Hirasawa Noriyasu 平澤典保

… Alternative Names

Researcher Number	80181155
Other IDs
External Links
Affiliation (Current)	2022: 東北大学, 薬学研究科, 教授
Affiliation (based on the past Project Information) *help	2021: 東北大学, 薬学研究科, 教授 2017 – 2018: 東北大学, 薬学研究科, 教授 2013 – 2016: 東北大学, 薬学研究科(研究院), 教授 2010 – 2011: 東北大学, 大学院・薬学研究科, 教授 1999 – 2005: 東北大学, 大学院・薬学研究科, 助教授 … More
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological Sciences / Environmental pharmacy / Pharmacology in pharmacy / Biological pharmacy / Pharmaceutical Sciences and related fields Except Principal Investigator Biological pharmacy / Biological pharmacy / General pharmacology / 医薬分子機能学 / General pharmacology / Basic Section 09040:Education on school subjects and primary/secondary education-related
Keywords	Principal Investigator Raf-1 / c-Jun N-terminal kinase / アレルギー / ヒスタミン / 肥満細胞 / MAPキナーゼ / MAP kinase / TSLP / 血管内皮増殖因子 / 血管新生 … More Except Principal Investigator ヒスタミン / ICAM-1 / 肥満細胞 / ヒスチジン脱炭酸酵素 / マスト細胞 / p44 / 42 MAP kinase / 気道上皮細胞 / アレルギー / histamine / アラキドン酸 / プロスタグランディン / ステロイド性抗炎症薬 / トランスジェニックマウス / 好酸球顆粒蛋白質 / major basic protein / eosinophil cationic protein / ribonuclease / cDNA / p38 MAP kinase / 好酸球 / STAT1 / Eosinophils / E-cadherin / グルココルチコイド / 抗炎症薬 / 血管透過性反応 / 空気嚢型炎症モデル / ザイモサン炎症 / Glucocorticoid / Vascular permeability / 発がん促進物質 / マクロファ-ジ / 脱顆粒反応 / タンパク質合成 / 皮内反応 / compound48 / 80 / アレルギー性空気嚢型炎症 / 血管透過性 / 白血球浸潤 / H_2受容体 / 脂質ラフト / Raf-1 / Spred-1 / LAT / HSP90 / p44-42 MAP kinase / KSR / dexamethasone / キナーゼ阻害薬 / MAP kinase阻害薬 / グルココルチコイド受容体 / プロテアソーム阻害薬 / RBL-2H3 / ヒスチジン脱炭酸酵素(HDC) / HDC-KOマウス / ヒスタミン産生細胞 / レポーターマウス / 蛍光 / 細胞傷害性 / ラット好酸球 / eosinophil-derived neurotoxin / ラットMBP / ラットMBP cDNA / rat eosinophils / eosinophil granule proteins / cytotoxicity / 好中球 / マクロファージ / p38MAP kinase / アポトーシス / デキサメサゾン / p42 / 44 MAP kinase / cyclooxygenase-2 / interleukin-4 / macrophage inflammatory protein-2 / Neutrophils / Mast cells / Macrophages / Epithelial cells / Steroid anti-inflammatory drug / ノックアウトマウス / 遺伝子 / 感染 / 行動 / 胃酸分泌 / 概日リズム / H2受容体 / SAGE法 / knockout mice / histidine decarboxylase / transgenic mice / gene / infection / allergy / behavior / HDAC阻害薬 / 好酸球分化 / E-Cadherin / E-カドヘリン / アデノウイルス / 分化・増殖 / Adherence junction / 12-O-tetradecanoylphorbol 13-acetate / NCI-H292 / BEAS-2B / HL-60 clone 15 / ヒストン脱アセチル化酵素阻害薬 / Eosinophil-associated rebonuclease / RNase activity / Bactericidal activity / Epitherial cells / Interferon-gamma / Cycline-dependent kinase / ケモカイン / 顆粒蛋白質 / RNase A / NF-κB / Bronchial epithelial cells / eosinophil granule protein / HDAC inhibitor / differentiation of eosinophil / リポコルチン / ホスホリパ-ゼ / 足浮腫反応 / グリココルチコイド / 抗炎症ステロイド / プロスタグランジン / インドメタシン / Lipocortin / Anti-inflammatory drugs / Phospholipase / Arachidonic acid / Prostaglandin / Footpad edema / 血管透過性亢進 / 好中球浸潤 / ペプチドロイコトリエン / 好中球遊走因子 / プロスタグランジンロイコトリエン / Neutrophil infiltration / Peptide-leukotriene / Chemotactic factor / 学校 / 学校医 / 学校薬剤師 / 養成大学 Less

アレルギー罹患児のQOL向上に向けた中核的役割を担う機関としての学校のあり方
- Principal Investigator
  
  石原研治
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 09040:Education on school subjects and primary/secondary education-related
- Research Institution
  Ibaraki University
Development of a novel anti-allergic drug: Identification of target proteinsPrincipal Investigator
- Principal Investigator
  
  Hirasawa Noriyasu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  Tohoku University
トランスジェニックマウスを使ったヒスタミン産生細胞の病態解析
- Principal Investigator
  
  OHTSU Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
Mechanism of short- and medium-chain fatty acid-induced TSLP productionPrincipal Investigator
- Principal Investigator
  
  HIRASAWA Noriyasu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Tohoku University
Novel recognition mechanisms to chemical compounds which enhance allergic responsesPrincipal Investigator
- Principal Investigator
  
  HIRASAWA Noriyasu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tohoku University
ステロイド感受性低下を改善するための標的分子の同定と創薬理論の構築
- Principal Investigator
  
  大内和雄
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Induction and termination of angiogenesis by regulation of angiogenesis-related factor productionPrincipal Investigator
- Principal Investigator
  
  HIRASAWA Noriyasu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
脂質ラフト形成を制御する機能蛋白質の探索
- Principal Investigator
  
  大内和雄
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Mechanism of tissue injury, repair and regeneration in inflammation, and regulation of remodeling
- Principal Investigator
  
  OHUCHI Kazuo
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Assessment of function of histamine using histidine decarboxylase gene-manupulated mice
- Principal Investigator
  
  OHTSU Hiroshi, 渡邉建彦
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
サイトカインによるマスト細胞の機能修飾とその制御についての研究Principal Investigator
- Principal Investigator
  
  平澤典保
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
ヒスチジン脱炭酸酵素欠損マウスを用いたアレルギー炎症におけるヒスタミンの役割解析
- Principal Investigator
  
  大内和雄
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Analysis of roles of MAP kinase in inflammation and establishment of the target for development of a new anti-inflammatory drug
- Principal Investigator
  
  OHUCHI Kazuo
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Research into the effects of steroidal anti-inflammatory drugs on MAP kinase activation and cytokine productionPrincipal Investigator
- Principal Investigator
  
  HIRASAWA Noriyasu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
多様なMAPキナーゼ活性化経路の集束点Raf1の活性制御についての研究Principal Investigator
- Principal Investigator
  
  平澤典保
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
MAPキナーゼ活性化抑制薬の作用機構及び抗アレルギー作用の研究Principal Investigator
- Principal Investigator
  
  平澤典保
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Research into Cytotoxicity of Eosinophil Granule Proteins
- Principal Investigator
  
  OHUCHI Kazuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tohoku University
遅発型アレルギ-におけるヒスタミン放出に関与する新規サイトカインの同定と役割解析Principal Investigator
- Principal Investigator
  
  平澤典保
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
発がん促進物質によるアラキドン酸代謝亢進機序解明に関する研究
- Principal Investigator
  
  OHUCHI Kazuo
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Mechanisms for anti-inflammatory actions of glucocorticoid
- Principal Investigator
  
  OHUCHI Kazuo, 鶴藤丞
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  TOHOKU UNIVERSITY
Comparison of anti-inflammatory activities between recombinant human lipocortin and glucocorticoid.
- Principal Investigator
  
  OHUCHI Kazuo, 鶴藤丞
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  TOHOKU UNIVERSITY

All 2019 2018 2015 2014 2012 2011 2010 2009 2006 2005 2004 2003 Other

All Journal Article Presentation Patent

[Journal Article] A chalcone derivative suppresses the induction of TSLP in mice and human keratinocytes and attenuates OVA-induced antibody production in mice.2019
- Author(s)
  Segawa Ryosuke、Shiraki Mika、Sudo Shiori、Shigeeda Kenichi、Saito Taiji、Mizuno Natsumi、Moriya Takahiro、Yonezawa Takayuki、Woo Je-Tae、Hiratsuka Masahiro、Hirasawa Noriyasu
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 851 Pages: 52-62
- DOI
  10.1016/j.ejphar.2019.02.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08518, KAKENHI-PROJECT-17K19470
[Journal Article] EGFR transactivation is involved in TNF-α-induced expression of thymic stromal lymphopoietin expression in human keratinocyte cell line.2018
- Author(s)
  Segawa R, Shigeeda K, Hatayama T, Dong J, Mizuno N, Moriya T, Hiratsuka M, Hirasawa N
- Journal Title
  
  J. Dermatol. Sci.
  
  Volume: 89 Pages: 290-298
- DOI
  10.1016/j.jdermsci.2017.12.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08518, KAKENHI-PROJECT-17K19470
[Journal Article] Induction of thymic stromal lymphopoietin by a steroid alkaloid derivative in mouse keratinocytes2018
- Author(s)
  Weng Y, Mizuno N, Dong J, Segawa R, Yonezawa T, Cha BY, Woo JT, Moriya T, Hiratsuka M, Hirasawa N.
- Journal Title
  
  Int. Immunopharm.
  
  Volume: 55 Pages: 28-37
- DOI
  10.1016/j.intimp.2017.11.045
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01810, KAKENHI-PROJECT-16K08518, KAKENHI-PROJECT-17K19470
[Journal Article] All-trans retinoic acid enhances antibody production by inducing the expression of thymic stromal lymphopoietin protein.2018
- Author(s)
  T. Hatayama, R. Segawa, N. Mizuno, S. Eguchi, H. Akamatsu, M. Fukuda, F. Nakata, WJ. Leonard, M. Hiratsuka, N. Hirasawa.
- Journal Title
  
  J. Immunol.
  
  Volume: 200 Pages: 2670-2676
- DOI
  10.4049/jimmunol.1701276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19470
[Journal Article] Nickel ions selectively inhibit lipopolysaccharide-induced interleukin-6 production by decreasing its mRNA stability.2015
- Author(s)
  Sanki Asakawa, Yu Kishimoto, Takayuki Takano, Kiyuki Okita, Shiho Takakuwa, Taiki Sato, Masahiro Hiratsuka, Osamu Takeuchi, Noriyasu Hirasawa
- Journal Title
  
  PLoS One
  
  Volume: 10(3)
- DOI
  10.1371/journal.pone.0119428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J06483, KAKENHI-PROJECT-25670034
[Journal Article] Glucocorticoids decrease the production of glucagon-like peptide-1 at the transcriptional level in intestinal L-cells.2015
- Author(s)
  Taiki Sato, Hiroto Hayashi, Masahiro Hiratsuka, Noriyasu Hirasawa
- Journal Title
  
  Mol. Cell. Endocrinol.
  
  Volume: 406 Pages: 60-67
- DOI
  10.1016/j.mce.2015.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J06483, KAKENHI-PROJECT-25670034
[Journal Article] Glucagon-like peptide-1 production in the GLUTag cell line is impaired by free fatty acids via endoplasmic reticulum stress.2014
- Author(s)
  Hiroto Hayashi, Ren Yamada, Siddhartha Shankar Das, Taiki Sato, Aki Takahashi, Masahiro Hiratsuka, Noriyasu Hirasawa
- Journal Title
  
  Metabolism
  
  Volume: 63(6) Pages: 800-811
- DOI
  10.1016/j.metabol.2014.02.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J06483, KAKENHI-PROJECT-25670034
[Journal Article] The Role of Histamine H1 and H4 Receptors in Atopic Dermatitis: From Basic Research to Clinical Study2014
- Author(s)
  Yusuke Ohsawa and Noriyasu Hirasawa
- Journal Title
  
  Allergology International
  
  Volume: 63 Issue: 4 Pages: 533-542
- DOI
  10.2332/allergolint.13-ra-0675
  10.2332/allergolint.13-RA-0675
- NAID
  130004705221
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670034
[Journal Article] Exacerbation of Allergic Diseases by Chemicals: Role of TSLP2014
- Author(s)
  Segawa, R. and Hirasawa, N.
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 124 Issue: 3 Pages: 301-306
- DOI
  10.1254/jphs.13r16cp
  10.1254/jphs.13R16CP
- NAID
  130003391499
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670034
[Journal Article] Identification of a cell line producing high levels of TSLP: Advantages for screening of anti-allergic drugs2014
- Author(s)
  Ryosuke Segawa, Saori Yamashita, Natsumi Mizuno, Mika Shiroki, Takahiro Hatayama, Nozomi Satou, Masahiro Hiratsuka, Michihiro Hide , and Noriyasu Hirasawa
- Journal Title
  
  J. Immunol. Method
  
  Volume: 402 Pages: 9-14
- DOI
  10.1016/j.jim.2013.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670034
[Journal Article] Regulation of dipeptidyl peptidase IV in adipocytes by glucose.2014
- Author(s)
  Siddhartha Shankar Das, Hiroto Hayashi, Taiki Sato, Ren Yamada, Masahiro Hiratsuka, Noriyasu Hirasawa
- Journal Title
  
  Diabetes, Metabolic Syndrome and Obesity: Target and Therapy
  
  Volume: 7 Pages: 185-194
- DOI
  10.2147/dmso.s62610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J06483, KAKENHI-PROJECT-25670034
[Journal Article] Histamine synthesis is required for granule maturation of murine mast cells.2014
- Author(s)
  Nakazawa, S., Sakanaka, M., Furuta, K., Natsuhara, M., Takano, H., Tsuchiya, S., Okuno, Y., Ohtsu, H., Nishibori, M., Thurmond, R.L., Hirasawa, N., Nakayama, K., Ichikawa, A., Sugimoto, Y., and Tanaka, S.
- Journal Title
  
  Eur J Immunol
  
  Volume: 44 Pages: 204-214
- DOI
  10.1002/eji.201343838
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22116001, KAKENHI-PROJECT-23590077, KAKENHI-PROJECT-23659044, KAKENHI-PUBLICLY-25113514, KAKENHI-PROJECT-25860049, KAKENHI-PROJECT-26460332
[Journal Article] Induction of thymic stromal lymphopoietin production by xylene and exacerbation of picryl chloride-induced allergic inflammation in mice.2012
- Author(s)
  N.Satou
- Journal Title
  
  Int Arch Allergy Immunol.
  
  Volume: 157 Pages: 194-201
- DOI
  10.1159/000327545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009, KAKENHI-PROJECT-22659025, KAKENHI-PROJECT-23791098
[Journal Article] Hetero-oligomerization between adenosine A1 and thromboxane A2 receptors affects cellular signal transduction on stimulation with high and low concentrations of agonists for both receptors2012
- Author(s)
  Mizuno, N., Suzuki, T., Hirasawa, N., Nakahata, N.
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: 677 Pages: 5-14
- DOI
  10.1016/j.ejphar.2011.12.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Enhancement of nickel elution by lipopolysaccharide-indued inflammation2011
- Author(s)
  Tanaka, R., Goi, Y., Ishihara, K., Ueda, K., Narushima, T., Ohtsu, H., Hiratsuka, M., Hirasawa, N
- Journal Title
  
  J. Derm. Sci
  
  Volume: 62 Pages: 50-57
- DOI
  10.1016/j.jdermsci.2010.12.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Association between Cancer Risk and Drug-metabolizing Enzyme Gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) Polymorphisms in Cases of Lung Cancer in Japan2011
- Author(s)
  Tamaki, Y., Arai, T., Sugimura, H., Sasaki, T., Honda, M., Muroi, Y., Matsubara, Y., Kanno, S., Ishikawa, M., Hirasawa, N., Hiratsuka, M.
- Journal Title
  
  DMPK
  
  Volume: 26 Issue: 5 Pages: 516-522
- DOI
  10.2133/dmpk.dmpk-11-rg-046
  10.2133/dmpk.DMPK-11-RG-046
- NAID
  130004463215
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025, KAKENHI-PROJECT-23790193, KAKENHI-PROJECT-221S0001
[Journal Article] Functional characterization of CYP2B6 allelic variants in demethylation of anti-malarial artemether2011
- Author(s)
  Honda, M., Muroi, Y., Tamaki, Y., Saigusa, D., Suzuki, N., Tomioka, Y., Matsubara Y., Oda, A., Hirasawa, N., Hiratsuka, M.
- Journal Title
  
  Drug Metab. Dispos
  
  Volume: 39 Pages: 1860-1865
- DOI
  10.1124/dmd.111.040352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025, KAKENHI-PROJECT-23659070
[Journal Article] Education of Graduate School of Pharmaceutical Sciences in New Generation: Introduction2011
- Author(s)
  平澤典保、奥直人
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 131 Issue: 6 Pages: 931-931
- DOI
  10.1248/yakushi.131.931
- NAID
  130000926977
- ISSN
  0031-6903, 1347-5231
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Education for Six-years Graduate School of Pharmaceutical Sciences: A Case of Tohoku University2011
- Author(s)
  富岡佳久、平澤典保、永沼章
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 131 Issue: 6 Pages: 932-938
- DOI
  10.1248/yakushi.131.933
- NAID
  130000926978
- ISSN
  0031-6903, 1347-5231
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Induction of Thymic stromal lymphopoietin production by xylene and exacerbation of picryl chloride-induced allergic inflammation in mice2011
- Author(s)
  Satou, N., Iwatate, Y., Leonard, W.J., Hirasawa, N.
- Journal Title
  
  Int.Arch.Allergy Immunol.
  
  Volume: 157 Pages: 194-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] ステロイド薬の基礎2011
- Author(s)
  平澤典保
- Journal Title
  
  アレルギー
  
  Volume: 60 Pages: 193-198
- NAID
  110008460516
- URL
  http://jja.jsaweb.mech.2011/060020193e.html
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Suppression of intracellular calcium levels and inhibition of degranulation in RBL-2H3 mast cells by the sesquiterpene lactone parthenolide2011
- Author(s)
  Hong, J., Aoyama, S., Hirasawa, N, Zee, O., Ishihara, K., Hashida, C., Kimura, M., Seyama, T., Ohuchi, K.
- Journal Title
  
  Planta Medica
  
  Volume: 77 Pages: 252-256
- DOI
  10.1055/s-0030-1250221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] TSLP2011
- Author(s)
  平澤典保
- Journal Title
  
  炎症と免疫
  
  Volume: (掲載確定)(未定)(印刷中)
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Induction of thymic stromal lymphopoietin by chemical compounds in vivo and exacerbation of allergy2011
- Author(s)
  Sato, N., Ishihara, K., Hiratsuka, M., Hirasawa, N.
- Journal Title
  
  Inflam.Regene.
  
  Volume: 31 Pages: 184-188
- NAID
  130004943785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] TSLP2011
- Author(s)
  平澤典保、Hong JangJa、木邑道夫、大内和雄
- Journal Title
  
  炎症と免疫
  
  Volume: 19 Pages: 437-440
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Assessment of the release of nickel from biomaterials in vivo and in vitro : enhancement by lipopolysaccharide2011
- Author(s)
  Tanaka, R., Goi, Y., Ishihara, K., Ueda, K., Narushima, T., Ohtsu, H., Ohuchi, K., Hiratsuka, M., Hirasawa, N.
- Journal Title
  
  Inflam.Regene.
  
  Volume: 31 Pages: 302-306
- NAID
  130004943799
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] キシレン、トリメチルベンゼンによる表皮からのTSLP産生誘導2011
- Author(s)
  平澤典保
- Journal Title
  
  臨床と免疫・アレルギー科
  
  Volume: 56 Pages: 478-484
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Assessment of the release of nickel from biomaterials in vivo and in vitro : enhancement by lipopolysaccharide2011
- Author(s)
  Tanaka, R., Goi, Y., Ishihara, K., Ueda, K., Narushima, T., Ohtsu, H., Ohuchi, K., Hiratsuka, M., Hirasawa, N.
- Journal Title
  
  Inflam. Regene
  
  Volume: 31 Pages: 302-306
- NAID
  130004943799
- URL
  http://www.jsir.library.gr.mech.journal/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] ステロイドの作用機序と耐性化メカニズム2011
- Author(s)
  平澤典保
- Journal Title
  
  アレルギーの臨床(The Allergy in Practice)
  
  Volume: 31 Pages: 1137-1141
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] 抗炎症薬2011
- Author(s)
  平澤典保、Hong JangJa、木邑道夫、大内和雄
- Journal Title
  
  OHNS
  
  Volume: 27 Pages: 1782-1786
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Novel Single Nucleotide Polymorphism of the CYP2A13 Gene in Japanese Individuals2011
- Author(s)
  Tamaki, Y., Honda, M., Muroi, Y., Arai, T., Sugimura, H., Matsubara, Y., Kanno, S., Ishikawa, M., Hirasawa, N, Hiratsuka, M.
- Journal Title
  
  DMPK
  
  Volume: 26 Issue: 5 Pages: 544-547
- DOI
  10.2133/dmpk.dmpk-11-sc-033
  10.2133/dmpk.DMPK-11-SC-033
- NAID
  130004463219
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025, KAKENHI-PROJECT-221S0001
[Journal Article] Enhancement of nickel elution by lipopolysaccharide-indued inflammation2011
- Author(s)
  Tanaka, R., Goi, Y., Ishihara, K., Ueda, K., Narushima, T., Ohtsu, H., Hiratsuka, M., Hirasawa, N.
- Journal Title
  
  J.Derm.Sci.
  
  Volume: 62 Pages: 50-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Involvement of prostaglandins and histamine in Nickel wire-induced acute inflammation in mice2010
- Author(s)
  Hirasawa, N., Goi, Y., Tanaka, R., Ishihara, K., Ohtsu, H., Ohuchi, K.
- Journal Title
  
  J. Biomedical Materials Research Part
  
  Volume: 93A Pages: 1306-1311
- DOI
  10.1002/jbm.a.32628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Salicylate restores transport function and anion exchanger activity of missense pendrin mutations2010
- Author(s)
  Ishihara, K., Okuyama, S., Kumano, S., Iida, K., Hamana, H., Murakoshi, M., Kobayashi, T., Usami, S., Ikeda, K, Haga, Y, , Tsumoto, K., Nakamura, H., Hirasawa, N., Wada, H.
- Journal Title
  
  Hearing Research
  
  Volume: 270 Pages: 110-118
- DOI
  10.1016/j.heares.2010.08.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Functional characterization of 26 CYP2B6 allelic variants (CYP2B6. 2-CYP2B6. 28, except CYP2B6. 22)2010
- Author(s)
  Watanabe, T., Sakuyama, K., Sasaki, T., Ishii, Y., Ishikawa, M., Hirasawa, N.
- Journal Title
  
  Hiratsuka, M. Pharmacogenet. Genom
  
  Volume: 20 Pages: 459-462
- DOI
  10.1097/fpc.0b013e32833bba0e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Kinetics of 6-Thioxanthine Metabolism by Allelic Variants of Xanthine Oxidase2010
- Author(s)
  Kudo, M., Sasaki, T., Ishikawa, M., Hirasawa, N., Hiratsuka, M.
- Journal Title
  
  DMPK
  
  Volume: 25 Issue: 4 Pages: 361-366
- DOI
  10.2133/dmpk.dmpk-10-rg-029
  10.2133/dmpk.DMPK-10-RG-029
- NAID
  10027583274
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] Functional Characterization of Genetic Polymorphisms Identified in the Promoter Region of the Xanthine Oxidase Gene2010
- Author(s)
  Kudo, M., Sasaki, S., Ishikawa, M., Hirasawa, N., Hiratsuka., M.
- Journal Title
  
  DMPK
  
  Volume: 25 Issue: 6 Pages: 599-604
- DOI
  10.2133/dmpk.dmpk-10-nt-054
  10.2133/dmpk.DMPK-10-NT-054
- NAID
  10027743970
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659025
[Journal Article] The accelerating effect of histamine on the cutaneous wound healing process through the action of bFGF.2006
- Author(s)
  Numata, Y., Terui, T., Okuyama, R., Hirasawa, N., Sugiura, Y., Miyoshi, I., Watanabe, T., Kuramasu, A., Tagami, H., Ohtsu, H.
- Journal Title
  
  J.Invest.Dermatol. (accepted)
- Data Source
  KAKENHI-PROJECT-14370738
[Journal Article] プロスタグランジンの血管新生制御機構2005
- Author(s)
  平澤典保
- Journal Title
  
  オレオサイエンス 5
  
  Pages: 65-71
- NAID
  10014305322
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390020
[Journal Article] プロスタグランジンの血管新生制御機構2005
- Author(s)
  平澤典保, 大内和雄
- Journal Title
  
  オレオサイエンス 5
  
  Pages: 65-71
- NAID
  10014305322
- Data Source
  KAKENHI-PROJECT-15390020
[Journal Article] Regulation of angiogenesis by Prostaglandin (J)2005
- Author(s)
  Hirasawa, N. et al.
- Journal Title
  
  Oleosci. 5
  
  Pages: 65-71
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390020
[Journal Article] Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-PI31and WHI-P154 in a Janus kinase 3-independent manner.2005
- Author(s)
  Linwong, W., Hirasawa, N., Aoyama, S., Hamada, H., Saito, T., Ohuchi, K.
- Journal Title
  
  Br.J.Pharmacol. 145
  
  Pages: 818-828
- Data Source
  KAKENHI-PROJECT-14370738
[Journal Article] Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1.2004
- Author(s)
  Kamei, D., Hirasawa, N., Ohuchi, K.他14名
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 33684-33695
- Data Source
  KAKENHI-PROJECT-15390020
[Journal Article] Histamine production in macrophages and its roles (J)2003
- Author(s)
  Hirasawa, N. et al.
- Journal Title
  
  Inflam.Immunol. 11
  
  Pages: 31-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390020
[Journal Article] Inhibition by dexamethasone of interleukin 13 production via glucocorticoid receptor-mediated inhibition of c-Jun phosphorylation.2003
- Author(s)
  Hirasawa, N. et al.
- Journal Title
  
  FEBS Lett 554
  
  Pages: 489-498
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390020
[Journal Article] マクロファージのヒスタミン産生とその制御2003
- Author(s)
  平澤典保
- Journal Title
  
  炎症と免疫 11
  
  Pages: 31-37
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390020
[Journal Article] Inhibition by dexamethasone of interleukin 13 production via glucocorticoid receptor.2003
- Author(s)
  Hirasawa, N.
- Journal Title
  
  FEBS Lett. 554
  
  Pages: 489-498
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390020
[Patent] 抗アレルギー剤2015
- Inventor(s)
  平澤典保
- Industrial Property Rights Holder
  平澤典保
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-072034
- Filing Date
  2015-03-31
- Data Source
  KAKENHI-PROJECT-25670034
[Patent] 特許(発明)TSLPを恒常的に高発現する細胞、および前記細胞を利用したTSLP調節剤のスクリーニング方法2011
- Inventor(s)
  平澤典保, 秀道広
- Industrial Property Rights Holder
  東北大学
- Filing Date
  2011-06-13
- Overseas
- Data Source
  KAKENHI-PROJECT-22659025
[Patent] TSLPを恒常的に高発現する細胞、および前記細胞を利用したTSLP調節剤のスクリーニング方法2011
- Inventor(s)
  平澤典保、秀道広
- Industrial Property Rights Holder
  東北大学
- Filing Date
  2011-06-13
- Overseas
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] ステロイド薬の作用機序2014
- Author(s)
  平澤典保
- Organizer
  アトピー性皮膚炎治療研究会第19回シンポジウム
- Place of Presentation
  広島
- Invited
- Data Source
  KAKENHI-PROJECT-25670034
[Presentation] TSLP産生抑制化合物の探索とその作用メカニズムの解析2014
- Author(s)
  白木美香、瀬川良佑、山下紗緒里、米澤貴之、車炳允、禹済泰、平澤典保
- Organizer
  日本薬学会第53回東北支部大会
- Place of Presentation
  いわき
- Year and Date
  2014-10-05
- Data Source
  KAKENHI-PROJECT-25670034
[Presentation] 化学物質とアレルギー2014
- Author(s)
  平澤典保
- Organizer
  NIHS特別講演会
- Place of Presentation
  東京
- Year and Date
  2014-07-14
- Invited
- Data Source
  KAKENHI-PROJECT-25670034
[Presentation] 恒常的TSLP高発現細胞を用いたTSLP産生阻害化合物の探索2014
- Author(s)
  白木美香、瀬川良佑，山下紗緒里、米澤貴之、車炳允、禹済泰、平澤典保
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25670034
[Presentation] マウスにおける金属からのニッケルイオン溶出過程とその制御機構の解析2012
- Author(s)
  高野貴幸、青島祐佑、田中里奈、浅川三喜、上田恭介、大津浩、成島尚之、平澤典保
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 中鎖脂肪酸によるTSLP産生誘導ととアレルギー増悪化作用の解析2012
- Author(s)
  山下紗緒里、佐藤望未、平澤典保
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 前脂肪細胞におけるHDAC阻害薬によるIL-6産生増加とその機序の検討2012
- Author(s)
  佐藤大樹、平澤典保
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 中鎖脂肪酸によるTSLP産生誘導とアレルギー増悪化作用の解析2012
- Author(s)
  山下紗緒里、佐藤望未、平澤典保
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 肺がん発症リスクと薬物代謝酵素遺伝子多型との関連2011
- Author(s)
  平塚真弘、田巻佑一朗、新井冨生、椙村春彦、平澤典保
- Organizer
  第21回日本医療薬学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 金属アレルギーの新たなアプローチ2011
- Author(s)
  平澤典保
- Organizer
  第15回日本ヒスタミン学会シンポジウム「炎症・アレルギーを巡る最近のトピックス」
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 東北大学病院における腎機能低下患者の割合と腎排泄型薬剤の使用状況調査2011
- Author(s)
  高橋亜希、平塚真弘、本田雅志、田巻佑一朗、室井祐佳、新沼優衣、眞野成康、平澤典保
- Organizer
  第5回日本腎と薬剤研究会学術大会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 空気嚢型炎症モデルにおけるTSLP産生制御機構の解析2011
- Author(s)
  瀬川良佑、平澤典保
- Organizer
  第50回記念日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 前脂肪細胞株OP9におけるTLR4刺激によるIL-6産生:HDAC阻害薬の効果2011
- Author(s)
  佐藤大樹、平澤典保
- Organizer
  第50回記念日本薬学会東北支部大会
- Place of Presentation
  仙台
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 化学物質によるTSLP産生とアレルギー増悪化2011
- Author(s)
  平澤典保
- Organizer
  平成23年度日本薬学会東北支部講演会第33回東北薬学セミナー
- Place of Presentation
  仙台
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] Oxidative metabolism of n-desmetyltamoxifen to endoxifen by 50 Cyp2D6 allelic variants2011
- Author(s)
  Masahiro Hiratsuka, Yuka Muroi, Kanako Sakuyama, Yui Niinuma, Takahiro Saito, Masamitsu Takahashi and Noriyasu Hirasawa
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 抗マラリア薬アーテメーター代謝におけるCYP2B6遺伝子多型バリアントの機能解析2011
- Author(s)
  平塚真弘、本田雅志、三枝大輔、鈴木直人、富岡佳久、平澤典保
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 化学物質によるTSLP産生とアレルギー増悪化2011
- Author(s)
  平澤典保
- Organizer
  平成23年度日本薬学会東北支部講演会第33回東北薬学セミナー
- Place of Presentation
  仙台(招待講演)
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] マウスアトピー性皮膚炎モデルにおけるヒスタミンH1およびH4受容体拮抗薬の併用による治療効果2011
- Author(s)
  大澤雄亮、平澤典保
- Organizer
  第15回日本ヒスタミン学会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] マスト細胞とTSLP2010
- Author(s)
  平澤典保
- Organizer
  シンポジウム「秋の夜長とマストセル」第14回日本ヒスタミン学会
- Place of Presentation
  川崎
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 金属系材料のマウス皮下における腐食挙動2010
- Author(s)
  青島有佑、上田恭介、大津浩、成島尚之、小笠原康悦、平澤典保
- Organizer
  日本金属学会第147回大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] An exacerbated allergic dermatitis model in mice and participation of histamine2010
- Author(s)
  Hirasawa, N.
- Organizer
  2010 International Symposium on New Drug Development
- Place of Presentation
  Cheondju, Korea
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] ステロイド薬の基礎シンポジウム「アレルギー疾患の薬物治療に役立つ基礎薬理学」2010
- Author(s)
  平澤典保
- Organizer
  第22回日本アレルギー学会春季臨床大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 薬物代謝酵素遺伝子多型と肺がんリスクとの関連2010
- Author(s)
  田巻佑一郎、新井富生、椙村春彦、佐々木崇光、平澤典保、平塚真弘
- Organizer
  第49回日本薬学会東北支部大会
- Place of Presentation
  郡山
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 増悪化アレルギー性皮膚炎症におけるヒスタミンの役割シンポジウム「アレルギー疾患におけるヒスタミン研究の新展開」2010
- Author(s)
  平澤典保
- Organizer
  第130年会日本薬学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] 生体内における金属からのニッケル溶出の簡易測定法の確立と溶出機序の解析2009
- Author(s)
  田中里奈、五井嘉明、石原研治、上田恭介、成島尚之、大津浩、大内和雄、平澤典保
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22659025
[Presentation] PAM212細胞におけるTNF-αによるTSLP産生に対するEGFRシグナルの関与
- Author(s)
  瀬川良佑、重枝健一、平澤典保
- Organizer
  第87回日本生化学会大会（2014年10月15-18日、京都）
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25670034
[Presentation] 上皮によるTSLP産生に対するニコチンの抑制作用機構の解析
- Author(s)
  董江旭、瀬川良佑、畑山昂大、白木美香、森下由加里、平澤典保
- Organizer
  第87回日本生化学会大会（2014年10月15-18日、京都）
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25670034

1. OHUCHI Kazuo (20006357)

# of Collaborated Projects: 15 results

# of Collaborated Products: 3 results
2. WATANABE Masako (90182948)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. OHTSU Hiroshi (60250742)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. ISHIHARA Kenji (00312596)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. WADA Yumiko (70167469)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 鶴藤丞 (40012596)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TERUI Tadashi (30172109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YANAI Kazuhiko (50192787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KURAMASU Atsuo (90302091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 渡邉建彦 (70028356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 瀧澤利行 (80222090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 古池雄治 (80736330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SAKURAI Eiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 桜井映子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 佐々木崇光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 平塚真弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 守屋孝洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
18. 禹済泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 杉本幸彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 田中智之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 中山和久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 古田和幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirasawa Noriyasu 平澤 典保

平澤 典保 ヒラサワ ノリヤス

HIRASAWA Noriyasu 平澤 典保

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Development of a novel anti-allergic drug: Identification of target proteinsPrincipal Investigator

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Mechanism of short- and medium-chain fatty acid-induced TSLP productionPrincipal Investigator

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Novel recognition mechanisms to chemical compounds which enhance allergic responsesPrincipal Investigator

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Induction and termination of angiogenesis by regulation of angiogenesis-related factor productionPrincipal Investigator

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サイトカインによるマスト細胞の機能修飾とその制御についての研究Principal Investigator

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Research into the effects of steroidal anti-inflammatory drugs on MAP kinase activation and cytokine productionPrincipal Investigator

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Hirasawa Noriyasu 平澤典保

平澤典保ヒラサワノリヤス

HIRASAWA Noriyasu 平澤典保