstalk mediated by fibroblast growth factor 232022
- Author(s)
  Taiki Mihara, Yoshiharu Tsuru, Masatoshi Hori
- Organizer
  JSICR MMCB Joint Symposium
- Data Source
  KAKENHI-PROJECT-21K20613

1. 堀正敏 (70211547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 小野竜一 (10401358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MIHARA TAIKI 三原 大輝

Mihara Taiki 三原 大輝

Research Projects

Research Products

Co-Researchers

代謝機能障害関連脂肪性肝疾患 (MASLD) における全身臓器連関の破綻メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

線維芽細胞増殖因子23に着目した肝硬変および続発する合併症の増悪メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of gastrointestinal stromal constituent cells in peristalsis and in the pathogenesis and repair of gastrointestinal diseases.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A Novel Pathogenic Mechanism of Osteoporosis; Liver-Bone Organ Crosstalk Mediated by Fibroblast Growth Factor 23Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel therapeutic strategy for fibrosis targeting Fibroblast Growth Factor 23Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Pemigatinib suppresses liver fibrosis and subsequent osteodystrophy in mice2025

Author(s)

Journal Title

DOI

Data Source

[Presentation] Liver-bone crosstalk mediated by fibroblast growth factor 23: Pemigatinib suppresses liver fibrosis and subsequent osteodystrophy2024

Author(s)

Organizer

Data Source

[Presentation] Pemigatinib suppresses liver fibrosis and subsequent osteoporosis2023

Author(s)

Organizer

Data Source

[Presentation] Novel osteoporosis mechanism: liver-bone crosstalk mediated by fibroblast growth factor 232022

Author(s)

Organizer

Data Source

[Presentation] Novel osteoporosis mechanism: liver-bone crosstalk mediated by fibroblast growth factor 232022

Author(s)

Organizer

Data Source

[Presentation] Novel osteoporosis mechanism: liver-bone crosstalk mediated by fibroblast growth factor 232022

Author(s)

Organizer

Data Source

[Presentation] Novel osteoporosis mechanism: liver-bone crosstalk mediated by fibroblast growth factor 232022

Author(s)

Organizer

Data Source

MIHARA TAIKI 三原大輝

Mihara Taiki 三原大輝