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KOIKE Kazuhiko  小池 和彦

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… Alternative Names

小池 和彦  コイケ カズヒコ

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Researcher Number 80240703
Other IDs
Affiliation (Current) 2025: 東京大学, 医学部附属病院, 病院診療医(出向)
Affiliation (based on the past Project Information) *help 2004 – 2017: University of Tokyo, Graduate School of Medicile, Proissor, 医学部附属病院, 教授
2007 – 2008: The University of Tokyo, 医学部・附属病院, 教授
2004: University of Tokyo, Faculty of Medicine, Research Associate
2004: The University of Tokyo, Graduate School of Medicine, Lecturer Professor, 大学院・医学系研究科, 教授
2003: 東京大学, 医学部・附属病院, 助教授 … More
2002 – 2003: THE UNIVERSITY OF TOKYO, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学部附属病院, 助教授
2001 – 2003: The University of Tokyo, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授
1997 – 2001: TOKYO UNIV., DPT OF MEDICINE,ASSOCIATE PROFESSOR, 医学部・附属病院, 助教授
2000: 東京大学, 医学研究科, 助教授
2000: TOKYO UNIV., DPT OF MEDICINE, ASSOCIATE PROFESSOR, 医学部附属病院, 助教授
1999: 東京大学, 医学部・付属病院, 助教授
1998: 東京大学, 医学部附属病院, 助教授
1997: 東京大学, 医学部・付属病院, 講師
1997: 東京大学, 医学部・附属病院, 講師
1997: 東京大学, 医学部附属病院, 講師
1996: 東京大学, 医学部・附属病院, 助手
1992 – 1995: 東京大学, 医学部(病), 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology / Biological Sciences / 内科学一般
Except Principal Investigator
Gastroenterology / Gastroenterology / Biological Sciences / 内科学一般
Keywords
Principal Investigator
トランスジェニックマウス / C型肝炎 / コア蛋白 / transgenic mice / 肝炎 / core protein / hepatitis C virus / C型肝炎ウイルス / 肝癌 / 肝発癌 … More / hepatitis / steatosis / ミトコンドリア / 脂肪化 / エンベロープ蛋白 / B型肝炎ウイルス / hepatocellular carcinoma / 酸化ストレス / HBx遺伝子 / transgenic mouse / ROS / hepatocarcinogenesis / 炎症 / 肝細胞癌 / インスリン抵抗性 / insulin resistance / 脂肪肝 / envelope protein / hepatitis C / 唾液腺炎 / シェ-グレン症候群 / ウイルス / 癌 / 脂質代謝 / プロテアーゼ / 細胞内シグナル伝達 / レプリコン / 肝線維化 / サイトカイン / バキュロウイルス / コア蛋白、 / トランスジェニックマウス、 / アンチセンスDNA / NASH / 内科 / 肥満 / B型肝炎 / nuclear receptor / proteasome activator / metabolism / HCV / プロテアゾームアクチベーター / プロテアゾームアクテベーター / 核内受容体 / プロテアゾームアクティベーター / 代謝 / 肝脂肪化 / electron transfer system / proteomics / mitochondrion / 肝発がん / 電子伝達系 / プロテオミクス / alcohol / cytotoxic lymphocytes / inflammation / hepatocarcinogeneis / アルコール / 細胞障害性リンパ球 / retinoid X receptor / intracellular signal transduction / oxidative stress / アポリポ蛋白 / DNA障害 / β酸化 / AP-1 / MAPK / レチノイドX受容体 / 肺発がん / caspase / protease / protein transduction / カスパーゼ / プロテイン・トランスダクション / reactive oxygen species / 中性脂肪 / トランスジェニックマスス / 不飽和脂肪酸、 / 脂肪化、 / C型肝炎、 / 肝癌、 / RXRレセプター / 不飽和脂肪酸 / IP蛋白 / トランスジェニックマクス / アデノウイルス / アデイウイルス / sialadenitus / auto immune disease / Siogren syndrome / 唾液線炎 / Sialadenitos / シェーグレン症候群 / DNA vaccine / DNAワクチン / vaccine / envelope proteins / ワクチン / 遺伝子変異 / 肝炎ウイルス / 感染症 / 脂肪酸 / 脂質代謝異常 / ウイルス肝炎 / siRNA / ウイルス増殖 / 肝再生 / HIV・HCV重複感染症 / HIV感染症 / 予防薬 / マウスモデル / Cre-loxP / CRE-loxP / 機能解析 / HBx蛋白 / インターフェロンガンマ / サイトカイン、 / バキュロウイルス、 / 肝炎、 / Creリコンビナーゼ / p53 / アポトーシス / 細胞増殖 / X遺伝子 / トランスジェニック・マウス / B型肝炎ウィルス / 遺伝子治療 / NIH3T3細胞 / DNA合成 / 細胞周期 … More
Except Principal Investigator
C型肝炎ウイルス / HCV / cytokine / mutation / HBV-DNA / トランスジェニックマウス / transgenic mouse / tolerance / ROS / TLR3 / HBV / immune suppression therapy / 免疫応答 / インターフェロン / apoptosis / 細胞周期 / 肝癌 / 肝発癌 / nuclear receptor / Lipid metabolism / Insulin resistance / ミトコンドリア / 核内レセプター / 脂質代謝 / インスリン抵抗性 / coagulated volume / development of liver tumors / tumor necrosis / microbubble / HIFU / 肝臓癌モデルrat / 経門脈的投与 / 焼灼体積 / 肺臓癌モデルrat / パルミチン酸 / 腫瘍壊死 / マイクロバブル / 強力集束超音波発信装置 / 核酸変異 / 抗原提示 / alcohol / hydroperoxide / Hepatitis C virus / 脂質 / アルコール / 過酸化脂質 / nuclear receptor hormone / replicon / innate immunity / cyclophilin / genome / hepatitis C virus / 小胞体膜 / NF-kB / コアタンパク質 / 脂肪代謝 / NS5A / リン酸化 / PKR / 細胞増殖 / 肝がん / サイクロスポリン / 複製 / ゲノム / HCVゲノムレプリコン複製 / ウイルスポリメラーゼ / サイクロフィリン / 自然免疫 / 核内受容体 / レプリコン / ウイルスゲノム / アポトーシス / fulminant hepatitis / IFNγ / IL1 / TNFα / 塩基配列 / HBVキャリアー / 免疫抑制剤 / 劇症肝炎 / fulminant hepatits / mouse / prognostic ralue / IgG subtype / interferon / vaccine / peptide / ペプタイト / C型肝炎 / IgGサブクラス / エペトープ / マウス / 治療効果 / IgGサブタイプ / ワクチン / ペプタイド / vitamin D receptor / prostagalndin receptor / FRLP / biopsy specimens / nephron / mRNA quantitation / polymerase chain reaction / reverse-transcription / 生検 / mRNA定量 / ネフロン / プロスタグランジン / 血小板活性化因子 / PCR / RT / anti-oncogene / calcium / tumor promoter / hepatitis virus / hepatoma / 転写調節 / B型肝炎ウイルス / 癌遺伝子 / 肝炎ウィルス / 癌抑制遺伝子 / カルシウム / アポプトーシス / 発癌プロモーター / 肝炎ウイルス / 肝細胞癌 / コア蛋白 / B型肝炎ウイルスX遺伝子 Less
  • Research Projects

    (41 results)
  • Research Products

    (245 results)
  • Co-Researchers

    (37 People)
  •  Elucidation of synergy in hepatocarcinogenesis by hepatitis B virus, inflammation and hypernutritionPrincipal Investigator

    • Principal Investigator
      KOIKE KAZUHIKO
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Elucidation of spiral interactions of virus and inflammation in hepatitis C-associated hepatocarcinogenesis as revealed by microRNA analysisPrincipal Investigator

    • Principal Investigator
      KOIKE KAZUHIKO
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Development of hepatitis C virus suicide therapy employing the viral proteasePrincipal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  C型肝炎ウイルスによる肝発癌機構の解明:細胞内標的の探索と治療法の開発Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Metabolic abnormalities in hepatitis C and its impact on the progression of liver diseasePrincipal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  C型肝炎ウイルスによる肝発癌機構の解明Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  C型肝炎ウイルスRNAのマイクロ断片化によるウイルス増殖制御法の開発Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Hepatitis C as a Metabolic Disease : Pathogenesis for liver cancer and lifestyle-related diseasesPrincipal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  C型肝炎ウイルスによる肝発癌機構の解明Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  HIV感染によるC型慢性肝炎進行促進機序の解明Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Functional abnormality in the mitochondria and pathogenesis of chronic hepatitis C: relation to hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Using microbubbles to increase the destruction of liver tumors by high-intensity focused ultrasound

    • Principal Investigator
      MARUYAMA Toshiyuki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Regulation of hepatocarcinogenesis by using antagonists to retinoid X receptor alpha RXRalpha.

    • Principal Investigator
      MORIYA Kyoji
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  強発癌性B型肝炎ウイルスの同定Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Study on the mechanism of hepatocarcinogenesis in hepatitis C viral infectionPrincipal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  THE ROLES OF HEPATITIS C VIRUS AND INFLAMMATION IN THE PATHOGENESIS OF HEPATOCELLULAR CARCINOMAPrincipal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  The comparison of virus genome and immune reaction between asymptomatic carriers and chronic hepatitis patients infected with HBV.

    • Principal Investigator
      MARUYAMA Toshiyuki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Preventive measure of the development of hepatocellular carcinoma by hepatitis C virus infection

    • Principal Investigator
      SHIMOTOHNO Kunitada
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  DEVELOPMENT OF THERAPY FOR HEPATITIS C USING PROTEIN TRANSDUCTION METHODPrincipal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Studies on synergistic effects of the HBV and HCV in hepatocarcinogenesis by using transgenic mice model

    • Principal Investigator
      MORITA Kyoji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  肝発癌制御ワクチンの開発Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  ELUCIDATION OF HEPATOCARINOGENESIS IN HEPATITIS C VIRUS INFECTION USING TRANSGENIC MICE.Principal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  THE MECHANISM OF STEATOSIS IN CHRONIC HEPATITIS : THE ROLE IN HEPATOCARCINOGENESIS.Principal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Gastroenterology
    • Research Institution
      UNIVERSITY OF TOKYO
  •  The mechanism which causes fulminant hepatic failure after immune suppression therapy on HBV carrier patients

    • Principal Investigator
      MARUYAMA Toshiyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  トランスジェニックマウスを用いたC型肝炎ウイルスによる肝発癌機構の解明Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  DEVELOPMENT OF ANT-VIRAL HEPATITIS THERAPY WITH BACULOVIRAL VECTORS CARRYING CYTOKINE GENES.Principal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      UNIVERSITY OF TOKYO
  •  トランスジェニックマウスを用いたC型肝炎ウイルスによる肝発癌機構の解明Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Investigation for the development of vaccine against hepatitis C virus

    • Principal Investigator
      MARUYAMA Toshiyuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Analysis of Mechanism of Sjogren Syndrome Developing in Chronic Investigator :Principal Investigator

    • Principal Investigator
      KOIKE Kazuhiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo
  •  B型肝炎ウイルスX蛋白の癌化・アポトーシス作用とp53蛋白との関連の解明Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  肝発癌におけるC型肝炎コア蛋白の遺伝子発現修飾作用とその細胞内結合蛋白の同定

    • Principal Investigator
      MARUYAMA Toshiyuki
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  DEVELOPMENT OF HEPATITIS THERAPY AND VACCINE USING HEPATITIS C VIRUS TRANSGENIC MICEPrincipal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Gastroenterology
    • Research Institution
      TOKYO UNIVERSITY
  •  B型肝炎肝発癌モデルを用いたアンチセンスオリゴヌクレオテドによる遺伝子治療Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  B型肝炎肝発癌マウスモデルを用いたアンチセンスオリゴヌクレオチドによる遺伝子治療Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  C型肝炎ウイルスコア蛋白の細胞同期進行中の細胞内局在の変化とその肝発癌への関与

    • Principal Investigator
      四柳 宏
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Development of easy and quantitative reverse transcription-polymerase chain reaction method (MRT-PCR) for minute clinical samples and its clinical applications

    • Principal Investigator
      WATANABE Tsuyoshi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      University of Tokyo
  •  Transgenic mice carrying hepatitis C Virus genomePrincipal Investigator

    • Principal Investigator
      KOIKE Kazuhiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo
  •  トランスジェニックマウスを用いたB型肝炎ウイルスX遺伝子による肝発癌機構の解析Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  B型肝炎ウイルスX遺伝子の肝発癌における細胞周期促進とアポトーシス誘発作用の解析Principal Investigator

    • Principal Investigator
      小池 和彦
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  トランスジェニックマウスを用いたB型肝炎ウイルスX遺伝子による肝発癌機構の解析

    • Principal Investigator
      HASHIMOTO Yoshiaki
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  Effects of hepatitis virus gene expression on the action of tumor promoters

    • Principal Investigator
      KANEKO Yoshiyasu
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tokyo

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All Journal Article Presentation Book Patent

  • [Book] 肝癌 診療ガイドラインUP-TO-DATE2012

    • Author(s)
      建石良介、小池和彦
    • Total Pages
      455
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Book] 肝癌 診療ガイドライン UP-TO-DATE2012

    • Author(s)
      建石良介、小池和彦
    • Total Pages
      455
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Book] 肝癌診療ガイドラインUP-TO-DATE2012

    • Author(s)
      建石良介,小池和彦
    • Total Pages
      455
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Book] 肥満と消化器疾患2010

    • Author(s)
      小池和彦(共著)
    • Total Pages
      224
    • Publisher
      金原出版
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Book] 肝臓病診療Q&A2009

    • Author(s)
      小池和彦, 他
    • Total Pages
      312
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Book] 肝臓病診療Q&A2009

    • Author(s)
      小池和彦, 他
    • Total Pages
      31
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-20012013
  • [Book] NASH診療best approach2008

    • Author(s)
      小池和彦、他
    • Total Pages
      20
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-20012013
  • [Book] NASH診療best approach2008

    • Author(s)
      小池和彦、他
    • Total Pages
      264
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Book] 肝癌診療マニュアル2007

    • Author(s)
      小池和彦
    • Total Pages
      135
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-18659203
  • [Book] 肝癌疹療マニュアル2007

    • Author(s)
      小池 和彦
    • Total Pages
      135
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-18390214
  • [Book] 肝癌診療マニュアル2007

    • Author(s)
      小池和彦
    • Total Pages
      135
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390214
  • [Book] 肝癌診療マニュアル2007

    • Author(s)
      小池和彦
    • Total Pages
      135
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-18012014
  • [Book] 肝癌の診療-最新の進歩2006

    • Author(s)
      小池和彦
    • Total Pages
      340
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-18390214
  • [Book] 肝癌の診療-最新の進歩2006

    • Author(s)
      小池和彦
    • Total Pages
      340
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-18012014
  • [Book] 肝癌の診療-最新の進歩2006

    • Author(s)
      小池和彦
    • Total Pages
      340
    • Publisher
      日本メディカルセンター
    • Data Source
      KAKENHI-PROJECT-18659203
  • [Book] 人体の構造と機能及び疾病の成り立ち2005

    • Author(s)
      小池和彦
    • Total Pages
      340
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-17659210
  • [Book] 人体の構造と機能及び疾病の成り立ち2005

    • Author(s)
      小池和彦
    • Total Pages
      340
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-17013026
  • [Journal Article] DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels2018

    • Author(s)
      Sekiba K, Otsuka M, Ohno M, Kishikawa T, Yamagami M, Suzuki T, Ishibashi R, Seimiya T, Tanaka E, Koike K.
    • Journal Title

      Oncotarget

      Volume: 9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Journal Article] CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity2018

    • Author(s)
      Fujiwara Naoto、Nakagawa Hayato、Enooku Kenichiro、Otsuka Motoyuki、Tateishi Keisuke、Koike Kazuhiko
    • Journal Title

      Gut

      Volume: 67 Issue: 8 Pages: 1493-1504

    • DOI

      10.1136/gutjnl-2017-315193

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K19313, KAKENHI-PROJECT-16K19075, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-16K09342
  • [Journal Article] Relationship of muscle cramps to quality of life and sleep disturbance in patients with chronic liver diseases: a nationwide study2018

    • Author(s)
      Iwasa Motoh、Karino Yoshiyasu、Kawaguchi Takumi、Nakanishi Hiroyuki、Miyaaki Hisamitsu、Shiraki Makoto、Nakajima Tomoaki、Sawada Yasuhiko、Yoshiji Hitoshi、Okita Kiwamu、Koike Kazuhiko
    • Journal Title

      Liver International

      Volume: 38 Issue: 12 Pages: 2309-2316

    • DOI

      10.1111/liv.13745

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Journal Article] RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis2017

    • Author(s)
      Takata Akemi、Otsuka Motoyuki、Kishikawa Takahiro、Yamagami Mari、Ishibashi Rei、Sekiba Kazuma、Suzuki Tatsunori、Ohno Motoko、Yamashita Yui、Abe Takaya、Masuzaki Ryota、Ikenoue Tsuneo、Koike Kazuhiko
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 39 Pages: 64840-64852

    • DOI

      10.18632/oncotarget.17609

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16KT0109, KAKENHI-PROJECT-16K09344, KAKENHI-PROJECT-17K15923, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-16H05149
  • [Journal Article] Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands.2017

    • Author(s)
      Nakagawa H, Suzuki N, Hirata Y, Hikiba Y, Hayakawa Y, Kinoshita H, Ihara S, Uchino K, Nishikawa Y, Ijichi H, Otsuka M, Arita J, Sakamoto Y, Hasegawa K, Kokudo N, Tateishi K, Koike K.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 114(19) Issue: 19

    • DOI

      10.1073/pnas.1619416114

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15107, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K09038, KAKENHI-PROJECT-15K09039
  • [Journal Article] Transcriptional activation of the MICA gene with an engineered CRISPR-Cas9 system2017

    • Author(s)
      Sekiba K, Yamagami M, Otsuka M, Suzuki T, Kishikawa T, Ishibashi R, Ohno M, Sato M, Koike K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: - Issue: 2 Pages: 521-525

    • DOI

      10.1016/j.bbrc.2017.03.076

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-26460984, KAKENHI-PROJECT-16KT0109, KAKENHI-PROJECT-17K09405, KAKENHI-PROJECT-17K15923, KAKENHI-PROJECT-16H05149
  • [Journal Article] Response criteria of tolvaptan for the treatment of hepatic edema2017

    • Author(s)
      Hiramine Yasunari、Uojima Haruki、Nakanishi Hiroyuki、Hiramatsu Akira、Iwamoto Takuya、Kimura Mutsuumi、Kawaratani Hideto、Terai Shuji、Yoshiji Hitoshi、Uto Hirofumi、Sakaida Isao、Izumi Namiki、Okita Kiwamu、Koike Kazuhiko
    • Journal Title

      Journal of Gastroenterology

      Volume: 53 Issue: 2 Pages: 258-268

    • DOI

      10.1007/s00535-017-1366-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Journal Article] Mortality and hemorrhagic complications associated with radiofrequency ablation for treatment of hepatocellular carcinoma in patients on hemodialysis for end-stage renal disease: A nationwide survey.2017

    • Author(s)
      Sato M, Tateishi R, Yasunaga H, Matsui H, Horiguchi H, Fushimi K, Koike K.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 32 Issue: 11 Pages: 1873-1878

    • DOI

      10.1111/jgh.13780

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09342, KAKENHI-PROJECT-17K09405, KAKENHI-PROJECT-15H04807
  • [Journal Article] Randomized prospective study showing the non-inferiority of tenofovir to entecavir in treatment-na?ve chronic hepatitis B patients2017

    • Author(s)
      Koike Kazuhiko、Suyama Kazuaki、Ito Hiroshi、Itoh Hiroshi、Sugiura Wataru
    • Journal Title

      Hepatology Research

      Volume: 48 Issue: 1 Pages: 59-68

    • DOI

      10.1111/hepr.12902

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Journal Article] The intrahepatic expression levels of bile acid transporters are inversely correlated with the histological progression of nonalcoholic fatty liver disease2016

    • Author(s)
      Okushin K, Tsutsumi T, Enooku K, Fujinaga H, Kado A, Shibahara J, Fukayama M, Moriya K, Yotsuyanagi H, Koike K
    • Journal Title

      J Gastroenterol

      Volume: 51 Issue: 8 Pages: 808-818

    • DOI

      10.1007/s00535-015-1148-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Journal Article] Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.2016

    • Author(s)
      Enooku K, Uranbileg B, Ikeda H, Kurano M, Sato M, Kudo H, Maki H, Koike K, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 9 Pages: e0161825-e0161825

    • DOI

      10.1371/journal.pone.0161825

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05906, KAKENHI-PROJECT-15H04807
  • [Journal Article] p62, upregulated during preneoplasia, induces hepatocellular carcinogenesis by maintaining survival of stressed HCC-initiating cells2016

    • Author(s)
      Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M
    • Journal Title

      Cancer Cell

      Volume: 29 Issue: 6 Pages: 935-948

    • DOI

      10.1016/j.ccell.2016.04.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-15K19313
  • [Journal Article] Mutual antagonism between hepatitis B viral mRNA and host microRNA let-7.2016

    • Author(s)
      Takata A, Otsuka M, Ohno M, Kishikawa T, Yoshikawa T, Koike K.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 23237-23237

    • DOI

      10.1038/srep23237

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293076, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-26860492
  • [Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine2015

    • Author(s)
      Kishikawa T, Otsuka M, Tan PS, Ohno M, Sun X, Yoshikawa T, Shibata C, Takata A, Kojima K, Takehana K, Ohishi M, Ota S, Noyama T, Kondo Y, Sato M, Soga T, Hoshida Y, Koike K
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 8339-8352

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Journal Article] Sarcopenia, Intramuscular Fat Deposition, and Visceral Adiposity Independently Predict the Outcomes of Hepatocellular Carcinoma2015

    • Author(s)
      Fujiwara N, Nakagawa H, Kudo Y, Tateishi R, Taguri M, Watadani T, Nakagomi R, Kondo M, Nakatsuka T, Minami T, Sato M, Uchino K, Enooku K, Kondo Y, Asaoka Y, Tanaka Y, Ohtomo K, Shiina S, Koike K
    • Journal Title

      J Hepatol

      Volume: 62 Issue: 1 Pages: 131-140

    • DOI

      10.1016/j.jhep.2015.02.031

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-26460985, KAKENHI-PROJECT-15H04806, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-25460979
  • [Journal Article] Mitochondrial iron accumulation exacerbates hepatic toxicity caused by hepatitis C virus core protein2015

    • Author(s)
      Sekine S, Ito K, Watanabe H, Nakano T, Moriya K, Shintani Y, Fujie H, Tsutsumi T, Miyoshi H, Fujinaga H, Shinzawa S, Koike K, Horie T.
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 282 Issue: 3 Pages: 237-243

    • DOI

      10.1016/j.taap.2014.12.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084
  • [Journal Article] DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences.2015

    • Author(s)
      Watanabe Y, Yamamoto H, Oikawa R, Toyota M, Yamamoto M, Kokudo N, Tanaka S, Arii S, Yotsuyanagi H, Koike K, Itoh F.
    • Journal Title

      Genome Research

      Volume: 25(3) Issue: 3 Pages: 328-337

    • DOI

      10.1101/gr.175240.114

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-22130005, KAKENHI-PUBLICLY-15H01484, KAKENHI-PROJECT-25253081, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-25460937
  • [Journal Article] ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression2015

    • Author(s)
      Yoshikawa, T. Wu, J. Otsuka, M. Kishikawa, T. Ohno, M. Shibata, C. Takata, A. Han, F. Kang, Y. J. Chen, C. A. Shyu, A. B. Han, J. Koike, K
    • Journal Title

      Nucleic Acids Res

      Volume: 43(15) Issue: 15 Pages: 7577-89

    • DOI

      10.1093/nar/gkv728

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860492, KAKENHI-PROJECT-15H04807, KAKENHI-PROJECT-25860520, KAKENHI-PROJECT-25293076
  • [Journal Article] ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development2014

    • Author(s)
      Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M.
    • Journal Title

      Cancer Cell

      Volume: 26 Issue: 3 Pages: 331-343

    • DOI

      10.1016/j.ccr.2014.07.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25893042
  • [Journal Article] In vitro selection of the 3'-untranslated regions of the human liver mRNA that bind to the HCV nonstructural protein 5B2014

    • Author(s)
      Yuhashi K, Ohnishi S, Kodama T, Koike K, Kanamori H
    • Journal Title

      Virology

      Volume: 4510 Pages: 13-23

    • DOI

      10.1016/j.virol.2013.11.036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Journal Article] Impact of IL28B Genetic Variation on HCV-Induced Liver Fibrosis, Inflammation, and Steatosis: A Meta-Analysis.2014

    • Author(s)
      Sato M, Kondo M, Tateishi R, Fujiwara N, Kato N, Yoshida H, Taguri M, Koike K
    • Journal Title

      PLoS One

      Volume: 9 Issue: 3 Pages: e91822-e91822

    • DOI

      10.1371/journal.pone.0091822

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-24390184
  • [Journal Article] Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models.2014

    • Author(s)
      Nguyen T, Xu J, Chikuma S, Hiai H, Kinoshita K, Moriya K, Koike K, Marcuzzi GP, Pfister H, Honjo T, Kobayashi M.
    • Journal Title

      Int Immunol

      Volume: 26 Issue: 7 Pages: 397-406

    • DOI

      10.1093/intimm/dxu040

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-25460363, KAKENHI-PROJECT-22000015
  • [Journal Article] Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.2014

    • Author(s)
      Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111 Issue: 3 Pages: 1090-1095

    • DOI

      10.1073/pnas.1322731111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390092, KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25290045, KAKENHI-PROJECT-25670186, KAKENHI-PROJECT-25893042
  • [Journal Article] Amphipathic α-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus Particles2014

    • Author(s)
      Fukuhara T, Wada M, Nakamura S, Ono C, Shiokawa M, Yamamoto S, Motomura T, Okamoto T, Okuzaki D, Yamamoto M, Saito I, Wakita T, Koike K, Matsuura Y
    • Journal Title

      PLoS Pathog

      Volume: 10(12) Issue: 12 Pages: e1004534-e1004534

    • DOI

      10.1371/journal.ppat.1004534

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-24390113, KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-24700429, KAKENHI-PUBLICLY-25115511, KAKENHI-PROJECT-25460566, KAKENHI-PROJECT-26670221
  • [Journal Article] High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential.2013

    • Author(s)
      Uranbileg B, Enooku K, Soroida Y, Ohkawa R, Kudo Y, Nakagawa H, Tateishi R, Yoshida H, Shinzawa S, Moriya K, Ohtomo N, Nishikawa T, Inoue Y, Tomiya T, Kojima S, Matsuura T, Koike K, Yatomi Y, Ikeda H.
    • Journal Title

      Int J Cancer.

      Volume: 134 Issue: 9 Pages: 2189-98

    • DOI

      10.1002/ijc.28547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590961, KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-25460981
  • [Journal Article] MiRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity via directly targeting Dnmt1 expression2013

    • Author(s)
      Takata A, Otsuka M, Yoshikawa T, Kishikawa T, Hikiba Y, Obi S, Goto T, Kang YJ, Maeda S, Yoshida H, Omata M, Asahara H, Koike K
    • Journal Title

      Hepatology

      Volume: 57 Pages: 162-170

    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Mortality and morbidity of hepatectomy, radiofrequency ablation, and embolization for hepatocellular carcinoma: a national survey of 54,145 patients2012

    • Author(s)
      Sato M, Tateishi R, Yasunaga H, Horiguchi H, Yoshida H, Matsuda S, Koike K
    • Journal Title

      J Gastroenterol

      Volume: 22426637 Pages: 1-5

    • NAID

      10031122101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] A miRNA machinery component DDX20 controls NF-κB via microRNA-140 function2012

    • Author(s)
      Takata A, Otsuka M, Yoshikawa T, Kishikawa T, Kudo Y, Goto T, Yoshida H, Koike K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 22445758 Pages: 1-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation2012

    • Author(s)
      Kudo Y, Tateishi K, Yamamoto K, Yamamto S, Asaoka Y, Ijichi H, Nagae G, Yoshida H, Aburatani H, Koike K
    • Journal Title

      Cancer Sci

      Volume: 103(4) Pages: 670-676

    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Expression of miR-122 facilitates an efficient replication innonhepatic cells upon infection with HCV2012

    • Author(s)
      Fukuhara T, Kambara H, Shiokawa M, Ono C, Katoh H, Morita E, Okuzaki D, Maehara Y, Koike K, Matsuura Y
    • Journal Title

      J Virol

      Volume: 86(15) Pages: 7918-7933

    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation2012

    • Author(s)
      Yoshikawa T, Takata A, Otsuka M, Kishikawa T, Kojima K, Yoshida H, Koike K
    • Journal Title

      Sci Rep

      Volume: 2 Pages: 637-637

    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Increased activity of serum mitochondrial isoenzyme ofcreatine kinase in hepatocellular carcinoma patients predominantly with recurrence2012

    • Author(s)
      Soroida Y, Ohkawa R, Nakagawa H, Satoh Y, Yoshida H, Kinoshita H, Tateishi R, Masuzaki R, Enooku K, Shiina S, Sato T, Obi S,Hoshino T, Nagatomo R, Okubo S, Yokota H, Koike K, Yatomi Y, Ikeda H
    • Journal Title

      J Hepatol

      Volume: 57(2) Pages: 330-336

    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Systemic combination therapy of intravenous continuous 5-fluorouracil and subcutaneous pegylated interferon alfa-2a for advanced hepatocellular carcinoma.2012

    • Author(s)
      Uchino K, Obi S, Tateishi R, Sato S, Kanda M, Sato T, Arano T, Enooku K, Goto E, Masuzaki R, Nakagawa H, Asaoka Y, Kondo Y, Yamashiki N, Goto T, Shiina S, Omata M, Yoshida H, Koike K
    • Journal Title

      J Gastroenterol

      Volume: 22438097 Pages: 1-5

    • NAID

      10031122104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Characteristics of hepatocellular carcinoma nodules newly detected by computed tomography during arteriography and arterial portography: preliminary report of a randomized controlled trial2011

    • Author(s)
      Ohki T, Tateishi R, Akahane M, Shiina S, Yamashiki N, Mikami S, Enooku K, Goto E, Masuzaki R, Kondo Y, Goto T, Inoo S, Ohtomo K, Omata M, Yoshida H, Koike K
    • Journal Title

      Hepatol Int

      Volume: 22020826 Pages: 1-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Autotaxin as a novel serum marker of liver fibrosis.2011

    • Author(s)
      Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y.
    • Journal Title

      Clin Chim Acta 412(13-14)

      Pages: 1201-1206

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Effect of treatment with polynsatured fatty acids on HCV-or diet-induced fatty liver.2011

    • Author(s)
      Koike K, Miyoshi H, Yotsyanagi H, Moriya K.
    • Journal Title

      J Hepatol 54

      Pages: 1326-1326

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: impact on patient's prognosis.2011

    • Author(s)
      Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
    • Journal Title

      Liver Int 31

      Pages: 197-205

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Plant sterols increased IL-6 and TNF-alpha secretion from macrophages, but to a lesser extent than cholesterol.2011

    • Author(s)
      Kurano M, Iso-O N, Hara M, Noiri E, Koike K, Kadowaki T, Tsukamoto K.
    • Journal Title

      J Atheroscler Thromb, [Epub ahead of print] PubMed PMID

      Pages: 21266789-21266789

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma2011

    • Author(s)
      Yasui K, Hashimoto E, Komorizono Y, Koike K, Arii S, Imai Y, Shima T, Kanhara Y, Saihara T, Mori T, Kawata S, Uto H, Takami S, Sumida Y, Takamura T, Kawanaka M, Okanoue T
    • Journal Title

      Clin Gastroenterol Hepatol

      Volume: 右記参照

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.2011

    • Author(s)
      Kumar V, Kato N, Urabe Y, Takahashi A, Muroyama R, Hosono N, Otuska M, Tateishi R, Omata M, Nakagawa H, Koike K, Kamatani N, Kubo M, Nakamura Y, Matsuda K.
    • Journal Title

      Nat Genet 43(5)

      Pages: 455-458

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Pathogenesis of lipid metabolism disorder in hepatitis C : polyunsaturated fatty acids counteract lipid alterations induced by the core protein.2011

    • Author(s)
      Miyoshi H, Moriya K, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K.
    • Journal Title

      J Hepatol

      Volume: 54 Pages: 432-438

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK2011

    • Author(s)
      Nakagawa H, Hirata Y, Iakeda K, Hayakawa Y, Sato T, Kinoshita H, Sakamoto K, Nakata W, Hikiba Y, Omata M, Yoshida H, Koike K, Ichijo H, Maeda S.
    • Journal Title

      Hepatology

      Volume: 右記参照

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Hepatocellular carcinoma with extrahepatic metastasis: Clinical features and prognostic factors.2011

    • Author(s)
      Uchino K, Tateishi R, Shiina S, Kanda M, Masuzaki R, Kondo Y, Goto T, Omata M, Yoshida H, Koike K.
    • Journal Title

      Cancer, [Epub ahead of print] PubMed PMID

      Pages: 21437884-21437884

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines2011

    • Author(s)
      Takata A, Otsuka M, Kogiso T, Kojima K, Yoshikawa T, Tateishi R, Kato N, Shiina S, Yoshida H, Omata M, Koike K
    • Journal Title

      Hepatol Int

      Volume: 21484132 Pages: 1-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK.2011

    • Author(s)
      Nakagawa H, Hirata Y, Takeda K, Hayakawa Y, Sato T, Kinoshita H, Sakamoto K, Nakata W, Hikiba Y, Omata M, Yoshida H, Koike K, Ichijo H, Maeda S.
    • Journal Title

      Hepatology, [Epub ahead of print] PubMed PMID

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Hepatocellular carcinoma with extrahepatic metastasis : Clinical features and prognostic factors2011

    • Author(s)
      Uchino K, Tateishi R, Shiina S, Kanda M, Masuzaki R, Kondo Y, Goto T, Omata M, Yoshida H, Koike K.
    • Journal Title

      Cancer

      Volume: 右記参照

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Utility of contrast enhanced ultrasonography with sonazoid in radiofrequency ablation for hepatocellular carcinoma.2011

    • Author(s)
      Masuzaki R, Shiina S, Tateishi R, Yoshida H, Goto E, Sugioka Y, Kondo Y, Goto T, Ikeda H, Omata M, Koike K.
    • Journal Title

      J Gastroenterol Hepatol 26(4)

      Pages: 759-764

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma : impact on patient's prognosis2011

    • Author(s)
      Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
    • Journal Title

      Liver Int

      Volume: 31 Pages: 197-205

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt.2011

    • Author(s)
      W.Sievert, I.Altraif, H.A.Razavi, A.Abdo, E.A.Ahmed, A.AlOmair, D.Amarapurkar, C.-H.Chen, X.Dou, H.El Khayat, M.elShazly, G.Esmat, R.Guan, K.-H.Han, K.Koike, A.Largen, G.McCaughan, S.Mogawer, A.Monis, A.Nawaz, T.Piratvisuth, F.M.Sanai, A.I.Sharara, S.Sibbel, A.Sood, D.J.Suh, C.Wallace, K.Young, F.Negro.
    • Journal Title

      Liver Int 31(S2)

      Pages: 61-80

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Living donor liver transplantations in HIV- and hepatitis C virus-coinfected hemophiliacs: Experience in a Single Center.2011

    • Author(s)
      Tsukada K, Sugawara Y, Kaneko J, Tamura S, Tachikawa N, Morisawa Y, Okugawa S, Kikuchi Y, Oka S, Kimura S, Yatomi Y, Makuuchi M, Kokudo N, Koike K.
    • Journal Title

      Transplantation, [Epub ahead of print] PubMed PMID

      Pages: 21593704-21593704

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Liquid chromatographic separation of proteins derivatized with a fluorogenic reagent at cysteinyl residues on a non-porous column for differential proteomics analysis.2011

    • Author(s)
      Koshiyama A, Ichibangase T, Moriya K, Koike K, Yazawa I, Imai K.
    • Journal Title

      J Chromatogr A, [Epub ahead of print] PubMed PMID

      Pages: 21511262-21511262

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Autotaxin as a novel serum marker of liver fibrosis2011

    • Author(s)
      Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki, J, Koike K, Yatomi Y.
    • Journal Title

      Clin Chim Acta

      Volume: 右記参照

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients2011

    • Author(s)
      Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K
    • Journal Title

      Int J Cancer

      Volume: 129(9) Pages: 2226-2235

    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines2011

    • Author(s)
      Takata A, Otsuka M, Kogiso T, Kojima K, Yoshikawa T, Tateishi R, Kato N, Shiina S, Yoshida H, Omata M, Koike K.
    • Journal Title

      Hepatol Int

      Volume: 右記参照

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Evaluation of molecular targeted cancer drug by changes in tumor marker doubling times2011

    • Author(s)
      Enooku K, Tateishi R, Kanai F, Kondo Y, Masuzaki R, Goto T, Shiina S, Yoshida H, Omata M, Koike K
    • Journal Title

      J Gastroenterol

      Volume: 21935635 Pages: 1-5

    • NAID

      10030295766

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Journal Article] Effect of treatment with polynsatured fatty acids on HCV-or diet-induced fatty liver2011

    • Author(s)
      Koike K, Miyoshi H, Yotsyanagi H, Moriya K.
    • Journal Title

      J Hepatol

      Volume: 右記参照

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines.2011

    • Author(s)
      Takata A, Otsuka M, Kogiso T, Kojima K, Yoshikawa T, Tateishi R, Kato N, Shiina S, Yoshida H, Omata M, Koike K.
    • Journal Title

      Hepatol Int, [Epub ahead of print] PubMed PMID

      Pages: 21484132-21484132

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] The Japan NASH Study Group, The Ministry of Health, Labour and Welfare of Japan.Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma.2011

    • Author(s)
      Yasui K, Hashimoto E, Komorizono Y, Koike K, Arii S, Imai Y, Shima T, Kanbara Y,Saibara T, Mori T, Kawata S, Uto H, Takami S, Sumida Y, Takamura T, Kawanaka M, Okanoue T
    • Journal Title

      Clin Gastroenterol Hepatol 9(5)

      Pages: 428-433

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] NegroThe global health burden of hepatitis C virus infection.2011

    • Author(s)
      D.Kershenobich, H.A.Razavi, C.L.Cooper, A.Alberti, G.M.Dusheiko, S.Pol, E.Zuckerman, K.Koike, K.-H.Han, C.M.Wallace, S.Zeuzem , F.
    • Journal Title

      Liver Int 31(S2)

      Pages: 4-17

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein.2011

    • Author(s)
      Miyoshi H, Moriya K, Tsutsumi T Shinzawa S, Fujie H, Shintani Y, Fujinaga H, Goto K, Todoroki T, Suzuki T, Miyamura T, Matsuura Y, Yotsuyanagi H, Koike K.
    • Journal Title

      J Hepatol 54

      Pages: 432-438

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.2011

    • Author(s)
      Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Kinoshita H, Nakata W, Takahashi R, Tateishi K, Tada M, Akanuma M, Yoshida H, Takeda K, Ichijo H, Omata M, Maeda S, Koike K.
    • Journal Title

      Proc Natl Acad Sci USA 108

      Pages: 780-785

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Lipid metabolism and pathogenesis of liver disease in hepatitis C viral infection.2010

    • Author(s)
      Koike K, Tsutsumi T, Yotsuyanagi H, Moriya K.
    • Journal Title

      Oncology 78 Suppl 1

      Pages: 24-30

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Impact of changes in obesity parameters on glucose metabolism and insulin resistance over a one-year period.2010

    • Author(s)
      Sakamoto A, Ishizaka Y, Toda EI, Nagai R, Koike K, Yamakado M, Ishizaka N.
    • Journal Title

      J Atheroscler Thromb

      Volume: 右記参照

    • NAID

      130004444393

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Identification of hepatitis C virus genotype 2a replicon variants with reduced susceptibility to ribavirin.2010

    • Author(s)
      Hmwe SS, Aizakia H, Date T, Murakami K, Ishii K, Miyamura T, Koike K, Wakita T, Suzuki T.
    • Journal Title

      Antiviral Res

      Volume: 85 Pages: 520-524

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Impact of Changes in Obesity Parameters on Glucose Metabolism and Insulin Resistance Over a One-Year Period.2010

    • Author(s)
      Sakamoto A, Ishizaka Y, Toda EI, Nagai R, Koike K, Yamakado M, Ishizaka N.
    • Journal Title

      J Atheroscler Thromb 17

      Pages: 1246-1255

    • NAID

      130004444393

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] RNA dependent RNA polymerase of hepatitis C virus binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand.2010

    • Author(s)
      Kanamori H, Yuhashi K, Ohnishi S, Koike K, Kodama T.
    • Journal Title

      J Gen Virol 91

      Pages: 1207-1212

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Association between gamma-glutamyl transferase levels and insulin resistance according to alcohol consumption and number of cigarettes smoked.2010

    • Author(s)
      Ishizaka N, Ishizaka Y, Toda E, Yamakado M, Koike K, Nagai R.
    • Journal Title

      J Atheroscler Thromb

      Volume: 17 Pages: 476-485

    • NAID

      130004845307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Effects of the AT(1) receptor blocker losartan and the calcium channel blocker benidipine on the accumulation of lipids in the kidney of a rat model of metabolic syndrome.2010

    • Author(s)
      Ishizaka N, Hongo M, Matsuzaki G, Furuta K, Saito K, Sakurai R, Sakamoto A, Koike K, Nagai R.
    • Journal Title

      Hypertens Res 33

      Pages: 263-268

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Animal models for hepatitis C and related liver disease.2010

    • Author(s)
      Koike K, Moriya K, Matsuura Y.
    • Journal Title

      Hepatol Res 40

      Pages: 69-82

    • NAID

      10027406832

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Usefulness of multi-detector helical CT with multiplanar reconstruction for depicting the duodenal varices with multiple collateral shunt vessels2010

    • Author(s)
      Yoshida S, Watahe H, Akahane M, Kyoden Y. Ishikawa H, Yamada A. Sugimoto T, Ohta M, Ogura K, Yamaji Y, Ohtomo K, Kokudo N, Koike K, Omata M.
    • Journal Title

      Hepatol Int

      Volume: 4 Pages: 775-778

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Utility of contrast enhanced ultrasonography with sonazoid in radiofre quency ablation for hepatocellular carcinoma2010

    • Author(s)
      Masuzaki R, Shiina S, Tateishi R, Yoshida H, Goto E, Sugioka Y, Kondo Y, Goto T, Ikeda H, Omata M, Koike K.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 右記参照

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Expression of pituitary tumor transforming gene 1 (PTTG1)/securin in hepatitis B virus-associated liver diseases: Evidence for a hepatitis B virus X protein-mediated inhibition of PTTG1 ubiquitination and degradation.2010

    • Author(s)
      Molina-Jimenez F, Benedicto I, Murata M, Martin-Vilchez S, Seki T, Pintor-Toro JA, Tortolero M, Moreno-Otero R, Okazaki K, Koike K, Barbero JL, Matsuzaki K, Majano PL, Lopez-Cabrera M.
    • Journal Title

      Hepatology 51

      Pages: 777-787

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Effect of nucleoside analogue-interferon sequential therapy on patients with acute exacerbation of chronic hepatitis B2010

    • Author(s)
      Okuse C, Yotsuyanagi H, Yamada N, Okamoto M, Ikeda H, Kobayashi M, Fukuda Y, Takahashi H, Nagase Y, Suzuki Y, Malsunaga K, Ishii T, Matsumoto N, Koike K, Suzuki M, Itoh F.
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 461-469

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] PERFECT STUDY GROUP.Prolonged treatment with PEG-IFN a-2b and ribavirin can improve SVR in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in Japan.2010

    • Author(s)
      Watanabe S, Enomoto N, Koike K, Izumi N, Takikawa H, Hashimoto E, Moriyasu F, Kumada H, Imawari M
    • Journal Title

      Hepatol Res 40

      Pages: 135-144

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Thrombocytopenia is more severe in advanced chronic hepatitis C than B with the same grade of splenomegaly.2010

    • Author(s)
      Tejima K, Masuzaki R, Ikeda H, Yoshida H, Tateishi R, Sugioka Y, Kume Y, Okano T, Iwai T, Gotoh H, Katoh S, Suzuki S, Yatomi Y, Omata M, Koike K.
    • Journal Title

      J Gastroeterol

      Volume: 45 Pages: 876-884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Expression of pituitary tumor transforming gene 1 (PTTG1)/securin in hepatitis B virus-associated liver diseases : Evidence for a hepatitis B virus X protein-mediated inhibition of PTTG1 ubiquitination and degradation2010

    • Author(s)
      Molina-Jimenez F, Benedicto I, Murata M, Martin-Vilchez S, Seki T, Pintor-Toro JA, Tortotero M, Moreno-Otero R, Okazaki K, Koike K, Barbero JL, Matsuzaki K, Majano PL, Lopez-Cabrera M
    • Journal Title

      Hepatology

      Volume: 51 Pages: 777-787

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients2010

    • Author(s)
      Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K.
    • Journal Title

      Int J Cancer

      Volume: 右記参照

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals.2010

    • Author(s)
      Ishizaka N, Ishizaka Y, Toda A, Tani M, Toda E, Koike K, Yamakado M, Nagai R.
    • Journal Title

      J Rheumatol 37

      Pages: 410-416

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Animal models for hepatitis C and related liver disease2010

    • Author(s)
      Koike K, Moriya K, Matsuura Y
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 69-82

    • NAID

      10027406832

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Identification of hepatitis C virus genotype 2a replicon variants with reduced susceptibility to ribavirin.2010

    • Author(s)
      Hmwe SS, Aizakia H, Date T, Murakami K, Ishii K, Miyamura T, Koike K, Wakita T, Suzuki T.
    • Journal Title

      Antiviral Res 85

      Pages: 520-524

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients.2010

    • Author(s)
      Arano T, Nakagawa H, Tateishi R, Ikeda H, Uchino K, Enooku K, Goto E, Masuzaki R, Asaoka Y, Kondo Y, Goto T, Shiina S, Omata M, Yoshida H, Koike K.
    • Journal Title

      Int J Cancer, [Epub ahead of print] PubMed PMID

      Pages: 21170963-21170963

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Thrombocytopenia is more severe in advanced chronic hepatitis C than B with the same grade of splenomegaly.2010

    • Author(s)
      Tejima K, Masuzaki R, Ikeda H, Yoshida H, Tateishi R, Sugioka Y, Kume Y, Okano T, Iwai T, Gotoh H, Katoh S, Suzuki S, Yatomi Y, Omata M, Koike K.
    • Journal Title

      J Gastroeterol 45

      Pages: 876-884

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Effect of nucleoside analogue-interferon sequential therapy on patients with acute exacerbation of chronic hepatitis B.2010

    • Author(s)
      Okuse C, Yotsuyanagi H, Yamada N, Okamoto M, Ikeda H, Kobayashi M, Fukuda Y, Takahashi H, Nagase Y, Suzuki Y, Matsunaga K, Ishii T, Matsumoto N, Koike K, Suzuki M, Itoh F.
    • Journal Title

      Hepatol Res 40

      Pages: 461-469

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Plasma sphingosine 1-phosphate level is reduced in patients with chronic liver disease caused by hepatitis C2010

    • Author(s)
      Ikeda H, Ohkawa R, Watanahe N, Nakamura K, Kume Y, Okubo S, Yokota H, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Koike K, Yatomi Y.
    • Journal Title

      Clin Chim Acta

      Volume: 411 Pages: 765-770

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Lipid metabolism and pathogenesis of liver disease in hepatitis C viral infection.2010

    • Author(s)
      Koike K, Tsutsumi T, Yotsuyanagi H, Moriya K.
    • Journal Title

      Oncology

      Volume: 78 Pages: 24-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Expression of alpha-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor.2010

    • Author(s)
      Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Ikeda H, Seyama Y, Kokudo N, Shibahara J, Fukayama M, Koike K, Shirataki H, Fujiwara K.
    • Journal Title

      Int J Oncol

      Volume: 37 Pages: 1417-1423

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Association between gamma-glutamyl transferase levels and insulin resistance according to alcohol consumption and number of cigarettes smoked.2010

    • Author(s)
      Ishizaka N, Ishizaka Y, Toda E, Yamakado M, Koike K, Nagai R.
    • Journal Title

      J Atheroscler Thromb 17

      Pages: 476-485

    • NAID

      130004845307

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Plasma sphingosine 1-phosphate level is reduced in patients with chronic liver disease caused by hepatitis C.2010

    • Author(s)
      Ikeda H, Ohkawa R, Watanabe N, Nakamura K, Kume Y, OkuboS, Yokota H, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Koike K, Yatomi Y.
    • Journal Title

      Clin Chim Acta 411

      Pages: 765-770

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] RNA dependent RNA polymerase of hepatitis C virus binds to its coding region RNA stem-loop structure, 5BSL3.2, and its negative strand2010

    • Author(s)
      Kanamori H, Yuhashi K, Ohnishi S, Koike K, Kodama T.
    • Journal Title

      J Gen Virol

      Volume: 91 Pages: 1207-1212

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Prolonged treatment with PEG-IFN a-2b and ribavirin can improve SVR in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in Japan2010

    • Author(s)
      Watanabe S, Enomoto N, Koike K, Izumi N, Takikawa H, Hashimoto E, Moriyasu F, Kumada H, Imawari M, PERFECT STUDY GROUP
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 135-144

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Cryptococcus gattii Genotype VGIIa Infection in Man, Japan2010

    • Author(s)
      Okamoto K, Hatakeyama S, Itoyama S, Nukui Y, Yoshino Y, Kitazawa T, Yotsuyanagi H, Reiko Ikeda, SugitaT, Koike K.
    • Journal Title

      2007.Emerg Infect Dis 16

      Pages: 1155-1157

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Expression of alpha-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor.2010

    • Author(s)
      Ohtomo N, Tomiya T, Tanoue Y, Inoue Y, Nishikawa T, Ikeda H, Seyama Y, Kokudo N, Shibahara J, Fukayama M, Koike K, Shirataki H, Fujiwara K.
    • Journal Title

      Int J Oncol 37

      Pages: 1417-1423

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells.2010

    • Author(s)
      Moriya K, Miyoshi H, Shinzawa S, Tsutsumi T, Fujie H, Goto K, Shintani Y, Yotsuyanagi H, Koike K.
    • Journal Title

      J Med Virol 82

      Pages: 776-792

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells2010

    • Author(s)
      Moriya K, Miyoshi H, Shinzawa S, Tsutsumi T, Fujie H, Goto K, Shintani Y, Yotsuyanagi H, Koike K.
    • Journal Title

      J Med Virol

      Volume: 82 Pages: 776-792

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperone, prohibitin, in cells expressing hepatitis C virus core protein.2009

    • Author(s)
      Tsutsumi T, Matsuda M, Aizaki H, Moriya K, Miyoshi H, Fujie H, Shintani Y, Yotsuyanagi H, Miyamura T, Suzuki T, Koike K.
    • Journal Title

      Hepatology 50

      Pages: 378-386

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Steatosis, Liver injury and hepatocarcinogenesis in hepatitis C viral infection.2009

    • Author(s)
      Koike K.
    • Journal Title

      J Gastroenterol 44supl

      Pages: 82-88

    • NAID

      10025177272

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperone, prohibitin, in cells expressing hepatitis C virus core protein2009

    • Author(s)
      Tsutsumi T, Matsuda M,…, Koike K.
    • Journal Title

      Hepatology 50

      Pages: 378-386

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20012013
  • [Journal Article] Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: Analysis using mouse model and cultured cells.2009

    • Author(s)
      Moriya K, Miyoshi H, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, Yotsuyanagi H, Moriishi K, Matsuura Y, Suzuki T, Miyamura T, Koike K.
    • Journal Title

      Am J Pathol 175

      Pages: 1515-1524

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Hepatitis B virus X protein shifts hepatic Smad3-mediated signaling from tumor-suppression to oncogenesis in chronic hepatitis B2009

    • Author(s)
      Murata M, Matsuzaki K,…, Koike K.
    • Journal Title

      Hepatology 492

      Pages: 1203-1217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20012013
  • [Journal Article] Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C viruscore protein : Analysis using mouse model and cultured cells2009

    • Author(s)
      Moriya K, Miyoshi H,…, Koike K.
    • Journal Title

      Am J Pathol 175

      Pages: 1515-1524

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20012013
  • [Journal Article] Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis Cvirus core protein : Analysis using mouse model and cultured cells2009

    • Author(s)
      Moriya K, Miyoshi H, Koike K.
    • Journal Title

      Am J Pathol 175

      Pages: 1515-1524

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Impacts of changes in obesity parameters for the prediction of blood pressure change in Japanese individuals.2009

    • Author(s)
      Ishizaka N, Ishizaka Y, Toda E, Koike K, Yamakado M, Nagai R.
    • Journal Title

      Kidney Blood Press Res 32

      Pages: 421-427

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Limitation of immunoaffinity column for the removal of abundant proteins from plasma in quantitative plasma proteomics.2009

    • Author(s)
      Ichibangase T, Moriya K, Koike K, Imai K.
    • Journal Title

      BiomedChromatogr 23

      Pages: 480-487

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Impact of changes in waist circumference and BMI over one-year period on serum lipid data in Japanese individuals.2009

    • Author(s)
      Ishizaka N, Ishizaka Y, Toda E, Koike K, Nagai R, Yamakado M.
    • Journal Title

      J Atheroscler Thromb 16

      Pages: 764-771

    • NAID

      10026144211

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Chronic hepatitis C in patients coinfected with human immunodeficiency virus in Japan: a retrospective multicenter analysis.2009

    • Author(s)
      Yotsuyanagi H, Kikuchi Y, Tsukada K, Nishida K, Kato M, Sakai H, Takamatsu J, Hige S, Chayama K, Moriya K, Koike K.
    • Journal Title

      Hepatol Res 39

      Pages: 657-663

    • NAID

      10025326580

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Association between changes in obesity parameters and incidence of chronic kidney disease in Japanese individuals.2009

    • Author(s)
      Ishizaka Y, Ishizaka N, Tani M, Toda A, Toda EI, Koike K, Nagai R, Yamakado M.
    • Journal Title

      Kidney Blood Press Res 32

      Pages: 141-149

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Identification of a novel mutation for phytosterolemia.Genetic analysis of two cases.2009

    • Author(s)
      Togo M, Hashimoto Y, Iso-O N, Kurano M, Hara M, Kadowaki T, Koike K, Tsukamoto K.
    • Journal Title

      Clin Chim Acta 401

      Pages: 165-169

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart.2009

    • Author(s)
      Hongo M, Ishizaka N, Furuta K, Yahagi N, Saito K, Sakurai R, Matsuzaki G, Koike K, Nagai R.
    • Journal Title

      Eur J Pharmacol 604

      Pages: 87-92

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] A single amino acid of toll-like receptor 4 that is pivotal for its signaltransduction and subcellular localization.2009

    • Author(s)
      Yanagimoto S, Tatsuno K, Okugawa S, Kitazawa T, Tsukada K, Koike K, Kodama T, Kimura S, Shibasaki Y, Ota Y.
    • Journal Title

      J Biol Chem 284

      Pages: 3513-3520

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Association between metabolic syndrome and carotid atherosclerosis in individuals without diabetes based on the oral glucose tolerance test.2009

    • Author(s)
      Ishizaka N, Ishizaka Y, Yamakado M, Toda E, Koike K, Nagai R.
    • Journal Title

      Atherosclerosis 204

      Pages: 619-623

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Hepatitis B virus X protein shifts hepatic Smad3-mediated signaling from tumor-suppression to oncogenesis in chronic hepatitis B.2009

    • Author(s)
      Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Uemura Y, Sakaida N, Fujisawa J, Seki T, Koike K, Okazaki K.
    • Journal Title

      Hepatology 49

      Pages: 1203-1217

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Proteomics analysis of mitochondrial proteins reveals overexpression of a mitochondrial protein chaperone, prohibitin, in cells expressing hepatitis C virus core protein2009

    • Author(s)
      Tsutsumi T, Matsuda M, Koike K
    • Journal Title

      Hepatology 50

      Pages: 378-386

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Hepatitis B virus X protein shifts hepatic Smad3-mediated signaling from tumor-suppression to oncogenesis in chronic hepatitis B2009

    • Author(s)
      Murata M, Matsuzaki K, Koike K
    • Journal Title

      Hepatology 49

      Pages: 1203-1217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Are serum carcinoembryonic antigen levels associated with carotid atherosclerosis in Japanese men?2008

    • Author(s)
      Ishizaka N, Ishizaka Y, Toda EI, Koike K, Yamakado M, Nagai R.
    • Journal Title

      Arterioscler Thromb Vasc Biol 28

      Pages: 160-165

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Effect of treatment with interferon alpha-2b and ribavirin in patients infected with genotype 2 hepatitis C virus.2008

    • Author(s)
      Nagase Y, Yotsuyanagi H, Okuse C, Yasuda K, Kato T, Koike K, Suzuki M, Nishioka K, Iino S, Itoh F.
    • Journal Title

      Hepatol Res 38

      Pages: 252-258

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Relationship between Albuminuria, Low eGFR, and Carotid Atherosclerosis in Japanese Women.2008

    • Author(s)
      Ishizaka Y, Ishizaka N, Tani M, Toda A, Toda EI, Koike K, Yamakado M.
    • Journal Title

      Kidney Blood Press Res 31

      Pages: 164-170

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Prevalence of hepatitis B virus infection in patients with human immunodeficiency virus in Japan.2008

    • Author(s)
      Koike K, Kikuchi Y, Kato M, Takamatsu J, Shintani Y, Tsutsumi T, Fujie H, Miyoshi H, Moriya K, Yotsuyanagi H.
    • Journal Title

      Hepatol Res 38

      Pages: 310-314

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Association between cigarette smoking and chronic kidney disease in Japanese men.2008

    • Author(s)
      Ishizaka N, Ishizaka Y, Toda E, Shimomura H, Koike K, Seki G, Nagai R, Yamakado M.
    • Journal Title

      Hypertens Res 31

      Pages: 485-92

    • NAID

      10021933819

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] PPAR-alpha is essential for severe hepatic steatosis and hepatocellular carcinoma induced by HCV core protein.2008

    • Author(s)
      Tanaka N, Moriya K, Kiyosawa K, Koike K, Gonzalez FJ, Aoyama T.
    • Journal Title

      J Clin Invest 118

      Pages: 683-694

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Molecular basis for the synergy between alcohol and hepatitis C virus in hepatocarcinogenesis.2008

    • Author(s)
      Koike K, Tsutsumi T, Miyoshi H, Shinzawa S, Shintani Y, Fujie H, Yotsuyanagi H, Moriya K.
    • Journal Title

      J Gastroenterol Hepatol 23

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Colonization and/or infection with methicillin-resistant Staphylococcus aureus after living donor liver transplantation: a case control study.2008

    • Author(s)
      Hashimoto M, Sugawara Y, Tamura S, Kaneko J, Matsui Y, Togashi J, Moriya K, Koike K, Makuuchi M.
    • Journal Title

      BMC Infectious Diseases 8

      Pages: 155-155

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Association between hepatitis B/C viral infection, chronic kidney disease and insulin resistance in individuals undergoing general health screening.2008

    • Author(s)
      Ishizaka N, Ishizaka Y, Seki G, Nagai R, Yamakado M, Koike K.
    • Journal Title

      Hepatol Res 38

      Pages: 775-783

    • NAID

      10021945875

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Methicillin-resistant Staphylococcus aureus infection after living-donor liver transplantation in adults.2008

    • Author(s)
      Hashimoto M, Sugawara Y, Tamura S, Kaneko J, Matsui Y, Moriya K, Koike K, Makuuchi M.
    • Journal Title

      Transpl Infect Dis 10

      Pages: 110-116

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis.2008

    • Author(s)
      Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T.
    • Journal Title

      Int J Cancer 122

      Pages: 124-131

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Experimental models of hepatocellular carcinoma.2008

    • Author(s)
      Newell P, Villanueva A, Friedman SL, Koike K, Llovet JM.
    • Journal Title

      J Hepatol 48

      Pages: 858-879

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Journal Article] Hepatitis C virus infection presenting with metabolic disease by inducing insulin resistance2006

    • Author(s)
      Koike K.
    • Journal Title

      Intervirology 19

      Pages: 51-57

    • Data Source
      KAKENHI-PROJECT-18012014
  • [Journal Article] Hepatitis C virus infection presenting with metabolic disease by inducing insulin resistance2006

    • Author(s)
      Koike K.
    • Journal Title

      Intervirology 19

      Pages: 51-57

    • Data Source
      KAKENHI-PROJECT-18659203
  • [Journal Article] Oxidative stress and hepatitis C viral infection2006

    • Author(s)
      Koike K, Miyoshi H
    • Journal Title

      Hepatol Res 34

      Pages: 65-76

    • NAID

      10020405552

    • Data Source
      KAKENHI-PROJECT-18012014
  • [Journal Article] Oxidative stress and hepatitis C viral infection2006

    • Author(s)
      Koike K, Miyoshi H
    • Journal Title

      Hepatol Res 34

      Pages: 65-76

    • NAID

      10020405552

    • Data Source
      KAKENHI-PROJECT-17659210
  • [Journal Article] Pathogenesis of HCV-associated HCC2006

    • Author(s)
      Koike K
    • Journal Title

      Hepatol Res 35(in press)

    • NAID

      10024364283

    • Data Source
      KAKENHI-PROJECT-17013026
  • [Journal Article] Antiviral treatment of hepatitis C : present status and future prospects2006

    • Author(s)
      Koike K
    • Journal Title

      J Infect Chemother 12

      Pages: 227-232

    • NAID

      10018347988

    • Data Source
      KAKENHI-PROJECT-18012014
  • [Journal Article] Hepatitis C virus infection presenting with metabolic disease by inducing insulin resistance2006

    • Author(s)
      Koike K.
    • Journal Title

      Intervirology 19

      Pages: 51-57

    • Data Source
      KAKENHI-PROJECT-17659210
  • [Journal Article] Oxidative stress and hepatitis C viral infection2006

    • Author(s)
      Koike K, Miyoshi H
    • Journal Title

      Hepatol Res 34

      Pages: 65-76

    • NAID

      10020405552

    • Data Source
      KAKENHI-PROJECT-17013026
  • [Journal Article] Pathogenesis of HCV-associated HCC2006

    • Author(s)
      Koike K
    • Journal Title

      Hepatol Res 35(in press)

    • NAID

      10024364283

    • Data Source
      KAKENHI-PROJECT-17659210
  • [Journal Article] Antiviral treatment of hepatitis C : present status an future prospects2006

    • Author(s)
      Koike K
    • Journal Title

      J Infect Chemother 12

      Pages: 227-232

    • NAID

      10018347988

    • Data Source
      KAKENHI-PROJECT-18659203
  • [Journal Article] Oxidative stress and hepatitis C viral infection2006

    • Author(s)
      Koike K, Miyoshi H
    • Journal Title

      Hepatol Res 34

      Pages: 65-76

    • NAID

      10020405552

    • Data Source
      KAKENHI-PROJECT-18659203
  • [Journal Article] Antiviral treatment of hepatitis C : present status and future prospects2006

    • Author(s)
      Koike K.
    • Journal Title

      J Infect Chemother 12

      Pages: 227-232

    • NAID

      10018347988

    • Data Source
      KAKENHI-PROJECT-18390214
  • [Journal Article] Hepatitis C virus infection presenting with metabolic disease by inducing insulin resistance2006

    • Author(s)
      Koike K.
    • Journal Title

      Intervirology 19

      Pages: 51-57

    • Data Source
      KAKENHI-PROJECT-18390214
  • [Journal Article] Hepatitis C virus infection presenting with metabolic disease by inducing insulin resistance2006

    • Author(s)
      Koike K.
    • Journal Title

      Intervirology 19

      Pages: 51-57

    • Data Source
      KAKENHI-PROJECT-17013026
  • [Journal Article] Oxidative stress and hepatitis C viral infection2006

    • Author(s)
      Koike K, Miyoshi H
    • Journal Title

      Hepatol Res 34

      Pages: 65-76

    • NAID

      10020405552

    • Data Source
      KAKENHI-PROJECT-18390214
  • [Journal Article] Metabolic aspects of hepatitis C : steatohepatitis distinct from NASH.2005

    • Author(s)
      Koike K, et al.
    • Journal Title

      J Gastroenterol (In press)

    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Molecular basis of hepatitis C virus-associated hepatocarcinogenesis : lessons from animal model studies2005

    • Author(s)
      Koike K.
    • Journal Title

      Clin Gastroenterol Hepatol 3

      Pages: 132-135

    • Data Source
      KAKENHI-PROJECT-17659210
  • [Journal Article] Hepatitis C virus infection presenting with metabolic disease by inducing insulin resistance.2005

    • Author(s)
      Koike K
    • Journal Title

      Intervirology (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Metabolic aspects of hepatitis C : steatohepatitis distinct from NASH.2005

    • Author(s)
      Koike K, et al.
    • Journal Title

      J Gastroenterol (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Molecular basis of hepatitis C virus-associated hepatocarcinogenesis : lessons from animal model studies.2005

    • Author(s)
      Koike K.
    • Journal Title

      Clin Gastroenterol Hepatol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Molecular basis of hepatitis C virus-associated hepatocarcinogenesis : lessons from animal model studies2005

    • Author(s)
      Koike K
    • Journal Title

      Clin Gastroenterol Hepatol 3

      Pages: 132-135

    • Data Source
      KAKENHI-PROJECT-17013026
  • [Journal Article] Hepatitis C virus infection presenting with metabolic disease by inducing insulin resistance.2005

    • Author(s)
      Koike K
    • Journal Title

      Intervirology (In press)

    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Hepatitis C as a metabolic disease : implication for the pathogenesis of NASH.2005

    • Author(s)
      Koike K.
    • Journal Title

      Hepatol Res (in press)

    • NAID

      10016809308

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Hepatitis C virus infection presenting with metabolic disease by inducing insulin resistance.2005

    • Author(s)
      Koike K.
    • Journal Title

      Intervirology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Metabolic aspects of hepatitis C : steatohepatitis distinct from NASH.2005

    • Author(s)
      Koike K, Mariya K.
    • Journal Title

      J Gastroenterol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Moriya K. Metabolic aspects of hepatitis C : steatohepatitis distinct from NASH.2005

    • Author(s)
      Koike K
    • Journal Title

      J Gastroenterol 40

      Pages: 329-336

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Hepatitis C as a metabolic disease : implication for the pathogenesis of NASH.2005

    • Author(s)
      Koike K
    • Journal Title

      Hepatol Res (印刷中)

    • NAID

      10016809308

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Hepatitis C virus infection presenting with metabolic disease by inducing insulin resistance.2005

    • Author(s)
      Koike K.
    • Journal Title

      Intervirology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Hepatitis C Virus Core Protein Exerts an Inhibitory Effect on Suppressor of Cytokine Signaling (SOCS)-1 Gene Expression.2005

    • Author(s)
      Miyoshi H, Fujie H, Shintani Y, Tsutsumi T, Shinzawa S, Makuuchi M, Kokudo N, Matsuura Y, Suzuki T, Miyamura T, Moriya K, Koike K.
    • Journal Title

      J Hepatol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Persisting humeral anti-smallpox immunity among current Japanese population after the discontinuation in 1976 of routine smallpox vaccinations.2005

    • Author(s)
      Hatakeyama S, Moriya K, Saijo M, Morisawa Y, Kurane I, Koike K, Kimura S, Morikawa S.
    • Journal Title

      Clin Diagn Lab Immun (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Metabolic aspects of hepatitis C : steatohepatitis distinct from NASH2005

    • Author(s)
      Koike K, Moriya K.
    • Journal Title

      J Gastroenterol 40

      Pages: 329-336

    • Data Source
      KAKENHI-PROJECT-17013026
  • [Journal Article] Metabolic aspects of hepatitis C : steatohepatitis distinct from NASH2005

    • Author(s)
      Koike K, Moriya K.
    • Journal Title

      J Gastroenterol 40

      Pages: 329-336

    • Data Source
      KAKENHI-PROJECT-17659210
  • [Journal Article] Hepatitis C as a metabolic disease : implication for the pathogenesis of NASH.2005

    • Author(s)
      Koike K
    • Journal Title

      Hepatol Res (In press)

    • NAID

      10016809308

    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Hepatitis C and Diabetes Mellitus : what is the metabolic pathway ?2004

    • Author(s)
      Koike K, et al.
    • Journal Title

      Gastroenterology 127

      Pages: 1280-1281

    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Hepatitis C and Diabetes Mellitus : what is the metabolic pathway?2004

    • Author(s)
      Koike K, et al.
    • Journal Title

      Gastroenterology 127

      Pages: 1280-1281

    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma.2004

    • Author(s)
      Miyoshi H, Fujie H, Moriya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K.
    • Journal Title

      Journal of Gastroenterology 39(6)

      Pages: 563-569

    • NAID

      10013296326

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Hepatitis C virus and diabetes : direct involvement of the virus in the development of insulin resistance.2004

    • Author(s)
      Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Kimura S, Moriya K, Koike K.
    • Journal Title

      Gastroenterology 126

      Pages: 840-848

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Fujie H, Shintani Y, Miyoshi H, Moriya K. Hepatitis C and Diabetes Mellitus : what is the metabolic pathway?2004

    • Author(s)
      Koike K
    • Journal Title

      Gastroenterology 127

      Pages: 1280-1281

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Hepatitis C virus and diabetes : direct involvement of the virus in the development of insulin resistance.2004

    • Author(s)
      Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Kimura S, Mariya K, Koike K.
    • Journal Title

      Gastroenterology 126

      Pages: 840-848

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Hepatitis C and Diabetes Mellitus : what is the metabolic pathway?2004

    • Author(s)
      Koike K, Fujie H, Shintani Y, Miyoshi H, Mariya K.
    • Journal Title

      Gastroenterology 127

      Pages: 1280-1281

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] hepatitis C virus infection and diabetes : direct involvement of the virus in the development of insulin resistance2004

    • Author(s)
      Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K
    • Journal Title

      Gastroenterology. 126

      Pages: 840-848

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390228
  • [Journal Article] Hepatitis C virus infection and diabetes : direct involvement of the virus in the development of insulin resistance.2004

    • Author(s)
      Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K.
    • Journal Title

      Gastroenterology 126(3)

      Pages: 840-848

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma.2004

    • Author(s)
      Miyoshi H, Fujie H, Moriya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K.
    • Journal Title

      J Gastroenterol. 39(6)

      Pages: 563-569

    • NAID

      10013296326

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Hepatitis C virus infection and diabetes : direct involvement of the virus in the development of insulin resistance.2004

    • Author(s)
      Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K.
    • Journal Title

      Gastraenterolagy. 126(3)

      Pages: 840-848

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Hepatitis C and Diabetes Mellitus : what is the metabolic pathway?2004

    • Author(s)
      Koike K, et al.
    • Journal Title

      Gastroenterology 127

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Hepatitis C virus infection and diabetes : direct involvement of the virus in the develonment of insulin resistance2004

    • Author(s)
      Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K.
    • Journal Title

      Gastroenterology 126(3)

      Pages: 840-848

    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Methylation status of suppressor of cytokine sigasling-1 gene in hepatocellular carcinoma2004

    • Author(s)
      Miyoshi H, Fujie H, Moriya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K.
    • Journal Title

      J Gastroenterol 39(6)

      Pages: 563-569

    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma.2004

    • Author(s)
      Miyoshi H, Fujie H, Mariya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K.
    • Journal Title

      J Gastroenterol 39

      Pages: 563-569

    • NAID

      10013296326

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390226
  • [Journal Article] Hepatitis C virus infection and diabetes : direct involvement of the virus in the development of insulin resistance.2004

    • Author(s)
      Shintani Y.Fujie H.Miyoshi H.Tsutsumi T.Tsukamoto K.Kimura S.Moriya K.Koike K.
    • Journal Title

      Gastroenterology 126

      Pages: 840-848

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390228
  • [Journal Article] Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core protein.2003

    • Author(s)
      Moriishi K, Okabayashi T, Nakai K, Moriya K, Koike K, Murata S, Chiba T, Tanaka K, Suzuki R, Suzuki T, Miyamura T, Matsuura Y.
    • Journal Title

      J Virol. 77(19)

      Pages: 10237-10249

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Serum lipid profile of patients with genotype 1b hepatitis C viral infection in Japan2003

    • Author(s)
      Moriya K, Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Yotsuyanagi H, Iino S, Kimura S, Koike K.
    • Journal Title

      Hepatology Research 25(4)

      Pages: 371-376

    • NAID

      50000829733

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core protein.2003

    • Author(s)
      Moriishi K, Okabayashi T, Nakai K, Moriya K, Koike K, Murata S, Chiba T, Tanaka K, Suzuki R, Suzuki T, Miyamura T, Matsuura Y.
    • Journal Title

      Journal of Virology 77(19)

      Pages: 10237-10249

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Suzuki R, Miyamura T, Matsuura Y. Proteasome activator PA28g-dependent nuclear retention and degradation of hepatitis C virus core protein.2003

    • Author(s)
      Moriishi K, Okabayashi T, Nakai K, Moriya K, Koike K, Murata K, Chiba T, Tanaka K
    • Journal Title

      J Virol 77

      Pages: 10237-10249

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Serum lipid profile of patients with genotype 1b hepatitis C viral infection in Japan.2003

    • Author(s)
      Moriya K, Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Yotsuyanagi H, Iino S, Kimura S, Koike K.
    • Journal Title

      Hepatol Res. 25(4)

      Pages: 371-376

    • NAID

      50000829733

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice.2003

    • Author(s)
      Tsutsumi T.Suzuki T.Moriya K.Shintani Y.Fujie H.Miyoshi H.Matsuura Y.Koike K.Miyamura T.
    • Journal Title

      Hepatology 38

      Pages: 820-828

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390228
  • [Journal Article] Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice.2003

    • Author(s)
      Tsutsumi T, Suzuki T, Moriya K, Shintani Y, Fujie H, Miyoshi H, Matsuura Y, Koike K, Miyamura T.
    • Journal Title

      Hepatology 38(4)

      Pages: 820-828

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanolin transgenic mice.2003

    • Author(s)
      Tsutsumi T, Suzuki T, Moriya K, Shintani Y, Fujie H, Miyoshi H, Matsuura Y, Koike K, Miyamura T.
    • Journal Title

      Hepatology. 38

      Pages: 820-828

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390228
  • [Journal Article] Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice.2003

    • Author(s)
      Tsutsumi T, Suzuki T, Moriya K, Shintani Y, Fujie H, Miyoshi H, Matsuura Y, Koike K, Miyamura T.
    • Journal Title

      Hepatology. 88(4)

      Pages: 820-828

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590624
  • [Journal Article] Tsutsumi T, Fujie H, Shintani Y, Moriya K. Role of hepatitis viruses in hepatocarcinogenesis.2002

    • Author(s)
      Koike K
    • Journal Title

      Oncology 62

      Pages: 29-37

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Miyamura T. Hepatitis C virus core protein activates ERK and p38 MAPK in cooperation with ethanol in transgenic mice.2002

    • Author(s)
      Tsutsumi T, Suzuki T, Moriya K, Shintani Y, Fujie H, Miyoshi H, Matsuura Y, Koike K
    • Journal Title

      Hepatology 38

      Pages: 820-828

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Chapman J, Barba G, Brechot C. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion : a model of viral-related steatosis.2002

    • Author(s)
      Perlemuter G, Sabile A, Letteron P, Topilco, Samson-Bouna M-E, Chretien Y, Pessayre D, Koike K
    • Journal Title

      FASEB J. 16

      Pages: 185-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Moriya K, Kimura S. Role of hepatitis C virus in the development of hepatocellular carcinoma : Transgenic approach to viral hepatocarcinogenesis.2002

    • Author(s)
      Koike K
    • Journal Title

      J Gastroenterol Hepatol. 17

      Pages: 394-400

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Miyamura T. Interaction of Hepatitis C Virus Core Protein with Retinoid X Receptor-a Modulates its Transcriptional Activity.2002

    • Author(s)
      Tsutsumi T, Suzuki T, Shimoike T, Moriya K, Yotsuyanagi H, Matsuura Y, Koike K
    • Journal Title

      Hepatology 35

      Pages: 937-946

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Miyamura T. Intrahepatic cytokine expression and AP-1 activation in mice transgenic for hepatitis C virus core protein.2002

    • Author(s)
      Tsutsumi T, Suzuki T, Moriya K, Yotsuyanagi H, Shintani Y, Fujie H, Matsuura Y, Kimura S, Koike K
    • Journal Title

      Virology 304

      Pages: 415-424

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocellular carcinogenesis.2001

    • Author(s)
      Moriya K, Nakagawa K, Santa T, Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Miyazawa T, Ishibashi K, Horie T, Imai K, Miyamura T, Kimura S, Koike K.
    • Journal Title

      Cancer Res 61

      Pages: 4365-4370

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] The role of hepatitis viruses in multistep hepatocarcinogenesis.2001

    • Author(s)
      Koike K.
    • Journal Title

      Dig Liver Dis 33

      Pages: 2-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Increase in the concentration of carbon 18 monounsaturated fatty acids in the liver with hepatitis C : analysis in transgenic mice and humans.2001

    • Author(s)
      Moriya K, Todoroki T, Tsutsumi T, Fujie H, Shintani Y, Miyoshi H, Ishibashi K, Takayama T, Makuuchi M, Watanabe K, Miyamura T, Kimura S, Koike K.
    • Journal Title

      Biophys Biochem Res Commun 281

      Pages: 1207-1212

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Kimura S, Yasuda K, Iino S, Green J. IgG1 anti-P2 as a marker of response to interferon in patients with chronic hepatitis C.2001

    • Author(s)
      Hirayama M, Maruyama T, Mitsui H, Maekawa H, Yamada H, Hashimoto N, Koike K
    • Journal Title

      Clin Exp Immunology 126

      Pages: 92-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Frequent β-catenin aberration in human hepatocellular carcinoma.2001

    • Author(s)
      Fujie H, Moriya K, Shintani Y, Tsutsumi T, Takayama T, Makuuchi M, Kimura S, Koike K.
    • Journal Title

      Hepatol Res 20

      Pages: 39-51

    • NAID

      10009899927

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] Virological analysis of non-B, non-C hepatocellular carcinoma in Japan : frequent involvement of hepatitis B virus2000

    • Author(s)
      Yotsuyanagi H, Shintani Y, Moriya K, Fujie H, Tsutsumi T, Kato T, Nishioka K, Takayama T, Makuuchi M, Iino S, Kimura S, Koike K.
    • Journal Title

      J Infect Dis 181

      Pages: 1920-1928

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13214018
  • [Journal Article] MicroRNA122 is a key regulator of α-fetoprotein expression and biologically aggressive behavior of hepatocellular carcinoma.

    • Author(s)
      Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H, Omata M, Nepveu A, Koike K.
    • Journal Title

      Nat Commun in press

    • Data Source
      KAKENHI-PROJECT-20390204
  • [Patent] 肝細胞癌発生予測因子としての血中ADAMTS132010

    • Inventor(s)
      池田均、矢冨裕、建石良介、小池和彦、小野智子
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2010-11-11
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Patent] 肝細胞癌発生予測因子としての血中ADAMTS132010

    • Inventor(s)
      池田均、矢冨裕、建石良介、小池和彦、小野智子
    • Industrial Property Rights Holder
      東京大学
    • Filing Date
      2010-11-05
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Presentation] NASH・肥満関連肝癌における特異的代謝異常に着目した発癌促進機構解明2017

    • Author(s)
      藤原直人、中川勇人、小池和彦
    • Organizer
      第53回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Presentation] 肝炎2016

    • Author(s)
      小池和彦
    • Organizer
      日本医学会公開フォーラム
    • Place of Presentation
      日本医師会館
    • Year and Date
      2016-06-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Presentation] Impact of demographic changes on Internal Medicine2016

    • Author(s)
      Kazuhiko Koike
    • Organizer
      122th DGIM(ドイツ内科学会)
    • Place of Presentation
      Mannheim Congress Center Rosengarten
    • Year and Date
      2016-04-11
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Presentation] 糖尿病・代謝と肝臓2016

    • Author(s)
      小池和彦
    • Organizer
      第29回肝臓フォーラム(東部)
    • Place of Presentation
      経団連会館
    • Year and Date
      2016-07-09
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Presentation] HBV mRNAと宿主microRNA let-7の相互作用2016

    • Author(s)
      小池和彦
    • Organizer
      犬山シンポジウム
    • Place of Presentation
      名鉄犬山ホテル
    • Year and Date
      2016-08-04
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Presentation] Body composition and prognosis of hepatocellular carcinoma2016

    • Author(s)
      Koike K
    • Organizer
      35thUS-Japan Cooperative Medical Sciences Program (USJCMSP) Meeting
    • Place of Presentation
      North Bethesda, MD, USA
    • Year and Date
      2016-01-13
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Presentation] MicroRNAと肝臓2015

    • Author(s)
      小池和彦
    • Organizer
      肝細胞研究会
    • Place of Presentation
      米子コンベンションセンター(鳥取県・米子市)
    • Year and Date
      2015-06-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Presentation] 50 years of hepatology in Japan: Past, Present and Future2015

    • Author(s)
      Koike K
    • Organizer
      20th Korean Association of the Study of the Liver
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2015-09-11
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Presentation] MicroRNA and HBV pathogenesis2015

    • Author(s)
      Koike K
    • Organizer
      3rd Italy-Japan Liver Work Shop
    • Place of Presentation
      Napoli University, Italy
    • Year and Date
      2015-10-26
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Presentation] 肝疾患と体質:我が国の肝臓病の現状2015

    • Author(s)
      小池和彦
    • Organizer
      第65回日本体質医学会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2015-07-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04807
  • [Presentation] Pathogenesis of HCV-associated HCC2014

    • Author(s)
      Koike K
    • Organizer
      2014 Taiwan Digestive Disease Week
    • Place of Presentation
      Kaohsiung
    • Year and Date
      2014-10-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Presentation] Japan’s Experience in Hepatitis C Treatment: the Way to Conquering HCV-associated HCC2014

    • Author(s)
      Koike K
    • Organizer
      20th Annual Meeting of KASL
    • Place of Presentation
      Cheju
    • Year and Date
      2014-06-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Presentation] Metabolic abnormality in hepatitis C2012

    • Author(s)
      Kazuhiko Koike
    • Organizer
      22nd Asian Pacific Association for the Study of Liver (APASL)
    • Place of Presentation
      in Taipei (Taiwan).(招待講演)
    • Year and Date
      2012-02-18
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Presentation] Metabolic abnormality in hepatitis C2012

    • Author(s)
      Kazuhiko Koike
    • Organizer
      14th International Symposium on Viral Hepatitis and Liver Disease
    • Place of Presentation
      中国、 上海(招待講演)
    • Year and Date
      2012-06-24
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Presentation] Viral factors for hepatocarcinogenesis in HBV infection2012

    • Author(s)
      Kazuhiko Koike
    • Organizer
      JSGE 3rd International Forum
    • Place of Presentation
      in Tokyo (Japan).(招待講演)
    • Year and Date
      2012-04-21
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Presentation] Metabolic aspects of hepatitis C2012

    • Author(s)
      Kazuhiko Koike
    • Organizer
      14th International Symposium on Viral Hepatitis and Liver Disease(招待 講演)
    • Place of Presentation
      in Shanghai (China)
    • Year and Date
      2012-06-24
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Presentation] Metabolic abnormality in hepatitis C2012

    • Author(s)
      Kazuhiko Koike
    • Organizer
      22nd Asian Pacific Association for the Study of Liver
    • Place of Presentation
      台湾、台北(招待講演)
    • Year and Date
      2012-02-18
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Presentation] Viral factors for hepatocarcinogenesis in HBV onfection2012

    • Author(s)
      Kazuhiko Koike
    • Organizer
      JSGE 3rd International Forum
    • Place of Presentation
      京王プラザホテル、東京(招待講演)
    • Year and Date
      2012-04-21
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Presentation] Association of the substitution of amino acid 75 in the hepatitis virus core region with IL-8 upregulation and hepatocarcinogenesis2010

    • Author(s)
      Tsutsumi T, Miyoshi H, Goto Koji, Moriya K, Koike K.
    • Organizer
      17th International Meeting on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Yokohama
    • Year and Date
      2010-09-17
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Presentation] Animal models in HCC research2009

    • Author(s)
      Koike K.
    • Organizer
      3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
    • Place of Presentation
      Kobe
    • Year and Date
      2009-05-28
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Presentation] Animal models in HCC research2009

    • Author(s)
      Koike K.
    • Organizer
      3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
    • Place of Presentation
      Kobe
    • Year and Date
      2009-05-28
    • Data Source
      KAKENHI-PROJECT-20012013
  • [Presentation] Steatosis, liver injury and hepatocarcinogenesis in HCV infection.2008

    • Author(s)
      Koike K.
    • Organizer
      Inflammation and Immunity 2008
    • Place of Presentation
      Galveston, TX, USA
    • Year and Date
      2008-01-20
    • Data Source
      KAKENHI-PROJECT-20390204
  • [Presentation] Metabolic abnormality in hepatitis C

    • Author(s)
      Kazuhiko Koike
    • Organizer
      22nd Asian Pacific Association for the Study of Liver
    • Place of Presentation
      台北 台湾
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Presentation] Fluvastatin Ameliorates Liver Desease in HCV Mouse Model with Improvements of Lipid Metabolism, Mitochondrial Dysfunction and Intrahepatic Cardiolipin Composition.

    • Author(s)
      Hidetaka Fujinaga ,Seiko Shinzawa,Junken Aoki,Kazuya Okushin,Kohji Goto,Hideyuki Miyoshi,Takeya Tsutsumi,Yoshizumi Shintani,Hiroshi Yotsuyanagi,Kyoji Moriya,Kazuhiko Koike
    • Organizer
      48th Annual Meeting of the European Association for the Study of the Liver
    • Place of Presentation
      Amsterdam RAI
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Presentation] 肝発癌においては自然免疫関連分子MICAはB型肝炎とC型肝炎では反対の役目を担っている可能性がある

    • Author(s)
      加藤直也、室山良介、小池和彦
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Presentation] Molecular Pathogenesis of HCC: Involvement of microRNA

    • Author(s)
      Kazuhiko Koike
    • Organizer
      Taiwan Association for the Study of the Liver single topic conference
    • Place of Presentation
      Sheraton Taipei
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Presentation] Experience of DAAs in Japan and perspectives of hepatitis C treatment

    • Author(s)
      Kazuhiko Koike
    • Organizer
      The 19th Fall Conference of the Korean Association for the Study of the Liver
    • Place of Presentation
      Sheraton Grande Waker Hill
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390183
  • [Presentation] Viral factors for hepatocarcinogenesis in HBV onfection

    • Author(s)
      Kazuhiko Koike
    • Organizer
      "JSGE 3rd International Forum (招待講演)"
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Presentation] Metabolic abnormality in hepatitis C

    • Author(s)
      Kazuhiko Koike
    • Organizer
      14th International Symposium on Viral Hepatitis and Liver Disease(招待講演)
    • Place of Presentation
      上海 中国
    • Invited
    • Data Source
      KAKENHI-PROJECT-23659393
  • [Presentation] Telaprevir/PegIFN/Ribavirin併用療法におけるTelaprevir血中濃度と副作用の関連についての検討

    • Author(s)
      南達也、四柳宏、建石良介、小池和彦
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル
    • Data Source
      KAKENHI-PROJECT-24390183
  • 1.  MORIYA Kyoji (00272550)
    # of Collaborated Projects: 28 results
    # of Collaborated Products: 28 results
  • 2.  YOTSUYANAGI Hiroshi (30251234)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 15 results
  • 3.  SHINTANI Yoshizumi (80261965)
    # of Collaborated Projects: 14 results
    # of Collaborated Products: 21 results
  • 4.  FUJIE Hajime (90332577)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 23 results
  • 5.  MARUYAMA Toshiyuki (30219571)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 6.  三好 秀征 (00401042)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 15 results
  • 7.  MITSUI Hiroshi (30239280)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  飯野 四郎 (30010309)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  堤 武也 (00726739)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 11 results
  • 10.  ISHIBASHI Kotaro
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  HASHIMOTO Yoshiaki (40172879)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  MATSUURA Yoshiharu
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  KANEKO Yoshiyasu (90124669)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NAKAYAMA Toshibumi (80150275)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  WATANABE Tsuyoshi (80158641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TANIGUCHI Shigeo (50188380)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  NAKAO Akihide (10159056)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  NOSAKA Kazuo (70150274)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  MAEKAWA Hisato (10301102)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  TOMA Shigeto (50207528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  AOKI Katsunori (40291322)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SHIMOTOHNO Kunitada (10000259)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  MATSUMOTO Yoichiro (60111473)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TAKAGI Shu (30272371)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  NANGAKU Masaomi (90311620)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  HATA Keishi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  UMEMURA Shinichiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  松浦 義治
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  大塚 基之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 30.  西川 祐司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 31.  矢富 裕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  田中 真二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  富谷 智明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  池田 均
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  建石 良介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  脇田 隆字
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  岸川 孝弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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