Kawashima Shusuke 川島秀介

Researcher Number	70916436
Other IDs
Affiliation (based on the past Project Information) *help	2023 – 2025: 千葉大学, 大学院医学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related Except Principal Investigator Basic Section 53050:Dermatology-related
Keywords	Principal Investigator 悪性黒色腫 / 抗腫瘍免疫応答 / 免疫チェックポイント阻害薬 / IFN-g / Nf-kB / JAK / PI3K/Akt経路 / CD155 / NF-κB / MHC class I / IFN-γ / 腫瘍免疫応答 … More Except Principal Investigator … More 白斑 / irAE / 免疫チェックポイント阻害薬 / メラノーマ Less

irAE白斑をモデルとした抗腫瘍効果と自己免疫を差別化するための基盤研究
- Principal Investigator
  
  猪爪隆史
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Chiba University
免疫関連有害事象を予防する超選択的免疫チェックポイント阻害療法の開発Principal Investigator
- Principal Investigator
  
  川島秀介
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Chiba University
Elucidation of the Mechanisms of Sensitivity and Resistance to Cancer Immunotherapy Independent of IFN-g SignalingPrincipal Investigator
- Principal Investigator
  
  Kawashima Shusuke
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Chiba University

All 2024 2023

All Journal Article Presentation

[Journal Article] Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024
- Author(s)
  Zhou Wenhao、Kawashima Shusuke、Ishino Takamasa、Kawase Katsushige、Ueda Youki、Yamashita Kazuo、Watanabe Tomofumi、Kawazu Masahito、Dansako Hiromichi、Suzuki Yutaka、Nishikawa Hiroyoshi、Inozume Takashi、Nagasaki Joji、Togashi Yosuke
- Journal Title
  
  Cell Reports
  
  Volume: 43 Issue: 2 Pages: 113797-113797
- DOI
  10.1016/j.celrep.2024.113797
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KK0149, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-23K14594, KAKENHI-PROJECT-23K15261
[Journal Article] ゲノム医療からみた併用療法2024
- Author(s)
  川島秀介、冨樫庸介
- Journal Title
  
  がん分子標的・免疫治療
  
  Volume: 21 Pages: 10-18
- Data Source
  KAKENHI-PROJECT-23K15261
[Journal Article] Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity2024
- Author(s)
  Mukohara F、Iwata K、Ishino T、Inozume T、Nagasaki J、Ueda Y、Suzawa K、Ueno T、Ikeda H、Kawase K、Saeki Y、Kawashima S、Yamashita K、Kawahara Y、Nakamura Y、Honobe-Tabuchi A、Watanabe H、Dansako H、Kawamura T、Suzuki Y、Honda H、Mano H、Toyooka S、Kawazu M、Togashi Y
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 35
- DOI
  10.1073/pnas.2320189121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-23K15261, KAKENHI-PROJECT-22KJ0489, KAKENHI-PROJECT-23K27442, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K11468, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling2024
- Author(s)
  Naoi Y, Morinaga T, Nagasaki J, Ariyasu R, Ueda Y, Yamashita K, Zhou W, Kawashima S, Kawase K, Honobe-Tabuchi A, Ohnuma T, Kawamura T, Umeda Y, Kawahara Y, Nakamura Y, Kiniwa Y, Yamasaki O, Fukushima S, Kawazu M, Suzuki Y, Nishikawa H, Hanazawa T, Ando M, Inozume T, Togashi Y.
- Journal Title
  
  Cancer Research
  
  Volume: - Issue: 13 Pages: 2109-2122
- DOI
  10.1158/0008-5472.can-23-0453
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14594, KAKENHI-PROJECT-23K07765, KAKENHI-PROJECT-21K08314, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-23K15261, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K11468, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-23KK0149
[Journal Article] High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects2023
- Author(s)
  Kawase K、Kawashima S、Nagasaki J、Inozume T、Tanji E、Kawazu M、Hanazawa T、Togashi Y
- Journal Title
  
  Cancer Immunology Research
  
  Volume: In press Issue: 7 Pages: 895-908
- DOI
  10.1158/2326-6066.cir-22-0815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-23K15261, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-21K09625, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-21H02772
[Presentation] TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024
- Author(s)
  Zhou W, Kawashima S, Ihino T, Kawase K, Ueda Y, Yamashita K, Watanabe T, Inozume T, Nishikawa H, Nagasaki J, and Togashi Y.
- Organizer
  第83回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K15261
[Presentation] インターフェロンγシグナルと抗腫瘍免疫応答2024
- Author(s)
  川瀬勝隆、川島秀介、長崎譲慈、猪爪隆史、河津正人、花澤豊行、冨樫庸介
- Organizer
  第28回日本がん免疫学会総会・第37回日本バイオセラピィ学会学術集会総会合同大会
- Data Source
  KAKENHI-PROJECT-23K15261
[Presentation] CD276は効果相においてPD-L1と協調的にメラノーマ特異的T細胞の抗腫瘍活性を減弱する2024
- Author(s)
  青山和弘、川島秀介、佐伯優佳、川原祐、松澤高光、斉藤宜子、及川綾子、河津正人、冨樫庸介、中村泰大、川村龍吉、木庭幸子、山崎修、福島聡、猪爪隆史
- Organizer
  第28回日本がん免疫学会総会・第37回日本バイオセラピィ学会学術集会総会合同大会
- Data Source
  KAKENHI-PROJECT-23K15261
[Presentation] Impact of somatic mutations in tumor-infiltrating lymphocytes on antitumor immunity2024
- Author(s)
  Ishino T, Mukohara F, Iwata K, Inozume T, Nagasaki J, Ueda Y, Ueno T, Ikeda H, Kawashima S, Watanabe H, Honda H, Toyooka S, Kawazu M and Togashi Y. (2024)
- Organizer
  Society for Immunotherapy of Cancer 2024
- Data Source
  KAKENHI-PROJECT-23K15261
[Presentation] MHC class I消失以外の腫瘍免疫エスケープ機序の網羅的解析2024
- Author(s)
  佐伯優佳、川島秀介、青山和弘、斉藤宜子、及川綾子、松澤高光、川原祐、猪爪隆史
- Organizer
  第123回日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-23K15261
[Presentation] Co-blockade for CD276 and PD-1 signal enhances anti-melanoma T cell response2024
- Author(s)
  Aoyama K（青山和弘）, Kawashima S, Saeki Y, Kawahara Y, Matsuzawa T, Saito N, Oikawa A, Kawazu M, Togashi Y, Nakamura Y, Kawamura T, Kiniwa Y, Yamasaki O, Fukushima S, Inozume T
- Organizer
  The 49th Annual Meeting of the Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-23K15261
[Presentation] CD4+T cell exhaustion in the tumor microenvironment and antitumor immunity2024
- Author(s)
  Nagasaki J, Zhou W, Kawashima S, Ishino T, Kawase K, Ueda Y, Yamashita K, Watanabe T, Inozume T, Togashi Y.
- Organizer
  AACR annual meeting 2024
- Data Source
  KAKENHI-PROJECT-23K15261
[Presentation] High major histocompatibility complex class I expression overcomes cancer immunotherapy resistance due to interferon gamma signaling pathway defects2023
- Author(s)
  Kawase K, Kawashima S, Nagasaki J, Inozume T, Yamamoto H, Kawazu M, Hanazawa T, Togashi Y. (2023)
- Organizer
  AACR ANNUAL MEETING 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15261

1. 猪爪隆史 (80334853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 谷口智憲 (40424163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 長崎譲慈

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 冨樫庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 上野敏秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawashima Shusuke 川島 秀介

Research Projects

Research Products

Co-Researchers

irAE白斑をモデルとした抗腫瘍効果と自己免疫を差別化するための基盤研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫関連有害事象を予防する超選択的免疫チェックポイント阻害療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Mechanisms of Sensitivity and Resistance to Cancer Immunotherapy Independent of IFN-g SignalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ゲノム医療からみた併用療法2024

Author(s)

Journal Title

Data Source

[Journal Article] Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024

Author(s)

Organizer

Data Source

[Presentation] インターフェロンγシグナルと抗腫瘍免疫応答2024

Author(s)

Organizer

Data Source

[Presentation] CD276は効果相においてPD-L1と協調的にメラノーマ特異的T細胞の抗腫瘍活性を減弱する2024

Author(s)

Organizer

Data Source

[Presentation] Impact of somatic mutations in tumor-infiltrating lymphocytes on antitumor immunity2024

Author(s)

Organizer

Data Source

[Presentation] MHC class I消失以外の腫瘍免疫エスケープ機序の網羅的解析2024

Author(s)

Organizer

Data Source

[Presentation] Co-blockade for CD276 and PD-1 signal enhances anti-melanoma T cell response2024

Author(s)

Organizer

Data Source

[Presentation] CD4+T cell exhaustion in the tumor microenvironment and antitumor immunity2024

Author(s)

Organizer

Data Source

[Presentation] High major histocompatibility complex class I expression overcomes cancer immunotherapy resistance due to interferon gamma signaling pathway defects2023

Author(s)

Organizer

Data Source

Kawashima Shusuke 川島秀介