MIZUMA TAKASHI 水間俊

… Alternative Names

水間俊ミズマタカシ

MIZUMA Takashi 水間俊

TAKASHI Mizuma 水間俊

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Researcher Number	80229715
Other IDs
External Links
Affiliation (Current)	2025: 帝京平成大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 帝京平成大学, 薬学部, 教授 2003 – 2005: 東京薬科大学, 薬学部, 助教授 2000 – 2001: 東京薬科大学, 薬学部, 助教授 1993 – 1994: Faculty of Pharmaceutical Sciences, Tokyo Coll.of Pharmacy (Associate Professor), 薬学部, 講師 1992: 東京理科大学, 薬学部, 助手 1991: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator 医薬分子機能学 / Medical pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Biological pharmacy / 応用薬理学・医療系薬学
Keywords	Principal Investigator spare space / SGLT1 / Caco-2 cells / sulfate conjugation metabolism / intestinal metabolism / drug-nutrient interactions / drug-drug interactions / bioavailability / intestinal availability / 薬物速度論 … More / 食物成分 / 培養細胞 / Caco-2 / 飲食物 / 相互作用 / カテキン / 腸管吸収 / 抱合代謝 / Caco-2細胞 / 硫酸抱合代謝 / 腸管代謝 / 薬物飲食物間相互作用 / 薬物間相互作用 / バイオアベイラビリティ / 腸管アベイラビリティ / disaccharidase / recognition / transportability / glucoside / glucose conjugate / glucose transporter / コンフォメーション / 二糖加水分解酵素 / 認識性 / 輸送性 / スペアスペース / グルコシド / 糖付加体 / グルコース輸送担体 / グルコース / 能動輸送 / 担体輸送 / グリコシド / ペプチド / 糖付加 / 小腸 / 吸収改善 … More Except Principal Investigator パイエル板 / Caco-2細胞 / 吸収促進剤 / 酸化ストレス / ポルフィリン / タモキシフェン / ヘムオキシゲナーゼ / 薬剤性肝障害 / ヘム / HO-1 / NASH / 非アルコール性脂肪性肝炎 / Enkephalin / VitaminA / Glucose transporter / Peptide / Intracellular calcium / Tight iunction / Caco-2 / Absorption enhancement / 糖付加 / レクチン / 吸収改善 / エンケファリン / ビタミンA / グルコース輸送担体 / ペプチド / 細胞内カルシウム / タイトジャンクション / 吸収促進 / Adsorptive Endocytosis / Peyer's Patches / Caprate / Caco-2 Cells / Actomyosin / Polypeptide / Paracellular Pathway / Absorption Enhancer / インピ-ダンス解析 / 高分子量物質 / 細胞内経路 / 結腸 / Caco‐2細胞 / M細胞 / 空腸 / 細胞間隙 / 高分子ペプチド / カルモジュリン / 吸着性エンドサイトーシス / カプリン酸 / アクトミオシン / ポリペプチド / 細胞間隙経路 Less

Involvement of heme metabolic disorders in hepatocytes in the development of nonalcoholic steatohepatitis.
- Principal Investigator
  
  NAKANO Takafumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Teikyo Heisei University
Intestinal absorption of dietary compounds and quantitative analysis of their influences on drug absorptionPrincipal Investigator
- Principal Investigator
  
  MIZUMA Takashi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Sciences
Analyses of SGLT1 function and cooperative function of SGLT1 with disaccharidasePrincipal Investigator
- Principal Investigator
  
  TAKASHI Mizuma
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo University of Pharmacy and Life Science
糖吸収機構による難吸収性薬物の吸収改善Principal Investigator
- Principal Investigator
  
  水間俊
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo University of Pharmacy and Life Science
Improvemrnt of Drug Absorption in Gastro intestinal Tract
- Principal Investigator
  
  AWAZU Shoji
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Membrane Permeability and Its Improvement in Intestinal Absorption of Macromolecular Drugs
- Principal Investigator
  
  HAYASHI Masahiro
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Faculty of Pharmaceutical Sciences, Science University of Tokyo
  Tokyo University of Pharmacy and Life Science

All 2022 2021 2020 2006 2005 2004

All Journal Article Presentation Book

[Book] 生物薬剤学2006
- Author(s)
  水間俊
- Publisher
  南江堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Book] 創薬方法論 : ソリューションガイド20052006
- Author(s)
  水間俊
- Publisher
  情報計算化学生物学会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Book] 創薬方法論 : ソリューションガイド20052005
- Author(s)
  水間俊
- Total Pages
  64
- Publisher
  情報計算化学生物学会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] 糖トランスポーターを利用したDDS2006
- Author(s)
  水間俊
- Journal Title
  
  Drug Delivery System 21
  
  Pages: 126-133
- NAID
  10018118893
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Differentiation of organ availability by sequential and simultaneous analyses : Intestinal conjugative metabolism impacts on intestinal availability in humans.2005
- Author(s)
  Mizuma T, Kawashima K, Sakai S, Sakaguchi S, Hayashi M.
- Journal Title
  
  J Pharm Sci 94(3)
  
  Pages: 571-575
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Simultaneous HPLC assay of lenampicillin (ampicillin prodrug), ampicillin, and marker compound for high - throughput in vitro assessment of intestinal absorption in vitro assessment of intestinal absorption2005
- Author(s)
  Takashi Mizuma, Sayaka Sakaguchi, Masahiro Hayashi
- Journal Title
  
  J. Liq. Chromtogr. Rel. Technol. 28
  
  Pages: 1531-1537
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Kinetic characterization of glycosidase activity from disaccharide conjugate to monosaccharide conjugate in Caco-2 cells.2005
- Author(s)
  Takashi Mizuma, Norihiko Fuseda, Masahiro Hayashi.
- Journal Title
  
  J.Pharm.Pharmacol. 57
  
  Pages: 661-664
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Intestinal SGLT1-mediated absorption and metabolism of benzyl β-glucoside contained in Purunus mume : carrier-mediated transport increases intestinal availability.2005
- Author(s)
  Takashi Mizuma, Maya Nakamura, Hiroji Ina, Toshio Miyazaki, Masahiro Hayashi.
- Journal Title
  
  Biochim.Biophys.Acta. 1722
  
  Pages: 218-223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Differentiation of organ availability by sequential analysis and simultaneous analysis : intestinal conjugative metabolism impacts on intestinal availability in humans2005
- Author(s)
  Takashi Mizuma, Kosuke Kawashima, Shuichi Sakai, Sayaka Sakaguchi, Masahiro Hayashi
- Journal Title
  
  J.Pharm.Sci. 94
  
  Pages: 571-575
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Intestinal SGLTI-mediated absorption and metabolism on benzyl β-glucoside contained in Purunus mume : carrier- mediated transport increases intestinal availability.2005
- Author(s)
  Takashi Mizuma, Maya Nakamura, Hiroji Ina, oshio Miyazaki, Masahiro Hayashi.
- Journal Title
  
  Aiochim. Biophys. Acta. 1722
  
  Pages: 218-223
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC SIMULTANEOUS ASSAY OF LENAMPICILLIN (AMPICILLIN PRODRUG), AMPICILLIN AND MARKER COMPOUND FOR HIGH-THROUGHPUT IN VITRO ASSESSMENT OF INTESTINAL ABSORPTION AND METABOLISM USING CACO-2 CELLS2005
- Author(s)
  Mizuma, T., Sakaguchi, S.et al.
- Journal Title
  
  J.Liquid Chromatography & Related Technologies 28
  
  Pages: 1531-1537
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Kinetic characterization of glycosidase activity from disaccharide conjugate to monosaccharide conjugate in Caco-2 cells2005
- Author(s)
  Takashi Mizuma, Norihiko Fuseda, Masahiro Hayashi
- Journal Title
  
  J. Pharm. Pharmacol 57
  
  Pages: 661-664
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Intestinal SGLT1-mediated absorption and metabolism of benzyl beta-glucoside contained in Prunus mume.2005
- Author(s)
  Mizuma T, Nakamura M, Ina H, Miyazaki T, Hayashi M.
- Journal Title
  
  Biochim Biophys Acta. 1722
  
  Pages: 218-223
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Differentiation of organ availability by sequential analysis and simultaneous analysis : intestinal conjugative metabolism impacts on intestinal availability in humans2005
- Author(s)
  Takashi Mizuma, Kosuke Kawashima, Shuichi Sakai, Sayaka Sakaguchi, Masahiro Hayashi
- Journal Title
  
  1. Pharm. Sci. 94
  
  Pages: 571-575
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Simultaneous HPLC assay of lenampicillin (ampicillin prodrug), ampicillin, and marker compound for high-throughput in vitro assessment of intestinal absorption and metabolism using Caco-2 cells.2005
- Author(s)
  Takashi Mizuma, Sayaka.Sakaguchi, Masahiro Hayashi.
- Journal Title
  
  J.Liq.Chromtogr.Rel.Technol. 28
  
  Pages: 1531-1537
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Dietary polyphenols (-)-epicatcchin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption2004
- Author(s)
  Takashi Mizuma, Shoji Awazu
- Journal Title
  
  J. Pharm. Sci. 93
  
  Pages: 2407-2410
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Does the well-stirred model assess the intestinal first-pass effect well?2004
- Author(s)
  Takashi Mizuma, Akira Tsuji, Masahiro Hayashi.
- Journal Title
  
  J Pharm Pharmacol. 56
  
  Pages: 1597-1599
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Factors affecting glucuronidation activity in Caco-2 cells.2004
- Author(s)
  Takashi Mizuma, Ryoichi Momota, Makoto Haga, Masahiro Hayashi.
- Journal Title
  
  Drug Metab Pharmacokinet. 19
  
  Pages: 130-134
- NAID
  10012923619
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Does the well-stirred model assess the intestinal first-pass effect well?2004
- Author(s)
  Mizuma T, Tsuji A, Hayashi M.
- Journal Title
  
  J Pharm Pharmacol. 56(12)
  
  Pages: 1597-1599
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Dietary polyphenols (-)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption2004
- Author(s)
  Mizuma T, Awazu S.
- Journal Title
  
  J Pharm Sci. 93(9)
  
  Pages: 2407-2410
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Does the well-stirred model assess the intestinal first -pass effect well2004
- Author(s)
  Takashi Mizuma, Akira Tsuji, Masahiro Hayashi
- Journal Title
  
  J Pharm Pharmacol. 56
  
  Pages: 1579-1599
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Factors affecting glucuronidation activity in Caco - 2 cells.2004
- Author(s)
  Takashi Mizuma, Ryoichi Momota, Makoto Haga, Masahiro Hayashi
- Journal Title
  
  Drug Metab Pharmacokinet. 19
  
  Pages: 130-134
- NAID
  10012923619
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Factors affecting glucuronidation activity in Caco-2 cells.2004
- Author(s)
  Mizuma T, Momota R, Haga M, Hayashi M.
- Journal Title
  
  Drug Metab Pharmacokinet. 19(2)
  
  Pages: 130-134
- NAID
  10012923619
- Data Source
  KAKENHI-PROJECT-15590141
[Journal Article] Dietary polyphenols (-)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption.2004
- Author(s)
  Takashi Mizuma, Shoji Awazu
- Journal Title
  
  J.Pharm.Sci. 93
  
  Pages: 2407-2410
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590141
[Presentation] タモキシフェンの細胞障害性に対するヘムオキシゲナーゼ-1のヘム分解非依存的な防御効果2022
- Author(s)
  中埜貴文，澤井貴則，菅原康矢，水間俊
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07203
[Presentation] メチオニン・コリン欠乏により惹起される肝細胞内ヘム・ポルフィリン生合成障害2021
- Author(s)
  中埜貴文，斎藤碧，水間俊
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07203
[Presentation] 脂質蓄積モデル細胞におけるヘム生合成変動に関する検討2020
- Author(s)
  中埜貴文、佐和田優弥、宮本裕吏、水間俊、堀江利治
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07203

1. HAYASHI Masahiro (20012669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. HORIE Toshiharu (90120154)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. TOMITA Mikio (60207610)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KAIHO Fusao (10120180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. AWAZU Shoji (60012621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. AKIRA Dobashi (40138962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKANO Takafumi (40720793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

MIZUMA TAKASHI 水間 俊

水間 俊 ミズマ タカシ

MIZUMA Takashi 水間 俊

TAKASHI Mizuma 水間 俊

Research Projects

Research Products

Co-Researchers

Involvement of heme metabolic disorders in hepatocytes in the development of nonalcoholic steatohepatitis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intestinal absorption of dietary compounds and quantitative analysis of their influences on drug absorptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of SGLT1 function and cooperative function of SGLT1 with disaccharidasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

糖吸収機構による難吸収性薬物の吸収改善Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvemrnt of Drug Absorption in Gastro intestinal Tract

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Membrane Permeability and Its Improvement in Intestinal Absorption of Macromolecular Drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 生物薬剤学2006

Author(s)

Publisher

Description

Data Source

[Book] 創薬方法論 : ソリューションガイド20052006

Author(s)

Publisher

Description

Data Source

[Book] 創薬方法論 : ソリューションガイド20052005

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] 糖トランスポーターを利用したDDS2006

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Differentiation of organ availability by sequential and simultaneous analyses : Intestinal conjugative metabolism impacts on intestinal availability in humans.2005

Author(s)

Journal Title

Data Source

[Journal Article] Simultaneous HPLC assay of lenampicillin (ampicillin prodrug), ampicillin, and marker compound for high - throughput in vitro assessment of intestinal absorption in vitro assessment of intestinal absorption2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Kinetic characterization of glycosidase activity from disaccharide conjugate to monosaccharide conjugate in Caco-2 cells.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Intestinal SGLT1-mediated absorption and metabolism of benzyl β-glucoside contained in Purunus mume : carrier-mediated transport increases intestinal availability.2005

MIZUMA TAKASHI 水間俊

水間俊ミズマタカシ

MIZUMA Takashi 水間俊

TAKASHI Mizuma 水間俊