WATANABE Toshihiro 渡部俊弘

Researcher Number	80175695
Other IDs
Affiliation (Current)	2022: 北海道文教大学, 国際学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2017: 東京農業大学, 生物産業学部, 教授 2010 – 2012: 東京農業大学, 生物産業学部, 教授 2003 – 2008: 東京農業大学, 生物産業学部, 教授
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including mycology) Except Principal Investigator Applied veterinary science / Basic veterinary science/Basic zootechnical science / Structural biochemistry / Biomedical engineering/Biological material science
Keywords	Principal Investigator ボツリヌス毒素複合体 / 小腸上皮細胞 / ボツリヌス食中毒 / 細菌学(含真菌学) / 受容体 / 糖鎖 / シアル酸 / 細胞毒性 / ボツリヌス毒素 / 空胞化 / タンパク質複合体 / エンドソーム / 小腸上皮組織 … More Except Principal Investigator … More

Involvement of nontoxic protein in botulinum toxin complex on digestive injury in botulism food poisoningPrincipal Investigator
- Principal Investigator
  
  WATANABE Toshihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Tokyo University of Agriculture
Signal transduction of intestinal epithelial cells involved in absorption of botulinum toxin.
- Principal Investigator
  
  NIWA Koichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Tokyo University of Agriculture
Identification of the botulinum toxin receptor protein on the intestinal epithelial cellsPrincipal Investigator
- Principal Investigator
  
  WATANABE Toshihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Tokyo University of Agriculture
Study on development of sugar feeding method that prevents animal botulism
- Principal Investigator
  
  NIWA Koichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Tokyo University of Agriculture
Study on the invasion of botulinum toxin protein via intestinal epithelial cells in botulism.
- Principal Investigator
  
  NIWA Koichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Tokyo University of Agriculture
Construction of innovated drug delivery system for proteins and peptides by alteration of botulinum toxin complex
- Principal Investigator
  
  OHYAMA Tohru
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo University of Agriculture
Studies on the Interaction between Subunits of the Botulinum Toxin Complex and X-Ray Crystallography
- Principal Investigator
  
  OHYAMA Tohru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Agriculture

All 2017 2016 2014 2013 2012 2011 2010 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] Structure and function of food engineering. Ayman Amer Eissa2012
- Author(s)
  Sagane, Y., Inui, K., Miyashita, S. -I., Miyata, K., Suzuki, T., Niwa, K., and Watanabe, T
- Publisher
  Botulinum toxin complex: a delivery vehicle of botulinum neurotoxin traveling digestive tract
- Data Source
  KAKENHI-PROJECT-22590405
[Book] Structure and Function of the Clostridium botulinum Serotypes C and D Toxin Complex.2005
- Author(s)
  Watanabe T, Sagane Y, Mutoh S, Suzuki T, Hasegawa K, Kouguchi H, Ohyama T.
- Total Pages
  17
- Publisher
  Research Signpost
- Data Source
  KAKENHI-PROJECT-15570103
[Book] Current Topics in Food Science and Technology2005
- Author(s)
  Toshihiro Watanabe
- Total Pages
  114
- Publisher
  RESEARCH SIGNPOST
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Book] Structure and function of the Clostridium botulinum serotypes C and D toxin complex2005
- Author(s)
  Watanabe T., Sagane, Y., Mutoh, S., Suzuki, T., Hasegawa, K., Kouguchi, H., Ohyama, T.
- Publisher
  Research Signpost
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570103
[Journal Article] Construction of "Toxin Complex" in a Mutant Serotype C Strain of Clostridium botulinum Harboring a Defective Neurotoxin Gene.2017
- Author(s)
  Suzuki T, Nagano T, Niwa K, Uchino M, Tomizawa M, Sagane Y, Watanabe T
- Journal Title
  
  Current Microbiology
  
  Volume: 7 Pages: 49-54
- DOI
  10.1007/s00284-016-1150-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08474, KAKENHI-PROJECT-15K08475
[Journal Article] Reversible Association of the Hemagglutinin Subcomplex, HA-33/HA-17 Trimer, with the Botulinum Toxin Complex2017
- Author(s)
  Sagane Y, Mutoh S, Koizumi R, Suzuki T, Miyashita S, Miyata K, Ohyama T, Niwa K, Watanabe T
- Journal Title
  
  The Protein Journal
  
  Volume: 36 Pages: 417-424
- DOI
  10.1007/s10930-017-9733-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08474, KAKENHI-PROJECT-15K08475
[Journal Article] Building-block architecture of botulinum toxin complex: Conformational changes provide insights into the hemagglutination ability of the complex2017
- Author(s)
  Suzuki T, Sagane Y, Matsumoto T, Hasegawa K, Yamano A, Niwa K, Watanabe T
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 9 Pages: 67-71
- DOI
  10.1016/j.bbrep.2016.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08474, KAKENHI-PROJECT-15K08475
[Journal Article] "Non-Toxic" Proteins of the Botulinum Toxin Complex Exert In-vivo Toxicity.2016
- Author(s)
  Shin-Ichiro Miyashita, Yoshimasa Sagane, Tomonori Suzuki, Takashi Matsumoto, Koichi Niwa, and Toshihiro Watanabe
- Journal Title
  
  Scientific Reports
  
  Volume: 6
- DOI
  10.1038/srep31043
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08474, KAKENHI-PROJECT-15K08475
[Journal Article] Conformational divergence in the HA-33/HA-17 trimer of serotype C and D botulinum toxin complex.2016
- Author(s)
  Yoshimasa Sagane, Shintaro Hayashi, Tomonori Akiyama, Takashi Matsumoto, Kimiko Hasegawa, Akihito Yamano, Tomonori Suzuki, Koichi Niwa, Toshihiro Watanabe, and Shunsuke Yajima
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 476 Pages: 280-285
- DOI
  10.1016/j.bbrc.2016.05.113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08474, KAKENHI-PROJECT-15K08475
[Journal Article] Data describing inhibitory profiles of sugars against hemagglutination by the botulinum toxin complex of Clostridium botulinum serotypes C and D2016
- Author(s)
  Yoshimasa Sagane, Minoru Ito, Keita Miyata, Tomonori Suzuki, Koichi Niwa, Suguru Oguri, and Toshihiro Watanabe
- Journal Title
  
  Data in Brief
  
  Volume: 9 Pages: 413-416
- DOI
  10.1016/j.dib.2016.09.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08474, KAKENHI-PROJECT-15K08475
[Journal Article] Isolation of botulinolysin, a thiol-activated hemolysin, from serotype D Clostridium botulinum: A species-specific gene duplication in Clostridia2016
- Author(s)
  Tomonori Suzuki, Thomas Nagano, Koichi Niwa, Shingo Mutoh, Masataka Uchino, Motohiro Tomizawa, Yoshimasa Sagane, and Toshihiro Watanabe
- Journal Title
  
  Microbiological Research
  
  Volume: 193 Pages: 20-29
- DOI
  10.1016/j.micres.2016.08.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08474, KAKENHI-PROJECT-15K08475
[Journal Article] Botulinum Toxin Complex Increases Paracellular Permeability in Intestinal Epithelial Cells via Activation of p38 Mitogen-Activated Protein Kinase2013
- Author(s)
  Miyashita S-I., Sagane Y., Inui K., Hayashi S., Miyata K., Suzuki T., Ohyama T., Watanabe T., Niwa K.
- Journal Title
  
  J. Vet. Med. Sci.
  
  Volume: 75 Issue: 12 Pages: 1637-1642
- DOI
  10.1292/jvms.13-0164
- NAID
  130003362264
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580432, KAKENHI-PROJECT-25860325
[Journal Article] HA-33 facilitates transport of the serotype D botulinum toxin across a rat intestinal epithelial cell monolayer2011
- Author(s)
  Ito, H., Sagane, Y., Miyata, K., Inui, K., Matsuo, T., Horiuchi, R., Ikeda, T., Suzuki, T., Hasegawa, K., Kouguchi, K., Oguma, K., Niwa, K., Ohyama, T., Watanabe T.
- Journal Title
  
  FEMS Immunol. Med. Microbiol
  
  Volume: 61 Pages: 323-331
- DOI
  10.1111/j.1574-695x.2011.00779.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J08286, KAKENHI-PROJECT-11J10275, KAKENHI-PROJECT-21580383, KAKENHI-PROJECT-22590405
[Journal Article] Characterization of sugar recognition by the toxin complex produced by the Clostridium botulinum serotype C variant strain Yoichi2011
- Author(s)
  Matsuo, T., Miyata, K., Inui, K., Ito, H., Horiuchi, R., Suzuki, T., Yoneyama, T., Oguma, K., Niwa, K., Watanabe, T., Ohyama, T.
- Journal Title
  
  FEMS Immunol. Med. Microbiol
  
  Volume: 63 Pages: 35-43
- DOI
  10.1111/j.1574-695x.2011.00825.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J08286, KAKENHI-PROJECT-11J10275, KAKENHI-PROJECT-21580383, KAKENHI-PROJECT-22590405
[Journal Article] Sialic acid-dependent binding and transcytosis of serotype D botulinum neurotoxin and toxin complex in rat intestinal epithelial cells2010
- Author(s)
  Niwa, K., Yoneyama, T., Ito, H., Taira, M., Chikai, T., Kouguchi, H., Suzuki, T., Hasegawa, K., Miyata, K., Inui, K., Ikeda, T., Watanabe, T. and Ohyama, T.
- Journal Title
  
  Vet. Microbiol
  
  Volume: 141 Pages: 312-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580383
[Journal Article] Involvement of sialic acid in transport of serotype C1 botulinum toxins through rat intestinal cells2010
- Author(s)
  Inui, K., Ito, H., Miyata, K., Matsuo, T., Horiuchi, R., Ikeda, T., Watanabe, T., Ohyanma, T. and Niwa, K.
- Journal Title
  
  J. Vet. Med. Sci
  
  Volume: 72 Pages: 1251-1255
- URL
  http://dx.doi.org/10.1292/jvms.10-0090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580383
[Journal Article] Clostridium botulinum Serotype D neurotoxin and toxin complex bind to bovine aortic endothelial cells via sialic acid2008
- Author(s)
  Yoneyama, T., Miyata, K., Chikai, T., Mikami, A., Suzuki, T., Hasegawa, K., Ikeda, T., Watanabe, T., Ohyama, T. and Niwa, K
- Journal Title
  
  FEMS Immunol. Med. Microbiol 54
  
  Pages: 290-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580364
[Journal Article] Role of non-toxic components of serotype D botulinum toxin complex in permeation through Caco-2 cell monolayer, a model for intestinal epithelium2007
- Author(s)
  Niwa, K., Koyama, K., Inoue, S., Suzuki, T., Hasegawa, K., Watanabe, T., Ikeda, T., Ohyama, T
- Journal Title
  
  FEMS. Immunol Medical Microbiol 49
  
  Pages: 346-352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Journal Article] Improved arterial wall model by co-culturing vascular endothelial and smooth muscle Cells2007
- Author(s)
  Niwa, K., Sakai, J., Watanabe, T., Ohyama, T., Karino, T
- Journal Title
  
  In Vitro Cell. & Develop. Biol 43
  
  Pages: 17-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Journal Article] Effect of nicking in the C-terminal of heavy chain of Clostridium botulinum sserotype D neurotoxin on its toxicity and molecular properties2007
- Author(s)
  Suzuki, T., Kouguchi, H., Sato, H., Hasegawa, K., Mutoh, S., Yoneyama, T., Niwa, K., Nishikawa, A., Lee, C-J., Oguma, K., Watanabe, T., Ohyama, T
- Journal Title
  
  Protein J 26
  
  Pages: 173-181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Journal Article] C Terminal half fragment (50 kDa) of heavy chain components of Clostridium botulinum type C and D neurotoxins can be used as an effective vaccine2007
- Author(s)
  Lee, J. C., Hwang, H. J., Sakaguchi, Y, Yamamoto, Y., Arimitsu, H., Tsuji, T., Watanabe, T., Ohyama, T., Tsuchiya, T., Oguma, K
- Journal Title
  
  Microbiol. Immunol 51
  
  Pages: 445-455
- NAID
  10020280881
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Journal Article] A Novel Subunit Structure of Clostridium botulinum Serotype D Toxin Complex with Three Extended Arms2007
- Author(s)
  Hasegawa, K., Watanabe, T., Suzuki, T., Yamano, A., Oikawa, T., Sato, Y., Kouguchi, H., Yoneyama, T., Niwa, K., Ikeda, T., Ohyama, T
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 24777-24783
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Journal Article] Cell internalization and traffic pathway of Clostridium botulinum type C neurotoxin in HT-29 cells2006
- Author(s)
  Uotsua, N., Nishikawaa, A., Watanabec, T., Ohyamac, T., Tonozukaa, T., Sakanoa, Y., Oguma, K
- Journal Title
  
  Biochim. Biophys. Acta 1763
  
  Pages: 120-128
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Journal Article] Quantitative detection of gene expression and toxin complex produced by Clostridium botulinum serotype D strain 49472006
- Author(s)
  Kouguchi, H., Suzuki, T., Hasegawa, K., Mutoh, S., Watanabe, T., Niwa, K., Yoneyama, T., Katoh, Y., Ohyama, T
- Journal Title
  
  J. Microbiol. Method 67
  
  Pages: 416-423
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Journal Article] Production of anti-neurotoxin antibody is enhanced by two subcomponents, HA1 and HA3b, of Clostridium botulinum type B 16S toxin-haemagglutinin2005
- Author(s)
  Lee, J. C., Yokota, K., Arimitsu, H., Hwang, H. J., Sakaguchi, Y., Cui, J., Takeshi, K., Watanabe, T., Ohyama, T., Oguma, K
- Journal Title
  
  Microbiology-UK 151
  
  Pages: 3739-3747
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Journal Article] Four molecules of 33 kDa hemagglutinin components (HA-33) of the Clostridium botulinum serotype C and D toxin complexes are required to aggregate erythrocytes2005
- Author(s)
  Mutoh, S., Suzuki, T., Hasegawa, K., Nakazawa, Y., Kouguchi, H., Sagane, Y., Niwa, K., Watanabe, T., Ohyama, T
- Journal Title
  
  Microbiology-UK 151
  
  Pages: 3847-3858
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Journal Article] Structure and function of the Clostridium botulinum serotypes C and D toxin complex2005
- Author(s)
  Watanabe, T.
- Journal Title
  
  Research Signpost
  
  Pages: 17-33
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570103
[Journal Article] Characterization of the interaction between subunits of the botulinum toxin complex produced by serotype D through tryptic susceptibility of the isolated components and complex forms2005
- Author(s)
  Suzuki, T., Watanabe, T., Mutoh, S., Hasegawa, K., Kouguchi, H., Fujinaga, F., Oguma, K., Ohyama, T
- Journal Title
  
  Microbiology-UK 151
  
  Pages: 1475-1483
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Journal Article] Characterization of the interaction between subunits of the botulinum toxin complex produced by serotype D through tryptic susceptibility of the isolated components and complex forms.2005
- Author(s)
  Suzuki T, Watanabe T, Mutoh S, Hasegawa K, Kouguchi H, Fujinaga F, Oguma K, Ohyama, T.
- Journal Title
  
  Microbiology -UK 151
- Data Source
  KAKENHI-PROJECT-15570103
[Journal Article] Molecular characterization of binding subcomponents of Clostridium botulinum type C progenitor toxin for intestinal cells and erythrocytes2004
- Author(s)
  Fujinaga, Y., Inoue, K., Watarai, S., Sakaguchi, Y., Arimitsu, H., Lee, J.C., Jin, Y., Matsumura, T., Kabumoto, Y., Watanabe, T., Ohyama, T., Nishikawa, A., Oguma, K.
- Journal Title
  
  Microbiology Vol.150
  
  Pages: 1529-1538
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570103
[Journal Article] Characterization of Toxin Complex Produced by a Unique Strain of Clostridium botulinum type D 4947.2004
- Author(s)
  Hasegawa K, Watanabe T, Sato H, Sagane Y, Mutoh S, Suzuki T, Yamano Y, Kouguchi H, Takeshi K, Kamaguchi A, Fujinaga Y, Oguma K, Ohyama T.
- Journal Title
  
  Protein J. 23
  
  Pages: 371-378
- Data Source
  KAKENHI-PROJECT-15570103
[Journal Article] Characterization of Toxin Complex Produced by a Unique Strain of Clostridium botulinum type D 49472004
- Author(s)
  Hasegawa, K., Watanabe, T., Sato, H., Sagane, Y., Mutoh, S., Suzuki, T., Yamano, Y., Kouguchi, H., Takeshi, K., Kamaguchi, A., Fujinaga, Y., Oguma, K., Ohyama, T.
- Journal Title
  
  Protein J. Vol.23
  
  Pages: 371-378
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570103
[Journal Article] The receptor and transporter for internalization of Clostridium botulinum type C progenitor toxin into HT-29 cells2004
- Author(s)
  Nishikawa, A., Uotsu, N., Arimitsu, H., Lee, J.C., Miura, Y., Fujinaga, Y., Nakada, H., Watanabe, T., Ohyama, T., Sakano, Y., Oguma, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. Vol.319
  
  Pages: 327-333
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570103
[Journal Article] Complete Subunit Structure of Clostridium botulinum Type D Toxin Complex via Intermediate Assembly with Nontoxic Components2003
- Author(s)
  Mutoh, S., Kouguchi, H., Sagane, Y., Suzuki, T., Hasegawa, K., Watanabe, T., Ohyama, T.
- Journal Title
  
  Biochemistry Vol.37
  
  Pages: 10991-10997
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570103
[Journal Article] Purification of Fully Activated Clostridium botulinum Serotype B Toxin for Treatment of Patients with Dystonia2003
- Author(s)
  Arimitsu, H., Inoue, K., Sakaguchi, Y., Lee, J.C., Fujinaga, Y., Watanabe, T., Ohyama, T., Hirst, R., Oguma, K.
- Journal Title
  
  Infect.Immun. Vol.71
  
  Pages: 1599-1603
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570103
[Journal Article] Molecular Characterization of GroES and GroEL Homologues from Clostridium botulinum2003
- Author(s)
  Sagane, Y., Hasegawa, K., Mutoh, S., Kouguchi, K., Suzuki, T., Sunagawa, H., Nakagawa, T., Kamaguchi, A., Okasaki, S., Nakayama, K., Watanabe, T., Oguma K., Ohyama, T.
- Journal Title
  
  J.Protein Chem. Vol.22
  
  Pages: 99-108
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570103
[Journal Article] Complete Subunit Structure of Clostridium botulinum Type D Toxin Complex via Intermediate Assembly with Nontoxic Components.2003
- Author(s)
  Mutoh S, Kouguchi H, Sagane Y, Suzuki T, Hasegawa K, Watanabe T, Ohyama T.
- Journal Title
  
  Biochemistry 37
  
  Pages: 10991-10997
- Data Source
  KAKENHI-PROJECT-15570103
[Presentation] Internalization and intercellular trafficking of the serotype D botulinum neurotoxin binding protein, nontoxic nonhemagglutinin, in epithelial and endothelial cells.2017
- Author(s)
  Sagane, Y., Miyashita, S. -I., Hosoya, K., Karatsu, S., Kurihara, A., Sugawara, C., Niwa, K., Watanabe, T.
- Organizer
  10th International Conference on the Molecular Biology and Pathogenesis of the Clostridia.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08475
[Presentation] “Non-toxic” proteins of the botulinum toxin complex exert cytotoxicity with vacuole formation in the cell.2017
- Author(s)
  Sagane, Y., Miyashita, S. -I., Kurihara, A., Sugawara, C., Hosoya, K., Karatsu, S., Niwa, K., Watanabe, T.
- Organizer
  10th International Conference on the Molecular Biology and Pathogenesis of the Clostridia.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08475
[Presentation] D 型ボツリヌス神経毒素結合タンパク質非毒非血球凝集素のヒト大腸癌細胞への結合および透過2014
- Author(s)
  宮下慎一郎, 相根義昌, 林慎太郎, 鈴木智典, 丹羽光一, 渡部俊弘
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-24580432
[Presentation] ボツリヌス神経毒素結合タンパク質非毒非血球凝集素の小腸上皮細胞への結合および透過機構2013
- Author(s)
  宮下慎一郎,相根義昌,犬井健,栗原小百合,鈴木智典,丹羽光一,渡部俊弘
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22590405
[Presentation] D 型ボツリヌス神経毒素結合タンパク質 NTNHA はラット小腸上皮細胞へ結合し細胞層を透過する2013
- Author(s)
  宮下慎一郎, 相根義昌, 林慎太郎, 鈴木智典, 丹羽光一 , 渡部俊弘
- Organizer
  第80回日本細菌学会北海道支部学術総会
- Place of Presentation
  東京農大生物産業学部（網走市）
- Data Source
  KAKENHI-PROJECT-24580432
[Presentation] ボツリヌス神経毒素結合タンパク質非毒非血球凝集素の小腸上皮細胞への結合および透過2012
- Author(s)
  宮下慎一郎,相根義昌,宮田恵多,犬井健,栗原小百合,狩野聡史,林慎太郎,川根武紘,鈴木智典,丹羽光一,渡部俊弘
- Organizer
  第79回日本細菌学会北海道支部会学術総会
- Place of Presentation
  帯広
- Data Source
  KAKENHI-PROJECT-22590405
[Presentation] Transport of the botulinum neurotoxin-associating protein, nontoxic nonhemagglutinin, across the intestinal epithelial cell layer2012
- Author(s)
  Miyashita, S. -I., Sagane, Y., Miyata, K., Inui, K., Kurihara, S., Kano, S., Hayashi, S., Kawane, T., Suzuki, T., Niwa, K., and Watanabe, T
- Organizer
  22nd IUBMB and 37th FEBS
- Place of Presentation
  Seville, Spain
- Data Source
  KAKENHI-PROJECT-22590405
[Presentation] D型ボツリヌス毒素の小腸上皮細胞層透過に関与する細胞内分子機構2012
- Author(s)
  狩野聡史、相根義昌、宮下慎一郎、犬井健、川根武紘、栗原小百合、林慎太郎、渡部俊弘、丹羽光一
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24580432
[Presentation] ボツリヌス神経毒素結合タンパク質-非毒非血球凝集素の小腸上皮細胞層への結合および透過機構2012
- Author(s)
  宮下慎一郎,相根義昌,犬井健,栗原小百合,狩野聡史,林慎太郎,川根武紘,鈴木智典,丹羽光一,渡部俊弘
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590405
[Presentation] C 型ボツリヌス毒素の小腸上皮細胞からの侵入機構の解析2010
- Author(s)
  犬井健,宮田恵多,伊藤博章,松尾 5,堀内亮太,吉田悠真,宮下慎一郎,村松将司,渡部俊弘,大山徹,丹羽光一
- Organizer
  第33回日本分子生物学会年会代 83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590405
[Presentation] C 型およびD 型ボツリヌス毒素の小腸上皮細胞の透過におけるシアル酸の役割2010
- Author(s)
  丹羽光一,伊藤博章,犬井健,宮田恵多,松尾智仁,堀内亮太,宮下慎一郎,吉田悠真,村松将司,渡部俊弘,大山徹
- Organizer
  第150回日本獣医学会学術集会
- Place of Presentation
  帯広
- Data Source
  KAKENHI-PROJECT-22590405
[Presentation] Mechanism of Clostridium botulinum type D toxin complex in binding to bovine aortic endothelial cells2007
- Author(s)
  Niwa, K., Miyata, K., Yoneyama, T., Taira, M., Mikami, A., Chikai, T., Ikeda, T., Watanabe, T., Ohyama, T
- Organizer
  BMB2007 (The 79th Annual Scientific Meeting of the Japanese Biochemical Society)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Presentation] Clostridium botulinum serotype D toxin complex binds to bovine artery endothelial cells via sialic acid moiety.2007
- Author(s)
  Yoneyama, T., Niwa, K., Miyata, K., Mikami, A., Chicai, T., Watanabe, T., Ohyama, T
- Organizer
  BMB2007 (The 79th Annual Scientific Meeting of the Japanese Biochemical Society)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Presentation] A novel electron microscopy structure of the toxin complex produced by the Clostridium botulinum serotpe D strain 49472007
- Author(s)
  Hasegawa, K., Suzuki, T., Watanabe, T., Mutoh, S., Oikawa, T., Satoh, Y., Niwa, K., Ohyama, T
- Organizer
  The 4th Takeda Science Foundation Symposium on PharmaSciences
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Presentation] A novel structure analysis of the toxin complex produced by the Clostridium botulinum serotype D June 2006,Kyoto2006
- Author(s)
  Hasegawa, K., Suzuki, T., Niwa, K., Miyata, K., Oikawa, T., Sagane, Y., Ikeda, T.,Watanabe, T., Ohyama, T
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Presentation] Characterization of the interaction regions between individual components in the botulinum toxin complex2006
- Author(s)
  Suzuki, T.,Hasegawa, K., Yoneyama, T., Miyata, K., Niwa, K., Ikeda, T., Watanabe, T., Ohyama, T
- Organizer
  16th International Microscopy Congress (IMC16)
- Place of Presentation
  Sapporo Conventional Center
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Presentation] Molecular characterization of protease responsible for nicking in botulinum neurotoxin complex.2005
- Author(s)
  Suzuki, T., Yoneyama, T., Miyata, K., Mikami, K., Chikai, T., Hasegawa, K., Niwa, K., Watanabe, T., Miyazaki, S., Ohyama, T
- Organizer
  The78th Annual Scientific Meeting of the Japanese Biochemical Society
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Presentation] Characterization of interaction between botulinum neurotoxin and notoxic components through the reconstitution of hybrid toxin complex2005
- Author(s)
  Hasegawa, K., Watanabe, T., Mutoh, S., Suzuki, T., Niwa, K., Ohyama, T
- Organizer
  The 78th Annual Scientific Meeting of the Japanese Biochemical Society
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Presentation] Characterization of trypsin like protease produced by Clostriduim botulinum type C strain Stockholm
- Author(s)
  Saitoh, R., Suzuki, T., Yoneyama, T., Mutoh, S., Hasegawa, K., Munehiro, M., Niwa, K., Watanabe, T., Ohyama, T
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300161
[Presentation] D 型ボツリヌス毒素複合体による小腸上皮の透過性上昇における MAP キナーゼの関与
- Author(s)
  宮下慎一郎、丹羽光一、相根義昌、林慎太郎、渡部俊弘
- Organizer
  第 81 回日本細菌学会北海道支部学術総会
- Place of Presentation
  札幌医科大学、札幌
- Year and Date
  2014-08-29 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-24580432

1. OHYAMA Tohru (60318178)

# of Collaborated Projects: 6 results

# of Collaborated Products: 35 results
2. NIWA Koichi (20301012)

# of Collaborated Projects: 6 results

# of Collaborated Products: 40 results
3. OGURI Suguru (70277250)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SAGANE Yoshimasa (00624660)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
5. NAKAGAWA Tomoyuki (70318179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. MUTOH Shingo (20749890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. SUZUKI Tomonori (90453836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

WATANABE Toshihiro 渡部 俊弘

Research Projects

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Co-Researchers

Involvement of nontoxic protein in botulinum toxin complex on digestive injury in botulism food poisoningPrincipal Investigator

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Signal transduction of intestinal epithelial cells involved in absorption of botulinum toxin.

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Identification of the botulinum toxin receptor protein on the intestinal epithelial cellsPrincipal Investigator

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Study on development of sugar feeding method that prevents animal botulism

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Study on the invasion of botulinum toxin protein via intestinal epithelial cells in botulism.

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Construction of innovated drug delivery system for proteins and peptides by alteration of botulinum toxin complex

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Studies on the Interaction between Subunits of the Botulinum Toxin Complex and X-Ray Crystallography

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[Book] Structure and function of food engineering. Ayman Amer Eissa2012

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[Book] Structure and Function of the Clostridium botulinum Serotypes C and D Toxin Complex.2005

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[Book] Current Topics in Food Science and Technology2005

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[Book] Structure and function of the Clostridium botulinum serotypes C and D toxin complex2005

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[Journal Article] Construction of "Toxin Complex" in a Mutant Serotype C Strain of Clostridium botulinum Harboring a Defective Neurotoxin Gene.2017

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[Journal Article] Reversible Association of the Hemagglutinin Subcomplex, HA-33/HA-17 Trimer, with the Botulinum Toxin Complex2017

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[Journal Article] Building-block architecture of botulinum toxin complex: Conformational changes provide insights into the hemagglutination ability of the complex2017

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WATANABE Toshihiro 渡部俊弘