Wang Ziyi 王紫儀

Researcher Number	71000113
Other IDs	https://orcid.org/0000-0003-1884-8053
Affiliation (Current)	2026: 岡山大学, 医歯薬学域, 助教
Affiliation (based on the past Project Information) *help	2024 – 2025: 岡山大学, 医歯薬学域, 助教
Review Section/Research Field	Principal Investigator 0907:Oral science and related fields / Basic Section 56060:Ophthalmology-related Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Basic Section 57070:Developmental dentistry-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 57050:Prosthodontics-related
Keywords	Principal Investigator Bioinformatics / scRNA-seq / Cleft Palate / 口唇口蓋裂 / シングルセル解析 / 細胞骨格 / 力学的刺激 / 口蓋発達 / バイオインフォマティクス / 単一細胞の遺伝子発現解析 / 補体系 / 網膜変性 / アルポート症候群 … More Except Principal Investigator … More scRNA-seq / 空間トランスクリプトーム解析 / spatial RNA-seq / 再生 / 歯 / 運動 / 脳３D画像解析 / ペリニューロナルネット / 神経性やせ症 / RNA-seq / 発生 / 間葉系幹細胞 / 系譜解析 / 空間トランスクリプトーム / DNAバーコード / XII型コラーゲン / 骨細胞ネットワーク / 骨形成 / を生体ボリュームイメージ解析 / 生体ボリュームイメージ解析 / FIB-SEM / コラーゲン線維 / メカニカルストレス / 骨モデリング / 1細胞解析 / 象牙質 / ダイレクトリプログラミング / 転写因子 / 象牙芽細胞 / 歯胚 / iPS干渉 / トランスクリプトーム / 歯胚由来上皮系細胞 / 歯胚由来間葉系細胞 / バイオインフォマティクス / Tooth Regeneration / Filamin A Less

歯胚発生初期における上皮間葉転換の分子メカニズムと役割の解明
- Principal Investigator
  
  早野暁
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Okayama University
Elucidation of the pathogenesis of retinal lesions in Alport syndrome by using scRNA-seqPrincipal Investigator
- Principal Investigator
  
  王紫儀
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Okayama University
Elucidation of the regulatory mechmisum of odontoblast differentiation by singl cell analysis and its application to therapeutics
- Principal Investigator
  
  大野充昭
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Okayama University
Elucidation of early bone tissue construction through biological volume image analysis - from both cell and bone matrix perspectives -
- Principal Investigator
  
  上岡寛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Okayama University
Constructing an in vivo High-Resolution Cell Lineage Analysis System Utilizing Cellular Barcoding Technology
- Principal Investigator
  
  大野充昭
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Okayama University
Understanding the Mechanisms of Tooth Germ Development Using Spatial Single-Cell Epigenome Analysis
- Principal Investigator
  
  窪木拓男
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Okayama University
Investigating Mechanotransduction in Embryonic Palatal Development: Bioinformatics Insights and Experimental Validation Using Public Genome-Wide Association Studies and scRNA-seq DataPrincipal Investigator
- Principal Investigator
  
  王紫儀
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  Okayama University
An international collaborative study to examine a novel hypothesis regarding the genetic background and mechanisms of anorexia nervosa caused by excessive exercise
- Principal Investigator
  
  大橋俊孝
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Okayama University
Development of tooth regenerative technology based on the spatiotemporal transcriptome analysis and iPS interference
- Principal Investigator
  
  Kuboki Takuo
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Okayama University

All 2025 2024

All Journal Article Presentation

[Journal Article] Gingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis2025
- Author(s)
  Zheng Yilin、Wang Ziyi、Weng Yao、Sitosari Heriati、He Yuhan、Zhang Xiu、Shiotsu Noriko、Fukuhara Yoko、Ikegame Mika、Okamura Hirohiko
- Journal Title
  
  Scientific Reports
  
  Volume: 15 Issue: 1
- DOI
  10.1038/s41598-025-94954-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24K23623
[Journal Article] Optimizing β-TCP with E-rhBMP-2-infused fibrin for vertical bone regeneration in a mouse calvarium model2025
- Author(s)
  Zhao Kun、Ono Mitsuaki、Mu Xindi、Wang Ziyi、Xie Shichao、Yonezawa Tomoko、Okada Masahiro、Matsumoto Takuya、Kuboki Takuo、Oohashi Toshitaka
- Journal Title
  
  Regenerative Biomaterials
  
  Volume: 12
- DOI
  10.1093/rb/rbae144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21679, KAKENHI-PROJECT-22K19625, KAKENHI-PROJECT-20KK0377, KAKENHI-PROJECT-23K24538, KAKENHI-PROJECT-24K02626
[Journal Article] Single Cell Spatial Transcriptomics of the Murine Embryonic Palate Links Pax9 to Patterning and Organization of Extracellular Matrix Components2025
- Author(s)
  Pina Jeremie Oliver、Raju Resmi、Stipano Evan、Myo Aye Chan、Wang Ziyi、Ono Mitsuaki、Chattaraj Parna、Furukawa Masae、D’Souza Rena N.
- Journal Title
  
  Res Sq
  
  Volume: rs.3
- DOI
  10.21203/rs.3.rs-5969552/v1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19625, KAKENHI-PROJECT-23K24538, KAKENHI-PROJECT-24K21302
[Journal Article] Gene expression profiles in human dental pulp stem cells treated short-term with lipopolysaccharides before and after osteoinduction2025
- Author(s)
  Orimoto Ai、Wang Ziyi、Ono Mitsuaki、Kitamura Chiaki、Ono Kentaro
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 67 Issue: 1 Pages: 100603-100603
- DOI
  10.1016/j.job.2024.100603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09910, KAKENHI-PROJECT-23K24538, KAKENHI-PROJECT-24K21302, KAKENHI-PROJECT-24K23623
[Journal Article] Local E-rhBMP-2/β-TCP Application Rescues Osteocyte Dendritic Integrity and Reduces Microstructural Damage in Alveolar Bone Post-Extraction in MRONJ-like Mouse Model2024
- Author(s)
  Dang Anh Tuan、Ono Mitsuaki、Wang Ziyi、Tosa Ikue、Hara Emilio Satoshi、Mikai Akihiro、Kitagawa Wakana、Yonezawa Tomoko、Kuboki Takuo、Oohashi Toshitaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 12 Pages: 6648-6648
- DOI
  10.3390/ijms25126648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04842, KAKENHI-PROJECT-23K09275, KAKENHI-PROJECT-22K19625, KAKENHI-PROJECT-20KK0377, KAKENHI-PROJECT-23K24538, KAKENHI-PROJECT-24K21302, KAKENHI-PROJECT-24K22188, KAKENHI-PROJECT-24K23623
[Journal Article] Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism families2024
- Author(s)
  Kittaka Mizuho、Mizuno Noriyoshi、Morino Hiroyuki、Yoshimoto Tetsuya、Zhu Tianli、Liu Sheng、Wang Ziyi、Mayahara Kotoe、Iio Kyohei、Kondo Kaori、Kondo Toshio、Hayashi Tatsuhide、Coghlan Sarah、Teno Yayoi、Doan Andrew Anh Phung、Levitan Marcus、Choi Roy B、Matsuda Shinji、Ouhara Kazuhisa
- Journal Title
  
  JBMR Plus
  
  Volume: 8 Issue: 6
- DOI
  10.1093/jbmrpl/ziae050
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09983, KAKENHI-PROJECT-24K23623
[Journal Article] Exploring the Regulators of Keratinization: Role of BMP-2 in Oral Mucosa2024
- Author(s)
  Xindi Mu; Mitsuaki Ono; Ha Thi Thu Nguyen; Ziyi Wang; Kun Zhao; Taishi Komori; Tomoko Yonezawa; Takuo Kuboki; Toshitaka Oohashi
- Journal Title
  
  Cells
  
  Volume: 13 Issue: 10 Pages: 807-807
- DOI
  10.3390/cells13100807
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KF0265, KAKENHI-PROJECT-21H04842, KAKENHI-PROJECT-22K10100, KAKENHI-PROJECT-24K21302, KAKENHI-PROJECT-24K22188, KAKENHI-PROJECT-24K23623
[Journal Article] O-GlcNAcyalation regulates osteoblast differentiation through the morphological changes in mitochondria, cytoskeleton, and endoplasmic reticulum.2024
- Author(s)
  Weng Y, Wang Z, Sitosari H, Ono M, Okamura H, Oohashi T.
- Journal Title
  
  BioFactors
  
  Volume: 51(1) Issue: 1
- DOI
  10.1002/biof.2131
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18431, KAKENHI-PROJECT-23K24768, KAKENHI-PROJECT-24K23552, KAKENHI-PROJECT-24K23623
[Journal Article] Inverse genetics tracing the differentiation pathway of human chondrocytes2024
- Author(s)
  Do H.T.、Ono M.、Wang Z.、Kitagawa W.、Dang A.T.、Yonezawa T.、Kuboki T.、Oohashi T.、Kubota S.
- Journal Title
  
  Osteoarthritis and Cartilage
  
  Volume: 32 Issue: 11 Pages: 1419-1432
- DOI
  10.1016/j.joca.2024.06.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04842, KAKENHI-PROJECT-24H00652, KAKENHI-PROJECT-20K21679, KAKENHI-PROJECT-23K24538, KAKENHI-PROJECT-23K17439, KAKENHI-PROJECT-24K21302, KAKENHI-PROJECT-24K22188, KAKENHI-PROJECT-24K23623
[Journal Article] Macrophages modulate mesenchymal stem cell function via tumor necrosis factor alpha in tooth extraction model2024
- Author(s)
  Mun Aung Ye、Akiyama Kentaro、Wang Ziyi、Zhang Jiewen、Kitagawa Wakana、Kohno Teisaku、Tagashira Ryuji、Ishibashi Kei、Matsunaga Naoya、Zou Tingling、Ono Mitsuaki、Kuboki Takuo
- Journal Title
  
  JBMR Plus
  
  Volume: 8 Issue: 8
- DOI
  10.1093/jbmrpl/ziae085
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04842, KAKENHI-PROJECT-20K21679, KAKENHI-PROJECT-22K19625, KAKENHI-PROJECT-22K19627, KAKENHI-PROJECT-20KK0377, KAKENHI-PROJECT-24K22188, KAKENHI-PROJECT-24K23623
[Journal Article] Filamin A mediates embryonical palatal fusion by linking mechanotransduction with β-Catenin/Smad22024
- Author(s)
  Wang Ziyi、Hayano Satoru、Weng Yao、Mu Xindi、Ono Mitsuaki、Pina Jeremie Oliver、D'Souza Rena N.、Yamashiro Takashi、Oohashi Toshitaka、Kamioka Hiroshi
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2024.02.16.580664
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K23623
[Presentation] Structural Changes in Mitochondria, Cytoskeleton, and Endoplasmic Reticulum During O-GleNAcylation-Mediated Osteoblast Differentiation: A Bioinformatics and Al Approach2025
- Author(s)
  Ziyi Wang, Yao Weng, Heriati Sitosari, Mitsuaki Ono, Hirohiko Okamura, Toshitaka Oohashi
- Organizer
  第130回日本解剖学会/第102回日本生理学会/第98回日本薬理学会合同大会
- Data Source
  KAKENHI-PROJECT-24K23623
[Presentation] R-Shinyを用いたインタラクティブなscRNA-seqデータ解析2024
- Author(s)
  大野充昭，Wang Z，米澤朋子，大橋俊孝，窪木拓男
- Organizer
  NGS EXPO 2024
- Data Source
  KAKENHI-PROJECT-21H04842
[Presentation] The Roles of BMP-2 on Modulating Oral Mucosal Keratinization2024
- Author(s)
  Xindi Mu, Mitsuaki Ono, Ha Nguyen, Ziyi Wang, Kun Zhao, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi
- Organizer
  102nd General Session & Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K23623
[Presentation] シングルセルRNA-seq解析のためのR-Shinyベースのバイオインフォマティクス環境の構築2024
- Author(s)
  大野充昭, Wang Z, 窪木拓男
- Organizer
  第45回岡山歯学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K24538
[Presentation] 単一細胞レベルでの老化マウス長管骨創傷治癒遅延メカニズムの理解2024
- Author(s)
  北川若奈，大野充昭，Wang Z，土佐郁恵，Dang AT，Do HT，石橋　啓，窪木拓男，大橋俊孝
- Organizer
  第56回日本結合組織学会学術大会
- Data Source
  KAKENHI-PROJECT-21H04842
[Presentation] Development of rhBMP-2/β-TCP artificial bone with controllable shape and mechanical strength.2024
- Author(s)
  Zhao K, Ono M, Nosho S, Mu XD, Wang ZY, Kuboki T, Oohashi T
- Organizer
  第55回日本結合組織学会学術大会
- Data Source
  KAKENHI-PROJECT-21H04842
[Presentation] Defining Cartilage Stem/Progenitor Cells During TMJ Development and Homeostasis2024
- Author(s)
  Ikue Tosa, Benjamin Kheyfets, Hyerin Yoon, Ziyi Wang, Mitsuaki Ono, Mildred Embree
- Organizer
  102nd General Session & Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K23623
[Presentation] Enhancing Vertical Bone Regeneration With Fibrin-Infused E-RhBMP-22024
- Author(s)
  Kun Zhao, Mitsuaki Ono, Xindi Mu, Ziyi Wang, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi
- Organizer
  102nd General Session & Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K23623
[Presentation] O-GlcNAcylation: A Morphologic Regulator of Osteoblast Differentiation2024
- Author(s)
  Ziyi Wang
- Organizer
  中国深セン大学総合病院招待講演
- Invited
- Data Source
  KAKENHI-PROJECT-24K23623

1. Kuboki Takuo (00225195)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. 大野充昭 (60613156)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. 土佐郁恵 (71014007)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 早野暁 (20633712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 井澤俊 (30380017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 宝田剛志 (30377428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 辻孝 (50339131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 渡辺亮 (60506765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 上岡寛 (80253219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 原徹 (70238161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中條真奈 (80824581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 伊豆弥生 (90431949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 大橋俊孝 (50194262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 酒本真次 (30747093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 宮崎晴子 (80525890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 應原一久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 岡村裕彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 折本愛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Wang Ziyi 王 紫儀

Research Projects

Research Products

Co-Researchers

歯胚発生初期における上皮間葉転換の分子メカニズムと役割の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathogenesis of retinal lesions in Alport syndrome by using scRNA-seqPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the regulatory mechmisum of odontoblast differentiation by singl cell analysis and its application to therapeutics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of early bone tissue construction through biological volume image analysis - from both cell and bone matrix perspectives -

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Constructing an in vivo High-Resolution Cell Lineage Analysis System Utilizing Cellular Barcoding Technology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the Mechanisms of Tooth Germ Development Using Spatial Single-Cell Epigenome Analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating Mechanotransduction in Embryonic Palatal Development: Bioinformatics Insights and Experimental Validation Using Public Genome-Wide Association Studies and scRNA-seq DataPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

An international collaborative study to examine a novel hypothesis regarding the genetic background and mechanisms of anorexia nervosa caused by excessive exercise

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of tooth regenerative technology based on the spatiotemporal transcriptome analysis and iPS interference

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Gingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Optimizing β-TCP with E-rhBMP-2-infused fibrin for vertical bone regeneration in a mouse calvarium model2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single Cell Spatial Transcriptomics of the Murine Embryonic Palate Links Pax9 to Patterning and Organization of Extracellular Matrix Components2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene expression profiles in human dental pulp stem cells treated short-term with lipopolysaccharides before and after osteoinduction2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Local E-rhBMP-2/β-TCP Application Rescues Osteocyte Dendritic Integrity and Reduces Microstructural Damage in Alveolar Bone Post-Extraction in MRONJ-like Mouse Model2024

Author(s)

Wang Ziyi 王紫儀