HASEGAWA HIROSHI 長谷川弘

… Alternative Names

Researcher Number	80218453
Other IDs
Affiliation (Current)	2021: 東京薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2011 – 2020: 東京薬科大学, 薬学部, 講師 1996: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / 医薬分子機能学 / Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator 安定同位体 / ホモシステイン / メチオニン / 腎不全 / GC-MS / 代謝フラックス / メチル基転移 / 血管平滑筋 / 心血管疾患 / 高ホモシステイン血症 … More

慢性腎不全における高ホモシステイン血症の成因機序とその心血管疾患発症への関与Principal Investigator
- Principal Investigator
  
  長谷川弘
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Effect of hyperhomocysteinemia on the cardiovascular disease in renal failurePrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Effect of hyperhomocysteinemia on vascular dysfunction in renal failurePrincipal Investigator
- Principal Investigator
  
  HASEGAWA HIROSHI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Effect of reduced renal function on homocysteine metabolismPrincipal Investigator
- Principal Investigator
  
  HASEGAWA HIROSHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
D-アミノ酸を含むペプチドの生体内動態に関する研究Principal Investigator
- Principal Investigator
  
  長谷川弘
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2021 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] The effect of dietary protein restriction in a case of molybdenum cofactor deficiency with MOCS1 mutation2021
- Author(s)
  Yu Abe, Yu Aihara, Wakaba Endo, Hiroshi Hasegawa, Kimiyoshi Ichida, Mitsugu Uematsu, Shigeo Kure
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 26 Pages: 100716-100716
- DOI
  10.1016/j.ymgmr.2021.100716
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07188, KAKENHI-PROJECT-19K17320
[Journal Article] Pharmacokinetics and toxicokinetics of D-serine in rats2019
- Author(s)
  Hiroshi Hasegawa, Nami Masuda, Hiromi Natori, Yoshihiko Shinohara, Kimiyoshi Ichida
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 162 Pages: 264-271
- DOI
  10.1016/j.jpba.2018.09.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08428
[Journal Article] Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats2018
- Author(s)
  Lei Li, Hiroshi Hasegawa, Niro Inaba, Wataru Yoshioka, Dennis Cahng, JianXun Liu, Kimiyoshi Ichida
- Journal Title
  
  Amino Acids
  
  Volume: 50 Pages: 1485-1494
- DOI
  10.1007/s00726-018-2626-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08428
[Journal Article] Hydrophilic-interaction liquid chromatography-tandem mass spectrometric determination of erythrocyte 5-phosphoribosyl 1-pyrophosphate in patients with hypoxanthine-guanine phosphoribosyltransferase deficiency.2015
- Author(s)
  Hiroshi Hasegawa, Yoshihiko Shinohara, Sayako Nozaki, Makiko Nakamura, Koei Oh, Osamu Namiki, Kiyotaka Suzuki, Akihiko Nakahara, Mari Miyazawa, Ken Ishikawa, Takahiro Himeno, Sayaka Yoshida, Takanori Ueda, Yasukazu Yamada, Kimiyoshi Ichida
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 976-977 Pages: 55-60
- DOI
  10.1016/j.jchromb.2014.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790051, KAKENHI-PROJECT-26460207
[Journal Article] Relationship between rotational barriers and structures in N-C axially chiral 3,4-dihydroquinolin-2-one and 3,4-dihydrobenzoquinolin-2-one.2015
- Author(s)
  Yuya Suzuki, Isao Takahashi, Yasuo Dobashi, Hiroshi Hasegawa, Christian Roussel, Osamu Kitagawa
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 56 Pages: 132-135
- DOI
  10.1016/j.tetlet.2014.11.040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460014, KAKENHI-PROJECT-26460207
[Journal Article] Synthesis of optically active N-C axially chiral tetrahydroquinoline and its response to acid-accelerated molecular rotor.2015
- Author(s)
  Yuya Suzuki, Masato, Kageyama, Ryuichi Morisawa, Yasuo Dobashi, Hiroshi Hasegawa, Satoshi Yokojima, Osamu Kitagawa
- Journal Title
  
  Chemical Communications
  
  Volume: 51 Pages: 11229-11232
- DOI
  10.1039/c5cc03659c
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460014, KAKENHI-PROJECT-26460207
[Journal Article] Evaluation of the metabolic chiral inversion of D-selenomethionine in rats by stable isotope dilution gas chromatography-mass spectrometry.2015
- Author(s)
  Takehisa Matsukawa, Hiroshi Hasegawa, Hitomi Goto, Yoshihiko Shinohara, Atsuko Shinohara, Yuki Omori, Kimiyoshi Ichida, Kazuhito Yokoyama.
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 116 Pages: 59-64
- DOI
  10.1016/j.jpba.2015.04.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460207
[Journal Article] Hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiencies: HPRT1 mutations in new Japanese families and PRPP concentration.2014
- Author(s)
  Yasukazu Yamada, Noriko Nomura, Kenichiro Yamada, Reiko Kimura, Daisuke Fukushi, Noubuaki Wakamatsu, Yasufumi Matsuda, Takahiro Yamauchi, Takanori Ueda, Hiroshi Hasegawa, Makiko Nakamura, Kimiyoshi Ichida, Kiyoko Kaneko, Shin Fujimori.
- Journal Title
  
  Nucleosides, Nucleotides, Nucleic Acids
  
  Volume: 33 Pages: 218-222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460207
[Journal Article] Studies on rotational barriers of N-C axially chiral compounds: increase in the rotational barrier by aromatization2012
- Author(s)
  Naomi Suzumura, Masato Kageyama, Daichi Kamimura, Takahiko Inagaki, Yasuo Dobashi, Hiroshi, Hasegawa, Haruhiko Fukaya, Osamu Kitagawa
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 53 Pages: 4332-4336
- DOI
  10.1016/j.tetlet.2012.06.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590015, KAKENHI-PROJECT-23590202
[Journal Article] Simultaneous determination of serine enantiomers in plasma using Mosher’s reagent and stable isotope dilution gas chromatography-mass spectrometry.2011
- Author(s)
  Hiroshi Hasegawa, Yoshihiko Shinohara, Nami Masuda, Takao Hashimoto and Kimiyoshi Ichida
- Journal Title
  
  Journal of Mass Spectrometry
  
  Volume: 46 Pages: 502-507
- DOI
  10.1002/jms.1917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590202
[Journal Article] Simultaneous determination of selenomethionine enantiomers in biological fluids by stable isotope dilution gas chromatography- mass spectrometry.2011
- Author(s)
  Takehisa Matsukawa, Hiroshi Hasegawa, Yoshihiko Shinohara, Jun Kobayashi, Atsuko Shinohara, Momoko Chiba, Kimiyoshi Ichida and Kazuhito Yokoyama
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 879 Pages: 3253-3258
- DOI
  10.1016/j.jchromb.2011.03.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590202
[Journal Article] Simultaneous determination of selenomethionine enantiomers in biological fluids by stable isotope dilution gas chromatography-mass spectrometry2011
- Author(s)
  Matsukawa T, Hasegawa H, Shinohara Y, Kobayashi J, Shinohara A, Chiba M, Ichida K, Yokoyama K
- Journal Title
  
  J. Chromatogr. B
  
  Volume: 879 Pages: 3253-3258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] GC-MSによる重水素標識及び非標識メチオニン及びホモシステイン測定法の開発とその生体内動態研究への応用2019
- Author(s)
  長谷川　弘、田村優香、重永恵理、松尾和恵、飯塚さやか、篠原佳彦、市田公美
- Organizer
  新アミノ酸分析研究会第9回学術講演会
- Data Source
  KAKENHI-PROJECT-17K08428
[Presentation] GC-MSとMosher試薬を用いたDL-アミノ酸の分別定量2019
- Author(s)
  長谷川　弘
- Organizer
  第79回分析化学討論会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08428
[Presentation] 血液透析による血中ホモシステイン、システインの変動2018
- Author(s)
  長谷川　弘、篠原佳彦、副島昭典、市田公美
- Organizer
  日本アミノ酸学会12回学術大会
- Data Source
  KAKENHI-PROJECT-17K08428
[Presentation] Goto-Kakizaki糖尿病モデルラットにおけるメチオニンーホモシステイン代謝系の代謝フラックス解析2018
- Author(s)
  長谷川　翔，廣野　真帆，長谷川　弘，市田　公美
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08428
[Presentation] GC-MSを検出手段とする安定同位体希釈分析法とMosher試薬を用いたDL-アミノ酸の分別定量2017
- Author(s)
  長谷川　弘，篠原　佳彦，市田　公美
- Organizer
  新アミノ酸分析研究会第7回学術講演会
- Data Source
  KAKENHI-PROJECT-17K08428
[Presentation] メチオニン強化食により誘導した高ホモシステイン血症が5/6腎摘除ラットの血管弛緩機能に及ぼす影響2016
- Author(s)
  長谷川　弘、Li Lei、稲葉　二朗、吉岡　亘、Liu JianXun、市田　公美
- Organizer
  日本アミノ酸学会10周年記念大会
- Place of Presentation
  東京
- Year and Date
  2016-09-11
- Data Source
  KAKENHI-PROJECT-26460207
[Presentation] 高ホモシステイン血症を呈した慢性腎不全モデルラットの血管弛緩機能障害2016
- Author(s)
  長谷川　弘、Li Lei、稲葉　二朗、吉岡　亘、Liu JianXun、市田　公美
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-26460207
[Presentation] 安定同位体希釈GC-MSによるセレノメチオニン光学異性体の分別定量法の開発とその生体内動態研究への応用2015
- Author(s)
  長谷川　弘、松川　岳久、後藤　瞳、篠原　佳彦、篠原　厚子、横山　和仁、市田　公美
- Organizer
  第28回バイオメディカル分析科学シンポジウム
- Place of Presentation
  長崎
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-26460207
[Presentation] 腎部分摘除のメチオニン−ホモシステイン代謝サイクルに及ぼす影響2013
- Author(s)
  長谷川弘、田村優香、重永恵理、松尾和恵、上田麻未、篠原佳彦、市田公美
- Organizer
  日本アミノ酸学会第7回学術大会
- Place of Presentation
  熊本市医師会館(熊本)
- Year and Date
  2013-11-02
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] 腎部分摘除のメチオニン−ホモシステイン代謝サイクルに及ぼす影響2013
- Author(s)
  長谷川弘、田村優香、重永恵理、上田麻未、松尾和恵、篠原佳彦、市田公美
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] 腎部分摘除のメチオニンーホモシステイン代謝サイクルに及ぼす影響2013
- Author(s)
  長谷川　弘、田村優香、重永恵理、上田麻未、松尾和恵、篠原佳彦、市田公美
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] メチオニン−ホモシステイン代謝サイクルに及ぼす腎部分摘除の影響2013
- Author(s)
  長谷川弘、田村優香、重永恵理、上田麻未、松尾和恵、篠原佳彦、市田公美
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2013-09-13
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] 5/6腎摘除ラットにおけるメチオニン−ホモシステイン代謝系の解析2013
- Author(s)
  長谷川弘、田村優香、重永恵理、篠原佳彦、市田公美
- Organizer
  第56回日本腎臓学会学術総会
- Place of Presentation
  東京フォーラム(東京)
- Year and Date
  2013-05-10
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] 5/6腎摘除ラットにおけるメチオニンーホモシステイン代謝系の解析2013
- Author(s)
  長谷川　弘，田村優香，重永恵理，篠原佳彦，市田公美
- Organizer
  第56回日本腎臓学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] メチオニン－ホモシステイン代謝サイクルに及ぼす腎部分摘除の影響2013
- Author(s)
  長谷川　弘，田村優香，重永恵理，上田麻未，松尾和恵，篠原佳彦，市田公美
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] 腎部分摘除のメチオニン－ホモシステイン代謝サイクルに及ぼす影響2013
- Author(s)
  長谷川　弘，田村優香，重永恵理，松尾和恵，上田麻未，篠原佳彦，市田公美
- Organizer
  第7回日本アミノ酸学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] ラットにおけるセレノメチオニン光学異性体の生体内動態に関する研究2012
- Author(s)
  後藤　瞳、松川岳久、長谷川　弘、篠原佳彦、篠原厚子、千葉百子、横山和仁、市田公美
- Organizer
  第8回D-アミノ酸研究会学術講演会
- Place of Presentation
  滋賀
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] 安定同位体トレーサー法によるメチオニンーホモシステイン代謝サイクルの解析2012
- Author(s)
  重永恵理、長谷川　弘、田村優香、篠原佳彦、市田公美
- Organizer
  第25回バイオメディカル分析科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] 安定同位体トレーサー法によるメチオニン−ホモシステイン代謝サイクルの解析2012
- Author(s)
  重永恵理、長谷川弘、田村優香、篠原佳彦、市田公美
- Organizer
  第25回バイオメディカル分析科学シンポジウム
- Place of Presentation
  慶應大学薬学部芝共立キャンパス(東京)
- Year and Date
  2012-08-09
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] GC-MSを用いた安定同位体希釈分析法によるセリン光学異性体の分別定量2012
- Author(s)
  長谷川　弘、篠原佳彦、増田奈美、名取拓実、橋本隆男、市田公美
- Organizer
  第72回分析化学討論会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] GC-MSを検出手段とする安定同位体希釈分析法によるDL-アミノ酸の分別定量2011
- Author(s)
  長谷川　弘，篠原　佳彦，市田　公美
- Organizer
  第７回D-アミノ酸研究会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] GC-MSによる重水素標識及び非標識メチオニン及びホモシステインの同時定量法の開発2011
- Author(s)
  長谷川弘、篠原佳彦、田村優香、金子知由、橋本隆男、市田公美
- Organizer
  日本分析化学会第60年会
- Place of Presentation
  名古屋大学東山キャンパス(名古屋)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] GC-MSによる重水素標識及び非標識メチオニン及びホモシステインの同時定量法の開発2011
- Author(s)
  長谷川　弘，篠原　佳彦，田村　優香，金子　友由，橋本　隆男，市田　公美
- Organizer
  日本分析化学会　第６０年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590202
[Presentation] Plasma kinetics of D-serine in rats.
- Author(s)
  Hiroshi Hasegawa, Yoshihiko Shinohara, Nami Masuda, Takumi Natori, Kimiyoshi Ichida.
- Organizer
  The 2nd International Conference of D-Amino Acid Research
- Place of Presentation
  栃木、宇都宮
- Year and Date
  2014-09-02 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-26460207
[Presentation] LC-MS/MSを用いた赤血球中5-ホスホリボシル-1-ピロリン酸測定法の開発とヒポキサンチン-グアニンホスホリボシルトランスフェラーゼ活性欠損症フェノタイピングへの応用
- Author(s)
  長谷川　弘，篠原　佳彦，野崎　早弥子，中村　真希子，山田　裕一，市田　公美．
- Organizer
  第27回バイオメディカル分析科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-08-20 – 2014-08-21
- Data Source
  KAKENHI-PROJECT-26460207
[Presentation] ラットにおけるD-セリンの血漿中動態．
- Author(s)
  長谷川　弘，増田　奈美，名取　拓実，篠原　佳彦，市田　公美．
- Organizer
  日本アミノ酸学会第8回学術大会
- Place of Presentation
  東京
- Year and Date
  2014-11-08 – 2014-11-09
- Data Source
  KAKENHI-PROJECT-26460207

1. ICHIDA Kimiyoshi (80183169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
2. NAKAMURA Makiko (80447557)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. SHINOHARA Yoshihiko (00154229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
4. 北川理

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 阿部裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASEGAWA HIROSHI 長谷川 弘

長谷川 弘 ハセガワ ヒロシ

Research Projects

Research Products

Co-Researchers

慢性腎不全における高ホモシステイン血症の成因機序とその心血管疾患発症への関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effect of hyperhomocysteinemia on the cardiovascular disease in renal failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of hyperhomocysteinemia on vascular dysfunction in renal failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of reduced renal function on homocysteine metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

D-アミノ酸を含むペプチドの生体内動態に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The effect of dietary protein restriction in a case of molybdenum cofactor deficiency with MOCS1 mutation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pharmacokinetics and toxicokinetics of D-serine in rats2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydrophilic-interaction liquid chromatography-tandem mass spectrometric determination of erythrocyte 5-phosphoribosyl 1-pyrophosphate in patients with hypoxanthine-guanine phosphoribosyltransferase deficiency.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship between rotational barriers and structures in N-C axially chiral 3,4-dihydroquinolin-2-one and 3,4-dihydrobenzoquinolin-2-one.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of optically active N-C axially chiral tetrahydroquinoline and its response to acid-accelerated molecular rotor.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of the metabolic chiral inversion of D-selenomethionine in rats by stable isotope dilution gas chromatography-mass spectrometry.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiencies: HPRT1 mutations in new Japanese families and PRPP concentration.2014

Author(s)

Journal Title

Data Source

[Journal Article] Studies on rotational barriers of N-C axially chiral compounds: increase in the rotational barrier by aromatization2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous determination of serine enantiomers in plasma using Mosher’s reagent and stable isotope dilution gas chromatography-mass spectrometry.2011

HASEGAWA HIROSHI 長谷川弘

長谷川弘ハセガワヒロシ