NAKASHIMA Mikio 中島幹夫

Researcher Number	80159061
External Links
Affiliation (based on the past Project Information) *help	2009: 佐賀大, 医学部, 教授 2004 – 2008: 佐賀大学, 医学部, 教授 2003: 佐賀大学, 医学部, 助教授 2002: 佐賀医科大学, 医学部, 助教授 1997 – 2000: SAGA MEDICAL SCHOOL,ASSISTANT PROFESSOR, 助教授 1994 – 2000: 佐賀医科大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Emergency medicine Except Principal Investigator Anesthesiology/Resuscitation studies / Circulatory organs internal medicine / Hygiene
Keywords	Principal Investigator EDHF / NO / Vibrio vulnificus / 敗血症性ショック / cyclic GMP / endothelium / 一酸化窒素 / 血管内皮 / gap-junction / halothane … More / 有明海 / Liver dysfunction / antibody titer / Septic Shock / Necrotizing fasciitis / Ariake Sea, / Food- and Water-borne infection / 生鮮魚介類 / 電気泳動 / Vibrio Vulnificus / 16RsDNA / パルスフィールド / 壊死性菌膜炎 / 肝機能障害 / 血清抗体価 / 壊死性筋膜炎 / 食水系感染症 / septic shock / iNOS protein / endotoxin / lipopolysaccharide / nitric oxide / 過分極 / EDRF / LPS / サイクリックGMP / ラット / リポポリサッカライド / サイクリック GMP / 内皮依存性過分極因子 / eNOS-knockout マウス / EET / 過酸化水素 / カタラーゼ / 血管内皮由来過分極因子 / 誘導型一酸化窒素合成酵素 / iNOS蛋白 / エンドトキシン / リボポリサッカライド / bradykinin / coronary artery / inhalation anesthetics / ハロセン / 内皮依存性過分極反応 / 一酸化窒素(NO) / 冠(状)動脈 / アラキドン酸 / K-チャンネル / P-450 / 血管平滑筋 / EDHF(内皮由来過分極因子) / ブラジキニン / 冠動脈 / 吸入麻酔薬 / 細菌培養 / 肝不全マウス / 迅速診断 / 遺伝子増幅法 / LAMP法 / CVA-1 … More Except Principal Investigator Fura-2 / 血管平滑筋 / 血管内皮 / EDHF / Mesenteric arteries / Ketamine / Resistance vessels / Intracellular caclium stores / Vascular endothelium / Vascular smooth muscle / Volatile anesthetics / 細胞内カルシウム濃度 / 細胞内カルシュウム濃度 / 吸入麻酔薬 / Fura2 / 抵抗血管 / スキンド筋 / Fura 2 / 細胞内Ca^<2+>濃度 / 血管拡張薬 / 揮発性吸入麻酔薬 / Microvessels / Nitric oxide / K channels / 内皮由来過分極因子 / 内皮依存性弛緩反応 / 一酸化窒素(NO) / 内皮由来過分極因子(EDHF) / 微小血管 / NO / Kチャネル / 食水系感染症 / 公衆衛生 / 地球観測衛星 / ビブリオ・バルニフィカス / 感染症 / リモートセンシング / 人工衛星 / 地球環境 Less

ビブリオ・バルニフィカス感染症に対する早期診断法の確立と臨床的有用性の検証Principal Investigator
- Principal Investigator
  
  中島幹夫
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Saga University
地球観測衛星リモートセンシング技術を応用した致死的感染症の予防
- Principal Investigator
  
  大石浩隆
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  Saga University
Pathogenesis of Vibrio vulnificus in Ariake See and Clinical and epidemiologic features using Micro IF assaysPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Mikio
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Saga University
  佐賀医科大学
Mechanisms of direct actions of perioperative drugs on splachnic resistance vessels
- Principal Investigator
  
  AKATA Takashi
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KYUSHU UNIVERSITY
Role of endothelium-derived relaxing factors (EDRFs) in vasodilation during septic shock.Principal Investigator
- Principal Investigator
  
  NAKASHIMA Mikio
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  SAGA MEDICAL SCHOOL
Physiological and pathophysiological roles of endothelium-derived hyperpotarizing factor in the control of organ perfusion.
- Principal Investigator
  
  TAKESHITA Akira
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY FACULTY OF MEDICINE
Effects of halothane, an inhalational anesthetics, on endothelium-dependent hyperpolarization in canine coronary arteriesPrincipal Investigator
- Principal Investigator
  
  NAKASHIMA Mikio
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  SAGA MEDICAL SCHOOL

All 2008 2006 2005 2004 2003 2002

All Journal Article Book

[Book] EDHF 2002(Gabexate mesilate inhibits endothelium-dependent relaxation, but causes endothelium-independent relaxation of rat blood vessels.)(ed.By Vanhoutte PM.)2003
- Author(s)
  Mikio Nakashima et al.
- Publisher
  Taylor & Francis, London and New York
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Book] Gabexate mesilate inhibits endothelium-depenndent relaxation, but causes endothelium-independent relaxation of rat blood vessels. In : EDHF 20022003
- Author(s)
  Mikio Nakashima et al.
- Publisher
  Taylor & Francis, London and New York
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Loop-mediated isothermal amplification (LAMP)法を用いたVibrio vulnificus の迅速検出2008
- Author(s)
  根本二郎, 小島禎, 草場耕二, 永沢善三, 大石浩隆, 中島幹夫
- Journal Title
  
  感染症学雑誌 82
  
  Pages: 407-413
- NAID
  130004331452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592123
[Journal Article] バルニフイカス感染症の臨床と日本における疫学2008
- Author(s)
  松本浩一, 大石浩隆, 中島幹夫
- Journal Title
  
  化学療法の領域 24
  
  Pages: 81-88
- Data Source
  KAKENHI-PROJECT-20592123
[Journal Article] 敗血症を伴う壊死性筋膜炎の2救命例2006
- Author(s)
  三溝慎次, 香川嘉彦, 雨森泰己, 前田祥範, 荒木和邦, 大石浩隆, 中島幹夫
- Journal Title
  
  佐賀大学有明海綜合研究プロジエクト成果報告集 2(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] ビブリオバルニフィカス感染症対策基礎医学的アプローチ第一報2006
- Author(s)
  大石浩隆, 中島幹夫
- Journal Title
  
  佐賀大学有明海綜合研究プロジエクト成果報告集 2(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] ビブリオバルニフィカス感染症対策臨床医学的アプローチ第一報2006
- Author(s)
  中島幹夫, 大石浩隆
- Journal Title
  
  佐賀大学有明海綜合研究プロジエクト成果報告集 2(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] 発色合成其質培地(CVAI)を利用した Vibrio vulnificusの検出と迅速同定法の開発2006
- Author(s)
  中島由佳里, 高柳恵, 草場耕二, 永沢善三, 大石浩隆, 中島幹夫, 小松里他
- Journal Title
  
  佐賀大学有明海綜合研究プロジエクト成果報告集 2(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] The regulatory mechanisms of contraction of vascular smooth muscle and its regulation Ca-sensitivity2005
- Author(s)
  Maeda S., Araki K., Mitsumizo S., Nakashima M.
- Journal Title
  
  Clinical Anesthesia 29-8
  
  Pages: 1271-1277
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] ビブリオ・バルニフィカス標準株に対する抗体価測定システムの開発2005
- Author(s)
  荒木和邦, 中島幹夫, 三溝慎次
- Journal Title
  
  佐賀大学有明海綜合研究プロジェクト成果概要集 1
  
  Pages: 66-67
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Establishment of antibody measurement against standard lines of Vibrio vulnificus2005
- Author(s)
  Araki K., Nakashima M, Mitsumizo S., Oishi H.
- Journal Title
  
  Archives of Ariake Sea Research Project, Saga University 1
  
  Pages: 153-156
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] An exterminatory measure against Vibrio vulnificus infection-experimental approach 12005
- Author(s)
  Oishi H., Nakashima M.
- Journal Title
  
  Archives of Ariake Sea Research Project, Saga University 2(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Two cured cases of septic shock with necrotizing fasciitis in Saga Medical School Hospital2005
- Author(s)
  Mitsumizo S., Kagawa Y, Amemori H, Ura Y, Maeda S, Araki K, Oishi H, Nakashima M.
- Journal Title
  
  Archives of Ariake Sea Research Project, Saga University 2(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] The effects of Ringer's bicarbonate solution, Ringer's Lactate solution and Ringer's Acetate solution on the rat mesenteric artery2005
- Author(s)
  Mitsumizo S., Araki K., Maeda S., Torikai A., Oishi H., Nakashima M
- Journal Title
  
  Anesthesia and Resuscitation 41・3
  
  Pages: 81-86
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Vibrio vulnificus infection in Japan and its characteristics in Ariake Sea area2005
- Author(s)
  Nakashima M, Oishi H., Araki K., Mitsumizo S.
- Journal Title
  
  Archives of Ariake Sea Research Project, Saga University 1
  
  Pages: 55-60
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] 明らかな皮膚病変を認めなかったVibrio vulnificusによる敗血症の2症例2005
- Author(s)
  荒木和邦, 三溝慎次, 吉田昌人, 前田祥範, 垣内好信, 中島幹夫
- Journal Title
  
  日本集中治療医学会雑誌 12
  
  Pages: 232-232
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] 血管平滑筋の収縮とカルシウム感受性の制御機序2005
- Author(s)
  前田祥範, 荒木和邦, 三溝慎次, 中島幹夫
- Journal Title
  
  臨床麻酔 29・8
  
  Pages: 1271-1277
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] わが国におけるVibrio vulnificus感染症の発生動向と有明海沿岸地域の状況2005
- Author(s)
  中島幹夫, 大石浩隆, 荒木和邦, 三溝慎次
- Journal Title
  
  佐賀大学有明海綜合研究プロジェクト成果報告集 1
  
  Pages: 55-60
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Development of rapid identification and isolation of Vibrio vulnificus using chromogenic substrate culture plate (CVA1)2005
- Author(s)
  Nakashima Y, Takayanagi M, Kusaba K, Nagasawa Z, Oishi H, Nakashima M, Komatsu S, Manome I.
- Journal Title
  
  Archives of Ariake Sea Research Project, Saga University 2(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] The effects of Ringer's bicarbonate solution, Ringer's Lactate solution and Ringer's Acetate solution on the rat mesenteric artery2005
- Author(s)
  Mitsumizo S., Araki K., Maeda S., Torikai A., Oishi H., Nakashima M
- Journal Title
  
  Anesthesia and Resuscitation 41-3
  
  Pages: 81-86
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Vibrio vulnificus標準株に対する抗体価測定システムの開発2005
- Author(s)
  荒木和邦, 中島幹夫, 三溝慎次, 大石浩隆
- Journal Title
  
  佐賀大学有明海綜合研究プロジェクト成果報告集 1
  
  Pages: 153-156
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Vibrio vulnificus標準株に対する抗体価測定システムの開発2005
- Author(s)
  荒木和邦, 中島幹夫, 三溝慎次, 大石浩隆
- Journal Title
  
  佐賀大学有明海綜合研究プロジエクト成果報告集 1
  
  Pages: 153-156
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] An exterminatory measure against Vibrio vulnificus infection-clinical approach 12005
- Author(s)
  Nakashima M., Oishi H.
- Journal Title
  
  Archives of Ariake Sea Research Project, Saga University 2(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] わが国におけるVibrio vulnificus感染症の発生動向と有明海沿岸地域の状況2005
- Author(s)
  中島幹夫他
- Journal Title
  
  佐賀大学有明海綜合研究プロジェクト成果概要集 1
  
  Pages: 18-19
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] わが国におけるVibrio vulnificus感染症の発生動向と有明海沿岸地域の状況2005
- Author(s)
  中島幹夫, 大石浩隆, 荒木和邦, 三溝槙次
- Journal Title
  
  佐賀大学有明海綜合研究プロジェクト成果報告集 1
  
  Pages: 55-60
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] NOS II inhibition restores attenuation of endothelium-dependent hyperpolarization in rat mesenteric artery exposed to lipopolysaccharide.2004
- Author(s)
  Mitsumizo S, Nakashima M, Hamada T, Totoki T.
- Journal Title
  
  Journal of Cardiovascular Pharmacology 43(4)
  
  Pages: 589-594
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] NOS II inhibition restores attenuation of endothelium-dependent hyperpolarization in ral mesenteric artery exposed to lipopolysaccharide2004
- Author(s)
  Mitsumizo S, Nakashima M, Hamada T, Totoki T
- Journal Title
  
  Journal of Cardiovascular Pharmacology 43・4
  
  Pages: 589-594
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Gabexate mesilate may cause skin flare along with regional vein-A case report2003
- Author(s)
  Nakashima M, Mitsumizo S, Totoki T
- Journal Title
  
  Pharmacoanesthesiology 15(1)
  
  Pages: 92-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Effects of gabexate mesilate on circulatory system of rats2003
- Author(s)
  Mitsumizo S, Nakashima M, Totoki T
- Journal Title
  
  Pharmacoanesthesiology 15(1)
  
  Pages: 89-91
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] 蛋白分解酵素阻害薬のラット循環系に及ぼす影響2003
- Author(s)
  三溝慎次, 中島幹夫, 十時忠秀
- Journal Title
  
  日本麻酔・薬理学会誌 15・1
  
  Pages: 89-91
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] メシル酸ガべキサート(FOY)により静脈走行に沿った皮膚発赤を認めた1例2003
- Author(s)
  中島幹夫, 三溝慎次, 十時忠秀
- Journal Title
  
  日本麻酔・薬理学会誌 15・1
  
  Pages: 92-93
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Sevoflurane and bradykinin-induced calcium mobiliztion in pulmonary arterial valvular endothelial cells in situ : sevoflurane stimulates plasmalemmal calcium influx into endothelial cells.2002
- Author(s)
  Kanna T, Akata T, Izumi K, Nakashima M, Yonemitsu Y, Hashizume M, et al.
- Journal Title
  
  J Cardiovascular Pharmacology 40・5
  
  Pages: 714-724
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571446
[Journal Article] Sevoflurane and bradykinin-induced calcium mobilization in pulmonary arterial valvular endothelial cells in situ : sevoflurane stimulates plasmalemmal calcium influx into endothelial cells2002
- Author(s)
  Kanna T, Akata T, Izumi K, Nakashima M, Yonemitsu Y, Hashizume M, et al.
- Journal Title
  
  Journal of Cardiovascular Pharmacology 40(5)
  
  Pages: 714-724
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571446

1. 大石浩隆 (10244021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 小林元太 (40291512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 東端晃 (30360720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TAKESHITA Akira (30038814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHIMOKAWA Hiroaki (00235681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ITOU Takeo (70159888)

# of Collaborated Projects: 1 results

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7. SUZUKI Hikaru (80037548)

# of Collaborated Projects: 1 results

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8. KANNO Morio (00109422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. AKATA Takashi (10260382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KANNA Tomoo (00274465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKASHIMA Mikio 中島 幹夫

Research Projects

Research Products

Co-Researchers

ビブリオ・バルニフィカス感染症に対する早期診断法の確立と臨床的有用性の検証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

地球観測衛星リモートセンシング技術を応用した致死的感染症の予防

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenesis of Vibrio vulnificus in Ariake See and Clinical and epidemiologic features using Micro IF assaysPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of direct actions of perioperative drugs on splachnic resistance vessels

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of endothelium-derived relaxing factors (EDRFs) in vasodilation during septic shock.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological and pathophysiological roles of endothelium-derived hyperpotarizing factor in the control of organ perfusion.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of halothane, an inhalational anesthetics, on endothelium-dependent hyperpolarization in canine coronary arteriesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] EDHF 2002(Gabexate mesilate inhibits endothelium-dependent relaxation, but causes endothelium-independent relaxation of rat blood vessels.)(ed.By Vanhoutte PM.)2003

Author(s)

Publisher

Description

Data Source

[Book] Gabexate mesilate inhibits endothelium-depenndent relaxation, but causes endothelium-independent relaxation of rat blood vessels. In : EDHF 20022003

Author(s)

Publisher

Description

Data Source

[Journal Article] Loop-mediated isothermal amplification (LAMP)法を用いたVibrio vulnificus の迅速検出2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] バルニフイカス感染症の臨床と日本における疫学2008

Author(s)

Journal Title

Data Source

[Journal Article] 敗血症を伴う壊死性筋膜炎の2救命例2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] ビブリオバルニフィカス感染症対策基礎医学的アプローチ 第一報2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] ビブリオバルニフィカス感染症対策臨床医学的アプローチ 第一報2006

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NAKASHIMA Mikio 中島幹夫

[Journal Article] ビブリオバルニフィカス感染症対策基礎医学的アプローチ第一報2006

[Journal Article] ビブリオバルニフィカス感染症対策臨床医学的アプローチ第一報2006