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Oishi Kazuhiko  大石 一彦

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… Alternative Names

OISHI Kazuhiko  大石 一彦

大石 一彦  オオイシ カズヒコ

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Researcher Number 80203701
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2016 – 2018: 明治薬科大学, 薬学部, 教授
2007 – 2009: Meiji Pharmaceutical University, 薬学部, 教授
2004 – 2006: 明治薬科大学, 薬学部, 助教授
2001 – 2003: 明治薬科大学, 薬学部, 講師
1995 – 1997: 明治薬科大学, 薬学部, 助手
1993: 明治薬科大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
Biological pharmacy / General pharmacology / Pharmacology in pharmacy
Except Principal Investigator
General pharmacology / Biological pharmacy
Keywords
Principal Investigator
分化 / 平滑筋細胞 / 三次元培養 / 内皮細胞 / 神経幹細胞 / endothelial cells / smooth muscle cells / differentiation / neural stem cells / コラーゲン … More / 脳血管 / 血管腔構造 / 膜透過性 / カルシウムイオン / 分泌 / RBL-2H3細胞 / 脳神経疾患 / アストログリオーシス / 逆行性輸送 / iPS細胞 / 神経分化 / リソソーム病 / cerebral blood vessels / collagen / 3-D culture / vascular tube structure / 脳虚血 / 脳室内移植 / 血管形成 / vascular tube structures / contractile responses / three dimensional culture / TGF-β1 / 管腔構造 / 収縮反応性 / calcium / cell shape / actin / desensitization / receptor / RBL-2H3 cells / secretion / リン酸化 / 形態変化 / アクチン / 脱感作 / 受容体刺激 / GSK3B / TCF / β-catenin / 不飽和脂肪酸 / リゾホスファチジルコリン / ホスホリパーゼA_2 / プロテインキナーゼC … More
Except Principal Investigator
平滑筋 / down-regulation / myosin light chain kinase / myosin / regulation / Smooth muscle / 遺伝子ノックアウト / ミオシン軽鎖キナーゼ / ミオシン / 収縮制御 / actin / acetylcholine / permeabilize / streptolysin-O / smooth muscle cells / guinea-pig stomach / protein kinase C / relaxation / 膜透過性 / カルシウムイオン / 張力 / ムスカリン受容体 / 分化 / 培養細胞 / ムスカリ受容体 / 収縮 / 自然弛緩 / アクチン / アセチルコリン / 透過性 / ストレプトリジン-O / 平滑筋細胞 / モルモット胃底部 / プロテインキナーゼC / 弛緩 Less
  • Research Projects

    (8 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (13 People)
  •  Molecular mechanisms underlying differentiation and developmental abnormalities of the nervous system that occurs during the asymptomatic phase of Sandhoff's disease and application to drug discoveryPrincipal Investigator

    • Principal Investigator
      Oishi Kazuhiko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pharmacology in pharmacy
    • Research Institution
      Meiji Pharmaceutical University
  •  Angiogenic potential of multipotent neural stem cellsPrincipal Investigator

    • Principal Investigator
      OISHI Kazuhiko
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Meiji Pharmaceutical University
  •  Angiogenic potential of neural stem cellsPrincipal Investigator

    • Principal Investigator
      OISHI Kazuhiko
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      MEIJI PHARMACEUTICAL UNIVERSITY
  •  Smooth muscle regulation

    • Principal Investigator
      KOHAMA Kazuhiro
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Gunma University
  •  Functional differentiation of neural stem cells into smooth muscle cells.Principal Investigator

    • Principal Investigator
      OISHI Kazuhiko
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Meiji Pharmaceutical University
  •  Spontaneous relaxation of isolated smooth muscle cells shortened with muscarinic receptor stimulation

    • Principal Investigator
      UCHIDA Masaatsu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      MEIJI COLLEGE OF PHARMACY
  •  Receptor-mediated restoration of exocytotic capacityPrincipal Investigator

    • Principal Investigator
      OISHI Kazuhiko
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      MEIJI COLLEGE OF PHARMACY
  •  ホスホリパーゼA_2を介したプロテインキナーゼC調節機構の膜透過性細胞内での解析Principal Investigator

    • Principal Investigator
      大石 一彦
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Meiji Pharmaceutical University

All 2018 2017 2016 2009 2008 2007 2006 2004

All Journal Article Presentation

  • [Journal Article] Improvement in dysmyelination by the inhibition of microglial activation in a mouse model of Sandhoff disease2018

    • Author(s)
      Ogawa Y, Irisa M, Sano T, Yanagi Y, Furusawa E, Saito T, Yamanaka S, Itoh K, Sakuraba H, Oishi K
    • Journal Title

      Neuroreport

      Volume: 29 Issue: 11 Pages: 962-967

    • DOI

      10.1097/wnr.0000000000001060

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10057, KAKENHI-PROJECT-17H04102, KAKENHI-PROJECT-16K08281
  • [Journal Article] Inhibition of astrocytic adenosine receptor A 2A attenuates microglial activation in a mouse model of Sandhoff disease2018

    • Author(s)
      Ogawa Yasuhiro、Furusawa Eiri、Saitoh Takahiro、Sugimoto Hiroki、Omori Takumi、Shimizu Shinya、Kondo Hisatsugu、Yamazaki Mika、Sakuraba Hitoshi、Oishi Kazuhiko
    • Journal Title

      Neurobiology of Disease

      Volume: 118 Pages: 142-154

    • DOI

      10.1016/j.nbd.2018.07.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Journal Article] Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage2017

    • Author(s)
      Ogawa Yasuhiro、Kaizu Katsutoshi、Yanagi Yusuke、Takada Subaru、Sakuraba Hitoshi、Oishi Kazuhiko
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 6 Pages: e0178978-e0178978

    • DOI

      10.1371/journal.pone.0178978

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Journal Article] FcRγ-dependent immune activation initiates astrogliosis during the asymptomatic phase of Sandhoff disease model mice.2017

    • Author(s)
      Ogawa Y, Sano T, Irisa M, Kodama T, Saito T, Furusawa E, Kaizu K, Yanagi Y, Tsukimura T, Togawa T, Yamanaka S, Itoh K, Sakuraba H, Oishi K
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 40518-40518

    • DOI

      10.1038/srep40518

    • NAID

      120006535048

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08281, KAKENHI-PROJECT-17K10057
  • [Journal Article] In vitro development of gut-like tissue demonstrating rhythmic contractions from embryonic mouse intestinal cells.2007

    • Author(s)
      Y. Ito-Dufros, Y. Funakoshi, A. Uehara, K. Oishi
    • Journal Title

      Neurogastroenterol Motil. 19

      Pages: 288-300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Journal Article] In vitro development of gut-like tissue demonstrating rhythmic contractions from embryonic mouse intestinal cells2007

    • Author(s)
      Ito-Duyfros Y, Funakoshi Y, Uehara A, and Oishi K.
    • Journal Title

      Neurogastroenterol Motil 19

      Pages: 288-800

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Journal Article] Isometric contraction of microvascular pericytes from mouse brain parenchyma.2007

    • Author(s)
      K. Oishi, T. Kamiyashiki, Y. Ito
    • Journal Title

      Microvasc Res. 73

      Pages: 20-28

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Journal Article] Isometrie contraetion of microvascular pericytes from mouse brain parenchyma2007

    • Author(s)
      Oishi K, Kamiyashiki T, and Ito Y.
    • Journal Title

      Microvase res 73

      Pages: 20-28

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Journal Article] Isometric contraction of microvascular pericytes from mouse brain parenchyma.2006

    • Author(s)
      Oishi K, Kamiyashiki T, Ito Y
    • Journal Title

      Microvasc Res. 73

      Pages: 20-28

    • Data Source
      KAKENHI-PROJECT-16590209
  • [Journal Article] Angiogenic potential of CD44+ CD90+ multipotent CNS stem cells in vitro.2006

    • Author(s)
      Oishi K, Ito-Dufros Y
    • Journal Title

      Biochem Biophys Res Commun. 349

      Pages: 1065-1072

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590209
  • [Journal Article] Angiogenic potential of CD44^+ CD90^+ multipotent CNS stem cells in vitro.2006

    • Author(s)
      Oishi K, Ito-Dufros Y
    • Journal Title

      Biochem Biophys Res Commun. 349

      Pages: 1065-1072

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590209
  • [Journal Article] Angiogenic potential of CD44+ CD90+ multipotent CNS stem cells in vitro.2006

    • Author(s)
      K. Oishi, Y. Ito-Dufros
    • Journal Title

      Biochem Biophys Res Commun. 349

      Pages: 1065-1072

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Journal Article] Angiogenesis in vitro : vascular tube formation from the differentiation of neural stem cells.2004

    • Author(s)
      Oishi K, Kobayashi A, Fujii K, Kanehira D, Ito Y, Uchida. MK
    • Journal Title

      J.Pharmacol.Sci. 96

      Pages: 208-218

    • Data Source
      KAKENHI-PROJECT-16590209
  • [Journal Article] Carbachol-induced secretion and homologous desensitization in rat basophilic leukemia (RBL-2H3) cells transfected with human m2 muscarinic acetylcholine receptors.2004

    • Author(s)
      Oishi K, Sakurai A, Seki N, Yoshizumi T, Uchida MK
    • Journal Title

      J. Pharmacol. Sci. 96

      Pages: 73-83

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590209
  • [Journal Article] Carbachol-induced secretion and homologous desensitization in rat basophilic leukemia (RBL-2H3) cells transfected with human m2 muscarinic acetylcholine receptors.2004

    • Author(s)
      Oishi K, Sakurai A, Seki N, Yoshizumi T, Uchida MK.
    • Journal Title

      J. Pharmacol. Sci. 96

      Pages: 73-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590209
  • [Journal Article] Angiogenesis in vitro : vascular tube formation from the differentiation of neural stem cells.2004

    • Author(s)
      Oishi K, Kobayashi A, Fujii K, Kanehira D, Ito Y, Uchida. MK
    • Journal Title

      J. Pharmacol. Sci. 96

      Pages: 208-218

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590209
  • [Journal Article] Carbachol-induced secretion and homologous desensitization in rat basophilic leukemia (RBL-2H3) cells transfected with human m2 muscarinic acetylcholine receptors.2004

    • Author(s)
      Oishi K, Sakurai A, Seki N, Yoshizumi T, Uchida MK
    • Journal Title

      J.Pharmacol.Sci. 96

      Pages: 73-83

    • Data Source
      KAKENHI-PROJECT-16590209
  • [Journal Article] Carbachol-induced membrane ruffling and its desensitization in rat basophilic leukemia (RBL-2H3) cells transfected with m3 muscaceptors.2004

    • Author(s)
      Oishi K, Yoshizumi T, Seki N, Uchida MK
    • Journal Title

      Biol.Pharm.Bull. 27

      Pages: 1544-1548

    • Data Source
      KAKENHI-PROJECT-16590209
  • [Journal Article] Carbachol-induced membrane ruffling and its desensitization in rat basophilic leukemia (RBL-2H3) cells transfected with m3 muscarinic acetylcholine receptors.2004

    • Author(s)
      Oishi K, Yoshizumi T, Seki N, Uchida MK.
    • Journal Title

      Biol. Pharm. Bull. 27

      Pages: 1544-1548

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590209
  • [Journal Article] Carbachol-induced membrane ruffling and its desensitization in rat basophilic leukemia (RBL-2H3) cells transfected with m3 muscarinic acetylcholine receptors.2004

    • Author(s)
      Oishi K, Yoshizumi T, Seki N, Uchida MK
    • Journal Title

      Biol. Pharm. Bull. 27

      Pages: 1544-1548

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590209
  • [Presentation] LPS誘導性脳炎症モデルマウスにおけるA2A受容体のグリア細胞での発現変化2017

    • Author(s)
      山崎美香、清水伸弥、小川泰弘、大石一彦
    • Organizer
      第19回応用薬理シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] ザンドホッフ病モデルマウスから樹立したiPS細胞の神経系への分化異常2017

    • Author(s)
      宇野可奈子、小川泰弘、櫻庭 均、大石一彦
    • Organizer
      第19回応用薬理シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] 多能性幹細胞の神経堤系譜への分化におけるFGF/ERKシグナル伝達経路の関与2017

    • Author(s)
      青野大輝、多田朋香、大上 望、小川泰弘、大石一彦
    • Organizer
      第19回応用薬理シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] アルツハイマー病治療薬ドネペジルは神経幹細胞をオリゴデンドロサイトへと分化誘導する2017

    • Author(s)
      今村 宰、新井仁明、伊達木穣、大石一彦、瀧嶋邦夫
    • Organizer
      第19回応用薬理シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] レトロマー複合体の安定化はザンドホッフ病モデルマウス由来iPS細胞の神経系への分化異常を改善する2017

    • Author(s)
      原 佑太、小川泰弘、柳 勇介、櫻庭 均、大石一彦
    • Organizer
      第19回応用薬理シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] ザンドホッフ病モデルマウスにおける脳炎症の長期的な抑制による治療効果2017

    • Author(s)
      設楽修平、齊藤貴洋、小川泰弘、櫻庭 均、大石一彦
    • Organizer
      第19回応用薬理シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] ザンドホッフ病モデルマウス由来iPS細胞の神経系への分化異常はザンドホッフ病の病態を反映している2017

    • Author(s)
      秋山裕理、小川泰弘、海津勝俊、櫻庭 均、大石一彦
    • Organizer
      第19回応用薬理シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] ザンドホッフ病モデルマウス由来iPS細胞の神経系への分化異常に対するレトロマー構成因子VPS35の効果2017

    • Author(s)
      柳 勇介、海津 勝俊、原 佑太、櫻庭 均、小川 泰弘、大石 一彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] ザンドホッフ病でのグリア細胞を標的とした治療薬の効果2017

    • Author(s)
      小川泰弘、櫻庭 均、大石一彦
    • Organizer
      第19回応用薬理シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] ザンドホッフ病モデルマウスにおいて活性化アストロサイトはA2A受容体を発現する2016

    • Author(s)
      古澤 栄梨、齊藤 貴洋、小川 泰弘、大石 一彦
    • Organizer
      生体機能と創薬シンポジウム2016
    • Place of Presentation
      東北大学川内北キャンパス(仙台)
    • Year and Date
      2016-08-25
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] ザンドホッフ病モデルマウスでの運動機能障害に対する早期免疫抑制剤による効果2016

    • Author(s)
      齊藤 貴洋、古澤 栄梨、小川 泰弘、大石 一彦
    • Organizer
      生体機能と創薬シンポジウム2016
    • Place of Presentation
      東北大学川内北キャンパス(仙台)
    • Year and Date
      2016-08-25
    • Data Source
      KAKENHI-PROJECT-16K08281
  • [Presentation] iPS細胞の分化と薬理学研究への応用2009

    • Author(s)
      大石一彦
    • Organizer
      第36回日本トキシコロジー学会学術年会
    • Place of Presentation
      盛岡
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Presentation] 幹細胞から作製する再構成組織標本とその薬理学的解析への応用2009

    • Author(s)
      小川泰弘、大石一彦
    • Organizer
      第22回日本動物実験代替法学会総会・学術大会
    • Place of Presentation
      大阪(シンポジウム講演)
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Presentation] iPS細胞の分化と薬理学研究への応用2009

    • Author(s)
      大石一彦
    • Organizer
      第36回日本トキシコロジー学会学術年会
    • Place of Presentation
      アイーナ(盛岡市)
    • Year and Date
      2009-07-07
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Presentation] 幹細胞から作製する再構成組織標本とその薬理学的解析への応用2009

    • Author(s)
      大石一彦
    • Organizer
      第22回日本動物実験代替法学会総会・学術大会
    • Place of Presentation
      大阪大学(大阪市)
    • Year and Date
      2009-11-14
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Presentation] Microvascular Pericytes from Mouse Brain Parenchyma Contract Isometrically.2008

    • Author(s)
      Oishi K
    • Organizer
      The 15^<th> International Vascular Biology Meeting
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2008-06-03
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Presentation] Microvascular Pericytes from Mouse Brain Parenchyma Contract Isometrically.2008

    • Author(s)
      Oishi K.
    • Organizer
      The 15th International Vascular Biology Meeting
    • Place of Presentation
      Sydney, Australia (workshop)
    • Data Source
      KAKENHI-PROJECT-19590262
  • [Presentation] Neuroangiogenic potential of neural stem cells.2007

    • Author(s)
      Oishi K
    • Organizer
      The JSPS 2nd Medicinal Chemistry Seminor of Asia/Africa Science Platform Program
    • Place of Presentation
      Phuket, Thailand (an invited lecture)
    • Data Source
      KAKENHI-PROJECT-19590262
  • 1.  UCHIDA Masaatsu (90097197)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  KOHAMA Kazuhiro (30101116)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  KUMAGAI Hiroyuki (20321945)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  NAKAMURA Akio (30282388)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  ISHIKAWA Ryoki (20212863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  宮崎 淳一 (80229830)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  小川 泰弘 (00531948)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 8.  Sakuraba Hitoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 9.  Togawa Tadayasu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  Kanekura Takuro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Kaizu Katsutoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 12.  Irisa Masahiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  山中 正二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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