Arai Toshiyuki 荒井俊之

… Alternative Names

ARAI Toshiyuki 荒井俊之

ARAI Yoichi 荒井陽一

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Researcher Number	80175950
Other IDs
External Links
Affiliation (Current)	2025: 京都大学, 医学研究科, 研究員
Affiliation (based on the past Project Information) *help	2012: 京都大学, 医学(系)研究科(研究院), 研究員 2009 – 2012: Kyoto University, 医学研究科, 准教授 2011: 京都大学, 医学(系)研究科(研究院), 准教授 2007: Kyoto University, Medicine, Associate Professor 2002 – 2006: 京都大学, 医学研究科, 助教授 … More 2000: Kyoto University, Medicine, Associated Professor, 医学研究科, 助教授 1999: 京都大学, 大学院・医学研究科, 助教授 1995 – 1998: Sch.of Medicine, Kyoto University Associate Professor, 医学研究科, 助教授 1993 – 1994: Kyoto University, Medicine, Associate, 医学部, 助教授 1990 – 1992: Kyoto University, Medicine, Lecturer, 医学部, 講師 1989 – 1990: 京都大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies / Laboratory medicine / 麻酔学 Except Principal Investigator 麻酔学 / Anesthesiology/Resuscitation studies / Urology
Keywords	Principal Investigator 活性酸素 / 6-formylpterin / 一重項酸素 / PBN / 神経細胞 / 細胞死 / アポトーシス / NF-κB / フローサイトメトリー / thioredoxin … More / iNOS / peroxynitrite / propofol / geranylgeranylacetone / 活性酸素消去剤 / gerbil / 遅発性神経細胞死 / neopterin / oxygen free radicals / ネオプテリン / 砂ネズミ / スーパーオキシド / ヒト好中球 / siRNA / プテリン化合物 / エダラボン / グルタミン酸 / カスパーゼ / 好中球 / 6-ホリミルプテリン / 過酸化水素 / 酸化ストレス / 抗Fas抗体 / Interleukin-8 / Human umbilical endothelial cells / Reactive oxygen species / Real time PCR / Short interfering RNA / RNA interference / Myeronperoxidaes / Neutreopils / 化学発光 / ミエロペルオキシダーゼ / 蛍光試薬DCFH / フローサイトメーター / RNA干渉 / インターロイキン-8 / ヒト臍帯静脈内皮細胞 / インターロイキン-8(IL-8) / ヒト臍帯静脈内皮細胞(HUVECs) / リアルタイムPCR / 短鎖干渉用RNA(siRNA) / RNA干渉(RNAi) / ミエロペルオキシダーゼ(MPO) / human dendritic cells / human leukemia cell line / human pancreatic cancer cell line / rat hepatocytes / photodynamic effects / singlet oxygen / ischemia-reperfusion injury / ヒトT細胞 / ヒスチジン / GSH / NAC / ヒト樹状細胞 / 白血病細胞株 / 膵臓癌細胞株 / ラット肝細胞 / 光動力学的効果 / 6-ホルミルプテリン / 虚血再灌流傷害 / immune responses / cell death / oxidative stress / T cells / lymphocytes / monocytes / 9-ホルミルプテリン / レポーターアッセイ / 細胞増殖 / サイトカイン産生 / 免疫反応 / T細胞 / リンパ球 / 単球 / apoptosis / ROS / シクロヘキサミド / 6FP / 活性酸素産生剤 / リポポリ多糖類 / 腫瘍壊死因子 / 肝細胞 / ラット / interleukin-1 receptor antagonist / immunohistochemistry / lactate / nuclear magnetic resonance / global brain ischemia / rat / focal cerebral ischemia / 組織化学染色 / 虚血再潅流障害 / 砂ネズミ全脳虚血 / 脳エネルギー代謝 / レセプターアンタゴニスト / インターロイキン-1 / 免疫組織化学 / 乳酸 / 核磁気共鳴 / 虚血再灌流障害 / ラット局所脳虚血 / oxygen-17 / water-17 / magnetic resonance imaging / cerebral metabolic rate for oxygen / cerebral blood flow / 神経膠細胞 / 組織標本 / 脳梗塞 / 中大脳動脈閉塞 / 酸素-17ガス / 水-17 / 核磁気共鳴画像法 / 脳酸素消費量 / 脳血流量 / mulecular orbital / spin trapper / ischemic-reperfusion injury / brain ischemia / 分子軌道 / ph-M_3PO / 酸素-18 / 揮発性神経細胞死 / 脳虚血再潅流 / 分子軌道法 / スピントラップ剤 / 虚血再潅流傷害 / 脳虚血 / EPR / MAP2 / MRI / NIR / gerbils / cerebral ischemia / 酸化型ヘモグロビン / 砂ネズミ虚血脳切片 / ネオプテリン抗体 / 好中球刺激系 / HPX-XOD反応系 / ビオプテリン / 免疫組織化学的手法 / マップII / 核磁気共鳴画像 / 近赤外線組織酸素モニター / 脳虚血モデル / GC-MS / oxygen-18 gas / water-18 / oxygen consumption / blood flow / brain / 人工血液 / 酸素安定同位元素 / 質量分析計 / 酸素ー18ガス / 水ー18 / トリフルオロヨ-ドメタン / 局所脳酸素消費量 / 局所脳血流量 / ラマン分光法 / アジ化ナトリウム / 放射線障害 / 皮膚細胞 / 特異的消去剤 / ELISA / ゲル電気泳動 / リアルタイムPC / MTTアッセイ / 遺伝子導入 / 組織因子 / 播種性血管内凝固症候 / NADPHオキシダーゼ-1 / インターロイキン8 / LPS / 血管内皮細胞 / 組織傷害 / 白血病細胞 / 新規一重項酸素消去剤 / オートファジー / 神経様細胞 / NETs / 細胞活性 / NETosis / 自己貪食型 / 壊死型 / ラット初代培養肝細胞 / JurkatヒトT細胞 / アポトーシス抑制 / 細胞増殖抑制 / アポトーシス誘導 / NAD(P)H / 6-フォルミルプテリン … More Except Principal Investigator GABA / thioredoxin / gene expression / Oxidative Stress / 酸素ストレス / チオレドキシン / 遺伝子発現 / 酸化的ストレス / Drug effects / Cerebral glucose utiliztion / Hepatic energy metabolism / Cerebral oxygen consumption / Cerebral blood flow / Phosphorus-31 NMR / Oxygen-17 NMR / Deutrium NMR / 脳酸素消費量 / 脳血流量 / 酸素ー17核磁気共鳴 / 化学シフトイメージング法 / 肝血流量 / 脳血流分布 / 超高速NMR画像 / リン核磁気共鳴 / ウサギ / 酸素-17ガス / 重水 / 化学シフトイメージング / 酸素-17核磁場共鳴 / 薬物効果 / 肝エネルギー代謝 / 局所脳酸素消費量 / 局所脳血流量 / 局所脳グルコース代謝 / リン-31 核磁気共鳴 / 酸素-17 核磁気共鳴 / 重水素核磁気共鳴 / Convulsion / NMDA receptor / c-fos / Barbiturate / Calcium Antagonist / Cerebral Hypoxia / Intracellular Calcium / 痙攣 / NMDA受容体 / cーfos / バルビツレ-ト / カルシウム拮抗薬 / 脳虚血 / 細胞内カルシウム濃度 / Molecular Biology / Northern Blot Method / Benign Prostatic Hyperplasia / Growth Factor / Prostate / 成長因子 / 分子生物学 / ノザン法 / 前立腺肥大症 / 増殖因子(成長因子) / 前立腺 / glumatate / aspartate / diazepam / lidocaine / pentobarbital / halothane / neurotransmitter / グリシン / パントバルビタ-ル / アスバルギン酸 / グルタミン酸 / アスパルギン酸 / ジアゼパム / リドカイン / ペントバルビタ-ル / ハロセン / 神経伝達物質 Less

Development of the novel compound which specifically scavenges singlet oxygen extra- and intracellularly.Principal Investigator
- Principal Investigator
  
  ARAI Toshiyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyoto University
Determination of the active reactive oxygen species that generated in cells during ischemia-reperfusion and selection of its specific scavenger.Principal Investigator
- Principal Investigator
  
  ARAI Toshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyoto University
RNA干渉を用いた血管内皮細胞インターロイキン発現抑制による敗血症組織傷害の緩和Principal Investigator
- Principal Investigator
  
  荒井俊之
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyoto University
Protection against ischemia-reperfusion injury using a short interfering RNA that inhibits the activity of myeloperoxidasePrincipal Investigator
- Principal Investigator
  
  ARAI Toshiyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyoto University
The role of singlet oxygen in ischemia-reperfusin injury : the study using laser scanning confocal microscopy and electron paramagnetic resinancePrincipal Investigator
- Principal Investigator
  
  ARAI Toshiyuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KYOTO UNIVERSITY
人為的酸化ストレス負荷によるアポートシスの抑制-Jurkat細胞、ヒト好中球、ラット肝細胞を用いた研究-Principal Investigator
- Principal Investigator
  
  荒井俊之
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyoto University
Effects of oxidative stress during ischemia-reperfusion on cytokine production in monocytes and lymphocytesPrincipal Investigator
- Principal Investigator
  
  ARAI Toshiyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KYOTO UNIVERSITY
プテリン誘導体の呼吸鎖における過酸化水素産生とそれにより生じる細胞傷害との関係Principal Investigator
- Principal Investigator
  
  荒井俊之
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyoto University
Reactive oxygen species induced apoptosis in ischemia-reperfusion injuryPrincipal Investigator
- Principal Investigator
  
  ARAI Toshiyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KYOTO UNIVERSITY
Evaluation of focal cerebral ischemia by NMR and histochemistry.Principal Investigator
- Principal Investigator
  
  ARAI Toshiyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KYOTO UNIVERSITY
A method for simultaneous measurements of cerebral blood flow and cerebral metabolic rate for oxygen by magnetic resonance imaging.Principal Investigator
- Principal Investigator
  
  TOSHIYUKI Arai
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KYOTO UNIVERSITY
A method for simultaneous measurements of cerebral blood flow and cerebral metabolic rate for oxygen by magnetic resonance imaging.Principal Investigator
- Principal Investigator
  
  ARAI Toshiyuki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory medicine
- Research Institution
  KYOTO UNIVERSITY
The analysis of the expression of antioxidative proteins against oxidative stress
- Principal Investigator
  
  TANIGUCHI Yoshihisa
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KYOTO UNIVERSITY
Estimation of oxygen delivery during cerebral ischemia and the consequent tissue damage.Principal Investigator
- Principal Investigator
  
  ARAI Toshiyuki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  KYOTO UNIVERSITY
Measurements of cerebral blood flow and metabolism using MMR
- Principal Investigator
  
  MORI Kenjiro
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  麻酔学
- Research Institution
  Kyoto University
A new method for the estimation of cerebral oxygen metabolismPrincipal Investigator
- Principal Investigator
  
  ARAI Toshiyuki
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  麻酔学
- Research Institution
  Kyoto University
The effects of cerebral hypoxia on intracellular Ca^<2+> concentration
- Principal Investigator
  
  NAKAO Shin-ichi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  麻酔学
- Research Institution
  Kyoto University
The Effects of Anesthetics on Neurotransmission
- Principal Investigator
  
  MORI Kenjiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  麻酔学
- Research Institution
  Kyoto University
Expression of Growth Factors in the Human Prostate and Identification of the Cells Producing Them (Analysis by Molecular Biological Method)
- Principal Investigator
  
  OISHI Kenji
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyoto University

All 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Singlet oxygen is essential for neutrophil extracellular trap formation2011
- Author(s)
  Yoko Nishinaka
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 413 Issue: 1 Pages: 75-79
- DOI
  10.1016/j.bbrc.2011.08.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J03388, KAKENHI-PROJECT-21390433, KAKENHI-PROJECT-23659740
[Journal Article] Uchiyama T : NB4 cells treated with all-trans retinoic acid generate toxic reactive oxygen species that cause endothelial hyper permeability2010
- Author(s)
  Miyoshi T, Arai T, Yamashita K, Sasada M
- Journal Title
  
  Leukemia Res
  
  Volume: 34 Issue: 3 Pages: 373-378
- DOI
  10.1016/j.leukres.2009.05.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390433
[Journal Article] The radical scavenger edaravone reacts with a pterin derivative and produces a cytotoxic substance which induces intracellular ROS generation and cell death.2008
- Author(s)
  Arai T, Nonogawa M, makino K, et. al.
- Journal Title
  
  J Pharmacol Exp Ther 324
  
  Pages: 529-538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Anticancer photodynamic and non-photodynamic effects of pterin derivatives on a pancreatic cancer cell line.2008
- Author(s)
  Miyoshi T, Arai T, Nonogawa M, et. al.
- Journal Title
  
  J Pharmacol Sci (in press)
- NAID
  10024321141
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] The radical scavenger edaravone(3-methyl-1-phenyl-2-pyrazolin-5-one)reacts with a pterin derivative and produces a cytotoxic substance that induces intracellular ROS generation and cell death.2008
- Author(s)
  Arai T, Nonogawa M, Makino K, et. al.
- Journal Title
  
  J Pharmacol Exp Ther 324
  
  Pages: 529-538
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Anticancer photodynamic and non-photodynamic effects of pterin derivatives on a pancreatic cancer cell line2008
- Author(s)
  Miyoshi, T., Arai, T., Nonogawa, M., Makino, K., Mori, H., Yamashita, K., Sasada, M., Uchiyama, T
- Journal Title
  
  J Pharmacol Sci (in press)
- NAID
  10024321141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] The radical scavenger edaravone (3-methyl-l-phenyl-2-pyrazolin-5-one) reacts with a pterin derivative and produces a cytotoxic substance that induces intracellular ROS generation and cell death2008
- Author(s)
  Arai, T., Nonogawa, M., Makino, K., Endo, N., Mori, H., Miyoshi, T., Yamashita, K., Sasada, M., Kakuyama, M., Fukuda, K
- Journal Title
  
  J Pharmacol Exp Ther 324
  
  Pages: 529-538
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Reactive oxygen species generation through NADH oxidation by 6-formylpterin derivatives in the dark.2007
- Author(s)
  Nonogawa M, Pack SP, Arai T, et. al.
- Journal Title
  
  Biochem Biophys Res Commun 35
  
  Pages: 1105-1110
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Inhibitory effects of 6-formylpterin on HIF-la protein accumulation2007
- Author(s)
  Sommani, P., Yamashita, K., Miyoshi, T., Tsunemine, H., Kodaki, T., Mori, H., Hirota, K., Arai, T., Sasada, M., Makino, K
- Journal Title
  
  Biol Pharm Bull 30
  
  Pages: 2181-2184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Synthesis of 6-formylpterin nucleoside analogs and their ROS generation activities in the presence of NADH in the dark.2007
- Author(s)
  Nonogawa M, Pack SP, Arai T, et. al.
- Journal Title
  
  Org Biochem Mol 5
  
  Pages: 3314-3319
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Reactive oxygen species generation through NADH oxidation by 6-formylpterin derivatives in the dark2007
- Author(s)
  Nonogawa, M., Pack, SP., Arai, T., Endo, N., Sommani, P., Kodaki, T., Makino, K
- Journal Title
  
  Biochem Biophys Res Commun 353
  
  Pages: 1105-1110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Effects of edaravone on singlet oxygen released from activated human neutrophils.2007
- Author(s)
  Sommani P, Arai T, Yamashita K, et. al.
- Journal Title
  
  J Pharmacol Sci 1003
  
  Pages: 117-120
- NAID
  10024312242
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Effects of edaravone on singlet oxygen released from activated human neutrophils2007
- Author(s)
  Sommani, P., Arai, T., Yamashita, K., Miyoshi, T., Mori, H., Sasada, M., Makino, K
- Journal Title
  
  J Pharmacol Sci 103
  
  Pages: 117-120
- NAID
  10024312242
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Reactive oxygen species generation through NADH oxidation by 6-formylpterin derivatives in the dark.2007
- Author(s)
  Nonogawa M, Pack SP, Arai T, et al.
- Journal Title
  
  Biochem Biophys Res Commun 353
  
  Pages: 1105-1110
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Synthesis of 6-formylpterin nucleoside analogs and their ROS generation activities in the presence of NADH in the dark2007
- Author(s)
  Nonogawa, M., Pack, SP., Arai, T., Endo, N., Sommani, P., Kodaki, T., Kotake, Y., Makino, K
- Journal Title
  
  Org Biomol Chem 5
  
  Pages: 3314-3319
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Synthesis of 6-formylpterin nucleoside analogs and their ROS generation activities in the presence of NADH in the dark.2007
- Author(s)
  Nonogawa M, Pack SP, Arai T, et. al.
- Journal Title
  
  Org Biomol Chem 5
  
  Pages: 3314-3319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Gene expression in enhanced apoptosis of human lymphoma U937 cells treated with the combination of different free radical generators and hyperthermia2007
- Author(s)
  Wada, S., Tabuchi, Y., Kondo, T., Cui, Z-G., Zhao, Q-L., Takasaki, I., Salunga, TL., Ogawa, R., Arai, T., Makino, K., Furuta, I
- Journal Title
  
  Free Radical Res 41
  
  Pages: 73-81
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Effects of edaravone on singlet oxygen released from activated human neutrophils.2007
- Author(s)
  Sommani P, Arai T, Yamashita K, et al.
- Journal Title
  
  J Pharmacol Sci 103
  
  Pages: 117-120
- NAID
  10024312242
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Effects of intravenous anesthesia with propofol on regional cortical blood flow and intracranial pressure in surgery for Moyamoya disease2007
- Author(s)
  Kikuta, K., Takagi, Y., Nozaki, K., Yamada, K., Miyamoto, S., Kataoka, H., Arai, T., Hashimoto, N
- Journal Title
  
  Surgical Neurology 68
  
  Pages: 421-424
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Journal Article] Novel 6-formylpterin derivatives : chemical synthesis and O_2 to ROS conversion activities2006
- Author(s)
  Nonogawa M, Arai T, Endo N, et al.
- Journal Title
  
  Org Biomol Chem 4
  
  Pages: 1811-1816
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] Activation of hypoxia-inducible factor 1 during macrophage differentiation.2006
- Author(s)
  Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, Arai T, Fukuda K, Kita T, Adachi T, Semenza GL, Nohara R
- Journal Title
  
  Am J Physiol Cell Physiol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] Novel 6-formylpterin derivatives : chemical synthesis and O_2 to ROS conversion activities.2006
- Author(s)
  Nonogawa M, Arai t, Endo N, Pack S-P, Kodaki T, Makino K
- Journal Title
  
  Org Biomol Chem 4
  
  Pages: 1811-1816
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] LPS-induced ROS generation and changes in glutathione level and their relation to the maturation of human monocyte-derived dendritic cells2006
- Author(s)
  Yamada H, Arai T, Endo N, et al.
- Journal Title
  
  Life Sciences 78
  
  Pages: 926-933
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] LPS-induced ROS generation and changes in glutsthione level and their relation to the maturation of human monocyte-derived dendritic cells.2006
- Author(s)
  Yamada H, Arai T, Endo N, Yamashita K, Fukuda K, Sasada M, Uchiyama T
- Journal Title
  
  Life Sciences 78
  
  Pages: 926-933
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] Novel 6-formylpterin derivatives : chemical synthesis and O_2 to ROS conversion activities2006
- Author(s)
  Nonogawa M, Arai T, Endo N, et al.
- Journal Title
  
  Org Biomol Chem (発表予定)
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] Protective effects of intracellular reactive oxygen species generated by 6-formylpterin on tumor necrosis factor-α-induced apoptotic cell injury in cultured rat hepatocytes.2005
- Author(s)
  Ishii H, Arai T, Mori H, Yamada H, Endo N, Makino K, Fukuda K
- Journal Title
  
  Life Sci 77
  
  Pages: 858-868
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] Photodynamic effects of a noel pterin derivative on a pancreatic cancer cell line.2005
- Author(s)
  Yamada H, Arai T, Endo N, Yamashita K, Nonogawa M, Makino K, Fukuda K, Sasada M, Uchiyama T
- Journal Title
  
  Biochem Biophys Res Commun 333
  
  Pages: 763-767
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] A hydrogen peroxide-generating agent, 6-formylpterin, enhances heat-induced apoptosis.2005
- Author(s)
  Wada S, Cui Z-G, Kondo T, Zhao Q-L, Ogawa R, Shoji M, Arai T, Makino K, Furuta I
- Journal Title
  
  Int J hyperthermia 21
  
  Pages: 231-246
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] Photodynamic effects of a novel pterin derivative on a pancreatic cancer cell line2005
- Author(s)
  Yamada H, Arai T, Endo N, et al.
- Journal Title
  
  Biochem Biophys Res Commun 333
  
  Pages: 763-767
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] Protective effects of intracellular reactive oxygen species generated by 6-formylpterin tumor necrosis factor-α-induced apoptotic cell injury in cultured rat hepatocytes2005
- Author(s)
  Ishii H, Arai T, Mori H, et al.
- Journal Title
  
  Life Sciences 77
  
  Pages: 858-868
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] Protective effects of intracellular reactive oxygen species generated by 6-formylpteron tumor necrosis factor-α-induced apoptotic cell injury in cultured rat hepatocytes2005
- Author(s)
  Ishii H, Arai T, Mori H, Yamada H, Endo N, Makino K, Fukuda K
- Journal Title
  
  Life Sciences (発表予定)
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] Protective effects of intracellular reactive oxygen species generated by 6-formylpter on tumor necrosis factor-α-induced apoptotic cell injury in cultured rat hepatocytes2005
- Author(s)
  Ishii H, Arai T, Mori H, et al.
- Journal Title
  
  Life Sciences 77
  
  Pages: 858-868
- Data Source
  KAKENHI-PROJECT-16390450
[Journal Article] Enhancement of radiation-induced apoptosis by 6-formylpterin2004
- Author(s)
  Cui Z, Kondo T, Ogawa R, Feril LB Jr, Zhao O, Wada S, Arai T, Makino K
- Journal Title
  
  Free Radical Research 38・4
  
  Pages: 363-373
- Data Source
  KAKENHI-PROJECT-16390450
[Presentation] A novel role of uric acid in neutrophils extracellular trap formation2012
- Author(s)
  Yoko Nishinaka, Toshiyuki Arai, Makiko Morita, Yasuyuki Arai, Kiyomi Mizugishi, Souichi Adachi, Akifumi Takaori-Kondo, Kouhei Yamashita
- Organizer
  第74回日本血液学会総会
- Place of Presentation
  京都(京都国際会議場)
- Data Source
  KAKENHI-PROJECT-23659740
[Presentation] 高濃度尿酸によるNADPH oxidase 非依存性 NETosis の誘導2012
- Author(s)
  西中瑶子、森田真紀子、山下浩平、荒井俊之、足立壮一
- Organizer
  第21回日本Cell Death学会
- Place of Presentation
  名古屋(名古屋大学)
- Data Source
  KAKENHI-PROJECT-23659740
[Presentation] Akifumi Takaori-Kondo : Singlet oxygen is essential for neutrophil extracellular trap formation2011
- Author(s)
  Kouhei Yamashita, Yoko Nishinaka, Toshiyuki Arai, Souichi Adachi
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] Singlet oxygen is essential for neutrophil extracellular trap formation2011
- Author(s)
  Yoko Nishinaka, Makiko Morita, Toshiyuki Arai, Souichi Adachi, Akifumi Takaori-Kondo, Kouhei Yamashita
- Organizer
  第53回米国血液学会
- Place of Presentation
  San Diego (San Diego Convention Center, CA, USA)
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-23659740
[Presentation] 細胞内で発生させた一重項酸素による細胞死に対する脳梗塞治療薬エダラボンの効果について2011
- Author(s)
  森浩子、西中瑶子、荒井俊之
- Organizer
  第58回日本麻酔科学会
- Place of Presentation
  神戸(神戸ポートピアホテル)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-23659740
[Presentation] 新規一重項酸素消去剤による細胞傷害の緩和2011
- Author(s)
  西中瑶子、遠藤伸之、荒井俊之
- Organizer
  日本化学会第91春期大会
- Place of Presentation
  横浜(神奈川大学)
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] 細胞内で発生させた一重項酸素による細胞死に対する脳梗塞治療薬エダラボンの効果について2011
- Author(s)
  森浩子、西中瑶子、荒井俊之
- Organizer
  第58回日本麻酔科学会
- Place of Presentation
  神戸(神戸ポートピアホテル)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] Singlet oxygen is essential for neutrophil extracellular trap formation2011
- Author(s)
  Kouhei Yamashita, Yoko Nishinaka, Toshiyuki Arai, Souichi Adachi, Akifumi Takaori-Kondo
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Data Source
  KAKENHI-PROJECT-23659740
[Presentation] Kouhei Yamashita : Singlet oxygen is essential for neutrophil extracellular trap formation2011
- Author(s)
  Yoko Nishinaka, Makiko Morita, Toshiyuki Arai, Souichi Adachi, Akifumi Takaori-Kondo
- Organizer
  第53回米国血液学会
- Place of Presentation
  San Diego(San Diego Convention Center, CA, USA)
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] NETosisにおける一重項酸素の役割2011
- Author(s)
  西中瑶子、森田真紀子、山下浩平、荒井俊之、足立壮一
- Organizer
  第20回日本CellDeath学会
- Place of Presentation
  東京(東京大学)
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] NETosisにおける一重項酸素の役割2011
- Author(s)
  西中瑶子、森田真紀子、山下浩平、荒井俊之、足立壮一
- Organizer
  第20回日本Cell Death学会
- Place of Presentation
  東京(東京大学)
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-23659740
[Presentation] 脳梗塞治療薬エダラボン一重項酸素消去能と細胞死抑制効果について2010
- Author(s)
  森浩子、荒井俊之、福田和彦
- Organizer
  第57回日本麻酔科学会
- Place of Presentation
  福岡(福岡国際会議場)
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] 酸素(ラジカル)-一重項酸素と細胞傷害について-2010
- Author(s)
  荒井俊之
- Organizer
  第14回日本医療ガス学会招待講演
- Place of Presentation
  金沢(金沢市アートホール)
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] 細胞内で発生させた一重項酸素による細胞死に対するエダラボンの効果2010
- Author(s)
  西中瑶子、荒井俊之、山下浩平、足立壮一
- Organizer
  第19回日本CellDeath学会
- Place of Presentation
  名古屋(愛知県産業労働センター)
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] 酸素(ラジカル)-一重項酸素と細胞傷害について-2010
- Author(s)
  荒井俊之
- Organizer
  第14回日本医療ガス学会
- Place of Presentation
  金沢(招待講演)
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] 一重項酸素による細胞傷害に対するPBNの効果2009
- Author(s)
  森浩子、荒井俊之、福田和彦
- Organizer
  第56回日本麻酔科学会
- Place of Presentation
  神戸(神戸ポートピアホテル)
- Year and Date
  2009-08-17
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] N-アセチルシステインの一重項酸素消去能と細胞死について2009
- Author(s)
  西中瑶子、荒井俊之、三好隆史、山下浩平、足立壮一
- Organizer
  第18回日本アポトーシス研究会学術集会
- Place of Presentation
  長崎(長崎大学)
- Year and Date
  2009-08-02
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] ATRA症候群における血管透過性亢進病態形成への活性酸素関与の可能性の検討2009
- Author(s)
  三好隆史、山下浩平、荒井俊之、笹田昌孝、内山卓
- Organizer
  第71回日本血液学会総会
- Place of Presentation
  京都(京都国際会議場)
- Data Source
  KAKENHI-PROJECT-21390433
[Presentation] ヒト好中球における6-フォルミルプテリンの新誘導体(6FP-tBu-DMF)の一重項酸素産生に及ぼす影響。2007
- Author(s)
  森浩子、荒井俊之、福田和彦
- Organizer
  日本麻酔科学会第54回学術集会
- Place of Presentation
  札幌
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Presentation] ヒト好中球における6-フォルミルプテリンの新誘導体(6FP-tBu-DMF)の一重項酸素産生に及ぼす影響2007
- Author(s)
  森浩子、荒井俊之、福田和彦
- Organizer
  第54回日本麻酔科学会
- Place of Presentation
  札幌
- Year and Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-18390428
[Presentation] Effects of a novel pterin derivative on singlet oxygen production in human neutrophils2007
- Author(s)
  Mori, H., Arai, T., Fukuda, K
- Organizer
  The 54th Annual Meeting of Japan Society of Anestheologist
- Place of Presentation
  Sapporo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Presentation] 敗血症におけるIL-8の新たな役割の解明-血管内皮細胞の活性酸素産生に対する作用-2007
- Author(s)
  三好隆史、山下浩平、荒井俊之, ら
- Organizer
  第69回日本血液学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390428
[Presentation] The new role of interleukin-8 in sepsis (Reactive oxygen production from endothelial cells by IL-B)2007
- Author(s)
  Miyoshi, T., Yamashita, K., Arai, T., Itoh, H., Uchiyama, T., Sasada, M
- Organizer
  The 69th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Presentation] 敗血症におけるIL-8の新たな役割の解明-血管内皮細胞の活性酸素産生に対する作用-。2007
- Author(s)
  三好隆史、山下浩平、荒井俊之、伊藤洋志、内山卓、笹田昌孝
- Organizer
  第69回日本血液学会総会・第49回日本臨床血液学会合同総会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Presentation] Photoactivation of pterin derivative induces apoptotic and necrotic cell death on a CTCL cell line2006
- Author(s)
  Tsunemine, H., Yamashita, K., Arai, T., Sasada, M., Uchiyama, T
- Organizer
  The 68th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Fukuoka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Presentation] Effects of 6-formylpterin on singlet oxygen production in human neutrophils2006
- Author(s)
  Mori, H., Arai, T., Ishii, H., Fukuda, K
- Organizer
  The 53th Annual Meeting of Japan Society of Anestheologist
- Place of Presentation
  Kobe
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Presentation] 細胞透過性プテリン化合物の光化学反応が誘導する皮膚T細胞性リンパ腫細胞株における細胞死の解析。2006
- Author(s)
  常峰紘子、山下浩平、荒井俊之、笹田昌孝、内山卓
- Organizer
  第68回日本血液学会総会・第48回日本臨床血液学会総会
- Place of Presentation
  福岡
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390428
[Presentation] ヒト好中球における一重項酸素産生におよぼすプテリン誘導体6-フォルミルプテリンの影響。2006
- Author(s)
  森浩子、荒井俊之、石井久成、福田和彦
- Organizer
  日本麻酔科学会第53回学術集会
- Place of Presentation
  神戸
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390428

1. MORI Kenjiro (20025620)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. NAKAO Shin-ichi (10207714)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. YAMASHITA Kouhei (80402858)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
4. ENDO Nobuyuki (30359244)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
5. MURAKAWA Masahiro (90182112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OISHI Kenji (10152042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YOSHIDA Osamu (70025584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TANIGUCHI Yoshihisa (20243016)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KEISUKE Makino (50159141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIKAWA Masatsune (20115786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. INUBUSHI Toshiro (20213142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SASADA Masataka (30144364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAMBA Tsunehisa (30283609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 荒井陽一 (50193058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SHIMIZU Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 鬼頭幸一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Arai Toshiyuki 荒井 俊之

ARAI Toshiyuki 荒井 俊之

ARAI Yoichi 荒井 陽一

Research Projects

Research Products

Co-Researchers

Development of the novel compound which specifically scavenges singlet oxygen extra- and intracellularly.Principal Investigator

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Determination of the active reactive oxygen species that generated in cells during ischemia-reperfusion and selection of its specific scavenger.Principal Investigator

Principal Investigator

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RNA干渉を用いた血管内皮細胞インターロイキン発現抑制による敗血症組織傷害の緩和Principal Investigator

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Protection against ischemia-reperfusion injury using a short interfering RNA that inhibits the activity of myeloperoxidasePrincipal Investigator

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The role of singlet oxygen in ischemia-reperfusin injury : the study using laser scanning confocal microscopy and electron paramagnetic resinancePrincipal Investigator

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人為的酸化ストレス負荷によるアポートシスの抑制-Jurkat細胞、ヒト好中球、ラット肝細胞を用いた研究-Principal Investigator

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Effects of oxidative stress during ischemia-reperfusion on cytokine production in monocytes and lymphocytesPrincipal Investigator

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プテリン誘導体の呼吸鎖における過酸化水素産生とそれにより生じる細胞傷害との関係Principal Investigator

Principal Investigator

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Reactive oxygen species induced apoptosis in ischemia-reperfusion injuryPrincipal Investigator

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Evaluation of focal cerebral ischemia by NMR and histochemistry.Principal Investigator

Principal Investigator

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A method for simultaneous measurements of cerebral blood flow and cerebral metabolic rate for oxygen by magnetic resonance imaging.Principal Investigator

Principal Investigator

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A method for simultaneous measurements of cerebral blood flow and cerebral metabolic rate for oxygen by magnetic resonance imaging.Principal Investigator

Principal Investigator

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The analysis of the expression of antioxidative proteins against oxidative stress

Principal Investigator

Arai Toshiyuki 荒井俊之

ARAI Toshiyuki 荒井俊之

ARAI Yoichi 荒井陽一