Wang Ji-Yang 王継揚

… Alternative Names

WANG Jiyang 王継揚

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Researcher Number	80231041
Other IDs	https://orcid.org/0000-0003-3038-3826
Affiliation (Current)	2025: 慶應義塾大学, 薬学部(芝共立), 訪問教授
Affiliation (based on the past Project Information) *help	2025: 慶應義塾大学, 薬学部(芝共立), 客員教授 2022: 慶應義塾大学, 薬学部(芝共立), 客員教授 2016 – 2021: 東京医科歯科大学, 難治疾患研究所, 特任講師 2013 – 2015: 東京医科歯科大学, 難治疾患研究所, 講師 2010 – 2012: 独立行政法人理化学研究所, 免疫多様性研究チーム, チームリーダー … More 2004 – 2006: RIKEN, Laboratory for Antigen Receptor Diversity, Head, 免疫多様性研究チーム, チームリーダー 2003: 独立行政法人理化学研究所, B細胞機能研究チーム, チームリーダー 2002: 千葉がんセンター, 病理研究部, 研究員 2001 – 2002: 千葉県がんセンター, 病理研究部, 研究員 1998 – 2000: 千葉県がんセンター, 研究局・病理研究部, 研究員 1998: CHIBA CANCER CENTER RESEARCH INSTITUTE,DIVISION OF PATHOLOGY,RESEARCHER, 病理研究部, 研究員 1995 – 1997: 九州大学, 生体防御医学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Immunology / Biological Sciences / Basic Section 49070:Immunology-related / Immunology / 免疫の制御機構 Except Principal Investigator Biological Sciences / Basic Section 48040:Medical biochemistry-related / Immunology
Keywords	Principal Investigator CD40 / アポトーシス / シグナル伝達 / リンパ球 / 遺伝子 / 免疫学 / transcription factor / proliferation / lymphocyte / 転写因子 … More / 増殖 / apoptosis / 遺伝子発現 / Fas / B細胞 / 液性免疫 / B lymphocyte / 胚中心B細胞 / ミスマッチ修復 / DNAポリメラーゼ / 体細胞変異 / DNA修復 / 突然変異 / 損傷乗り越えDNA合成 / 炎症 / 腸管 / 分子シャペロン / IgA分泌 / Ｂ細胞 / 二量体 / Ｊ鎖 / J鎖 / 形質細胞 / 腸内細菌 / 大腸炎 / 腸管免疫 / Colorectal cancer / Colitis / Mucosal inflammation / MZB1 / IgA / 自己抗体 / 転写伸張因子 / 転写伸長因子 / differentiation / 分化 / B cell antigen receptor / immune response / gene expression / B細胞抗原レセプター / 免疫応答 / activation / B cell / CD40 ligand / Apoptosis / Fas expression / Anti-IgM antibody / zinc fingerモチーフ / CD40L / Fasの発現 / 抗IgM抗体 / IgG受容体 / Bリンパ球 / IgM受容体 / Humoral immunity / IgM Fc receptor / DNA polymerase η / Uracil DNA glycosylase / 胚中心Ｂ細胞 / 細胞分裂 / 抗体遺伝子 / affinity maturation / uracil-DNA glycosylase / abasic site / activation-induced cytidine deaminase / low fidelity DNA polymerase / immunoglobulin gene / somatic hypermutation / 遺伝子改変マウス / DNA損傷修復 / 高親和性抗体 / 免疫グロブリン遺伝子 / 細胞がん化 / ノックアウトマウス / 発がん / DNAポリメラーゼζ … More Except Principal Investigator アポトーシス / シグナル伝達 / ALL / 白血病細胞 / IL7 / 増殖抑制 / 初期T細胞 / 初期B細胞 / インターフェロン / CEACAM-1 / proximity labeling / CD72 / 分化過程での制御 / Proximity labeling / チロシンホスファターゼ / 糖鎖シスリガンド / BCR / CD22 / Siglec / シアル酸 / 免疫不全 / Bリンパ球 / シスリガンド / レクチン / Glycocalyx / signal transduction / G-protein / knockout mouce / apoptosis / tolerance / autoimmunity / tyrosine kinase / antigen receptor / Btk / Lyn / プレB細胞受容体 / リンパ球形成 / 抗体親和性 / 胚中心 / チロンシンキナーゼ / B1細胞 / 自己抗体 / 自己免疫病 / ジーンターゲティング / チロシンキナーゼ / B細胞分化 / Sez4遺伝子 / トランスジェニックマウス / ノックアウトマウス / 損傷乗り越えDNA合成 / DNAポリメラーゼζ / 抗原提示 / 遺伝子治療 / Fasリガンド / TNF-alpha / CD40リガンド Less

記憶B細胞の形成、生存、活性化および分化におけるFcμRの役割と分子機構の解明Principal Investigator
- Principal Investigator
  
  王継揚
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Keio University
Role of MZB1 in the regulation of gut IgA secretion during inflammatory conditionsPrincipal Investigator
- Principal Investigator
  
  Wang Ji-Yang
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Keio University
  Tokyo Medical and Dental University
Regulation of B lymphocyte activation by molecular interactions in glycocalyx
- Principal Investigator
  
  Tsubata Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Tokyo Medical and Dental University
Mechanism of EAF2-mediated elimination of autoreactive germinal center B cellsPrincipal Investigator
- Principal Investigator
  
  WANG JIYANG
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Role of IgM Fc receptor in enhancing humoral immune responses and preventing autoimmunityPrincipal Investigator
- Principal Investigator
  
  Wang Ji-Yang
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Mechanisms of the induction of A:T mutations in the germinal center B cellsPrincipal Investigator
- Principal Investigator
  
  WANG Jiyang
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
Bリンパ球の生存、増殖及びゲノム変異に果すDNAポリメラーゼシータの役割の解明Principal Investigator
- Principal Investigator
  
  王継揚
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Role of novel genes expressed in activated B cells in the regulation of immune responsesPrincipal Investigator
- Principal Investigator
  
  O-WANG Jiyang
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  RIKEN
不忠実なDNAポリメラーゼ群の突然変異誘発及び発がん過程で果たす役割の解明Principal Investigator
- Principal Investigator
  
  王継揚
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba Cancer Center (Research Institute)
B細胞の抗体産生とアポトーシスを制御する新規遺伝子in vivoにおける機能Principal Investigator
- Principal Investigator
  
  王継揚
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba Cancer Center (Research Institute)
アポトーシス細胞死を制御するDNAポリメラーゼζの細胞生存因子としての機能解析
- Principal Investigator
  
  梶原景正
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokai University
Functional analysis of novel genes involved in the regulation of B cell activation and deathPrincipal Investigator
- Principal Investigator
  
  OH Keiyou
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba Cancer Center Research Institute
DNA複製エラーを惹起するDNAポリメラーゼ・ゼータが発がん過程で果たす役割Principal Investigator
- Principal Investigator
  
  王継揚
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba Cancer Center (Research Institute)
遺伝子導入によって活性化された樹状細胞による抗原提示能の強化に基づいた抗腫瘍効果
- Principal Investigator
  
  田川雅敏
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba Cancer Center (Research Institute)
Functional analysis of a novel zinc-finger protein that is expressed in activated B lymphocytes.Principal Investigator
- Principal Investigator
  
  WANG J.o.
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba Cancer Center Research Institute
インターフェロンによるアポトーシス誘導の分子機構-プロB細胞を用いた解析
- Principal Investigator
  
  渡邊武
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Analysis for molecular and cellular mechanism regulating differentiation, activation and programmed cell death of B lymphocytes.
- Principal Investigator
  
  WATANABE Takeshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  KYUSHU UNIVERSITY
Isolation of apoptosis-related genes induced by CD40 ligationPrincipal Investigator
- Principal Investigator
  
  WANG Jiyang
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  免疫の制御機構
- Research Institution
  KYUSHU UNIVERSITY
インターフェロンによる初期B細胞のアポトーシス誘導の分子機構と白血病治療への応用
- Principal Investigator
  
  WATANABE Takeshi
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University

[Journal Article] Cellular Mechanisms Underlying B Cell Abnormalities in Patients With Gain-of-Function Mutations in the PIK3CD Gene2022
- Author(s)
  Wang Wenjie、Min Qing、Lai Nannan、Csomos Krisztian、Wang Ying、Liu Luyao、Meng Xin、Sun Jinqiao、Hou Jia、Ying Wenjing、Zhou Qinhua、Sun Bijun、Hui Xiaoying、Ujhazi Boglarka、Gordon Sumai、Buchbinder David、Schuetz Catharina、Butte Manish、Walter Jolan E.、Wang Xiaochuan、Wang Ji-Yang
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13
- DOI
  10.3389/fimmu.2022.890073
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07547
[Journal Article] Glia maturation factor-γ is involved in S1P-induced marginal zone B-cell chemotaxis and optimal IgM production to type II T-independent antigen2022
- Author(s)
  Li Y, Tang Y, Liu J, Meng X, Wang Y, Min Q, Hong R, Tsubata T, Hase K, Wang JY.
- Journal Title
  
  International Immunology
  
  Volume: 34 Issue: 1 Pages: 35-43
- DOI
  10.1093/intimm/dxab097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07547
[Journal Article] LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway2022
- Author(s)
  Wang Ying、Liu Jun、Akatsu Chizuru、Zhang Runyun、Zhang Hai、Zhu Han、Liu Kangwei、Zhu Han-Ying、Min Qing、Meng Xin、Cui Chaoqun、Tang Yue、Yu Meiping、Li Yaxuan、Feng Xiaoqian、Wei Hao、Wen Zichao、Ji Sihan、Weigert Martin G.、Tsubata Takeshi、Wang Ji-Yang
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 36
- DOI
  10.1073/pnas.2205629119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07547, KAKENHI-PROJECT-21H02679
[Journal Article] RAG1 splicing mutation causes enhanced B cell differentiation and autoantibody production.2021
- Author(s)
  Min Q, Meng X, Zhou Q, Wang Y, Li Y, Lai N, Xiong E, Wang W, Yasuda S, Yu M, Zhang H, Sun J, Wang X, Wang JY.
- Journal Title
  
  JCI Insight
  
  Volume: 6 Issue: 19
- DOI
  10.1172/jci.insight.148887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07547
[Journal Article] Role of Polymeric Immunoglobulin Receptor in IgA and IgM Transcytosis.2021
- Author(s)
  Wei H, Wang JY
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 5 Pages: 2284-2284
- DOI
  10.3390/ijms22052284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07547
[Journal Article] CTLA-4 expression by B-1a B cells is essential for immune tolerance2021
- Author(s)
  Yang Yang、Li Xiao、Ma Zhihai、Wang Chunlin、Yang Qunying et al
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 525-525
- DOI
  10.1038/s41467-020-20874-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07547, KAKENHI-PROJECT-16H06295, KAKENHI-PROJECT-18K07175
[Journal Article] SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination2020
- Author(s)
  Husain Afzal、Xu Jianliang、Fujii Hodaka、Nakata Mikiyo、Kobayashi Maki、Wang Ji‐Yang、Rehwinkel Jan、Honjo Tasuku、Begum Nasim A
- Journal Title
  
  The EMBO Journal
  
  Volume: 39 Issue: 15
- DOI
  10.15252/embj.2019102931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07547, KAKENHI-PROJECT-19H01027, KAKENHI-PROJECT-19K06485
[Journal Article] Effective and safe treatment of a novel IL2RA deficiency with rapamycin2020
- Author(s)
  Lai Nannan、Liu Luyao、Lin Li、Cui Chaoqun、Wang Ying、Min Qing、Xiong Ermeng、Wang Wenjie、Ying Wenjing、Zhou Qinhua、Hou Jia、Sun Jinqiao、Wang Ji-Yang、Wang Xiaochuan
- Journal Title
  
  The Journal of Allergy and Clinical Immunology: In Practice
  
  Volume: 8 Issue: 3 Pages: 1132-1135.e4
- DOI
  10.1016/j.jaip.2019.09.027
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878, KAKENHI-PROJECT-20K07547
[Journal Article] The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis2019
- Author(s)
  Hong Rongjian、Lai Nannan、Ouchida Rika、Xiong Ermeng、Zhou Yang、Min Qing、Liu Jun、Tang Yue、Hikida Masaki、Tsubata Takeshi、Wang Yanqing、Wang Ji‐Yang
- Journal Title
  
  European Journal of Immunology
  
  Volume: 49 Issue: 6 Pages: 911-917
- DOI
  10.1002/eji.201847985
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] MZB1 promotes the secretion of J-chain?containing dimeric IgA and is critical for the suppression of gut inflammation2019
- Author(s)
  Xiong Ermeng、Li Yingqian、Min Qing、Cui Chaoqun、Liu Jun、Hong Rongjian、Lai Nannan、Wang Ying、Sun Jiping、Matsumoto Ryohtaroh、Takahashi Daisuke、Hase Koji、Shinkura Reiko、Tsubata Takeshi、Wang Ji-Yang
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 27 Pages: 13480-13489
- DOI
  10.1073/pnas.1904204116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] Essential role of NADPH oxidase-dependent production of reactive oxygen species in maintenance of sustained B cell receptor signaling and B cell proliferation.2019
- Author(s)
  Feng, Y.-y., Tang, M., Suzuki, M., Gunasekara, C., Anbe, Y., Hiraoka, Y., Liu. J., Grasberger, H., Ohkita, M., Matsumura, Y., Wang, J.-y. and Tsubata, T.
- Journal Title
  
  J. Immunol.
  
  Volume: 202 Pages: 2546-2557
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02610
[Journal Article] The B cell novel protein 1 regulates BCR signaling and B cell apoptosis.2019
- Author(s)
  Hong, R., Lai, N., Ouchida, R., Xiong, E., Zhou, Y., Hikida, M., Tsubata, T., Wang Y.Q. and Wang, J.-Y.
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] A tetrameric form of CD40 ligand with potent biological activities in both mouse and human primary B cells2019
- Author(s)
  Lai Nannan、Min Qing、Xiong Ermeng、Liu Jun、Zhang Lumin、Yasuda Shoya、Wang Ji-Yang
- Journal Title
  
  Molecular Immunology
  
  Volume: 105 Pages: 173-180
- DOI
  10.1016/j.molimm.2018.11.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] Essential Role of NADPH Oxidase?Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation2019
- Author(s)
  Feng Yang-Yang、Tang Miao、Suzuki Mitsuhiro、Gunasekara Chinthika、Anbe Yuki、Hiraoka Yuichi、Liu Jun、Grasberger Helmut、Ohkita Mamoru、Matsumura Yasuo、Wang Ji-Yang、Tsubata Takeshi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 202 Issue: 9 Pages: 2546-2557
- DOI
  10.4049/jimmunol.1800443
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] Distinct roles of BCNP1 in B-cell development and activation2019
- Author(s)
  Hong Rongjian、Lai Nannan、Xiong Ermeng、Ouchida Rika、Sun Jiping、Zhou Yang、Tang Yue、Hikida Masaki、Tsubata Takeshi、Tagawa Masatoshi、Wang Yanqing、Wang Ji-Yang
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 1 Pages: 17-26
- DOI
  10.1093/intimm/dxz055
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878, KAKENHI-PROJECT-20K07547
[Journal Article] MZB1 promotes the secretion of J chain-containing dimeric IgA and is critical for the suppression of gut inflammation2019
- Author(s)
  Xiong, E., Li, Y., Min, Q., Cui, C., Liu, J., Hong, R., Lai, N., Wang, Y., Sun, J., Matsumoto, R., Takahashi, D., Hase, K., Shinkura, R., Tsubata, T. and Wang, J.-Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] A tetrameric form of CD40 ligand with potent biological activities in both mouse and human primary B cells2018
- Author(s)
  Lai, N., Min, Q., Xiong, E., Liu, J., Zhang, L., Yasuda, S. and Wang, J.-Y.
- Journal Title
  
  Mol. Immunol.
  
  Volume: 105 Pages: 173-180
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] Role of the IgM Fc receptor in immunity and tolerance2018
- Author(s)
  Liu, J., Wang, Y., Xiong, E., Hong, R., Ohno, H. and Wang, J.-Y.
- Journal Title
  
  Front. Immunol.
  
  Volume: 10 Pages: 529-529
- DOI
  10.3389/fimmu.2019.00529
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] TLR2 Promotes Glioma Immune Evasion by Downregulating MHC Class II Molecules in Microglia2018
- Author(s)
  Qian, J., Luo, F., Yang, J., Liu, J., Liu, R., Wang, L., Wang, C., Deng, Y., Lu, Z., Wang, Y., Lu, M., Wang, J.-Y. and Chu, Y.
- Journal Title
  
  Cancer Immunol. Res.
  
  Volume: 6 Issue: 10 Pages: 1220-1233
- DOI
  10.1158/2326-6066.cir-18-0020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] FcµR promotes the survival and activation of marginal zone B cells and protects mice against bacterial sepsis2018
- Author(s)
  Liu, J., Zhu, H., Qian, J., Xiong, E., Zhang, L., Chu, Y., Kubagawa, H., Tsubata, T. and Wang, J.-Y.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 160-160
- DOI
  10.3389/fimmu.2018.00160
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development2018
- Author(s)
  Li, S., Liu, J., Min, Q., Ikawa, T., Yasuda, S., Yang, Y., Wang, Y.-Q., Tsubata, T., Zhao, Y. and Wang, J.-Y.
- Journal Title
  
  Int. Immunol.
  
  Volume: 30 Issue: 7 Pages: 311-318
- DOI
  10.1093/intimm/dxy033
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878, KAKENHI-PROJECT-18K19569, KAKENHI-PROJECT-17H04214
[Journal Article] Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development2018
- Author(s)
  Li, S., Liu, J., Min, Q., Ikawa, T., Yasuda, S., Yang, Y., Wang, Y., Tsubata, T., Zhao, Y. and Wang, J.-Y.
- Journal Title
  
  International Immunology
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878
[Journal Article] A model integrating tonic and activated BCR signals to predict the survival of primary B cells2017
- Author(s)
  Yasuda, S., Zhou, Y., Wang, Y., Yamamura, M. and Wang, J.-Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 14888-14888
- DOI
  10.1038/s41598-017-13993-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878, KAKENHI-PROJECT-26280095, KAKENHI-PROJECT-16J10309
[Journal Article] Efficient induction of Ig gene hypermutation in ex vivo-activated primary B cells.2017
- Author(s)
  Liu, J., Xiong, E., Zhu, H., Mori, H., Yasuda, S., Kinoshita, K., Tsubata, T. and Wang, J.-Y.
- Journal Title
  
  Journal of Immunology
  
  Volume: 199 Issue: 9 Pages: 3023-3030
- DOI
  10.4049/jimmunol.1700868
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08878, KAKENHI-PROJECT-16J10309
[Journal Article] EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity2016
- Author(s)
  1.Li, Y., Takahashi, Y., Fujii, S., Zhou, Y., Hong, R., Suzuki, A., Tsubata, T., Hase, K., Wang, J.-Y.
- Journal Title
  
  Nature Commun.
  
  Volume: 7 Issue: 1 Pages: 1-13
- DOI
  10.1038/ncomms10836
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460604, KAKENHI-PUBLICLY-26116709, KAKENHI-PROJECT-25293114
[Journal Article] Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy2016
- Author(s)
  Kawamura, K., Wada, A., Wang, J.-Y., Li, Q., Ishii, A., Tsujimura, H., Takagi, T., Itami, M., Tada, Y., Tatsumi, K., Shimada, H., Hiroshima, K. and Tagawa, M.
- Journal Title
  
  J. Cancer Res. Clin. Oncol.
  
  Volume: 142 Issue: 1 Pages: 27-36
- DOI
  10.1007/s00432-015-2001-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460604
[Journal Article] The bullseye synapse formed between CD4+ T-cell and staphylococcal enterotoxin B-pulsed dendritic cell is a suppressive synapse in T-cell response2015
- Author(s)
  Lin, W., Fan, Z., Suo, Y., Deng, Y., Zhang, M., Wang, J.-Y., Wei, X. and Chu, Y.
- Journal Title
  
  Immunol. Cell Biol.
  
  Volume: 93 Issue: 1 Pages: 99-110
- DOI
  10.1038/icb.2014.76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460604
[Journal Article] B cells expressing CD11b effectively inhibit CD4+ T cell responses and ameliorate experimental autoimmune hepatitis2015
- Author(s)
  Liu, X., Jiang, X., Liu, R., Wang, L., Qian, T., Zheng, Y., Deng, Y., Huang, E., Xu, F., Wang, J.-Y. and Chu, Y.
- Journal Title
  
  Hepatology
  
  Volume: 62 Issue: 5 Pages: 1563-1575
- DOI
  10.1002/hep.28001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460604
[Journal Article] T regulatory cells and B cells cooperate to form a regulatory loop that maintains gut homeostasis and suppresses dextran sulfate sodium-induced colitis2015
- Author(s)
  4.Wang, L., Ray, A., Jiang, X., Wang, J.-Y., Basu, S., Liu, X., Qian, T., He, R., Dittel, B.N. and Chu, Y.
- Journal Title
  
  Mucosal Immunol.
  
  Volume: 8 Issue: 6 Pages: 1297-1312
- DOI
  10.1038/mi.2015.20
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460604
[Journal Article] LAPTM5 promotes lysosomal degradation of intracellular but not the cell surface CD3ζimmunol..2014
- Author(s)
  Kawai, Y., Ouchida, R., Yamasaki, S., Dragone, L., Tsubata, T. and Wang, J.-Y.
- Journal Title
  
  Cell Biol.
  
  Volume: 92 Issue: 6 Pages: 527-534
- DOI
  10.1038/icb.2014.18
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390063, KAKENHI-PROJECT-25460604, KAKENHI-PLANNED-26110009, KAKENHI-PROJECT-26293062, KAKENHI-PROJECT-26293099, KAKENHI-PROJECT-26670213
[Journal Article] A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells2014
- Author(s)
  Zhang, Y., Wang, J.-Y. and Han, W.
- Journal Title
  
  Int. Immunol.
  
  Volume: 26 Issue: 1 Pages: 47-57
- DOI
  10.1093/intimm/dxt042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460604
[Journal Article] FcmR interacts and cooperates with the B cell receptor to promote B cell survival.2014
- Author(s)
  Ouchida. R., Lu. Q., Liu. J., Li. Y., Chu. Y., Tsubata. T. and Wang, J.Y.
- Journal Title
  
  J. Immunol.
  
  Volume: 194 Issue: 7 Pages: 3096-4101
- DOI
  10.4049/jimmunol.1402352
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390063, KAKENHI-PROJECT-25460604, KAKENHI-PROJECT-26293062
[Journal Article] Self DNA from lymphocytes that have undergone activation-induced cell death enhances murine B cell proliferation and antibody production2014
- Author(s)
  Lu, Q., Wang, J.-Y., Wang, L., Jiang, X. and Chu, Y.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 10 Pages: e109095-e109095
- DOI
  10.1371/journal.pone.0109095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460604
[Journal Article] Analysis of Ig gene hypermutation in Ung~<-/->Polh^<-/-> mice suggests that UNG and A:T mutagenesis pathway target different U:G lesions2013
- Author(s)
  Li, S., Zhao, Y. and Wang, J.-Y.
- Journal Title
  
  Mol. Immunol.
  
  Volume: 53 Issue: 3 Pages: 214-217
- DOI
  10.1016/j.molimm.2012.08.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445
[Journal Article] ADAR1 induces adenosine-targeted DNA mutations in senescent Bcl6-deficient cells2013
- Author(s)
  Tsuruoka, N., Arima, M., Yoshida, N., Okada, S., Sakamoto, A., Hatano, M., Satake, H., Arguni, E., Wang, J.-Y., Yang, J.-H., Nishikura, K., Sekiya, S., Shozu, M. and Tokuhisa, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 2 Pages: 826-836
- DOI
  10.1074/jbc.m112.365718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-23659428, KAKENHI-PROJECT-23659772, KAKENHI-PROJECT-24591460, KAKENHI-PROJECT-25460380, KAKENHI-PROJECT-25460604, KAKENHI-PROJECT-25670227
[Journal Article] High levels of AID cause strand bias of mutations at A versus T in Burkitt's lymphoma cells2013
- Author(s)
  Kano, C. and Wang, J.-Y.
- Journal Title
  
  Mol. Immunol.
  
  Volume: 54 Issue: 3-4 Pages: 397-402
- DOI
  10.1016/j.molimm.2013.01.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-25460604
[Journal Article] Complement-activating IgM enhances the humoral but not the T cell immune response in mice2013
- Author(s)
  Ding, Z., Bergman, A., Rutemark, C., Ouchida, R., Ohno, H., Wang, J.-Y. and Heyman, B.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: e81299-e81299
- DOI
  10.1371/journal.pone.0081299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460604
[Journal Article] FcμR (Toso/Faim3) is not an inhibitor of Fas-mediated cell death in mouse T and B cells2013
- Author(s)
  Ouchida, R., Mori, H., Ohno, H. and Wang, J.-Y.
- Journal Title
  
  Blood
  
  Volume: 121 Issue: 12 Pages: 2368-2370
- DOI
  10.1182/blood-2012-12-470906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-25460604
[Journal Article] HSP90α deficiency does not affect Ig gene hypermutation and class switch but causes enhanced MHC class II antigen presentation2012
- Author(s)
  Li, Y., Li, S., Hoshino, M., Ishikawa, R., Kajiwara, C., Gao, X., Zhao, Y., Ishido, S., Udono, H., Wang, J. -Y.
- Journal Title
  
  Int. Immunol.
  
  Volume: 24 Issue: 12 Pages: 751-758
- DOI
  10.1093/intimm/dxs076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02784, KAKENHI-PROJECT-22501027, KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-24590466
[Journal Article] CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema2012
- Author(s)
  Shigeta, A., Tada, Y., Wang, J.-Y., Ishizaki, S., Tuyusaki, J., Yamauchi, K., Kasahara, Y., Iesato, K., Tanabe, N., Takiguchi, Y., Sakamoto, A., Tokuhisa, T., Shibuya, K., Hiroshima, K., West, J. and Tatsumi, K.
- Journal Title
  
  American Journal of Physiology
  
  Volume: 303 Issue: 2 Pages: 141-151
- DOI
  10.1152/ajplung.00337.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-22590850, KAKENHI-PROJECT-23390121, KAKENHI-PROJECT-23591114, KAKENHI-PROJECT-23591136
[Journal Article] LAPTM5 is a positive regulator of pro-inflammatory signaling pathways in macrophages2012
- Author(s)
  Glowacka, W.K., Alberts, P., Ouchida, R., Wang, J.-Y. and Rotin, D.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Issue: 33 Pages: 27691-27702
- DOI
  10.1074/jbc.m112.355917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445
[Journal Article] Analysis of mice deficient in both REV1 catalytic activity and POLH reveals an unexpected role for POLH in the generation of C to G and G to C transversions during Ig gene hypermutation.2012
- Author(s)
  Kano C
- Journal Title
  
  Int Immunol
  
  Volume: 24 Issue: 3 Pages: 169-174
- DOI
  10.1093/intimm/dxr109
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22131001, KAKENHI-PLANNED-22131008, KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-22249005
[Journal Article] Critical role of the IgM Fc receptor in IgM homeostasis, B cell survival and humoral immune responses2012
- Author(s)
  Ouchida, R., Mori, H., Hase, K., Takatsu, H., Kurosaki, T., Tokuhisa, T., Ohno, H., Wang. J. -Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 109 Issue: 40 Pages: 2699-2706
- DOI
  10.1073/pnas.1210706109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02784, KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-22689017, KAKENHI-PROJECT-23390121, KAKENHI-PLANNED-20113003, KAKENHI-PUBLICLY-24117723
[Journal Article] A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosomal-associated protein transmembrane 5.2012
- Author(s)
  Yohei Kawano
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 32 Issue: 21 Pages: 4462-4471
- DOI
  10.1128/mcb.00531-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390097, KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-23790530, KAKENHI-PROJECT-24659225
[Journal Article] Rapid cell division contributes to efficient induction of A/T mutations during Ig gene hypermutation2011
- Author(s)
  Kano C, Ouchida R, Kokubo T, Wane JY
- Journal Title
  
  Molecular Immunology
  
  Volume: 48(15-16) Issue: 15-16 Pages: 1993-1999
- DOI
  10.1016/j.molimm.2011.06.218
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113517, KAKENHI-PROJECT-22590445, KAKENHI-PROJECT-23370077
[Journal Article] HSP90 contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells.2011
- Author(s)
  Imai T, Kato Y, Kajiwara C, Mizukami S, Ishige I, Ichiyanagi T, Hikida M, Wang JY, Udono H.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 108 Issue: 39 Pages: 16363-16368
- DOI
  10.1073/pnas.1108372108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501027, KAKENHI-PROJECT-22590445
[Journal Article] Comparison of two POLQ mutants reveals that a polymerase-inactive POLQ retains significant function in tolerance to etoposide and γ-irradiation in mouse B cells2011
- Author(s)
  Li, Y., Gao, X. and Wang, J.-Y.
- Journal Title
  
  Genes Cells
  
  Volume: 16 Issue: 9 Pages: 973-983
- DOI
  10.1111/j.1365-2443.2011.01550.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445
[Journal Article] Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: confounding role of the inhibitory FcγRIIb(Featured in "In This Issue")2010
- Author(s)
  Masuda, K., Mori, H., Ohara, O., Nakayama, M., Wang, J.-Y. and Burrows, P.
- Journal Title
  
  Cell. Immunol.
  
  Volume: 266 Issue: 1 Pages: 24-31
- DOI
  10.1016/j.cellimm.2010.08.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445
[Journal Article] Identification of TOSO/FAIM3 as an Fc receptor for IgM2010
- Author(s)
  Shima, H., Takatsu, H., Fukuda, S., Ohmae, M., Hase, K., Kubagawa, H., Wang, J.-Y., and Ohno, H.
- Journal Title
  
  Int. Immunol.
  
  Volume: 22 Issue: 3 Pages: 149-156
- DOI
  10.1093/intimm/dxp121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445
[Journal Article] A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface BCR levels and B cell activation2010
- Author(s)
  Ouchida, R., Kurosaki, T. and Wang, J.-Y.
- Journal Title
  
  J. Immunol.
  
  Volume: 185 Issue: 1 Pages: 294-301
- DOI
  10.4049/jimmunol.1000371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445
[Journal Article] Defining the immunological phenotype of Fc receptor-like B(FCRLB)deficient mice : confounding role of the inhibitory FcγRIIb.2010
- Author(s)
  Masuda, K., Mori, H., Ohara, O., Nakayama, M., Wang J.-Y., Burrows, P.
- Journal Title
  
  Cell.Immunol.
  
  Volume: 266 Pages: 24-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445
[Journal Article] A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface BCR levels and B cell activation.2010
- Author(s)
  Ouchida, R., Kurosaki, T., Wang, J.-Y.
- Journal Title
  
  J.Immunol.
  
  Volume: 185 Pages: 294-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445
[Journal Article] A role for c-Fos/AP-1 in B lymphocyte terminal differentiation.2005
- Author(s)
  Ohkubo, Y. et al.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 7703-7710
- Data Source
  KAKENHI-PROJECT-17047047
[Journal Article] Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation elevated expression in human B lymphomas.2003
- Author(s)
  Seimiya, M., O-Wang, J.et al.
- Journal Title
  
  Int.J.Oncol. 22
  
  Pages: 301-304
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590445
[Journal Article] Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation : ubiquitous expression in human B lymphomas.2003
- Author(s)
  Seimiya, M., O-Wang, J.et al.
- Journal Title
  
  Int.J.Oncol. 22
  
  Pages: 301-304
- Data Source
  KAKENHI-PROJECT-15590445
[Journal Article] Fas ligand-expressing tumors induce tumor-specific protective immunity in the inoculate d hosts but vaccination with the apoptotic tumors suppresses antitumor immunity.2003
- Author(s)
  Tada Y., O-Wang, J.et al.
- Journal Title
  
  Cancer Gene Ther. 10
  
  Pages: 134-140
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590445
[Journal Article] T.Appearance of the LAT protein at an early stage of B-cell development and its possible role.2003
- Author(s)
  Oya, K., Wang, J.et al.
- Journal Title
  
  Immunology 109
  
  Pages: 351-359
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590445
[Journal Article] T cell-dependent antitumor effects produced by CD40 ligand expressed on mouse lung carcinoma cells are linked with the maturation of dendritic cells and secretion of a variety of cytokines.2003
- Author(s)
  Tada, Y., O-Wang, J.et al.
- Journal Title
  
  Cancer Gene Ther. 10
  
  Pages: 451-456
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590445
[Journal Article] Fas ligand-expressing tumors induce tumor-specific protective immunity in the inoculated hosts but vaccination with the apoptotic tumors suppresses antitumor immunity.2003
- Author(s)
  Tada Y., O-Wang, J.et al.
- Journal Title
  
  Cancer Gene Ther. 10
  
  Pages: 134-140
- Data Source
  KAKENHI-PROJECT-15590445
[Journal Article] Analysis of mice deficient in both REV1 catalytic activity and POLH reveals an unexpected role for POLH in the generation of C to G and G to C transversions during Ig gene hypermutation
- Author(s)
  Kano C, Hanaoka F, Wang J-Y
- Journal Title
  
  Int.Immunol.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] Development of anti-CD22 antibody that inhibits ligand binding of CD22.2019
- Author(s)
  Long Wang、Endo Ayaka、Takematsu Hiromu、Fedder Thomas、Tsubata Takeshi.
- Organizer
  The Regular Meeting of the Japanese Biochemical Society Kanto Branch
- Data Source
  KAKENHI-PROJECT-18H02610
[Presentation] The IgM Fc receptor positively regulates B cell survival and humoral immune responses2013
- Author(s)
  王　継揚
- Organizer
  BcellNET Meeting
- Place of Presentation
  Uppsala, Sweden
- Invited
- Data Source
  KAKENHI-PROJECT-25460604
[Presentation] Critical role of the IgM Fc receptor in IgM homeostasis, B cell survival and humoral immune responses2012
- Author(s)
  Wang, J.-Y.
- Organizer
  International Symposium of the Japanese Society of Immunology
- Place of Presentation
  Kobe
- Invited
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] The Fc receptor for IgM (FcμR) positively regulates primary and memory B cell responses2012
- Author(s)
  Ouchida R, Mori H, Hase K, Kurosaki T, Ohno H, Wang J-Y
- Organizer
  Keystone Symposium on Regulation of Lymphocyte Signaling
- Place of Presentation
  Keystone, USA
- Year and Date
  2012-03-13
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] Critical role of the IgM Fc receptor in IgM homeostasis2012
- Author(s)
  Wang J-Y
- Organizer
  B cell survival and humoral immune responses International Symposium of the Japanese Society of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] The IgM Fc receptor positively regulates B cell survival and antibody production2012
- Author(s)
  Wang J-Y
- Organizer
  Innovation Summit Tokyo 2012 - Chronic Inflammation and Autoimmune Diseases
- Place of Presentation
  Tokyo
- Year and Date
  2012-04-17
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] The Fc receptor for IgM (FcμR) positively regulates B cell survival and activation2011
- Author(s)
  王継揚
- Organizer
  第40回日本免疫学会総会学術集会
- Place of Presentation
  幕張メッセ(千葉市)(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] The Fc receptor for IgM (FcμR) positively regulates B cell survival and activation2011
- Author(s)
  Wang J-Y
- Organizer
  International Symposium of the Japanese Society of Immunology
- Place of Presentation
  Chiba, Japan
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] The lysosomal protein LAPTM5 negatively regulates B cell activation and antibody production by downmodulating cell surface BCR expression2010
- Author(s)
  Ouchida, R., Wang, J.-Y.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] Induction of A:T mutations is dependent on cellular environment but independent of mutation frequency and target gene location2010
- Author(s)
  Kano C, Ouchida R, Moritan T, Wang J-Y
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] Induction of A:T mutations is dependent on cellular environment but independent of target gene location.2010
- Author(s)
  Wang J, Kano C
- Organizer
  Experimental Biology
- Place of Presentation
  Anaheim, USA
- Year and Date
  2010-04-28
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] The autonomous termination of pre-BCR expression through BLNK-mediated induction of LAPTM52010
- Author(s)
  Kawano Y, Ouchida R, Wang J, Yoshikawa S, Yamamoto M, Kitamura D, Karasuyama H
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] Induction of A : T mutations is dependent on cellular environment but independent of target gene location2010
- Author(s)
  Wang, J.-Y., Kano C.
- Organizer
  Experimental Biology 2010
- Place of Presentation
  USA, Anaheim
- Year and Date
  2010-04-28
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] The lysosomal protein LAPTM5 negatively regulates B cell activation and antibody production by downmodulating cell surface BCR expression2010
- Author(s)
  Ouchida R, Mori H, Wang J-Y
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] LAPTM5 controls B cell antigen receptor levels and negatively regulates B cell activation2010
- Author(s)
  Ouchida R, Wang J-Y
- Organizer
  Keystone Symposium on Lymphocyte Activation and Gene Expression
- Place of Presentation
  Breckenridge, USA
- Year and Date
  2010-03-01
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] Identification and characterization of the elusive IgM Fc receptor (FcμR)2010
- Author(s)
  Kubagawa H, Oka S, Kubagawa Y, Torii I, Takayama E, Kang D, Gartland GL, Bertoli L, Mori H, Takatsu H, Kitamura T, Ohno H, Wang J-Y
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] A transcription factor regulates apoptosis of germinal center B cells and the production of high-affinity antibodies2010
- Author(s)
  Li Y, Ouchida R, Wang J-Y
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] A critical role for REV1 in induction of C : G transitions and A : T mutations during immunoglobulin gene hypermutation2010
- Author(s)
  Masuda K., Li Y., Ouchida, R.Mori H., Wang, J.-Y.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] Induction of A : T mutations is dependent on cellular environment but independent of mutation frequency and target gene location2010
- Author(s)
  Kano C., Ouchida, R., Moritan T., Wang, J.-Y.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] Identification of TOSO/FAIM3 as an Fc receptor for IgM2010
- Author(s)
  Shima H, Takatsu H, Fukuda S, Ohmae M, Hase K, Kubagawa H, Wang J, Ohno H
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] A transcription factor regulates apoptosis of germinal center B cells and the production of high-affinity antibodies2010
- Author(s)
  Li Y., Ouchida, R., Wang, J.-Y.
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] A critical role for REV1 in induction of C:G transitions and A:T mutations during immunoglobulin gene hypermutation2010
- Author(s)
  Masuda K, Li Y, Ouchida R, Mori H, Wang J-Y
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-22590445
[Presentation] EAF2 mediates germinal center B cell apoptosis to suppress excessive humoral immune responses and prevent autoimmunity
- Author(s)
  王　継揚
- Organizer
  2014 Chinese Society of Immunology Annual Meeting
- Place of Presentation
  Jinan, China
- Year and Date
  2014-10-19 – 2014-10-21
- Invited
- Data Source
  KAKENHI-PROJECT-25460604

1. TAGAWA Masatoshi (20171572)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. WATANABE Takeshi (40028684)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. OUCHIDA Rika (80391887)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
4. 梶原景正 (00204397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Tsubata Takeshi (80197756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 幡野雅彦 (20208523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 増田啓次 (60392122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 赤津ちづる (60735984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 古久保哲朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. LI Yingqian

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 今井孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 鵜殿平一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Wang Ji-Yang 王 継揚

WANG Jiyang 王 継揚

Research Projects

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記憶B細胞の形成、生存、活性化および分化におけるFcμRの役割と分子機構の解明Principal Investigator

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Role of MZB1 in the regulation of gut IgA secretion during inflammatory conditionsPrincipal Investigator

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Regulation of B lymphocyte activation by molecular interactions in glycocalyx

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Mechanism of EAF2-mediated elimination of autoreactive germinal center B cellsPrincipal Investigator

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Role of IgM Fc receptor in enhancing humoral immune responses and preventing autoimmunityPrincipal Investigator

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Mechanisms of the induction of A:T mutations in the germinal center B cellsPrincipal Investigator

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Bリンパ球の生存、増殖及びゲノム変異に果すDNAポリメラーゼシータの役割の解明Principal Investigator

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Role of novel genes expressed in activated B cells in the regulation of immune responsesPrincipal Investigator

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不忠実なDNAポリメラーゼ群の突然変異誘発及び発がん過程で果たす役割の解明Principal Investigator

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B細胞の抗体産生とアポトーシスを制御する新規遺伝子in vivoにおける機能Principal Investigator

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アポトーシス細胞死を制御するDNAポリメラーゼζの細胞生存因子としての機能解析

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Functional analysis of novel genes involved in the regulation of B cell activation and deathPrincipal Investigator

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DNA複製エラーを惹起するDNAポリメラーゼ・ゼータが発がん過程で果たす役割Principal Investigator

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Wang Ji-Yang 王継揚

WANG Jiyang 王継揚