Akiyama Masahiro 秋山昌広

… Alternative Names

AKIYAMA Masahiro 秋山昌広

秋山昌広アキヤママサヒロ

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Researcher Number	80273837
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2023: 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 2013 – 2016: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 准教授 1999 – 2001: Nara Institute of Science and Technology, Grad. Sch. of Biol. Sci., Associate Professor, バイオサイエンス研究科, 助教授 1996 – 1997: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教授
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related / Molecular biology / Molecular biology Except Principal Investigator Molecular biology
Keywords	Principal Investigator 複製フォーク / DNAポリメラーゼ / ゲノム不安定性 / 染色体構造タンパク質 / チミン飢餓死 / ゲノム不安定化 / 突然変異 / DNA複製フォーク / DNA複製 / ゲノム安定性 … More / プログラム複製阻害 / 染色体構造 / 人工染色体 / 染色体構造解析 / ゲノム安定化 / ヌクレオチド欠乏 / 複製ストレス / 複製阻害 / DNA複製阻害 / 複製と転写の衝突 / 複製遅延領域 / 染色体高次構造 / 鋳型スイッチ / ヒストン様タンパク質 / ゲノム複製 / 転写伸長因子 / 複製遅延 / 微生物ゲノム / replication fork / mutation / DNA damages / REV3 gene / DNA polymerase zeta / Xenopus / translesion DNA replication / bypass DNA synthesis / スライディングクランプ / アフリカツメガエル卵母細胞 / DNA損傷 / REV3遺伝子 / DNAポリメラーゼ・ゼータ / アフリカツメガエル / 損傷乗り越えDNA複製 / バイパスDNA合成 / 複製装置 / チェックポイント / レプリソーム / 分子マシナリー / DNA組み換え酵素 / DNA複製速度 / DNA組換え酵素 / DNAコーミング / 一分子解析 / SOS応答 / DNA損傷応答 / 自然突然変異 / 枯草菌 / ミスマッチ修復 … More Except Principal Investigator DNA修復 / DNA複製 / SOS repair / SOS response / Error-pronerepair / DNA repair / DNA replication / Mutagen / Carciniogen / DNA polymerase / SOS修復 / SOS応答 / 誤りがち修復 / 変異原 / 発がん物質 / DNAポリメラーゼ / E2F-1 / 蛋白質リン酸化 / MCM / ライセンシング因子 / S期導入因子 / 複製開始点結合因子 / PCNA / ORC / 染色体構造 / クロマチン集合 / DNAメチル転移酵素 / S期 / 細胞周期 / PCNA結合タンパク質 Less

Roles and their molecular mechanisms of replication barrier zones programmed on chromosome for genome stability maintenancePrincipal Investigator
- Principal Investigator
  
  秋山昌広
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Nara Institute of Science and Technology
A role of genome dynamics in dramatic cell death caused by thymine synthesis inhibitorsPrincipal Investigator
- Principal Investigator
  
  Akiyama Masahiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Nara Institute of Science and Technology
Study of mechanisms that decrease speed of replication fork progression in DNA damage responsePrincipal Investigator
- Principal Investigator
  
  Akiyama Masahiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Nara Institute of Science and Technology
Biochemical studies of eukaryotic DNA polymerase zeta functioning in bypass DNA synthesisPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Masahiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
Molecular mechanisms of mutagenesis caused by transletion DNA synthesis
- Principal Investigator
  
  MAKI Hisaji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Molecular biology
- Research Institution
  Nara Institute of Science and Technology
ミスマッチ認識および修復過程の生化学的研究Principal Investigator
- Principal Investigator
  
  秋山昌広
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nara Institute of Science and Technology
p21によるPCNAの機能制御と細胞のがん化
- Principal Investigator
  
  釣本敏樹
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nara Institute of Science and Technology

All 2021 2020 2019 2018 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Nutritional conditions and oxygen concentrations affect spontaneous occurrence of homologous recombination events but not spontaneous mutagenesis in Escherichia coli2020
- Author(s)
  Lan Anh Thi Le, Sayaka Ando, Thomas M. Conrad, Shohei Nunose, Akiko Sakai, Haruka Uefune, Masahiro Tatsumi Akiyama, Asako Furkohri, and Hisaji Maki
- Journal Title
  
  Genes and Genetic Systems
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06182
[Journal Article] Replication fork progression is paused in two large chromosomal zones flanking the DNA replication origin in Escherichia coli2016
- Author(s)
  Masahiro Tatsumi Akiyama, Taku Oshima, Onuma Chumsakul, Shu Ishikawa and Hisaji Mak
- Journal Title
  
  Genes to Cells
  
  Volume: 21 Issue: 8 Pages: 907-914
- DOI
  10.1111/gtc.12388
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-26450090
[Journal Article] Recombinase and translesion DNA polymerase decrease the speed of replication fork progression during the DNA damage response in Escherichia coli cells.2015
- Author(s)
  Tan K.W., Pham M.T., Furukohri A, Maki H. and Akiyama T.M.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 43 Issue: 3 Pages: 1715-1725
- DOI
  10.1093/nar/gkv044
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-25840009
[Journal Article] DNA polymeraes IV mediates efficient and quick recovery at N2-dG adducts.2014
- Author(s)
  Ikeda M, Furukohri A, Philippin G, Loechler E, Akiyama MT, Katayama T, Fuchs RP, Maki H.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 42 Issue: 13 Pages: 8461-8472
- DOI
  10.1093/nar/gku547
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-25840009
[Journal Article] A single-molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerase III is a major determinant of fork speed.2013
- Author(s)
  Pham M.T., Tan K.W., Sakumura Y., Okumura K., Maki H. and Akiyama T.M.
- Journal Title
  
  Molecular Microbiology
  
  Volume: 90 Issue: 3 Pages: 584-596
- DOI
  10.1111/mmi.12386
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009
[Presentation] 大腸菌ゲノムは、低濃度チミジンに依存してDNA複製をoriC近傍で一時停止するようにプログラムされている2021
- Author(s)
  秋山昌広、高橋弘喜、大島拓
- Organizer
  第17回21世紀大腸菌研究会
- Data Source
  KAKENHI-PROJECT-21K06120
[Presentation] 大腸菌ゲノムは、低濃度チミジンに依存してDNA複製をoriC近傍で一時停止するようにプログラムされている2021
- Author(s)
  秋山昌広、高橋弘喜、大島拓
- Organizer
  第17回21世紀大腸菌研究会
- Data Source
  KAKENHI-PROJECT-18K06182
[Presentation] 大腸菌ゲノムのoriC近傍にプログラムされた低濃度チミジンでの複製停止2021
- Author(s)
  秋山昌広、大島拓
- Organizer
  日本遺伝学会第93回大会
- Data Source
  KAKENHI-PROJECT-18K06182
[Presentation] 大腸菌ゲノムのoriC近傍にプログラムされた低濃度チミジンでの複製停止2021
- Author(s)
  秋山昌広、大島拓
- Organizer
  日本遺伝学会第93回大会
- Data Source
  KAKENHI-PROJECT-21K06120
[Presentation] 三種類のヌクレアーゼ活性による鋳型スイッチの協調的な抑制2019
- Author(s)
  大橋慧也、唐住勇多、村尾雅司、愿山(岡本)郁、秋山昌広、真木寿治
- Organizer
  第16回 21世紀大腸菌研究会
- Data Source
  KAKENHI-PROJECT-18K06182
[Presentation] DinBによる複製フォーク進行の減速はゲノムの恒常性に影響しない2018
- Author(s)
  新川直道、桝本愛、Tan Kang Wei、中手直哉、山本幸弘、古郡麻子、真木寿治、秋山昌広
- Organizer
  第15回大腸菌研究会2018
- Data Source
  KAKENHI-PROJECT-18K06182
[Presentation] 大腸菌の複製フォークの動態プロファイリング2016
- Author(s)
  秋山昌広
- Organizer
  日本遺伝学会第88回大会(三島大会)
- Place of Presentation
  日本大学（静岡県三島市）
- Year and Date
  2016-09-09
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] Replication profiles in Escherichia coli cells2016
- Author(s)
  Masahiro Tatsumi Akiyama
- Organizer
  3R International Symposium
- Place of Presentation
  ホテル一畑（島根県島根市）
- Year and Date
  2016-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌のrecAまたはdinB遺伝子の過剰発現による複製フォーク進行の遅延2015
- Author(s)
  Tan Kang Wei、Pham Minh Tuan、古郡麻子、真木寿治、秋山昌広
- Organizer
  第38回・日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] recAまたはdinB遺伝子の過剰発現による複製フォーク速度の低下2015
- Author(s)
  Tan Kang Wei、Pham Minh Tuan、古郡麻子、真木寿治、秋山昌広
- Organizer
  日本遺伝学会・第87回大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌の栄養環境が酸化ＤＮＡ損傷と活性酸素種に与える影響2015
- Author(s)
  布瀬翔平、Tom Conrad、安藤さやか、豊本奈美江、中村葵、秋山昌広、真木壽治
- Organizer
  日本遺伝学会・第87回大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌損傷乗り越え型DNA Polymerase IVの複製フォークにおける役割2015
- Author(s)
  古郡麻子、池田美央、秋山昌広、片山勉、Robert P. Fuchs、真木壽治
- Organizer
  第12回21世紀大腸菌研究会
- Place of Presentation
  琵琶湖グランドホテル（滋賀県大津市）
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] DNA損傷応答による複製マシナリーの進行速度の低下2015
- Author(s)
  Tan Kang Wei、Pam Minh Tuan、古郡麻子、真木壽治、秋山昌広
- Organizer
  第12回21世紀大腸菌研究会
- Place of Presentation
  琵琶湖グランドホテル（滋賀県大津市）
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] DNA polymerase III is a major determinant of replication fork speed in Escherichia coli cells2013
- Author(s)
  Tuan Minh Pham, Kang Wei Tan, Yuichi Sakumura, Katsuzumi Okumura, Hisaji Maki and Masahiro Tatsumi Akiyama
- Organizer
  日本遺伝学会第85回大会
- Place of Presentation
  慶應義塾大学日吉キャンパス、横浜市
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌細胞のDNA複製フォーク速度の単分子解析2013
- Author(s)
  Pham Minh Tuan、Tan Kang Wei、作村諭一、奥村克純、真木寿治、秋山昌広
- Organizer
  日本遺伝学会第85回大会
- Place of Presentation
  慶應義塾大学日吉キャンパス、横浜市
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌細胞における複製フォークの進行速度に関する一分子解析2013
- Author(s)
  Pham Minh Tuan、Tan Kang Wei、作村諭一、奥村克純、真木寿治、秋山昌広
- Organizer
  第22回DNA複製･組換え･修復ワークショップ
- Place of Presentation
  ホテルニュー水戸屋、仙台市
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌細胞のDNA複製フォーク速度の単分子解析2013
- Author(s)
  Pham Minh Tuan、Tan Kang Wei、作村諭一、奥村克純、真木寿治、秋山昌広
- Organizer
  第10回21世紀大腸菌研究会
- Place of Presentation
  ラフォーレ修善寺、伊豆市
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌細胞におけるDNA複製フォークの進行速度に関する一分子解析2013
- Author(s)
  秋山昌広
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド、神戸市
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌のSOS応答による複製フォークの進行速度の低下
- Author(s)
  Tang Kang Wei、Pham Minh Tuan、古郡麻子、奥村克純、真木寿治、秋山昌広
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] Escherichia coli DNA polymerase IV mediates quick recpovery of repliaction forks stalled at N2-dG adducts.
- Author(s)
  Furukohri, A., Ikead, M., Akiyama, M., Katayama, T., Fuchs R.P., and Maki, H.
- Organizer
  The 9th 3R International Symposium
- Place of Presentation
  御殿場高原ホテル（静岡県、御殿場市）
- Year and Date
  2014-11-11 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] Escherichia coli DNA polymerase IV mediates quick recpovery of repliaction forks stalled at N2-dG adducts
- Author(s)
  Furukohri, A., Ikead, M., Akiyama, M., Katayama, T., Fuchs R.P., and Maki, H.
- Organizer
  DNA polymerases: Biology, Diseases and Biomediacal Appliatiuon Conference 2014
- Place of Presentation
  Robinson collage (Cambridge, England)
- Year and Date
  2014-08-31 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌のSOS応答による複製フォーク速度の減速
- Author(s)
  Tang Kang Wei、Pham Minh Tuan、古郡麻子、真木寿治、秋山昌広
- Organizer
  日本遺伝学会第86回大会
- Place of Presentation
  長浜バイオ大学（滋賀県、長浜市）
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] A single molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerae III is a major determinant of fork speed
- Author(s)
  Pham, TM., Tan, K.W., Sakumura, Y., Okumura,K., Furukohri, A., Maki, H.,and Akiyama, T.M.
- Organizer
  DNA polymerases: Biology, Diseases and Biomediacal Appliatiuon Conference 2014
- Place of Presentation
  Robinson collage (Cambridge, England)
- Year and Date
  2014-08-31 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] A single molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerae III is a major determinant of fork speed
- Author(s)
  Pham, TM., Tan, K.W., Sakumura, Y., Okumura,K., Furukohri, A., Maki, H.,and Akiyama, T.M.
- Organizer
  The 9th 3R International Symposium
- Place of Presentation
  御殿場高原ホテル（静岡県、御殿場市）
- Year and Date
  2014-11-11 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌損傷乗り越え型 DNA Polymerase IV の複製フォークにおける役割
- Author(s)
  古郡麻子、池田美央、西川義人、秋山昌広、片山　勉、Robert P. Fuchs、真木寿治
- Organizer
  日本遺伝学会第86回大会
- Place of Presentation
  長浜バイオ大学（滋賀県、長浜市）
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-25440009

1. Maki Hisaji (20199649)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. 大島拓 (50346318)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. Katayama Tsutomu (70264059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. UMEZU Keiko (20223612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 釣本敏樹 (30163885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 小布施力史 (00273855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 藤田雅俊 (30270713)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大谷清 (30201974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 村上洋太 (20260622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 正井久雄 (40229349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 加藤順也 (00273839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 関峰秋 (40304167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 末次正幸 (00363341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 日詰光治 (10378846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 松本吉博

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. FUCHS Robert

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Akiyama Masahiro 秋山 昌広

AKIYAMA Masahiro 秋山 昌広

秋山 昌広 アキヤマ マサヒロ

Research Projects

Research Products

Co-Researchers

Roles and their molecular mechanisms of replication barrier zones programmed on chromosome for genome stability maintenancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A role of genome dynamics in dramatic cell death caused by thymine synthesis inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of mechanisms that decrease speed of replication fork progression in DNA damage responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biochemical studies of eukaryotic DNA polymerase zeta functioning in bypass DNA synthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of mutagenesis caused by transletion DNA synthesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ミスマッチ認識および修復過程の生化学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

p21によるPCNAの機能制御と細胞のがん化

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Nutritional conditions and oxygen concentrations affect spontaneous occurrence of homologous recombination events but not spontaneous mutagenesis in Escherichia coli2020

Author(s)

Journal Title

Data Source

[Journal Article] Replication fork progression is paused in two large chromosomal zones flanking the DNA replication origin in Escherichia coli2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recombinase and translesion DNA polymerase decrease the speed of replication fork progression during the DNA damage response in Escherichia coli cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA polymeraes IV mediates efficient and quick recovery at N2-dG adducts.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A single-molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerase III is a major determinant of fork speed.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] 大腸菌ゲノムは、低濃度チミジンに依存してDNA複製をoriC近傍で一時停止するようにプログラムされている2021

Author(s)

Organizer

Data Source

[Presentation] 大腸菌ゲノムは、低濃度チミジンに依存してDNA複製をoriC近傍で一時停止するようにプログラムされている2021

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Organizer

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[Presentation] 大腸菌ゲノムのoriC近傍にプログラムされた低濃度チミジンでの複製停止2021

Author(s)

Akiyama Masahiro 秋山昌広

AKIYAMA Masahiro 秋山昌広

秋山昌広アキヤママサヒロ