TAKAGI Kenji 高木健次

Researcher Number	80126870
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2011: Nagoya University, School of Medicine, Associate professor 1999 – 2006: 名古屋大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Risk sciences of radiation/Chemicals Except Principal Investigator Laboratory medicine / Risk sciences of radiation/Chemicals / Public health/Health science / Laboratory medicine / Public health/Health science
Keywords	Principal Investigator UDP-グルクロン酸転移酵素 / 3-フェノキシ安息香酸 / 3-フェノキシベンズアルデヒド / 3-フェノキシベンジルアルコール / ピレスロイド系殺虫剤代謝物 Except Principal Investigator エンドトキシン / 生物学的モニタリング / TNF-α / トランスポーター / 生体膜輸送 … More / endotoxin / 肝薬物代謝酵素活性 / 生体膜輸送機構 / サイトカイン / 代謝物 / 尿 / 殺虫剤 / 農薬 / リスク評価 / Oxidative stress / Ornithine decarboxylase / Triglyceride / Advanced glycation end product / Metabolic syndrome / Spermine / Spermidine / Polyamine / 閉経 / 共分散分析 / 遺伝的多型 / 抗酸化作用 / 糖化抑制 / メタボリック症候群 / 酸化ストレス / オルニチン脱炭酸酵素 / 中性脂肪 / 最終糖化産物 / メタポリック症候群 / スペルミン / スペルミジン / ポリアミン / Toxicity / Risk assessment / Urine / Biological monitoring / Metabolite / Pesticide / Insecticide / 毒性 / TNF-α-knockout mice / Cytokine / Transporter / Drug Transport / Endotoxin / iNOS / 一酸化窒素(NO) / PPARγリガンド / ピオグリタゾン / TNF-αノックアウトマウス / aldehydes / biological monitoring / adducts / hemoglobin / formaldehyde / アルデヒド類 / 付加体 / ヘモグロビン / ホルムアルデヒド / cytokines / blood-brain barrier / P-glycoprotein / transporters / membrane transport / サイトカイン類 / 血液脳関門 / P糖蛋白質 / transport / P-glycoproten / hepatic drug-metabolizing enzyme / nitric oxide / cytokine / 薬物動態学 / 一酸化窒素発生薬 / 一酸化窒素合成酵素阻害薬 / P糖蛋白 / 肝薬物代謝酵素 / 一酸化窒素 / ピレスロイド / 有機リン / 社会医学 / 環境 / 衛生 / 人体有害物質 Less

生活習慣病病態時における殺虫剤の曝露影響によるリスク評価研究Principal Investigator
- Principal Investigator
  
  高木健次
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagoya University
INTRODUCTION OF METABONOMICS TO RISK ASSESSMENT OF INSECTICIDES
- Principal Investigator
  
  KAMIJIMA Michihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagoya City University
  Nagoya University
Quantitation of body burden of insecticides by means of profiling their urinary metabolites and risk assessment of insecticide-induced health effects
- Principal Investigator
  
  MICHIHIRO Kamijima
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagoya University
Blood polyamine as a biomarkder in predicting lifestye-related diseases and evaluating oxidative stress exposure
- Principal Investigator
  
  KONDO Takaaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Public health/Health science
- Research Institution
  Nagoya University
Molecular pharmacokinetic studies of drug transport in endotoxemia
- Principal Investigator
  
  HASEGAWA Takaaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Aichi Medical University
  Nagoya University
Department of Health and Psychosocial Medicine
- Principal Investigator
  
  SHIBATA Eiji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Public health/Health science
- Research Institution
  Aichi Medical University School of Medicine
  Nagoya University
Investigation of drug transport function through biological membranes and physiological role in endotoxemia
- Principal Investigator
  
  HASEGAWA Takaaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagoya University
Elucidation of physiological role of nitric oxide (NO) and cytokines in endotoxemia
- Principal Investigator
  
  HASEGAWA Takaaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagoya University

All 2011 2010 2009 2008 2005 2004 2003

All Journal Article Presentation

[Journal Article] Effect of DDVP on urinary excretion levels of 3-phenoxybenzoic acid for pyrethroid exposure in rats2011
- Author(s)
  Hirosawa N, Ueyama J, Kondo T, Kamijima M, Takagi K, Fujinaka S, Hirate A, Hasegawa T, Wakusawa S
- Journal Title
  
  Toxicol Lett
  
  Volume: 203 Pages: 28-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310035
[Journal Article] Toxicokinetics of pyrethroid metabolites in male and female rats2010
- Author(s)
  Ueyama J, Hirosawa N, Mochizuki A, Kimata A, Kamijima M, Kondo T, Takagia K, Wakusawa S, Hasegawa T.
- Journal Title
  
  Environmental Toxicology and Pharmacology
  
  Volume: 30 Pages: 88-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510068
[Journal Article] Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry2010
- Author(s)
  Ueyama J, Kamijima M, Kondo T, Takagi K, Shibata E, Hasegawa T, Wakusawa S, Taki T, Gotoh M, Saito I
- Journal Title
  
  J Chromatogr B Analyt Technol Biomed Life Sci
  
  Volume: 878 Pages: 1257-63
- NAID
  10028035703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310035
[Journal Article] β-Glucuronidase activity is a sensitive biomarker to assess low-level organophosphorus insecticide exposure2010
- Author(s)
  Ueyama J, Satoh T, Kondo T, Takagi K, Shibata E, Goto M, Kimata A, Saito I, Hasegawa T, Wakusawa S, Kamijima M
- Journal Title
  
  Toxicol Lett
  
  Volume: 193 Pages: 115-119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310035
[Journal Article] Toxicokinetics of pyrethroid metabolites in male and female rats2010
- Author(s)
  Ueyama J, Hirosawa N, Mochizuki A, Kimata A, Kamijima M, Kondo T, Takagi K, Wakusawa S, Hasegawa T
- Journal Title
  
  Environ Toxicol Pharmacol
  
  Volume: 30 Pages: 88-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310035
[Journal Article] Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry2010
- Author(s)
  Ueyama J, Kamijima M, Kondo T, Takagi K, Shibata E, Hasegawa T, Wakusawa S, Taki T, Gotoh M, Saito I
- Journal Title
  
  J.Chromatogra.B
  
  Volume: 878 Pages: 1257-1263
- NAID
  10028035703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510068
[Journal Article] Relationship between urinary pesticide metabolites and pest control operation among occupational pesticide sprayers2009
- Author(s)
  Kimata A, Kondo T, Ueyama J, Yamamoto K, Mochizuki A, Asai K, Takagi K, Okamura A, Wang D, Kamijima M, Nakajima T, Fukaya Y, Shibata E, Gotoh M, Saito I
- Journal Title
  
  J Occup Health
  
  Volume: 51 Pages: 100-5
- NAID
  110007055426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310035
[Journal Article] Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan2009
- Author(s)
  Ueyama J, Kimata A, Kamijima M, Hamajima N, Ito Y, Suzuki K, Inoue T, Yamamoto K, Takagi K, Saito I, Miyamoto K, Hasegawa T, Kondo T
- Journal Title
  
  Environ Res
  
  Volume: 109 Pages: 175-80
- NAID
  120001008419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310035
[Journal Article] Comparison of urinary concentrations of 3-phenoxybenzoic acid among general residents in rural and suburban areas and employees of pest control firms2009
- Author(s)
  Kimata A, Kondo T, Ueyama J, Yamamoto K, Yoshitake J, Takagi K, Suzuki K, Inoue T, Ito Y, Hamajima N, Kamijima M, Gotoh M, Shibata E
- Journal Title
  
  Int Arch Occup Environ Health
  
  Volume: 82 Pages: 1173-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310035
[Journal Article] Effect of the organophosphorus pesticide diazinon on glucose tolerance in type 2 diabetic rats2008
- Author(s)
  Ueyama J, Kamijima M, Asai K, Mochizuki A, Wang D, Kondo T, Suzuki T, Takagi K, Kanazawa H, Miyamoto K, Wakusawa S, Hasegawa T
- Journal Title
  
  Toxicol Lett
  
  Volume: 182 Pages: 42-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310035
[Journal Article] Role of tumor necrosis factor-α in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.2005
- Author(s)
  Miyoshi, M., Nadai, M., Nitta, A., Ueyama, J., Shimizu, A., Takagi, K., Nabeshima, T., Takagi, K., Saito, K., Hasegawa, T.
- Journal Title
  
  Eur.J.Pharmacol. 507
  
  Pages: 229-237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Endotoxin from various gram-negativebacteria has differential effects on function of hepatic cytochrome P450 and drug transporters.2005
- Author(s)
  Ueyama, J., Nadai, M., Kanazawa, H., Iwase, M., Nakayama, H., Hashimoto, K., Yokoi, T., Baba, K., Takagi, K., Takagi, K., Hasegawa, T.
- Journal Title
  
  Eur.J.Pharmacol. 510
  
  Pages: 127-134
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Azithromycin reverses anticancer drug-resistance and modifies hepatobiliary excretion of doxorubicin in rats.2004
- Author(s)
  Asakura, E., Nakayama, H., Sugie, M., Zhao, Y.L., Nadai, M, Kitaichi, K., Shimizu, A., Miyoshi, M., Takagi, K., Takagi, K., Hasegawa, T.
- Journal Title
  
  Eur.J.Pharmacol. 484
  
  Pages: 333-339
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity andexpression of CYP3A2 and CYP2C11.2004
- Author(s)
  Ueyama, J., Kitaichi, K., Nadai, M., Iwase, M., Tomyo, N., Kanazawa, H., Suzuki, R., Takagi, K., Takagi, K., Hasegawa, T.
- Journal Title
  
  Eur.J.Pharmacol. 498
  
  Pages: 257-265
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats.2004
- Author(s)
  Shimizu, A., Miyoshi, M., Sugie, M., Ueyama, J., Yamaguchi, T., Sasaki, T., Takagi, K., Kim, M., Miyamoto, K., Tsuji, A., Hasegawa, T.
- Journal Title
  
  Eur.J.Pharmacol. 501
  
  Pages: 151-159
- NAID
  130005024056
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Possible involvement of drug transporters P-glycoproteinand multidrug resistance-associated protein Mrp2 indisposition of azithromycin.2004
- Author(s)
  Sugie, M., Asakura, E., Zhao, Y.L., Torita, S., Nadai, M., Baba, K., Kitaichi, K., Takagi, K., Takagi, K., Hasegawa, T.
- Journal Title
  
  Antimicrob.Agents Chemother. 48
  
  Pages: 809-814
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] The altered disposition of methamphetamine in the model of methamphetamine-induced neurotoxicity.2004
- Author(s)
  Kitaichi, K., Ito, Y., Fukuda, M., Aoyama, N., Nakayama, H., Takagi, K., Hasegawa, T.
- Journal Title
  
  Ann.N.Y.Acad.Sci. 1025
  
  Pages: 248-256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] A sensitive colometric assay for polyamines in erythrocytesusing oat seedling polyamine oxidase.2004
- Author(s)
  Takagi, K., Tatsumi, Y., Kitaichi, K., Iwase, M., Shibata, E., Nakao, M., Matsumoto, T., Takagi, K., Hasegawa, T.
- Journal Title
  
  Clinica.Chemica.Acta 340
  
  Pages: 219-227
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia. coli O157 : H7.2004
- Author(s)
  Kitaichi, K., Nakayama, H., Ueyama, J., Nadai, M., Baba, K., Takagi, K., Takagi, K., Ohta, M., Hasegawa, T.
- Journal Title
  
  Biochem.Pharmacol. 67
  
  Pages: 1427-1435
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Journal Article] Application of ultrafiltration method to measurement of catecholamines in plasma of human and rodents by high-performance liquid chromatography.2003
- Author(s)
  Ueyama, J., Kitaichi, K., Iwase, M., Takagi, K., Takagi, K., Hasegawa, T.
- Journal Title
  
  J.Chromatogr B. 789
  
  Pages: 35-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590484
[Presentation] 使い捨て紙おむつを利用した尿中殺虫剤代謝物測定の試み2010
- Author(s)
  上山純、伊藤牧、齋藤勲、高木健次、近藤高明、涌澤伸哉、仲井邦彦、佐藤洋、上島通浩
- Organizer
  第80回日本衛生学会学術総会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2010-04-01
- Data Source
  KAKENHI-PROJECT-22510068

1. UEYAMA Jun (00397465)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. SHIBATA Eiji (90206128)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. HASEGAWA Takaaki (80198720)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. KITAICHI Kiyoyuki (40301220)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. KAMIJIMA Michihiro (80281070)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
6. NAKAJIMA Tamie (10020794)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. TAKAGI Kenzo (50093050)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. ITO Yuki (80452192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. WATANABE Misuzu (30298624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TSUBOI Hirohito (20319338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HON Reiko (80329812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YAMONO Yuko (30167580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KONDO Takaaki (00195900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TOYOSHIMA Hideaki (10023657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 涌澤伸哉 (30121297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 橋本克訓 (70324423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 河合俊夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 酒井潔

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAGI Kenji 高木 健次

Research Projects

Research Products

Co-Researchers

生活習慣病病態時における殺虫剤の曝露影響によるリスク評価研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

INTRODUCTION OF METABONOMICS TO RISK ASSESSMENT OF INSECTICIDES

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitation of body burden of insecticides by means of profiling their urinary metabolites and risk assessment of insecticide-induced health effects

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Blood polyamine as a biomarkder in predicting lifestye-related diseases and evaluating oxidative stress exposure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pharmacokinetic studies of drug transport in endotoxemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Department of Health and Psychosocial Medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of drug transport function through biological membranes and physiological role in endotoxemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of physiological role of nitric oxide (NO) and cytokines in endotoxemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of DDVP on urinary excretion levels of 3-phenoxybenzoic acid for pyrethroid exposure in rats2011

Author(s)

Journal Title

Data Source

[Journal Article] Toxicokinetics of pyrethroid metabolites in male and female rats2010

Author(s)

Journal Title

Data Source

[Journal Article] Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] β-Glucuronidase activity is a sensitive biomarker to assess low-level organophosphorus insecticide exposure2010

Author(s)

Journal Title

Data Source

[Journal Article] Toxicokinetics of pyrethroid metabolites in male and female rats2010

Author(s)

Journal Title

Data Source

[Journal Article] Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Relationship between urinary pesticide metabolites and pest control operation among occupational pesticide sprayers2009

Author(s)

TAKAGI Kenji 高木健次