OKUMURA TADAYOSHI 奥村忠芳

… Alternative Names

OKUMURA Tadayoshi 奥村忠芳

奥村忠義オクムラタダヨシ

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Researcher Number	80113140
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2017: 立命館大学, 総合科学技術研究機構, 客員協力研究員 2007 – 2008: 関西医科大学, 医学部, 准教授 1999 – 2006: 関西医科大学, 医学部, 助教授 1987: Kansai Medical School, 医学部, 助教授 1986: 関西医大, 医学部, 助教授
Review Section/Research Field	Principal Investigator Biological pharmacy Except Principal Investigator General surgery / Pediatric surgery / Applied pharmacology / General medical chemistry / Digestive surgery
Keywords	Principal Investigator liver injury / nitric oxide / nuclear factor-kB / interleukin 1β / inducible nitric oxide synthase / hepatocyte / シクロスポリンA / 免疫抑制剤FK506 / ミトコンドリア機能障害 / Hypoxia-response element … More / 酸化フェニルアルシン / 低酸素 / 一酸化窒素合成酵素 / インターメイキン1β / 肝障害 / 一酸化窒素 / 転写因子NF-κB / インターロイキン1β / 誘導型一酸化窒素合成酵素 / 肝細胞 … More Except Principal Investigator nitric oxide / inducible nitric oxide synthase / 誘導型一酸化窒素合成酵素 / EGF / epidermal growth factor / 一酸化窒素 / 小腸移植 / intestinal adaptation / pitavastatin / HMG-CoA reductase inhibitor / statins / ピタバスタチン / SGLT1 / small bowel transplantation / 上皮成長因子 / 肝細胞 / センスオリゴ / 敗血症 / pertussis toxin / receptor / prostaglandins / cultured hepatocytes / 初代培養 / ラット肝細胞 / プロスタグランジンの代謝 / 血小板活性化因子 / 百日咳毒素 / リセプター / プロスタグランジン / 培養肝細胞 / interleukin-1β / bacterial translocation / rat small bowel transplantation / mRNA3'-untranslated region / mevalonate / HMG-CoAreductaseinhibitor / intestinal endothelical cells / インターロイキン1β / 細菌感染 / 腸管適応 / ラット小腸移植モデル / mRNA stabilizatio / primary cultured rat hepatocyte / cirrhosis / 肝障害 / シグナル伝達 / 外科 / primary cultured hepatocyte / iNOS antisense-transcript / mRNA stabilization / 転写後調節 / ラット初代培養肝細胞 / 肝硬変 / HMG-CoA還元酵素阻害剤 / Interleukin(IL)-1 receptor 1 / epidermal growth factor(EGF) / Nitric oxide(NO) / IL-1β / NF-κB / Nitric oxide / small intestine / 組織培養 / IEC6 / small bowel translantation / 虚血再還流障害 Less

A molecular basis to develop the new nucleic acid drugs for sepsis
- Principal Investigator
  
  Nishizawa Mikio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Ritsumeikan University
Detection of intestinal adaptation enhancing agents by induction of nitric oxide in small bowel transplantation
- Principal Investigator
  
  HAMADA Yoshinori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatric surgery
- Research Institution
  Kansai Medical University
Studies on the regulation of inducible nitric oxide synthase (iNOS) induction with statins in liver injury
- Principal Investigator
  
  MATSUI Yoichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kansai Medical University
Studies on a graft-protective effect of nitric oxide in small bowel transplantation
- Principal Investigator
  
  HAMADA Yoshinori
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatric surgery
- Research Institution
  Kansai Medical University
Signal transduction of epidermal growth factor on the production of nitric oxide in rat intestinal epithelial cells
- Principal Investigator
  
  SATO Masahito
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kansai Medical University
Enhancement of intestinal adaptation by epidermal growth factor in the rat small bowel transplantation
- Principal Investigator
  
  HAMADA Yoshinori
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kansai Medical University
Beneficial or deleterious role of nitric oxide in the liverPrincipal Investigator
- Principal Investigator
  
  OKUMURA Tadayoshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kansai Medical University
Prostaglandins and Platelet-activating Factor in Cultured Hepatocytes - Its Metabolism and Physiological Significance -
- Principal Investigator
  
  SAITO Kunihiko
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kansai Medical School

All 2018 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] A Sense Oligonucleotide to Inducible Nitric Oxide Synthase mRNA Increases the Survival Rate of Rats in Septic Shock.2018
- Author(s)
  Nakatake R, Okuyama T, Kaibori M, Okumura T, Kon M, Nishizawa M.
- Journal Title
  
  Nitric Oxide
  
  Volume: 72 Pages: 32-40
- DOI
  10.1016/j.niox.2017.11.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18252, KAKENHI-PROJECT-15K08602
[Journal Article] Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes2008
- Author(s)
  Habara K, Hamada Y, Yamada M, Tokuhara K, Tanaka H, Kaibori M, Kamiyama Y, Nishizawa M, Ito S, Okumura T
- Journal Title
  
  Nitric Oxide 18(1)
  
  Pages: 19-27
- Data Source
  KAKENHI-PROJECT-19592066
[Journal Article] Rebamipide, anti-gastric ulcer drug, up-regulates the induction of iNOS in proinflammatory cytokine-stimulated hepatocytes2008
- Author(s)
  Tokuhara K, Hamada Y, Tanaka H, Yamada M, Ozaki T, Matsui K, Kamiyama Y, Nishizawa M, Ito S, Okumura T
- Journal Title
  
  Nitric Oxide 18(1)
  
  Pages: 28-36
- Data Source
  KAKENHI-PROJECT-19592066
[Journal Article] Rebamipide,anti-gastric ulcer drug,up-regulates the induction of iNOS inproinflamtnatory cytokine-stimulated hepatocytes2008
- Author(s)
  Tokuhara K, Hamada Y, Tanaka H, Yamada M, Ozaki T, Matsui K, Kamiyama Y, Nishizawa M, Ito S, Okumura T
- Journal Title
  
  Nitric Oxide-Biol Chem 18(1)
  
  Pages: 28-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592066
[Journal Article] Administration of rhHGF-activator via portal vein stimulates the generation of cirrhotic liver following partial hepatectomy in rats.2006
- Author(s)
  Yanagida H, Kaibori M, Hijikawa T, Kwon A-H, Kamiyama Y, Okumura T.
- Journal Title
  
  Surg Res 130
  
  Pages: 38-44
- Data Source
  KAKENHI-PROJECT-17591447
[Journal Article] Hepatocyte growth factor stimulates the induction of cytokine-induced neutrophil chemoattractant through the activation of NF-□B in rat hepatocytes2006
- Author(s)
  Kaibori M, Yanagida H, Nakanishi H, Ozaki T, Yoshida H, Matsui K, Hijikawa T, Kamiyama Y, Okumura T.
- Journal Title
  
  J Surg Res 130
  
  Pages: 88-93
- Data Source
  KAKENHI-PROJECT-17591447
[Journal Article] Fibronectin prevents D-galactosamine/lipopolysaccharide-induced lethal hepatic failure in mice2006
- Author(s)
  Qiu Z, Kwon AH, Tsuji K, Kamiyama Y, Okumura T, Hirao Y
- Journal Title
  
  Shock 25(1)
  
  Pages: 80-87
- Data Source
  KAKENHI-PROJECT-17591447
[Journal Article] Cytoprotection by nipradilol, an anti-glaucomatous agent, via down-regulation of apoptosis related gene expression and activation of NF-□B2005
- Author(s)
  Ando A, Yamazaki Y, Kaneko S, Miyake M, Nambu R, Taomoto M, Unezaki S, Okuda-Ashitaka E, Okumura T, Ito S, Matsumura M.
- Journal Title
  
  Exp Eye Res 80(4)
  
  Pages: 501-507
- Data Source
  KAKENHI-PROJECT-17591447
[Journal Article] Free radical scavenger(edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats.2005
- Author(s)
  Tsuji K, Kwon A-H, Yoshida H, Qiu Z, Kaibori M, Okumura T, Kamiyama Y
- Journal Title
  
  J Hepatol 42(1)
  
  Pages: 94-101
- Data Source
  KAKENHI-PROJECT-17591870
[Journal Article] Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats2005
- Author(s)
  Tsuji K, Kwon A-H, Yoshida H, Qiu Z, Kaibori M, Okumura T, Kamiyama Y
- Journal Title
  
  J Hepatol 42(1)
  
  Pages: 94-101
- Data Source
  KAKENHI-PROJECT-17591447
[Journal Article] Enhanced production of IL-6 in peripheral blood monocytes stimulated with mucins, secreted into the bloodstream2005
- Author(s)
  Yokoigawa N, Takeuchi N, Toda M, Inoue M, Kaibori M, Yanagida H, Tanaka H, Ogura T, Takada H, Okumura T, Kwon A-H, Kamiyama Y, Nakada H
- Journal Title
  
  Clin Cancer Res 11
  
  Pages: 6127-6132
- Data Source
  KAKENHI-PROJECT-17591447
[Presentation] iNOS sense oligonucleotides to treat septic shock2018
- Author(s)
  Mikio Nishizawa, Tetsuya Okuyama, Rich Nakatake, Tadayoshi Okumura
- Organizer
  The 8th Annual Basic Science International Conference 2018 (BaSIC 2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08602
[Presentation] The up-regulation of iNOS induction by pitavastatin in inflammatory cytokine-stimulated IEC-62007
- Author(s)
  K. Habara, K. Nakai, K. Kitagawa, Y. Hamada, Y. Kamiyama, M. Nishizawa, T. Okumura
- Organizer
  Xth International Small Bowel Transplant Symposium
- Place of Presentation
  Santa Monica, USA
- Year and Date
  2007-09-04
- Data Source
  KAKENHI-PROJECT-19592066
[Presentation] The up-regulation of iNOS induction by pitavastatin in inflaminatory cytokine-stimulated IEC-62007
- Author(s)
  K.Habara, K.Nakai, K.Kitagawa, Y.Hamada, Y.Kamiyama, M.Nishizawa, and T.Okumura
- Organizer
  Xth International Small Bowel Transplant Svmbosium
- Place of Presentation
  Santa Monica,California,USA
- Data Source
  KAKENHI-PROJECT-19592066

1. HAMADA Yoshinori (00172982)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. KAIBORI Masaki (30333199)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. TAKETANI Shigeru (20121949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SATO Masahito (30278626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUI Yoichi (60278637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SAITO Kunihiko (80077560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAYAMA Reiko (60172483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SATOUCHI Kiyoshi (50098125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Nishizawa Mikio (40192687)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 奥山哲矢 (80614966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 中竹利知 (40779401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

OKUMURA TADAYOSHI 奥村 忠芳

OKUMURA Tadayoshi 奥村 忠芳

奥村 忠義 オクムラ タダヨシ

Research Projects

Research Products

Co-Researchers

A molecular basis to develop the new nucleic acid drugs for sepsis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Detection of intestinal adaptation enhancing agents by induction of nitric oxide in small bowel transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the regulation of inducible nitric oxide synthase (iNOS) induction with statins in liver injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on a graft-protective effect of nitric oxide in small bowel transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Signal transduction of epidermal growth factor on the production of nitric oxide in rat intestinal epithelial cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Enhancement of intestinal adaptation by epidermal growth factor in the rat small bowel transplantation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Beneficial or deleterious role of nitric oxide in the liverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prostaglandins and Platelet-activating Factor in Cultured Hepatocytes - Its Metabolism and Physiological Significance -

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Sense Oligonucleotide to Inducible Nitric Oxide Synthase mRNA Increases the Survival Rate of Rats in Septic Shock.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pitavastatin up-regulates the induction of iNOS through enhanced stabilization of its mRNA in pro-inflammatory cytokine-stimulated hepatocytes2008

Author(s)

Journal Title

Data Source

[Journal Article] Rebamipide, anti-gastric ulcer drug, up-regulates the induction of iNOS in proinflammatory cytokine-stimulated hepatocytes2008

Author(s)

Journal Title

Data Source

[Journal Article] Rebamipide,anti-gastric ulcer drug,up-regulates the induction of iNOS inproinflamtnatory cytokine-stimulated hepatocytes2008

Author(s)

Journal Title

Data Source

[Journal Article] Administration of rhHGF-activator via portal vein stimulates the generation of cirrhotic liver following partial hepatectomy in rats.2006

Author(s)

Journal Title

Data Source

[Journal Article] Hepatocyte growth factor stimulates the induction of cytokine-induced neutrophil chemoattractant through the activation of NF-□B in rat hepatocytes2006

Author(s)

Journal Title

Data Source

[Journal Article] Fibronectin prevents D-galactosamine/lipopolysaccharide-induced lethal hepatic failure in mice2006

OKUMURA TADAYOSHI 奥村忠芳

OKUMURA Tadayoshi 奥村忠芳

奥村忠義オクムラタダヨシ