Watanabe Takumi 渡辺匠

… Alternative Names

WATANABE Takumi 渡辺匠

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Researcher Number	80270544
Other IDs
Affiliation (Current)	2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 部長
Affiliation (based on the past Project Information) *help	2016 – 2023: 公益財団法人微生物化学研究会, 微生物化学研究所, 部長 2015: 公益財団法人微生物化学研究会, 微生物化学研究所有機合成研究部, 部長 2014: 公益財団法人微生物化学研究会, 微生物化学研究所, 主席研究員 2013 – 2014: 公益財団法人微生物化学研究会, 微生物化学研究所有機合成研究部, 主席研究員 2012: 公益財団法人微生物化学研究会, 微生物化学研究所, 主席研究員 … More 2011: 公益財団法人微生物化学研究会, 微生物化学研究所有機合成研究部, 主席研究員 2008: Microbial Chemistry Research Foundation, 微化研センター分子構造検討G構造分析U, 研究員 2008: Microbial Chemistry Research Foundation, 微生物化学研究センター・分子構造検討グループ構造分析ユニット, 研究員 2007: Microbial Chemistry Research Foundation, 微生物化学研究センター・分子構造検討グループ・構造分析ユニット, 研究員 2006: (財)微生物化学研究会, 微生物化学研究センター・分子構造検討グループ構造分析ユニット, 研究員 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Chemical pharmacy Except Principal Investigator Living organism molecular science
Keywords	Principal Investigator 全合成 / 天然物 / 構造活性相関 / がん－間質相互作用 / 抗がん剤 / ペプチド系天然物 / 抗がん剤リード / 医薬化学 / がんー間質相互作用 / 抗結核薬 … More / 触媒的不斉反応 / 有機化学 / 創薬化学 / 共役付加反応 / 抗グラム陰性菌薬 / がん分子標的薬 / 呼吸鎖阻害剤 / complex V / がん・間質相互作用 / 分子標的薬 / ペプチド / ロイシノスタチン / XDR-TB / ケミカルバイオロジー / 触媒的不斉合成 / 抗結核剤 / 天然有機化合物 / 生物活性物質 / 高脂血症 … More Except Principal Investigator 経口投与 / 経口剤 / プロテアソーム阻害剤 / プロテアソーム / インビボイメージング Less

Catalytic asymmetric total synthesis of a novel antibacterial natural product, MM249-143F7Principal Investigator
- Principal Investigator
  
  渡辺匠
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Microbial Chemistry Research Foundation
Medicinal Chemistry of Anti-tumor Agents Targetd at Stromal Complex VPrincipal Investigator
- Principal Investigator
  
  Watanabe Takumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Microbial Chemistry Research Foundation
Development of anticancer lead based on catalytic asymmetric total synthesis of leucinostatin APrincipal Investigator
- Principal Investigator
  
  Watanabe Takumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Microbial Chemistry Research Foundation
Development of anti-XDR-TB leads based on catalytic asymmetric synthesis and chemical biologyPrincipal Investigator
- Principal Investigator
  
  WATANABE Takumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Microbial Chemistry Research Foundation
Development of orally active proteasome inhibitors using in vivo imaging.
- Principal Investigator
  
  MOMOSE Isao
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Microbial Chemistry Research Foundation
Catalytic asymmetric total synthesis of caprazamycin, an anti-tuberculosis antibioticPrincipal Investigator
- Principal Investigator
  
  WATANABE Takumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Microbial Chemistry Research Foundation
Screening for Inhibitors of Intestinal Cholesterol Transporter NPC1L1Principal Investigator
- Principal Investigator
  
  WATANABE Takumi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Microbial Chemistry Research Foundation

[Journal Article] Direct Catalytic Enantioselective Conjugate Addition of α-Substituted Benzyl Nitriles to Alkyl Acrylates2024
- Author(s)
  Sadhanendu Samanta, Jin Cui, Yasunari Otsuka, Takumi Watanabe, Masakatsu Shibasaki
- Journal Title
  
  Organic Letters
  
  Volume: 26 Issue: 11 Pages: 2255-2259
- DOI
  10.1021/acs.orglett.4c00427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KF0375, KAKENHI-PROJECT-23K27308
[Journal Article] Catalytic Asymmetric Vinylogous Conjugate Addition of Butenolide to 2-Ester-Substituted Chromones: Access to Chiral Chromanone Lactones via Trapping of a Copper(I) Enolate by Trimethyl Borate2023
- Author(s)
  Cui Jin、Oriez Raphael、Samanta Sadhanendu、Noda Hidetoshi、Watanabe Takumi、Shibasaki Masakatsu
- Journal Title
  
  Organic Letters
  
  Volume: 25 Issue: 46 Pages: 8367-8371
- DOI
  10.1021/acs.orglett.3c03503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06957, KAKENHI-PROJECT-22KF0375, KAKENHI-PUBLICLY-22H05383, KAKENHI-PROJECT-23K27308
[Journal Article] Asymmetric Syn-Selective Vinylogous Addition of Butenolides to Chromones via Al-Li-BINOL Catalysis2023
- Author(s)
  Samanta Sadhanendu、Cui Jin、Noda Hidetoshi、Watanabe Takumi、Shibasaki Masakatsu
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 88 Issue: 2 Pages: 1177-1184
- DOI
  10.1021/acs.joc.2c02731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06957, KAKENHI-PUBLICLY-22H05383, KAKENHI-PROJECT-20H03371, KAKENHI-PROJECT-22KF0375, KAKENHI-PROJECT-20K15966
[Journal Article] Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment2021
- Author(s)
  J. Yoshida, T. Ohishi, H. Abe, S. Ohba, H. Inoue, I. Usami, M. Amemiya, R. Oriez, C. Sakashita, S. Dan, M. Sugawara, T. Kawaguchi, J. Ueno, Y. Asano, A. Ikeda, M. Takamatsu, G. Amori, Y. Kondoh, K. Honda, H. Osada, T. Noda, T. Watanabe, T. Shimizu, M. Shibasaki and M. Kawada
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 12 Pages: 103497-103497
- DOI
  10.1016/j.isci.2021.103497
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15333, KAKENHI-PROJECT-19K15716, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-20K06956, KAKENHI-PROJECT-16H06276, KAKENHI-PLANNED-17H06412
[Journal Article] Catalytic asymmetric total synthesis of leucinostatin A.2021
- Author(s)
  T. Watanabe, H. Abe, M. Shibasaki
- Journal Title
  
  Chem. Rec.
  
  Volume: 21 Issue: 1 Pages: 175-187
- DOI
  10.1002/tcr.202000108
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06956
[Journal Article] Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin-like growth factor-1 secretion by prostate stromal cells2020
- Author(s)
  Tomokazu Ohishi, Hikaru Abe, Chiharu Sakashita, Uzma Saqib, Mirza S. Baig, Shun‐ichi Ohba, Hiroyuki Inoue, Takumi Watanabe, Masakatsu Shibasaki, Manabu Kawada
- Journal Title
  
  Int. J. Cancer
  
  Volume: 146 Issue: 12 Pages: 3474-3484
- DOI
  10.1002/ijc.32959
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08384, KAKENHI-PROJECT-20K06956, KAKENHI-PROJECT-18K08693
[Journal Article] Catalytic Asymmetric Synthesis of Natural Products Directed Toward Development of Novel Anti-infective and Anti-cancer Medicines2018
- Author(s)
  渡辺匠，柴﨑正勝
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 76 Issue: 8 Pages: 781-791
- DOI
  10.5059/yukigoseikyokaishi.76.781
- NAID
  130007431790
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2018-08-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08384
[Journal Article] Structure-activity relationship study of leucinostatin A, a modulator of tumor－stroma interaction2018
- Author(s)
  Abe, H.; Kawada M.; Sakashita, C.; Watanabe, T.; Shibasaki M.
- Journal Title
  
  Tetrahedron
  
  Volume: 74 Issue: 38 Pages: 5129-5137
- DOI
  10.1016/j.tet.2018.05.064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08384
[Journal Article] Catalytic Asymmetric Total Synthesis and Stereochemical Revision of Leucinostatin A, a Modulator of Tumor-Stroma Interaction2017
- Author(s)
  Abe, H.; Ouchi, H.; Sakashita, C.; Kawada, M.; Watanabe, T.; Shibasaki, M.
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 23 Issue: 49 Pages: 11792-11796
- DOI
  10.1002/chem.201703239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08384, KAKENHI-PROJECT-15K06888
[Journal Article] SYNTHESIS OF CAPRAZAMYCINS AND RELATED NATURAL PRODUCTS2017
- Author(s)
  Takumi Watanabe
- Journal Title
  
  Heterocycles
  
  Volume: 95 Issue: 2 Pages: 662-693
- DOI
  10.3987/rev-16-sr(s)5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460168
[Journal Article] Catalytic Asymmetric Synthesis of CPZEN-452016
- Author(s)
  Takeuchi, T.; Abe, H.; Watanabe, T.; Shibasaki, M.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 57 Issue: 26 Pages: 2901-2904
- DOI
  10.1016/j.tetlet.2016.05.072
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460168
[Journal Article] Synthesis of caprazamycin B2015
- Author(s)
  Hikaru Abe, Purushothaman Gopinath, Gandamala Ravi, Lu Wang, Takumi Watanabe, Masakatsu Shibasaki
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 印刷中 Issue: 24 Pages: 3782-3785
- DOI
  10.1016/j.tetlet.2015.04.065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460168
[Journal Article] Quinofuracins A-E, produced by the fungus Staphylotrichum boninense PF1444, show p53-dependent growth suppression.2015
- Author(s)
  Tatsuda D, Momose I, Someno T, Sawa R, Kubota Y, Iijima M, Kunisada T, Watanabe T, Shibasaki M, Nomoto A.
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 78 Issue: 2 Pages: 188-195
- DOI
  10.1021/np500581m
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23510270, KAKENHI-PROJECT-15K01811
[Journal Article] Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors.2014
- Author(s)
  Momose I, Abe H, Watanabe T, Ohba S, Yamazaki K, Dan S, Yamori T, Masuda T, Nomoto A.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Issue: 12 Pages: 1609-1615
- DOI
  10.1111/cas.12542
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23510270
[Journal Article] Catalytic asymmetric total synthesis of (+)-caprazol2014
- Author(s)
  Gopinath, P., Wang, L., Abe, H., Ravi, G., Masuda, T., Watanabe, T., Shibasaki, M.
- Journal Title
  
  Org. Lett
  
  Volume: 16 Issue: 12 Pages: 3364-3367
- DOI
  10.1021/ol501397b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590037
[Journal Article] Catalytic eiantioselective desymmetrization of meso-glutaric anhydrides using a stable Ni_2-Schiff base catalys2012
- Author(s)
  Gopinath, P., Watanabe, T., Shibasaki, M.
- Journal Title
  
  Org.Lett.
  
  Volume: 14 Issue: 5 Pages: 1358-1361
- DOI
  10.1021/ol3002078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01520, KAKENHI-PROJECT-23590037
[Journal Article] Studies on Catalytic Enantioselective Total Synthesis of Caprazamycin B : Construction of the Western Zone2012
- Author(s)
  Gopinath, P., Watanabe, T. & Shibasaki M
- Journal Title
  
  J. Org. Chem.
  
  Volume: 77 Issue: 20 Pages: 9260-9267
- DOI
  10.1021/jo301803h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01520, KAKENHI-PROJECT-23590037
[Presentation] Direct Catalytic Enantioselective Conjugate Addition of α-Substituted Benzyl Nitriles to Alkyl Acrylates2024
- Author(s)
  Sadhanendu Samanta, Jin Cui, Yasunari Otsuka, Takumi Watanabe, Masakatsu Shibasaki
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22KF0375
[Presentation] Asymmetric syn-selective vinylogous addition of butenolides to chromones catalyzed by ALB2023
- Author(s)
  Sadhanendu Samanta, Jin Cui, Hidetoshi Noda, Takumi Watanabe, Masakatsu Shibasaki
- Organizer
  日本薬学会143年会
- Data Source
  KAKENHI-PROJECT-22KF0375
[Presentation] Asymmetric syn-Selective Vinylogous Addition of Butenolides to Chromones via ALB Catalysis2023
- Author(s)
  Sadhanendu Samanta, Jin Cui, Yasunari Otsuka, Takumi Watanabe, Masakatsu Shibasaki
- Organizer
  第55回有機金属若手の会
- Data Source
  KAKENHI-PROJECT-22KF0375
[Presentation] Copper(I)-Catalyzed Direct Asymmetric Conjugate Addition of α-Alkyl-α-Arylnitriles to α,β-Unsaturated Esters for the Construction of a Quaternary Stereocenter2023
- Author(s)
  Sadhanendu Samanta, Jin Cui, Yasunari Otsuka, Takumi Watanabe, Masakatsu Shibasaki
- Organizer
  第49回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-22KF0375
[Presentation] ミトコンドリアcomplex I阻害剤による細胞内外の酸性化を介した新規抗がんメカニズム2022
- Author(s)
  吉田潤次郎、雨宮昌秀、立田大輔、大石智一、大庭俊一、井上裕幸、阿部光、旦慎吾、野田哲生、渡辺匠、清水孝雄、柴﨑正勝、川田学
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06956
[Presentation] Mitochondrial complex I inhibitors suppress tumor growth through intra- and extracellular acidification2022
- Author(s)
  Junjiro Yoshida, Tomokazu Ohishi, Hikaru Abe, Shun-ichi Ohba, Hiroyuki Inoue, Ihomi Usami, Masahide Amemiya, Raphael Oriez, Takumi Watanabe, Takao Shimizu, Masakatsu Shibasaki, Manabu Kawada
- Organizer
  The 26th JFCR-ISCC
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06956
[Presentation] Chemistry and biology of antitumor quinolones, intervenolin and related compounds: structure-activity relationship, inhibitory activity toward mitochondrial complex I, and in vivo efficacy2022
- Author(s)
  Takumi Watanabe, Hikaru, Abe, Manabu Kawada, Junjiro Yoshida, Chiharu Sakashita, Shun-ichi Ohba, Hiroyuki Inoue, Tomokazu Ohishi, Masakatsu Shibasaki
- Organizer
  37th ACS NMCS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06956
[Presentation] 生物活性天然物の触媒的不斉合成研究2021
- Author(s)
  渡辺匠
- Organizer
  第65回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06956
[Presentation] ミトコンドリアcomplex I 阻害剤による細胞内外の酸性化を介した新規抗がん活性2021
- Author(s)
  吉田潤次郎，雨宮昌秀，立田大輔，大石智一，大庭俊一，井上裕幸，阿部光，Raphael Oriez，渡辺匠，柴崎正勝，川田学
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06956
[Presentation] Chemical biology of leucinostatin A and its analogs, modulators of tumor-stroma interaction.2021
- Author(s)
  Abe H,; Kawada, M.; Ohishi, T.; Sakashita, C.; Saqib, U.; Baig, M. S.; Ohba, S.; Inoue, H.; Watanabe, T.; Shibasaki, M.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06956
[Presentation] がんー間質相互作用に干渉する天然物ロイシノスタチンA類縁体の構造活性相関研究2019
- Author(s)
  阿部光, 川田学, 坂下千春, 大石智一, 大庭俊一, 井上裕幸, 渡辺匠, 柴﨑正勝
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08384
[Presentation] Leucinostatin A, a Modulator of Tumor－Stroma Interaction: Catalytic Asymmetric Synthesis, Stereochemical Revision, and Structure－Activity Relationship Study2019
- Author(s)
  Takumi Watanabe
- Organizer
  ICPAC Yangon 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08384
[Presentation] Chemistry and biology of intervenolin analogs: antiproliferative and anti-Helicobacter pylori activities2019
- Author(s)
  Takumi Watanabe, Hikaru, Abe, Manabu Kawada, Chiharu Sakashita, Shun-ichi Ohba, Hiroyuki Inoue, Tomokazu Ohishi, Tohru Masuda, Chigusa Hayashi, Masayuki Igarashi, Masakatsu Shibasaki
- Organizer
  The 8th International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08384
[Presentation] 天然物創薬を志向した有機合成　抗感染症薬および抗がん剤のリード創製を目指して2018
- Author(s)
  渡辺匠
- Organizer
  早稲田大学理工学術院講演
- Invited
- Data Source
  KAKENHI-PROJECT-17K08384
[Presentation] がん-間質相互作用に干渉する天然物ロイシノスタチンAの全合成，および類縁体の構造活性相関2018
- Author(s)
  阿部光，大内仁志，坂下千春，川田学，渡辺匠，柴崎正勝
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08384
[Presentation] 抗感染症薬および抗がん剤のリード創製を指向した生物活性天然物の化学的研究2018
- Author(s)
  渡辺匠
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08384
[Presentation] がん-間質相互作用を制御する天然物ロイシノスタチンAの触媒的不斉全合成2017
- Author(s)
  阿部光，大内仁志，坂下千春，川田学，渡辺匠，柴崎正勝
- Organizer
  第59回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-17K08384
[Presentation] Catalytic asymmetric total synthesis of leucinostatin A2017
- Author(s)
  Takumi Watanabe
- Organizer
  ワルシャワ大学講演会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08384
[Presentation] 抗超多剤耐性結核化合物CPZEN-45の触媒的不斉全合成2016
- Author(s)
  竹内倫文、阿部光、渡辺匠、柴﨑正勝
- Organizer
  第110回有機合成シンポジウム
- Place of Presentation
  早稲田大学国際会議場（東京都新宿区）
- Year and Date
  2016-11-10
- Data Source
  KAKENHI-PROJECT-26460168
[Presentation] 抗超多剤耐性結核化合物CPZEN-45の合成研究2016
- Author(s)
  竹内倫文，渡辺匠，柴崎正勝
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-26460168
[Presentation] Catalytic asymmetric synthesis of biologically active natural products2016
- Author(s)
  Takumi Watanabe
- Organizer
  Stereochemistry 2016
- Place of Presentation
  Hotel Grand Mercure Sao Paulo Ibirapuera (Sao Paulo, Brazil)
- Year and Date
  2016-08-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460168
[Presentation] Synthesis of anti-TB and anti-cancer natural products2015
- Author(s)
  Takumi Watanabe
- Organizer
  International Conference on “Current Challenges in Drug Discovery Research"
- Place of Presentation
  Malaviya National Institute of Technology (Jaipur, India)
- Year and Date
  2015-11-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460168
[Presentation] カプラザマイシン類の合成研究：（＋）-カプラゾールの触媒的不斉全合成2015
- Author(s)
  Gopinath Purushothaman，阿部光，Lu Wang，Ravi Gandamala，舛田岳史，渡辺　匠，柴﨑正勝
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸，神戸市
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-26460168
[Presentation] Catalytic Asymmetric Synthesis of Caprazamycin B and Caprazol2015
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Lu Wang, Hikaru Abe, Gandamala Ravi, Takashi Masuda, Masakatsu Shibasaki
- Organizer
  6th International Symposium on Advances in Synthetic and Medicinal Chemistry
- Place of Presentation
  Weizmann Institute (Rehovot, Israel)
- Year and Date
  2015-11-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460168
[Presentation]2014
- Author(s)
  Gopinath Purushothaman,Ravi Gandamala,舛田岳史,渡辺匠,柴﨑正勝
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学・黒髪キャンパス(熊本市)
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Staphylotrichum boninense PF1444 株の生産する新規化合物キノフラシンの単離・構造決定2014
- Author(s)
  百瀬功、立田大輔、染野哲也、澤竜一、久保田由美子、山崎洋子、飯島正富、渡辺匠、國定孝夫、柴崎正勝、野本明男
- Organizer
  第56回天然有機化合物討論会
- Place of Presentation
  高知県立県民文化ホール（高知）
- Year and Date
  2014-10-15
- Data Source
  KAKENHI-PROJECT-23510270
[Presentation] カプラザマイシン類の合成研究：(+)-カプラゾールの触媒的不斉全合成2014
- Author(s)
  渡辺　匠，Gopinath Purushothaman，Lu Wang，阿部光，Ravi Gandamala，舛田岳史，柴崎正勝
- Organizer
  第56回天然有機化合物討論会
- Place of Presentation
  高知県立県民文化ホール，高知市
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-26460168
[Presentation] Catalytic Asymmetric Total Synthesis of (+)-Caprazol2014
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Lu Wang, Hikaru Abe, Takashi Masuda, Gandamala Ravi and Masakatsu Shibasaki
- Organizer
  5th EuCheMS Chemistry Congress
- Place of Presentation
  Wow Convension Center Istanbul, Istunbul, Turkey
- Year and Date
  2014-09-02
- Data Source
  KAKENHI-PROJECT-26460168
[Presentation] Study on catalytic asymmetric total synthesis of caprazamycin B2013
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Takashi Masuda, Gandamala Ravi, Masakatsu Shibasaki
- Organizer
  18th European symposium on organic chemistry
- Place of Presentation
  Palais du Pharo (Marseille,France)
- Year and Date
  2013-07-08
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Antitumor activity of new proteasome inhibitors, tyropeptin-boronic acid derivatives.2013
- Author(s)
  Isao Momose, Hikaru Abe, Takumi Watanabe, Shun-ichi Ohba, Masatomi Iijima, Yohko Yamazaki, Tohru Masuda, Akio Nomoto
- Organizer
  Ninth AACR-Japanese Cancer Association Joint Conference
- Place of Presentation
  ハイアットリージェンシーマウイ（アメリカ）
- Data Source
  KAKENHI-PROJECT-23510270
[Presentation] Studies on catalytic enantioselective total synthesis of caprazamycin B2013
- Author(s)
  Gopinath Purushothaman,舛田岳史,渡辺匠,柴﨑正勝
- Organizer
  第103回有機合成シンポジウム
- Place of Presentation
  慶應義塾大学薬学部・芝共立キャンパス(東京都港区)
- Year and Date
  2013-06-06
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Studies on catalytic enantioselective total synthesis of caprazamycin B2013
- Author(s)
  Gopinath Purushothaman,舛田岳史,渡辺匠,柴﨑正勝
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Progress towards the catalytic enantioselective total synthesis of caprazamycin B : Synthesis of the western zone2012
- Author(s)
  Gopinath Purushothaman,渡辺匠,柴﨑正勝
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学・札幌キャンパス(札幌市)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Caprazamycin Bの触媒的不斉合成研究:1,2-syn-アミノアルコール部位の立体選択的構築2012
- Author(s)
  渡辺匠、プルショタマンゴピナス、柴﨑正勝
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学・札幌キャンパス(札幌市)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Study on catalytic asymmetric total synthesis of caprazamycin B2012
- Author(s)
  T akumi Watanabe, Purushothaman Gopinath, Masakatsu Shibasaki
- Organizer
  19th Intrnational conference on organic synthesis
- Place of Presentation
  Melbourne Convention & Exhibition Centre (Melbourne,Australia)
- Year and Date
  2012-07-04
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Study on catalytic asymmetric total synthesis of caprazamycin B2012
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Takashi Masuda, Masakatsu Shibasaki
- Organizer
  第6回武田科学振興財団薬科学シンポジウム
- Place of Presentation
  武田薬品工業㈱研修所(吹田市)
- Year and Date
  2012-09-13
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] 抗結核活性を有する核酸系抗生物質caprazamycinBの触媒的不斉合成研究2012
- Author(s)
  プルショタマンゴピナス,渡辺匠,柴﨑正勝
- Organizer
  第38回反応と合成の進歩シンポジウム
- Place of Presentation
  タワーホール船堀(東京都江戸川区)
- Year and Date
  2012-11-05
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Caprazamycin Bの触媒的不斉合成研究：1,2-syn-アミノアルコール部位の立体選択的構築2012
- Author(s)
  渡辺　匠、プルショタマン　ゴピナス、柴崎正勝
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌（北海道大学札幌キャンパス）
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] プロテアソーム阻害剤チロぺプチンボロン酸誘導体の抗腫瘍活性2012
- Author(s)
  百瀬　功、阿部　光、渡辺　匠、大庭俊一、増田　徹、池田大四郎、赤松　穰
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学、札幌
- Data Source
  KAKENHI-PROJECT-23510270
[Presentation] Progress towards the catalytic enantioselective total synthesis of caprazamycin B: Synthesis of the western zone.2012
- Author(s)
  Gopinath Purushothaman, 渡辺　匠、柴崎正勝
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌（北海道大学札幌キャンパス）
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors.2011
- Author(s)
  Isao Momose, Hikaru Abe, Takumi Watanabe, Shun-ichi Ohba, Masatomi Iijima, Tohru Masuda, Akio Nomoto
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル東京、東京
- Data Source
  KAKENHI-PROJECT-23510270
[Presentation] Structure-activity relationship of tyropeptin-boronic acid derivatives: New proteasome inhibitors.2011
- Author(s)
  Hikaru Abe, Takumi Watanabe, Isao Momose, Yoshikazu Takahashi, Daishiro Ikeda, Yuzuru Akamatsu
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル東京、東京
- Data Source
  KAKENHI-PROJECT-23510270
[Presentation] ヴァーチャルスクリーニングによるオキシドスクアレン環化酵素阻害剤の探索2009
- Author(s)
  渡辺匠、梅沢洋二、高橋良和、赤松穣
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-18790097
[Presentation] Study on catalytic asymmetric total synthesis of caprazamycin B
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Takashi Masuda, Masakatsu Shibasaki
- Organizer
  第6回武田科学技術振興財団薬科学シンポジウム
- Place of Presentation
  大阪・吹田市（武田薬品工業（株）研修所）
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Study on catalytic asymmetric total synthesis of caprazamycin B
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Masakatsu Shibasaki
- Organizer
  19th International Conference on Organic Synthesis
- Place of Presentation
  オーストラリア・メルボルン（Melbourne Convention & Exhibition Centre）
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Caprazamycin Bの触媒的不斉全合成研究
- Author(s)
  Gopinath Purushothaman， Ravi Gandamala，舛田岳史、渡辺　匠、柴﨑正勝
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市（熊本大学・黒髪キャンパス）
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Study on Catalytic Asymmetric Total Synthesis of Caprazamycin B
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Takashi Masuda, Gandamala Ravi, Masakatsu Shibasaki
- Organizer
  18th European Symposium on Organic Chemistry
- Place of Presentation
  Marseille (Palais du Pharo), France
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Progress towards the catalytic enantioselective total synthesis of Caprazamycin B: Synthesis of the western zone
- Author(s)
  プルショタマンゴピナス，渡辺匠，柴﨑正勝
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] 医薬関連化合物の触媒的不斉合成研究
- Author(s)
  渡辺　匠
- Organizer
  東京大学医科学研究所-微生物化学研究所連携研究キックオフシンポジウム
- Place of Presentation
  東京・東京大学医科学研究所
- Invited
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] 抗結核活性を有する核酸系抗生物質Caprazamycin Bの触媒的不斉合成研究
- Author(s)
  プルショタマンゴピナス，渡辺匠，柴﨑正勝
- Organizer
  第38回反応と合成の進歩シンポジウム
- Place of Presentation
  東京都江戸川区（タワーホール船堀）
- Data Source
  KAKENHI-PROJECT-23590037

1. ABE Hikaru (10462269)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
2. MOMOSE Isao (10270547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. MASUDA Toru (90165720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. TATSUDA Daisuke (20442569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. OHBA Shun-ichi (00601600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. SHIBASAKI Masakatsu (30112767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ISHIZAKI Yoshimasa (10414103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. UMEZAWA Yoji (60160313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SAKAMOTO Shuichi (60346070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Gandamala Ravi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. Wang Lu

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. SAMANTA SADHANENDU

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
13. YOSHIDA Junjiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 柴崎正勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 18 results
15. GOPINATH Purushothaman

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
16. 野田秀俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Watanabe Takumi 渡辺 匠

WATANABE Takumi 渡辺 匠

Research Projects

Research Products

Co-Researchers

Catalytic asymmetric total synthesis of a novel antibacterial natural product, MM249-143F7Principal Investigator

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Medicinal Chemistry of Anti-tumor Agents Targetd at Stromal Complex VPrincipal Investigator

Principal Investigator

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Development of anticancer lead based on catalytic asymmetric total synthesis of leucinostatin APrincipal Investigator

Principal Investigator

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Research Institution

Development of anti-XDR-TB leads based on catalytic asymmetric synthesis and chemical biologyPrincipal Investigator

Principal Investigator

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Development of orally active proteasome inhibitors using in vivo imaging.

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Catalytic asymmetric total synthesis of caprazamycin, an anti-tuberculosis antibioticPrincipal Investigator

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Screening for Inhibitors of Intestinal Cholesterol Transporter NPC1L1Principal Investigator

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[Journal Article] Direct Catalytic Enantioselective Conjugate Addition of α-Substituted Benzyl Nitriles to Alkyl Acrylates2024

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[Journal Article] Catalytic Asymmetric Vinylogous Conjugate Addition of Butenolide to 2-Ester-Substituted Chromones: Access to Chiral Chromanone Lactones via Trapping of a Copper(I) Enolate by Trimethyl Borate2023

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[Journal Article] Asymmetric Syn-Selective Vinylogous Addition of Butenolides to Chromones via Al-Li-BINOL Catalysis2023

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[Journal Article] Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment2021

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[Journal Article] Catalytic asymmetric total synthesis of leucinostatin A.2021

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[Journal Article] Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin-like growth factor-1 secretion by prostate stromal cells2020

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[Journal Article] Catalytic Asymmetric Synthesis of Natural Products Directed Toward Development of Novel Anti-infective and Anti-cancer Medicines2018

Author(s)

Journal Title

Watanabe Takumi 渡辺匠

WATANABE Takumi 渡辺匠