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NISHIMOTO Ikuo  西本 征央

ORCIDConnect your ORCID iD *help
… Alternative Names

西本 郁夫  ニシモト イクオ

西本 育夫  ニシモト イクオ

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Researcher Number 80180652
Affiliation (based on the past Project Information) *help 1997 – 2003: 慶應義塾大学, 医学部, 教授
1999: 慶応義塾大学, 医学部, 教授
1998: 慶應大, 医学部, 教授
1991: 東京大学, 保健管理センター, 助手
1991: 東京大学, 保健管理センター内科, 助手 … More
1990: 東京大学, 医学部, 助手
1988: 東京大学, 保健管理センター, 助手
1988: 東京大学, 医学部, 助手
1986 – 1987: 東京大学, 医学部(分), 助手 Less
Review Section/Research Field
Principal Investigator
Neurology / General pharmacology / Pediatrics / General medical chemistry / 内分泌・代謝学
Except Principal Investigator
Neurology / Kidney internal medicine / 内分泌・代謝学 / Biological Sciences / General physiology
Keywords
Principal Investigator
神経細胞死 / RAP / LRP / Neuronal disease / G蛋白 / カルシウムチャネル / APP / receptor / serine isomerase / dimerization … More / neurodegenerative disease / Alzheimer's disease / Humanin / βFGF / IGF-I / 生体内発現 / ADNF / bFGF / IGF-1 / 分泌機構 / 構造機能相関 / HN / Apolipoprotein E3 / α2-macroglobullin / Neuronal Death / Apolipoprotein E4 / 細胞死抑制 / ApoE3 / α2マクログロブリン / ApoE4 / Neurodegenerative disease / Alzhimer's disease / 膜貫通型 / 家族性アルツハイマー病 / βγサブユニット / Go / 神経変性疾患 / アルツハイマー病 / Hetrotrimeric G protein / トロンボキサン受容体 / ソマトスタチン受容体 / Gs / 受容体 / 生物学的効果 / 三量体G蛋白 / IGF-I受容体 / 脱共役 / EGF / PDGF / IGF-II受容体 / DNA合成 / 細胞周期依存性 / GTP結合トランスデューサー / IGF受容体 / influx / Calcium / IGF / 細胞死 / レチノイン酸 / モノクローナル抗体 / ヒト神経芽細胞腫株 / カスペース / セリン残基 / リン酸化 / プロティンキナ-ゼA / アデニ-ル酸シクラ-ゼ / RRSS構造 / G_s活性化配列 / G_s蛋白 / βアドレナリン受容体 … More
Except Principal Investigator
アルツハイマー病 / ノックイン / G蛋白 / 成長因子 / カルシウム / 遺伝子ターゲティング / 神経変性疾患 / G PROTEIN / RECEPTOR / ANGIOTENSIN / G蛋白質 / 受容体 / アンジオテンシン / 副甲状腺ホルモン様蛋白 / イオンチャンネル / カルシウムイオン / HHM因子 / ホルモン不応症 / 遺伝子発現 / 情報伝達系 / GTP結合蛋白 / 細胞内【Ca^(2+)】濃度 / 【Ca^(2+)】流入 / ホルモンの作用機序 / 神経細胞 / 疾患モデル / 分化誘導 / ES細胞 / cdk3 / cdk2 / 細胞周期停止 / アポトーシス / ARF / Bax / BCL6 / CR / p53 / ik3-2 / ik3-1 / 疾患モデルマウス / Cre-loxP / V642I点変異 / APP / αシヌクレイン / 細胞死 / 神経細胞死 / アミロイド前駆体蛋白 / IGF‐II受容体 / βアドレナリン受容体 / α_2アドレナリン受容体 / ムスカリン性アセチルコリン受容体 / G蛋白サブユニット / 受容体‐G蛋白共役機構 / 増殖因子受容体 / モチ-フ / G蛋白共役 / 一次構造 / G蛋白活性化配列 / IGFーII受容体 Less
  • Research Projects

    (20 results)
  • Research Products

    (1 results)
  • Co-Researchers

    (26 People)
  •  cdk2/cdk3の新しい基質ik3遺伝子群の機能解析

    • Principal Investigator
      松岡 正明
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
  •  アミロイド前駆体蛋白の変異導入ES細胞を用いたアルツハイマー病神経細胞の確立

    • Principal Investigator
      阿部 陽一郎
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Keio University
  •  新規のAPP変異ノックインマウスを用いたアルツハイマー病発症関連遺伝子の探索

    • Principal Investigator
      神山 圭介
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Keio University
  •  Detailed characterization of Humanin, a newly identified anti-Alzheimer's disease peptide and potential starting point for development of the first curative therapy for Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      NISHIMOTO Ikuo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      KEIO UNIVERSITY
  •  神経細胞におけるアミロイド前駆体蛋白とαシヌクレインの機能の解析

    • Principal Investigator
      YAMOCHI Tadanori
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Keio University
  •  レチノイン酸と、神経細胞死誘導性抗APP抗体を併用した神経芽細胞腫の萌芽的治療Principal Investigator

    • Principal Investigator
      西本 征央 (西本 育夫)
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Keio University
  •  Elucidation of the principal mechanism for dementia and identification of anti-dementia genes through the analysis of ApoE4 neurotoxicityPrincipal Investigator

    • Principal Investigator
      NISHIMOTO Ikuo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      Keio University
  •  神経細胞における正常及び異常アミロイド前駆体蛋白のシグナル伝達機能の解析

    • Principal Investigator
      紅 江
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General physiology
    • Research Institution
      Keio University
  •  G蛋白βγサブユニットの新しい標的分子としての細胞死遺伝子カスパーゼの研究Principal Investigator

    • Principal Investigator
      西本 育夫
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Keio University
  •  ノックインを用いた新しい遺伝子組換え戦略によるアルツハイマー病モデルマウスの開発

    • Principal Investigator
      福田 亨
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Keio University
  •  INVESTIGATION OF SIGNAL TRANSDUCTION AND ANTI-PROLIPERATIVE ACTIONS OF ANGIOTENSIN II TYPE 2 PECEPTOR

    • Principal Investigator
      SASAMURA Hiroyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Keio University
  •  Comprehensive analysis of hetrotrimeric G protein subunits for the purpose of elucidation and treatment of human diseasesPrincipal Investigator

    • Principal Investigator
      NISHIMOTO Ikuo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      General pharmacology
    • Research Institution
      KEIO university
  •  Elucidation of molecular mechanisms for cell death in neurodegenerative diseases and extensive research of their antagonistsPrincipal Investigator

    • Principal Investigator
      NISHIMOTO Ikuo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Neurology
    • Research Institution
      KEIO university
  •  増殖因子受容体とGTP結合蛋白との共役機構の解明

    • Principal Investigator
      尾形 悦郎
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  βーアドレナリン受容体による酸シクラ-ゼ活性型G蛋白の認識制御機構の解析Principal Investigator

    • Principal Investigator
      西本 育夫
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      The University of Tokyo
  •  増殖因子受容体とGTP結合蛋白との共役機構の解明

    • Principal Investigator
      尾形 悦郎
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  情報伝達系不全による病態に関する研究

    • Principal Investigator
      尾形 悦郎
    • Project Period (FY)
      1987 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      The University of Tokyo
  •  インスリン様増殖因子の細胞内シグナル調節制御機構の解析Principal Investigator

    • Principal Investigator
      西本 育夫
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  インスリン様増殖因子による細胞増殖調節機構の解明Principal Investigator

    • Principal Investigator
      西本 育夫
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  ホルモン作用機構におけるCaイオンの役割

    • Principal Investigator
      尾形 悦郎
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      The University of Tokyo

All 2000

All Patent

  • [Patent] 神経細胞死を抑制するポリペプチド、Humanin2000

    • Inventor(s)
      西本征央
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Filing Date
      2000-09-14
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13307022
  • 1.  NIIKURA Takako (10301491)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  MATSUOKA Masaaki (70222297)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  KOUYAMA Keisuke (30296553)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  MATSUDA Shuji (70296721)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  尾形 悦郎 (70013761)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  小島 至 (60143492)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  YAMOCHI Tadanori (80306844)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  HASHIMOTO Yuichi (00317330)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  村山 芳武 (40219952)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  松永 浩 (50165841)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  笹川 展幸 (20187107)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  岡本 卓
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  SASAMURA Hiroyuki (00235293)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  紅 江 (60296720)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  福田 亨 (20301492)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  阿部 陽一郎 (10317331)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  高橋 俊二 (90221358)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  峯 徹哉 (20157572)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  松本 俊夫 (20157374)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  五十嵐 徹也 (00134601)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  岡崎 具樹 (60203973)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  山下 孝之 (10166671)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  貴田岡 正央 (20153091)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  原田 俊一 (70228641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  安川 孝史 (60291936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  田島 裕久 (50306833)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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