Higo Junichi 肥後順一

… Alternative Names

肥後順一ヒゴジユンイチ

HIGO Junichi 肥後順一

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Researcher Number	80265719
Other IDs
Affiliation (Current)	2025: 兵庫県立大学, 情報科学研究科, 特任教授
Affiliation (based on the past Project Information) *help	2023: 兵庫県立大学, 情報科学研究科, 特任教授 2022: 立命館大学, 総合科学技術研究機構, プロジェクト研究員 2021: 立命館大学, 総合科学技術研究機構, 教授 2018 – 2019: 兵庫県立大学, シミュレーション学研究科, 特任教授 2017: 大阪大学, 蛋白質研究所, 特任教授 … More 2016 – 2017: 大阪大学, たんぱく質研究所, 特任教授(常勤) 2013: 大阪大学, たんぱく質研究所, 特任研究員(客員教授) 2013: 大阪大学, たんぱく質研究所, 研究員 2013: 大阪大学, 蛋白質研究所, 特任研究員 2012 – 2013: 大阪大学, たんぱく質研究所, 特任研究員 2012: 大阪大学, たんぱく質研究所, 招聘研究員 2009 – 2011: 大阪大学, 蛋白質研究所, 特任研究員 2010: 大阪大学, 蛋白質研究所, 特任研究員(客員教授) 2007 – 2008: Osaka University, 臨床医工学融合研究教育センター, 特任研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Biological physics/Chemical physics/Soft matter physics / Biological Sciences / Biophysics Except Principal Investigator Biophysics / Biological Sciences
Keywords	Principal Investigator 自由エネルギー地形 / 全原子モデル / フォールディング / 膜蛋白質 / 効率的立体構造探索 / 阻害効果 / conformational selection / 自由エネルギー障壁 / orientation selection / fly-casting … More / 結合過程 / エンドセリンリセプター / ボセンタン / GPCR / MD シミュレーション / 分子間結合 / 速度論 / 平衡論 / 分子動力学 / 生物物理一般 / enhanced sampling / generalized ensemble / 構造サンプリング / アダプティブアンブレラ / 平衡定数 / カノニカルサンプリング / 効率的サンプリング / 自由エネルギー / 仮装系 / 遷移確率 / 速度定数 / 構造変化 / 生体高分子 / GA / AI / 多次元 / 反応座標 / 状態遷移 / 自由エネルギー計算 / 分子動力学シミュレーション / 粗視化モデル / 計算機シミュレーション / ドッキング / ヒューマニン / WWドメイン / マルチカノニカル … More Except Principal Investigator 蛋白質間相互作用 / 分子シミュレーション / バイオインフォマティクス / プロテオーム / 蛋白質相互作用 / 天然変性 / 理論生物学 / 蛋白質 / 構造・機能予測 / タンパク質のダイナミクス / ハブタンパク質 / ダイナミクス / タンパク質のゆらぎ / X線小角散乱 / 核内タンパク質 / NMR / 高速AFM / Ｘ線小角散乱 / 天然変性タンパク質 / データベース / 分子動力学 / 生体分子 / 蛋白質の構造・機能予測 / 生物物理 Less

膜蛋白質 GPCR と薬剤化合物ボセンタンの結合自由エネルギー地形Principal Investigator
- Principal Investigator
  
  肥後順一
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  University of Hyogo
  Ritsumeikan University
kinetic constants of molecular binding calculated from equilibriumPrincipal Investigator
- Principal Investigator
  
  Higo Junichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological physics/Chemical physics/Soft matter physics
- Research Institution
  University of Hyogo
  Osaka University
Computational study for multistery of intrinsic disordered region of proteins with post-translational modification
- Principal Investigator
  
  Nakamura Haruki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
Quantitative computational and informatics studies on protein-protein interaction systems based on their dynamic structures
- Principal Investigator
  
  NAKAMURA Haruki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
Target recognition and expression mechanism of intrinsically disordered protein
- Principal Investigator
  
  SATO Mamoru
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Analysis on the structural polymorphism of IDPs by computer simulationPrincipal Investigator
- Principal Investigator
  
  HIGO Junichi
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Structural Interactome Studies from Computational and Bioinformatics Approaches
- Principal Investigator
  
  NAKAMURA Haruki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
Computation of the free-energy landscape of a protein involving α and β secondary-structure elementsPrincipal Investigator
- Principal Investigator
  
  HIGO Junichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University

[Book] Protein Conformational Dynamics, Advances in Experimental Medicine and Biology2014
- Author(s)
  J. Higo, K. Umezawa
- Total Pages
  21
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-21113006
[Book] Protein Conformational Dynamics in Advances in Experimental Medicine and Biology Vol.8052014
- Author(s)
  Higo J., Umezawa K.
- Total Pages
  21
- Publisher
  Springer
- Data Source
  KAKENHI-ORGANIZER-21113001
[Book] “Protein Conformational Dynamics” in “Advances in Experimental Medicine and Biology” Vol. 8052014
- Author(s)
  Junichi Higo, Koji Umezawa
- Total Pages
  21
- Publisher
  Springeｒ
- Data Source
  KAKENHI-ORGANIZER-21113001
[Book] Free-energy landscape of Intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics, Chapter 14 in "Protein Conformational Dynamics" (Han, K., Zhang, X., and Yang, M.eds.) Advances in Experimental Medicine and Biology 8052014
- Author(s)
  Higo, J., Umezawa, K
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-21113006
[Book] 全原子コンピュータシミュレーションで解き明かす、天然変成タンパク質の分子認識機構2013
- Author(s)
  肥後順一
- Total Pages
  5
- Publisher
  生物物理学会会誌「生物物理」
- Data Source
  KAKENHI-ORGANIZER-21113001
[Book] 生物物理学会会誌「生物物理」2013
- Author(s)
  肥後順一
- Total Pages
  5
- Publisher
  全原子コンピュータシミュレーションで解き明かす、天然変成タンパク質の分子認識機構
- Data Source
  KAKENHI-PLANNED-21113006
[Book] Protein Conformational Dynamics (Springer)2013
- Author(s)
  Junichi Higo
- Total Pages
  10
- Publisher
  Free-energy landscape of Intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics
- Data Source
  KAKENHI-PLANNED-21113006
[Book] "Prediction of Protein-Protein Complex Structures" in Biomolecular Forms and Functions : A Celebration of 50 years of the Ramachandran Map(Eds. Manju Bansal & N. Srinivasan)2013
- Author(s)
  Kanamori E, Murakami Y, Sarmiento J, Liang S, Standley DM, Shirota M, Kinoshita K, Tsuchiya Y, Higo J, Nakamura H
- Publisher
  World Scientific Publishing
- Data Source
  KAKENHI-PROJECT-23370071
[Book] Protein Conformational Dynamics: Free-energy landscape of Intrinsically disordered proteins investigated by all-atommulticanonical molecular dynamics2012
- Author(s)
  Junichi Higo
- Total Pages
  10
- Publisher
  Springer
- Data Source
  KAKENHI-ORGANIZER-21113001
[Book] Protein conformational dynamics : Free-energy land scope of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics2012
- Author(s)
  Higo J.
- Total Pages
  10
- Publisher
  Springer
- Data Source
  KAKENHI-ORGANIZER-21113001
[Book] タンパク質計算科学2009
- Author(s)
  神谷成敏・肥後順一・福西快文・中村春木
- Total Pages
  251
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-20370061
[Book] 蛋白質の水和とフォールディング2008
- Author(s)
  肥後順一
- Publisher
  「物性研究」(物性研究刊行会)
- Data Source
  KAKENHI-PROJECT-19570156
[Book] 物性研究2008
- Author(s)
  肥後順一
- Total Pages
  4
- Publisher
  京都大学物性研究刊行会
- Data Source
  KAKENHI-PROJECT-19570156
[Journal Article] Binding mechanism of riboswitch to natural ligand elucidated by McMD-based dynamic docking simulations.2024
- Author(s)
  Bekker, G.-J. Fukunishi, Y., Higo, J., Kamiya, N
- Journal Title
  
  ACS Omega
  
  Volume: 10 Pages: 3412-3422
- DOI
  10.1021/acsomega.3c06826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06052
[Journal Article] Molecular mechanisms of functional modulation of transcriptional coactivator PC4 via phosphorylation on its intrinsically disordered region.2023
- Author(s)
  Qilin Xie, Kota Kasahara, Junichi Higo, Takuya Takahashi.
- Journal Title
  
  ACS Omega
  
  Volume: 8 Issue: 16 Pages: 14572-14582
- DOI
  10.1021/acsomega.3c00364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06052
[Journal Article] Binding free-energy landscapes of small molecule binder and non-binder to FMN riboswitch: All-atom molecular dynamics2023
- Author(s)
  3.Junichi Higo, Gert-Jan Bekker, Narutoshi Kamiya, Ikuo Fukuda and Yoshifumi Fukunishi.
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 20 Issue: 4 Pages: n/a
- DOI
  10.2142/biophysico.bppb-v20.0047
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06052
[Journal Article] A cutoff-based method with charge-distribution-data driven pair potentials for efficiently estimating electrostatic interactions in molecular systems.2023
- Author(s)
  Ikuo Fukuda, Kei Moritsugu, Junichi Higo, Yoshifumi Fukunishi.
- Journal Title
  
  J. Chem. Phys.
  
  Volume: 159 Issue: 23 Pages: 234116-234116
- DOI
  10.1063/5.0172270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06052, KAKENHI-PROJECT-23K03344, KAKENHI-PROJECT-23K11134, KAKENHI-PROJECT-20K03883, KAKENHI-PROJECT-20K11854
[Journal Article] Fly-casting with ligand-sliding and orientational selection to support the complex formation of a GPCR and a middle-sized flexible molecule.2022
- Author(s)
  Junichi Higo, Kota Kasahara, et al.
- Journal Title
  
  BioRxiv
  
  Volume: -
- DOI
  10.1101/2022.02.28.482421
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06052
[Journal Article] Computer simulation of molecular recognition in biomolecular system: from in silico screening to generalized ensembles2022
- Author(s)
  Fukunishi Yoshifumi、Higo Junichi、Kasahara Kota
- Journal Title
  
  Biophysical Reviews
  
  Volume: 14 Issue: 6 Pages: 1423-1447
- DOI
  10.1007/s12551-022-01015-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06052
[Journal Article] Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR and a middle sized flexible molecule.2022
- Author(s)
  Junichi Higo, Kota Kasahara, Gert-Jan Bekker, Benson Ma, Shun Sakuraba, Shinji Iida, Narutoshi Kamiya, Ikuo Fukuda, Hidetoshi Kono, Yoshifumi Fukunishi, Haruki Nakamura
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 13792-13792
- DOI
  10.1038/s41598-022-17920-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06052, KAKENHI-PLANNED-18H05534
[Journal Article] Mutual population-shift driven antibody-peptide binding elucidated by molecular dynamics simulations.2020
- Author(s)
  98.Gert-Jan Bekker, Ikuo Fukuda, Junichi Higo, Narutoshi Kamiya.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1406-1406
- DOI
  10.1038/s41598-020-58320-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] GA-based mD-VcMD: A genetic-algorithm-based method for multi-dimensional virtual-system coupled molecular dynamics.2020
- Author(s)
  14.Higo, J.; Kusaka, A.; Kasahara, K.; Kamiya, N.; Fukuda, I.; Mori, K.; Hata, Y.; Fukunishi, F.
- Journal Title
  
  arXiv
  
  Volume: 未配布
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Molecular interaction mechanism of 14-3-3e protein with phosphorylated Myeloid leukemia factor 1 revealed by an enhanced conformational sampling2020
- Author(s)
  13.Junichi Higo, Takeshi Kawabata, Ayumi Kusaka, Kota Kasahara, Narutoshi Kamiya, Ikuo Fukuda, Kentaro Mori, Yutaka Hata, Yoshifumi Fukunishi, Haruki Nakamura
- Journal Title
  
  bioRxiv
  
  Volume: 未配布
- DOI
  10.1101/2020.05.24.113209
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Effects of number of parallel runs and frequency of bias-strength replacement in generalized ensemble molecular dynamics simulations.2019
- Author(s)
  97.Takuya Shimato, Kota Kasahara, Junichi Higo, Takuya Takahashi
- Journal Title
  
  PeerJ Phys. Chem.
  
  Volume: 1 Pages: e4-e4
- DOI
  10.7717/peerj-pchem.4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Free-energy landscape of molecular interactions between endothelin 1 and human endothelin type B receptor: Fly-casting mechanism.2019
- Author(s)
  96.Junichi Higo, Kota Kasahara, Mitsuhito Wada, Bhaskar Dasgupta, Narutoshi Kamiya, Tomonori Hayami, Ikuo Fukuda, Yoshifumi Fukunishi, Haruki Nakamura
- Journal Title
  
  Protein Engineering, Design & Selection
  
  Volume: 32 Issue: 7 Pages: 297-308
- DOI
  10.1093/protein/gzz029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Multimodal Structural Distribution of the p53 C-Terminal Domain upon Binding to S100B via a Generalized Ensemble Method: From Disorder to Extradisorder2019
- Author(s)
  Iida Shinji、Kawabata Takeshi、Kasahara Kota、Nakamura Haruki、Higo Junichi
- Journal Title
  
  Journal of Chemical Theory and Computation
  
  Volume: 15 Issue: 4 Pages: 2597-2607
- DOI
  10.1021/acs.jctc.8b01042
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K05517, KAKENHI-PROJECT-17J07112, KAKENHI-PROJECT-16K18526
[Journal Article] Studies on molecular dynamics of intrinsically disordered proteins and their fuzzy complexes: a mini-review2019
- Author(s)
  12.Kota Kasahara, Hiroki Terazawa, Takuya Takahashi, Junichi Higo
- Journal Title
  
  Computational and Structural Biotechnology Journal
  
  Volume: 17 Pages: 712-720
- DOI
  10.1016/j.csbj.2019.06.009
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Multidimensional virtual-system coupled canonical molecular dynamics to compute free-energy landscapes of peptide multimer assembly.2019
- Author(s)
  95.Tomonori Hayami, Junichi Higo, Haruki Nakamura, Kota Kasahara
- Journal Title
  
  J Comput. Chem.
  
  Volume: 40 Issue: 28 Pages: 2453-2463
- DOI
  10.1002/jcc.26020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Phosphorylation of an intrinsically disordered region of Ets1 shifts a multi-modal interaction ensemble to an out-inhibitory state.2018
- Author(s)
  Kota Kasahara, Masaaki Shiina, Junichi Higo, Kazuhiro Ogata, Haruki Nakamura.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 46 Issue: 5 Pages: 2243-2251
- DOI
  10.1093/nar/gkx1297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05517, KAKENHI-PROJECT-16K18526, KAKENHI-PROJECT-16K14711, KAKENHI-PROJECT-18K19305, KAKENHI-PROJECT-16H03293
[Journal Article] 理論と実験の連携による蛋白質天然変性領域の機能解析2018
- Author(s)
  21.笠原浩太，椎名政昭，肥後順一，緒方一博，中村春木
- Journal Title
  
  分子シミュレーション研究会会誌「アンサンブル」
  
  Volume: 20 Pages: 253-259
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Molecular dynamics coupled with a virtual system for effective conformational sampling.2018
- Author(s)
  Tomonori Hayami, Kota Kasahara, Haruki Nakamura, Junichi Higo
- Journal Title
  
  J Comput Chem
  
  Volume: 1 Issue: 19 Pages: 1-1
- DOI
  10.1002/jcc.25196
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05517, KAKENHI-PROJECT-16K18526
[Journal Article] Multi-dimensional virtual system introduced to enhance canonical sampling.2017
- Author(s)
  Junichi Higo, Kota Kasahara, Haruki Nakamura.
- Journal Title
  
  J. Chem. Phys.
  
  Volume: 147 Issue: 13 Pages: 134102-134102
- DOI
  10.1063/1.4986129
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K05517, KAKENHI-PROJECT-16K18526, KAKENHI-PROJECT-16K14711
[Journal Article] Enhancement of canonical sampling by virtual-state transitions2017
- Author(s)
  Junichi Higo, Kota Kasahara, Bhaskar Dasgupta, Haruki Nakamura
- Journal Title
  
  J. Chem. Phys.
  
  Volume: 146 Issue: 4 Pages: 44104-44104
- DOI
  10.1063/1.4974087
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-16K14711, KAKENHI-PROJECT-16K18526, KAKENHI-PROJECT-16K05517
[Journal Article] myPresto/omegagene: a GPU-accelerated molecular dynamics simulator tailored for enhanced conformational sampling methods with a non-Ewald electrostatic scheme2016
- Author(s)
  Kota Kasahara, Benson Ma, Kota Goto, Bhaskar Dasgupta, Junichi Higo, Ikuo Fukuda, Tadaaki Mashimo, Yutaka Akiyama, Haruki Nakamura
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 13 Issue: 0 Pages: 209-216
- DOI
  10.2142/biophysico.13.0_209
- NAID
  130007041560
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-16K05517, KAKENHI-PROJECT-16K18526
[Journal Article] Enhanced conformational sampling to visualize a free-energy landscape of protein complex formation.2016
- Author(s)
  Sinji Iida, Haruki Nakamura, Junichi Higo.
- Journal Title
  
  Biochemical J.
  
  Volume: 473 Issue: 12 Pages: 1651-1662
- DOI
  10.1042/bcj20160053
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Flexible binding simulation by a novel and improved version of virtual-system coupled adaptive umbrella sampling.2016
- Author(s)
  Bhaskar Dasgupta, Haruki Nakamura, Junichi Higo.
- Journal Title
  
  Chem. Phys. Lett.
  
  Volume: 662 Pages: 327-332
- DOI
  10.1016/j.cplett.2016.09.059
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Intrinsic disorder accelerates dissociation rather than association2016
- Author(s)
  K. Umezawa, J. Ohnuki, J. Higo, and M. Takano
- Journal Title
  
  Proteins: Structure, Function and Bioinformatics
  
  Volume: - Issue: 8 Pages: 1489-1501
- DOI
  10.1002/prot.25057
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J07605, KAKENHI-PROJECT-16K05517, KAKENHI-PROJECT-16K14715
[Journal Article] Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIH.2016
- Author(s)
  Masahiko Okuda, Junichi Higo, Tadashi Komatsu, Tsuyoshi Konuma, Kenji Sugase, Yoshifumi Nishimura.
- Journal Title
  
  Biophysical J.
  
  Volume: 111 Issue: 5 Pages: 950-962
- DOI
  10.1016/j.bpj.2016.07.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Enhanced sampling simulations to construct free energy landscape of protein-partner substrate interaction.2016
- Author(s)
  Jinzen Ikebe, Koji Umezawa, Junichi Higo
- Journal Title
  
  Biophysical Rev.
  
  Volume: 8 Issue: 1 Pages: 45-62
- DOI
  10.1007/s12551-015-0189-z
- Data Source
  KAKENHI-PROJECT-16K05517
[Journal Article] Variation of Free-Energy Landscape of the p53 C-terminal Domain Induced by Acetylation: Enhanced Conformational Sampling2016
- Author(s)
  Shinji Iida, Tadaaki Mashimo, Takashi Kurosawa, Hironobu Hojo, Hiroya Muta, Yuji Goto, Yoshifumi Fukunishi, Haruki Nakamura, Junichi Higo
- Journal Title
  
  J. Comput. Chem.
  
  Volume: 37 Issue: 31 Pages: 2687-2700
- DOI
  10.1002/jcc.24494
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-16H04180, KAKENHI-PROJECT-16K05517
[Journal Article] 全原子コンピュータシミュレーションで解き明かす、天然変成タンパク質の分子認識機構2014
- Author(s)
  肥後順一、梅澤公二
- Journal Title
  
  生物物理学会会誌「生物物理」
  
  Volume: 54 Pages: 96-99
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] High-resolution modeling of antibody structures by a combination of bioinformatics, expert knowledge, and molecular simulations.2014
- Author(s)
  Hiroki Shirai, Kazuyoshi Ikeda, Kazuo Yamashita, Yuko Tsuchiya, Jamica Sarmiento, Shide Liang, Tatsuaki Morokata, Kenji Mizuguchi, Junichi Higo, Daron M. Standley, Haruki Nakamura
- Journal Title
  
  Proteins
  
  Volume: 印刷中 Issue: 8 Pages: 1624-1635
- DOI
  10.1002/prot.24591
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23370071, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-25430186
[Journal Article] High-resolution modeling of antibody structures by a combination of bioinformatics, expert knowledge, and molecular simulations2014
- Author(s)
  H. Shirai, K. Ikeda, K. Yamashita, Y. Tsuchiya, J. Sarmiento, S. Liang, T. Morokata, K. Mizuguchi, J. Higo, D. M. Standley, H. Nakamura
- Journal Title
  
  Proteins
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] Local representation of N-body Coulomb energy with path integrals2014
- Author(s)
  T. Sugihara, J. Higo, H. Nakamura
- Journal Title
  
  J. Phys. Soc. Jpn.
  
  Volume: 未定
- NAID
  40020091368
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] A virtual-system coupled multicanonical molecular dynamics simulation: Principle and its application to free-energy landscape of protein-protein interaction with an all-atom model in explicit solvent2013
- Author(s)
  Junichi Higo
- Journal Title
  
  J. Chem. Phys.
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] Gas-phase structure of the histone multimers characterized by ion mobility mass spectrometry and molecular dynamics simulation2013
- Author(s)
  Saikusa K, Fuchigami S, Takahashi K, Asano Y, Nagadoi A, Tachiwana H, Kurumizaka H, Ikeguchi M, Nishimura Y, Akashi S
- Journal Title
  
  Anal Chem
  
  Volume: 85 Issue: 8 Pages: 4165-4171
- DOI
  10.1021/ac400395j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20227009, KAKENHI-ORGANIZER-21113001, KAKENHI-PLANNED-21113003, KAKENHI-PROJECT-22570120
[Journal Article] A virtual-system coupled multicanonical molecular dynamics simulation: Principles and applications to free-energy landscape of protein–protein interaction with an all-atom model in explicit solvent2013
- Author(s)
  Higo, J., Umezawa, K., Nakamura, H.
- Journal Title
  
  Journal of Chemical Physics
  
  Volume: 138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370071
[Journal Article] A virtual-system coupled multicanonical molecular dynamics simulation : Principles and applications to free-energy landscape of protein-protein interaction with an all-atom model in explicit solvent2013
- Author(s)
  J. Higo, K. Umezawa, H. Nakamura
- Journal Title
  
  Journal of Chemical Physics
  
  Volume: 138 Issue: 18 Pages: 184106-184106
- DOI
  10.1063/1.4803468
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J07605, KAKENHI-ORGANIZER-21113001, KAKENHI-PLANNED-21113006, KAKENHI-PROJECT-23370071, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008
[Journal Article] A virtual-system coupled multicanonical molecular dynamics simulation: Principle and its application to free-energy landscape of protein-protein interaction with an all-atom model in explicit solvent2013
- Author(s)
  J. Higo, K. Umezawa, H. Nakamura
- Journal Title
  
  J. Chem. Phys.
  
  Volume: 138 Pages: 184106-184106
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] A virtual-system coupled multicanonical molecular dynamics simulation: Principle and its application to free-energy landscape of protein-protein interaction with an all-atom model in explicit solvent2013
- Author(s)
  Junichi Higo
- Journal Title
  
  J. Chem. Phys.
  
  Volume: 138
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21113001
[Journal Article] Conformational Ensembles of an Intrinsically Disordered Protein pKID with and without a KIX Domain in Explicit Solvent Investigated by All-Atom Multicanonical Molecular Dynamics2012
- Author(s)
  Umezawa, K., Ikebe, J., Takano, M., Nakamura, H., Higo, J
- Journal Title
  
  Biomolecules
  
  Volume: 2 Issue: 1 Pages: 104-121
- DOI
  10.3390/biom2010104
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006, KAKENHI-PROJECT-23370071
[Journal Article] Virtual states introduced for overcoming entropic barriers in conformational space2012
- Author(s)
  Junichi Higo
- Journal Title
  
  Biophysics
  
  Volume: 8 Pages: 104-121
- NAID
  130002061588
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] Enhanced and effective conformational sampling of protein molecular systems for their free energy landscapes2012
- Author(s)
  J.Higo, J.Ikebe, N.Kamiya, H.Nakamura
- Journal Title
  
  Biophysical Rev.
  
  Volume: 4 Pages: 27-44
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] Enhanced and effective conformational sampling of protein molecular systems for their free energy landscapes2012
- Author(s)
  Higo, J., Ikebe, J., Kamiya, N., Nakamura, H
- Journal Title
  
  Biophysical Rev
  
  Volume: 4 Issue: 1 Pages: 27-44
- DOI
  10.1007/s12551-011-0063-6
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006, KAKENHI-PROJECT-22570160, KAKENHI-PROJECT-23370071
[Journal Article] Virtual states introduced for overcoming entropic barriers in conformational space2012
- Author(s)
  Higo, J., Nakamura, H
- Journal Title
  
  BIOPHYSICS
  
  Volume: 8 Issue: 0 Pages: 139-144
- DOI
  10.2142/biophysics.8.139
- NAID
  130002061588
- ISSN
  1349-2942
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006, KAKENHI-ORGANIZER-21113001
[Journal Article] Theory for trivial trajectory parallelization of multicanonical molecular dynamics and application to a polypeptide in water.2011
- Author(s)
  J.Ikebe, K.Umezawa, N.Kamiya, T.Sugihara, Y.Yonezawa, Y.Takano, H.Nakamura, J.Higo
- Journal Title
  
  J.Comput.Chem. 32
  
  Pages: 1286-1297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370061
[Journal Article] Theory for Trivial Trajectory Parallelization of Multicanonical Molecular Dynamics and Application to a Polypeptide in Water2011
- Author(s)
  Ikebe, J., Umezawa, K., Kamiya, N., Sugihara, T., Yonezawa, Y., Takano, Y., Nakamura, H., Higo J.
- Journal Title
  
  Journal of Computational Chemistry
  
  Volume: 32 Pages: 1286-1297
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] A Free-energy Landscape for Coupled Folding and Binding of an Intrinsically Disordered Protein in Explicit Solvent from Detailed All-atom Computations2011
- Author(s)
  J.Higo, Y.Nishimura, H.Nakamura
- Journal Title
  
  J.Am.Chem.Soc.
  
  Volume: 133 Pages: 10448-10458
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] Ab initio simulation of a 57-residue protein in explicit solvent reproduces the native conformation in the lowest free-energy cluster2011
- Author(s)
  Ikebe, J., Standley, D.M., Nakamura, H., Higo J.
- Journal Title
  
  Protein Science
  
  Volume: 20 Pages: 187-196
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] Free-energy Landscape for Coupled Folding and Binding of an Intrinsically Disordered Protein in Explicit Solvent from Detailed All-atom Computations2011
- Author(s)
  Higo J, Nishimura Y, Nakamura H
- Journal Title
  
  J Am Chem Soc
  
  Volume: 133 Issue: 27 Pages: 10448-10458
- DOI
  10.1021/ja110338e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20227009, KAKENHI-PLANNED-21113003, KAKENHI-PLANNED-21113006, KAKENHI-PROJECT-23370071
[Journal Article] Ab initio simulation of a 57-residue protein in explicit solvent reproduces the native conformation in the lowest free-energy cluster.2011
- Author(s)
  J.Ikebe, D.M.Standley, H.Nakamura, J.Higo
- Journal Title
  
  Protein Science 20
  
  Pages: 187-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370061
[Journal Article] Theory for Trivial Trajectory Parallelization of Multicanonical Molecular Dynamics and Application to a Polypeptide in Water2011
- Author(s)
  Ikebe, J., Umezawa, K., Kamiya, N., Sugihara, T., Yonezawa, Y., Takano, Y., Nakamura, H., Higo, J
- Journal Title
  
  J. Comput. Chem.
  
  Volume: 32 Issue: 7 Pages: 1286-1297
- DOI
  10.1002/jcc.21710
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] 単純軌跡和マルチカノニカル分子動力学法2010
- Author(s)
  肥後順一
- Journal Title
  
  アンサンブル(分子シミュレーション研究会会誌)
  
  Volume: 12 Pages: 8-10
- NAID
  130004566659
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] Theory for Trivial Trajectory Parallelization of Multicanonical Molecular Dynamics and Application to a Polypeptide in Water2010
- Author(s)
  Ikebe, J., Higo, J.
- Journal Title
  
  Journal Computational Chemistry
  
  Volume: (in press 現在未定)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113006
[Journal Article] Verifying trivial parallelization of multicanonical molecular dynamics for conformational sampling of a polypeptide in explicit water2009
- Author(s)
  Junichi Higo
- Journal Title
  
  Chem.Phys.Lett. 473
  
  Pages: 326-329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370061
[Journal Article] arXiv2009
- Author(s)
  Takanori Sugihara, Junichi Higo, Haruki Nakamura
- Journal Title
  
  0812
  
  Pages: 2964-2964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570156
[Journal Article] Verifying trivial parallelization of multicanonical molecular dynamics for conformational sampling of a polypeptide in explicit water2009
- Author(s)
  J. Higo, N. Kamiya, T. Sugihara, Y.Yonezawa, H. Nakamur
- Journal Title
  
  Chem. Phys. Lett 473
  
  Pages: 326-329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570156
[Journal Article] Parallelization of Markov chain generation and its application to the multicanonical method2009
- Author(s)
  T. Sugihara, J. Higo, H. Nakamura
- Journal Title
  
  J. Phys. Soc. Jpn. (in press)
- NAID
  10025962130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570156
[Journal Article] Structure dependency of a 24-residue peptide humanin on solvent and preferential solvation by trifluoroethanol studied by multicanonical sampling2008
- Author(s)
  R. Yagisawa, N. Kamiya, J. Ikebe, K.Umezawa, J. Higo
- Journal Title
  
  Chem. Phys. Lett. 455
  
  Pages: 293-296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] 膜に埋もれたヒトエンドセリン受容体に結合するボセンタンの結合メカニズム：スライドするフライ・キャストィングと配向選択メカニズム2021
- Author(s)
  肥後順一
- Organizer
  第５９回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06052
[Presentation] AIで効率化されたMD法による、蛋白質-リガンドの結合・解離自由エネルギー地形の算出2021
- Author(s)
  肥後順一
- Organizer
  第8回HPCIシステム利用研究課題成果報告会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06052
[Presentation] Oct4の2つのDNA結合サブドメインを結ぶLinker領域の構造多様性2017
- Author(s)
  速水智教、高田彰二、笠原浩太、中村春木、肥後順一
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-16K14711
[Presentation] Oct4の2つのDNA結合サブドメインを結ぶLinker領域の構造多様性2017
- Author(s)
  速水智教、高田彰二、笠原浩太、中村春木、肥後順一
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16K14711
[Presentation] Oct4の2つのDNA結合サブドメインを結ぶ柔軟なlinker領域の自由エネルギー地形2016
- Author(s)
  速水智教、高田彰二、中村春木、肥後順一
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県、つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16K14711
[Presentation] Free-energy Landscape of Coupled Folding and Binding of IDP-partner Systems in an Explicit Solvent Investigated by All-atom Multicanonical Molecular Dynamics2013
- Author(s)
  Junichi Higo, Koji Umezawa, Haruki Nakamura
- Organizer
  Protein Society the 27th Annual Symposium
- Place of Presentation
  Boston Marriott, Boston, USA
- Data Source
  KAKENHI-PROJECT-23370071
[Presentation] 全原子シミュレーションによる天然変性蛋白質の自由エネルギー地形2011
- Author(s)
  肥後　順一
- Organizer
  第49回日本生物物理学会
- Place of Presentation
  兵庫県立大学
- Data Source
  KAKENHI-PROJECT-23370071
[Presentation] 天然変死蛋白質NRSFとそのパートナー蛋白質mSin3の結合／折れ畳みの詳細な自由エネルギー地形2011
- Author(s)
  肥後　順一
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  大阪千里
- Data Source
  KAKENHI-PROJECT-23370071
[Presentation] Free Energy Landscape: the road map for protein conformational changes2011
- Author(s)
  肥後　順一
- Organizer
  第34回日本分子生物学会年会シンポジウム
- Place of Presentation
  パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23370071
[Presentation] Free-energy landscape : the road map for protein conformational changes2011
- Author(s)
  肥後順一
- Organizer
  第34回に本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜)(招待講演)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PLANNED-21113006
[Presentation] 天然変性蛋白質NRSFとパートナー蛋白質Sin3の結合/折り畳みの自由エネルギー地形2010
- Author(s)
  肥後順一
- Organizer
  第10回日本蛋白質科学会年会ワークショップ「タンパク質間相互作用の計算・情報科学」
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-ORGANIZER-21113001
[Presentation] 単純並列化によるマルチカノニカル分子動力学法のサンプリング効率の向上2010
- Author(s)
  肥後順一
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター・札幌
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-20370061
[Presentation] 天然変性蛋白質pKIDのKIXドメインとの結合に共役したフォールディングのマルチカノニカル分子動力学計算による解析2010
- Author(s)
  肥後順一
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター・札幌
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-20370061
[Presentation] 天然変性蛋白質NRSFはパートナー蛋白質Sin3の存在下のみでヘリックス構造をとる-全原子マルチカノニカル計算-2010
- Author(s)
  肥後順一
- Organizer
  文科省「新学術領域研究(天然変性蛋白質)」第1回公開シンポジウム
- Place of Presentation
  理化学研究所横浜研究所
- Year and Date
  2010-01-19
- Data Source
  KAKENHI-ORGANIZER-21113001
[Presentation] 天然変性タンパク質NRSFとパートナー蛋白質Sin3の結合/折れ畳みの自由エネルギー地名2010
- Author(s)
  肥後順一
- Organizer
  第10回蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター(札幌)(招待講演)
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PLANNED-21113006
[Presentation] 天然変性蛋白質NRSF とパートナー蛋白質Sin3 の結合/折り畳みの自由エネルギー地形2010
- Author(s)
  肥後順一
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-ORGANIZER-21113001
[Presentation] マルチカノニカル分子動力学シミュレーションによる天然変性蛋白質の自由エネルギー地形2009
- Author(s)
  肥後順一
- Organizer
  第82回日本生化学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-ORGANIZER-21113001
[Presentation] アルツハイマーβアミロイドペプチド構造の分子シミュレーション2009
- Author(s)
  肥後順一
- Organizer
  物理学会年会(春)
- Place of Presentation
  東京
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Disordered proteinである水中アルツハイマーβアミロイドペプチドAβ(12-36)の自由エネルギー地形2008
- Author(s)
  池部仁善、神谷成敏、伊東純一、神藤平三郎、肥後順一
- Organizer
  蛋白質科学会年会
- Place of Presentation
  東京
- Year and Date
  2008-06-10
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] 蛋白質周辺における水分子の協調的挙動の分子動力学シミュレーションによる解析2008
- Author(s)
  梅澤公二、肥後順一、中村春木、田代櫻子、神藤平三郎
- Organizer
  物理学会年会(秋)
- Place of Presentation
  山形
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] アルファ/ベータ両二次構造を含む40残基蛋白質の立体構造サンプリング2008
- Author(s)
  肥後順一、池部仁善、神谷成敏、中村春木
- Organizer
  蛋白質科学会年会
- Place of Presentation
  東京
- Year and Date
  2008-06-11
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] アルファ/ベーダ両方の二次構造要素を含む40残基蛋白質のフォールディングシミュレーション2008
- Author(s)
  肥後順一
- Organizer
  日本物理学会2008年秋期大会
- Place of Presentation
  岩手大学上田キャンパス
- Year and Date
  2008-09-22
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Structure variation of a 24-residue peptide on solvent, and preferential solvation by trifluroethanol by multicanonical sampling2008
- Author(s)
  R. Yagisawa, N. Kamiya, A. Yamagishi, J.Higo
- Organizer
  生物物理学会年会
- Place of Presentation
  福岡
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] An enhanced conformational sampling of a 40-residue protein consisting of alpha and beta secondary structures in explicit solvent2008
- Author(s)
  J. Higo, N. Kamiya
- Organizer
  The Joint 2nd Pacific Rim International Conference on Protein Science and 4th Asian-Oceania Human Proteome Organization
- Place of Presentation
  ケアンズ、オーストラリア
- Year and Date
  2008-06-24
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Two types universality of a fold universe of 50-residue segment2008
- Author(s)
  J. Ito, Y. Sonobe, K. Ikeda, K. Tomii, A.Yamagishi, J. Higo
- Organizer
  生物物理学会年会
- Place of Presentation
  福岡
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] 蛋白質周辺における水の協調的な流れの分子動力学シミュレーションによる解析2008
- Author(s)
  梅澤公二、肥後順一、山岸明彦、中村春木、田代櫻子、神藤平三郎
- Organizer
  蛋白質科学会年会
- Place of Presentation
  東京
- Year and Date
  2008-06-11
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Brownian dynamics simulation of hERG potassium ion channel and development of an accurate molecular docking method for protein and ligand2008
- Author(s)
  N. Kamiya, J. Higo
- Organizer
  The 3rd MEI International Symposium
- Place of Presentation
  San Francisco, USA.
- Year and Date
  2008-11-30
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] マルチカノニカル分子動力学法によるアミロイドペプチド4本鎖の会合シミュレーション2008
- Author(s)
  神谷成敏、米澤康滋、中村春木、肥後順一
- Organizer
  蛋白質科学会年会
- Place of Presentation
  東京
- Year and Date
  2008-06-10
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] アルファ/べータ両方の二次構造要素を含む40残基蛋白質のフォールディングシミュレーション2008
- Author(s)
  肥後順一、池部仁善、神谷成敏、中村春木
- Organizer
  物理学会年会(秋)
- Place of Presentation
  山形
- Year and Date
  2008-09-22
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Fair current, vortex, and drying/wetting water flow around lysozyme investigated by molecular dynamics simulation2008
- Author(s)
  K. Umezawa, R. Morikawa, H. Nakamura, J.Higo
- Organizer
  生物物理学会年会
- Place of Presentation
  福岡
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Multicanonical molecular dynamics simulation of a protein with 57 residues in explicit water2008
- Author(s)
  J, Ikebe, J. Higo, H. Nakamura
- Organizer
  生物物理学会年会
- Place of Presentation
  福岡
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Identification of essential variables for medium-size protein-segment and application to structural class assignment2008
- Author(s)
  K. Ikeda, J. Higo, K. Tomii
- Organizer
  生物物理学会年会
- Place of Presentation
  福岡
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Assembly simulation of four peptide chains in explicit water by multicanonical molecular dynamics2008
- Author(s)
  N. Kamiya, Y. Yonezawa, H. Nakamura, J.Higo
- Organizer
  The Joint 2nd Pacific Rim International Conference on Protein Science and 4th Asian-Oceania Human Proteome Organization
- Place of Presentation
  ケアンズ、オーストラリア
- Year and Date
  2008-06-24
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] マルチカノニカル分子動力学シミュレーションによって描かれるdisordered protein (水中アミロイドβ 12-36 残基断片)の自由エネルギー地形2008
- Author(s)
  池部仁善、神谷成敏、伊東純一,神藤平三郎、中村春木、肥後順一
- Organizer
  物理学会年会(秋)
- Place of Presentation
  山形
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] マルチカノニカル分子動力学法によるアミロイドペプチドの会合シミュレーション2008
- Author(s)
  神谷成敏,米澤康滋、中村春木、肥後順一
- Organizer
  物理学会年会(秋)
- Place of Presentation
  山形
- Year and Date
  2008-09-20
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Collective water flows around a protein : a novel insight into explicit solvent characteristics2007
- Author(s)
  K. Umezawa, J. Higo, A. Yamagishi, S.Tashiro, H. Shindo
- Organizer
  情報計算化学生物学会2007年大会
- Place of Presentation
  広島
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Free-energy landscapes of humanin in water and in TFE/water using multicanonical molecular dynamics2007
- Author(s)
  R. Yagisawa, N. Kamiya, A. Yamagishi, J.Higo
- Organizer
  情報計算化学生物学会2007年大会
- Place of Presentation
  広島
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Structure universe of 50-residue protein segments constructed by residue-residue native contacts2007
- Author(s)
  Y. Sonobe, J. Ito, A. Yamagishi, K. Tomii, J.Higo
- Organizer
  情報計算化学生物学会2007年大会
- Place of Presentation
  広島
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Prediction of protein structure from the free-energy landscapes2007
- Author(s)
  J. Higo, N. Kamiya
- Organizer
  The 2nd MEI International Symposium
- Place of Presentation
  Osaka
- Year and Date
  2007-12-08
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] A process of protein-ligand approach mediated by solvent-dipole field2007
- Author(s)
  N. Takano, N. Hamasaki, H. Miyagawa, A.Yamagishi, J. Higo
- Organizer
  情報計算化学生物学会2007年大会
- Place of Presentation
  広島
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Conformational sampling of a 40-residue protein consisting of alpha and beta secondary-structure elements in explicit solvent2007
- Author(s)
  J. Higo, J. Ikebe, N. Kamiya, H. Nakamura,H. Shindo
- Organizer
  情報計算化学生物学会2007年大会
- Place of Presentation
  広島
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-19570156
[Presentation] Free-energy landscape of the disordered state of an Altzheimer's beta amyloid peptide in water studied by multicanonical molecular dynamics2007
- Author(s)
  J. Ikebe, N. Kamiya, J. Ito, H. Shindo, A.Yamagishi, J, Higo
- Organizer
  情報計算化学生物学会2007年大会
- Place of Presentation
  広島
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-19570156

1. NAKAMURA Haruki (80134485)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
2. KAMIYA Narutoshi (80420462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. KINOSHITA Kengjo (60332293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SATO Mamoru (60170784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SHIBATA Takehiko (70087550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OTA Motonori (40290895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. AKASHI Satoko (10280728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. ISHONO Yoshizumi (30346837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NISHIMURA Yoshifumi (70107390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. FUJII Yoshiaki (00098146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ISHIKAWA Fuyuki (30184493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MORIKAWA Kousuke (80012665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKANO Mitsunori (40313168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. KIKUCHI Macoto (50195210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KINJO Akira R (30370117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YONEZAWA Yasushige (40248753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 笠原浩太 (90634965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
18. ISHI Shunsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 長土居有隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higo Junichi 肥後 順一

肥後 順一 ヒゴ ジユンイチ

HIGO Junichi 肥後 順一

Research Projects

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Co-Researchers

膜蛋白質 GPCR と薬剤化合物ボセンタンの結合自由エネルギー地形Principal Investigator

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kinetic constants of molecular binding calculated from equilibriumPrincipal Investigator

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Computational study for multistery of intrinsic disordered region of proteins with post-translational modification

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Quantitative computational and informatics studies on protein-protein interaction systems based on their dynamic structures

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Target recognition and expression mechanism of intrinsically disordered protein

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Analysis on the structural polymorphism of IDPs by computer simulationPrincipal Investigator

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Structural Interactome Studies from Computational and Bioinformatics Approaches

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Computation of the free-energy landscape of a protein involving α and β secondary-structure elementsPrincipal Investigator

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[Book] Protein Conformational Dynamics, Advances in Experimental Medicine and Biology2014

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[Book] Protein Conformational Dynamics in Advances in Experimental Medicine and Biology Vol.8052014

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[Book] “Protein Conformational Dynamics” in “Advances in Experimental Medicine and Biology” Vol. 8052014

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[Book] Free-energy landscape of Intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics, Chapter 14 in "Protein Conformational Dynamics" (Han, K., Zhang, X., and Yang, M.eds.) Advances in Experimental Medicine and Biology 8052014

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[Book] 全原子コンピュータシミュレーションで解き明かす、天然変成タンパク質の分子認識機構2013

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[Book] 生物物理学会会誌「生物物理」2013

Author(s)

Higo Junichi 肥後順一

肥後順一ヒゴジユンイチ

HIGO Junichi 肥後順一