SHIMIZU Kazuhiro 清水和宏

Researcher Number	80170968
External Links
Affiliation (based on the past Project Information) *help	2013: 長崎大学, 医歯(薬)学総合研究科, 客員研究員 2012: 長崎大学, 医歯(薬)学総合研究科, 准教授 2012: 長崎大学, 大学院・医歯薬学総合研究科, 准教 2007 – 2011: 長崎大学, 大学院・医歯薬学総合研究科, 准教授 2008: 長崎大学, 医歯薬学総合研究科, 准教授 … More 2006: Graduate Schoolof Biomedical Sciences, Department of Dermatology, Associate professor, 大学院医歯薬学総合研究科, 助教授 2005: 長崎大学, 大学院・医歯薬学総合研究科, 助教授 2002: University Hospital Attached to School of Medicine, Assistant Professor, 医学部附属病院, 講師 2001: 長崎大学, 医学部・付属病院, 講師 1998 – 2001: 長崎大学, 医学部・附属病院, 講師 1998: NAGASAKI UNIV.MEDICAL HOSPITAL LECTURE, 医学部附属病院, 講師 Less
Review Section/Research Field	Principal Investigator Dermatology / Dermatology Except Principal Investigator Dermatology / Dermatology
Keywords	Principal Investigator tropoelastin / solar elastosis / MMP / SOD / UVA / hairless mouse / photoaging / Hydrogen sulfide / Nitric oxide / Carbon monoxide … More / 紫外線 / ヘアレスマウス / 光老化 / Auditory stress / Contact hypersensitivity / Immune complex disease / Arthus reaction / 硫化水素 / 一酸化炭素 / 一酸化窒素 / 活性酸素種 / アルサス反応 … More Except Principal Investigator substance P / histamine / atopic dermatitis / CCL3 / CCR5 / CCR1 / neutral endopeptidase / IL-4 / TGF β / fibroblast / eotaxin / ケモカイン / 好酸球 / サイトカイン / アレルギー / サブスタンスP / アトピー性皮膚炎 / ストレス / 皮膚生理学 / Vasculitis / Arthus reaction / Chemokine receptor / Chemokine / Immune complex / アルザス抗体 / 血管炎 / アルサス反応 / ケモカイン受容体 / 免疫複合体 / TGFβ / Histamine / Substance P / Fibroblast / Eotaxin / Atopic dermatitis / stress / eosinophil / chemokine / cytokine / allergy / IL5 / ケラチノサイト / ニューロペプチド / 神経内分泌 / ヒスタミン / IL10 / IL1 / CYTOKINE / GLUCOCORTICOID / EXPERIMENT MODEL / CONTACT DERMATITIS / INFLAMMATION / SKIN / ステロイド / T細胞 / IgE / 肥満細胞 / グルココルチユイド / 皮膚炎症 / ピストン脱アセチル化酵素 / トリコスタチンＡ / ヒストン脱アセチル化酵素 / 皮膚硬化 / トリコスタチンA / モデルマウス / ストン脱アセチル化酵素 / 膚硬化 / 強皮症 / methionine sulfoxide reducctase(MSRA) / autoantibody / Hsp70 / 8-isoprostane / oxidative stress / systemic sclerosis / methionine sulfoxide reducctase (MSRA) / 接着分子 / マウス / 接触皮膚炎 Less

音ストレス増悪接触皮膚炎実験モデルを用いたガス状伝達分子ＮＯ，ＣＯ，Ｈ２Ｓの解析Principal Investigator
- Principal Investigator
  
  清水和宏
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagasaki University
The effect of trichostatin A, one of the histone deacetylaseinhibitor, on skin fibrosis of systemic sclerosis mouse model
- Principal Investigator
  
  OGAWA Fumihide
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagasaki University
Analysis of reactive oxygen species, NO, CO and H_2S as therapeutic targets in the immune complex diseasesPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Kazuhiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagasaki University
Role of neuropeptide stress in atopic dermatitis
- Principal Investigator
  
  SANGJAE Bae
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagasaki University
Analysis of autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A (MSRA) and treatments, in systemic sclerosis
- Principal Investigator
  
  OGAWA Fumihide
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagasaki University
Role of C-C Chemokine Receptors 1 and 5 and CCL3/Macrophage Inflammatory Protein-la in the Cutaneous Arthus Reaction
- Principal Investigator
  
  SATO Shinichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagasaki University
Analysis of function of fibroblast derived from atopic dermatitis and skin remodeling
- Principal Investigator
  
  BAE SangJae
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagasaki University
Regulatory mechanisms of neuro-endocine-immune system in the skin
- Principal Investigator
  
  KATAYAMA Ichiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Nagasaki University
Antioxidant system in photoaged skin of hairless mousePrincipal Investigator
- Principal Investigator
  
  SHIMIZU Kazuhiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagasaki University
IDENTIFICATION AND REGULATORY MECHANISMS OF INTRINSIC ANTI-INFLAMMATORY MOLECULES IN THE SKIN
- Principal Investigator
  
  KATAYAMA Ichiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  NAGASAKI UNIVERSITY

All 2013 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through L-selectin involved pathway in the cutaneous reverse passive Arthus reaction.2013
- Author(s)
  Shimizu K
- Journal Title
  
  J Leukoc Biol
  
  Volume: 93 Issue: 4 Pages: 573-584
- DOI
  10.1189/jlb.0212079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591245, KAKENHI-PROJECT-24591630
[Journal Article] Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through L-selectin involved pathway in the cutaneous reverse passive Arthus reaction2013
- Author(s)
  Shimizu K, Ogawa F, Hara T, Yoshizaki A, Muroi E, Akiyama Y, Yanaba K, Yamaoka T, Sato S
- Journal Title
  
  J Leukoc Biol: accepted
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591245
[Journal Article] A case of palmoplantar lichen planus in a patient with congenital sensorineural deafness.2013
- Author(s)
  Ogawa A, Shimizu K, Yoshizaki A, Sato S, Kanda Y, Kumagami H, Takahashi H, Usami S
- Journal Title
  
  Clin Exp Dermatol
  
  Volume: 38 Issue: 1 Pages: 30-32
- DOI
  10.1111/j.1365-2230.2012.04374.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591630
[Journal Article] Increased serum levels of soluble CD163 in patients with scleroderma2012
- Author(s)
  Shimizu K, Ogawa F, Yoshizaki A, Akiyama Y, Kuwatsuka Y, Okazaki S, Tomita H, Takenaka M, Sato S
- Journal Title
  
  Clin Rheumatol
  
  Volume: 31(7) Pages: 1059-1064
- NAID
  120006985709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591245
[Journal Article] Increased serum levels of soluble CD163 in patients with scleroderma.2012
- Author(s)
  Shimizu K
- Journal Title
  
  Clin Rheumatol
  
  Volume: 31 Issue: 7 Pages: 1059-1064
- DOI
  10.1007/s10067-012-1972-x
- NAID
  120006985709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591245, KAKENHI-PROJECT-24591630
[Journal Article] Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction.2010
- Author(s)
  Hara T, Shimizu K, Ogawa F, Yanaba K, Iwata Y, Muroi E, Takenaka M, Komura K, Hasegawa M, Fujimoto M, Sato S
- Journal Title
  
  Am J Pathol. 176(1)
  
  Pages: 259-269
- Data Source
  KAKENHI-PROJECT-20591349
[Journal Article] Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction.2009
- Author(s)
  Ishii T, Fujita T, Matsushita T, Yanaba K, Hasegawa M, Nakashima H, Ogawa F, Shimizu K, Takehara K, Tedder TF, Sato S, Fujimoto M
- Journal Title
  
  Am J Pathol. 174(6)
  
  Pages: 2225-2233
- Data Source
  KAKENHI-PROJECT-20591349
[Journal Article] Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction : cytoprotective action of carbon monoxide.2008
- Author(s)
  Shimizu K, Bae SJ, Hara T, Iwata Komura K, Muroi E, Takenaka M Sato S
- Journal Title
  
  Clin Exp Immunol 153
  
  Pages: 245-257
- NAID
  120006983393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591349
[Journal Article] Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction : cytoprotective action of carbon monoxide2008
- Author(s)
  Shimizu K., et al
- Journal Title
  
  Clinical and Experimental Immunology 153
  
  Pages: 245-257
- NAID
  120006983393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591349
[Journal Article] Increased levels of urinary nitrite and nitrotyrosine in Yusho victims 40 year after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan2008
- Author(s)
  Shimizu K, Ogawa F, Thile JJ, Lee JB, Bae SJ, Sato S
- Journal Title
  
  J Appl Toxicol. 28(8)
  
  Pages: 1040-1044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591349
[Journal Article] Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction : cytoprotective action of carbon monoxide.2008
- Author(s)
  Shimizu K, Bae SJ, Hara T, Iwata Y, Yamaoka T, Komura K, Muroi E, Takenaka M, Ogawa F, Sato S
- Journal Title
  
  Clin Exp Immunol. 153(2)
  
  Pages: 245-257
- NAID
  120006983393
- Data Source
  KAKENHI-PROJECT-20591349
[Journal Article] Increased Serum Levels of N(epsilon)-(hexanoyl)lysine, A New Marker of Oxidative Stress, in Systemic Sclerosis.2008
- Author(s)
  Shimizu K, Ogawa F, Akiyama Yoshizaki A, Iwata Y, Komura K, Bae S, Sato S
- Journal Title
  
  J Rheumatol 35(11)
  
  Pages: 2214-2219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591349
[Presentation] The effect of trichostatin a, one of the histone deacetylase inhibitor, on skin fibrosis mouse.2011
- Author(s)
  Ogawa F, Tomita H, Kuwatsuka Y, Shimizu K, Sato S, Utani A
- Organizer
  2011 ACR 75th/ARHP 46th Annual Scientific Meeting
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-22591245
[Presentation] Hydrogen sulfide attenuates the inflammatory reaction in the cutaneous reverse passive Arthus reaction2009
- Author(s)
  Shimizu K, et al
- Organizer
  The 34^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  JAL Resort Sea Hawk Hotel(Fukuoka)
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-20591349
[Presentation] Hydrogen sulfide attenuates the inflammatory reactions in the cutaneous reverse passive Arthus reaction.2009
- Author(s)
  Shimizu K, et al.
- Organizer
  日本研究皮膚科学会第34回年次学術大会・総会
- Place of Presentation
  福岡市・JALリゾートシーホークホテル福岡
- Data Source
  KAKENHI-PROJECT-20591349
[Presentation] Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction2008
- Author(s)
  Shimizu K., et al
- Organizer
  2^<nd> International Conference on Cutaneous Lupus Erythematosus
- Place of Presentation
  Shiran Kaikan(Kyoto)
- Data Source
  KAKENHI-PROJECT-20591349
[Presentation] Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction2008
- Author(s)
  Kazuhiro Shimizu, SangJae Bae, Toshihide Hara, Fumihide Ogawa, Eiji Muroi, Shinichi Sato
- Organizer
  2^<nd> International Conference on Cutaneous Lupus Erythematosus
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2008-05-12
- Data Source
  KAKENHI-PROJECT-20591349

1. SATO Shinichi (20215792)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. KATAYAMA Ichiro (80191980)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. BAE Sangjae (30281207)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. OGAWA Fumihide (10333519)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. SANGJAE Bae (90325647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HAMASAKI Yoichiro (10180936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山本憲嗣 (90240093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIMIZU Kazuhiro 清水 和宏

Research Projects

Research Products

Co-Researchers

音ストレス増悪接触皮膚炎実験モデルを用いたガス状伝達分子ＮＯ，ＣＯ，Ｈ２Ｓの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of trichostatin A, one of the histone deacetylaseinhibitor, on skin fibrosis of systemic sclerosis mouse model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of reactive oxygen species, NO, CO and H_2S as therapeutic targets in the immune complex diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of neuropeptide stress in atopic dermatitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A (MSRA) and treatments, in systemic sclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of C-C Chemokine Receptors 1 and 5 and CCL3/Macrophage Inflammatory Protein-la in the Cutaneous Arthus Reaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of function of fibroblast derived from atopic dermatitis and skin remodeling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanisms of neuro-endocine-immune system in the skin

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Antioxidant system in photoaged skin of hairless mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IDENTIFICATION AND REGULATORY MECHANISMS OF INTRINSIC ANTI-INFLAMMATORY MOLECULES IN THE SKIN

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through L-selectin involved pathway in the cutaneous reverse passive Arthus reaction.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through L-selectin involved pathway in the cutaneous reverse passive Arthus reaction2013

Author(s)

Journal Title

Data Source

[Journal Article] A case of palmoplantar lichen planus in a patient with congenital sensorineural deafness.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased serum levels of soluble CD163 in patients with scleroderma2012

Author(s)

SHIMIZU Kazuhiro 清水和宏