AKIYAMA Masahiro 秋山昌広

Researcher Number	80273837
Other IDs
Affiliation *help	2018 : 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 2013 – 2017 : 奈良先端科学技術大学院大学, バイオサイエンス研究科, 准教授 1999 – 2001 : Nara Institute of Science and Technology, Grad. Sch. of Biol. Sci., Associate Professor, バイオサイエンス研究科, 助教授 1996 – 1997 : 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教授
Review Section/Research Field	Principal Investigator Molecular biology / Molecular biology / Basic Section 43050:Genome biology-related Except Principal Investigator Molecular biology
Keywords	Principal Investigator 複製フォーク / 突然変異 / DNA複製フォーク / DNAポリメラーゼ / バイパスDNA合成 / DNA組換え酵素 / 自然突然変異 / bypass DNA synthesis / translesion DNA replication / DNA複製速度 … More Except Principal Investigator DNA修復 / DNA複製 / 蛋白質リン酸化 / DNA replication / 複製開始点結合因子 / 発がん物質 / クロマチン集合 / 細胞周期 / 誤りがち修復 / SOS repair / DNA polymerase / S期 / S期導入因子 / 染色体構造 / DNA repair / SOS response / SOS応答 / PCNA / Error-pronerepair / PCNA結合タンパク質 / Mutagen / E2F-1 / SOS修復 / ライセンシング因子 / 変異原 / MCM / Carciniogen / ORC / DNAメチル転移酵素 / DNAポリメラーゼ Less

A role of genome dynamics in dramatic cell death caused by thymine synthesis inhibitorsPrincipal InvestigatorOngoing
- Principal Investigator
  
  秋山昌広
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Nara Institute of Science and Technology
Study of mechanisms that decrease speed of replication fork progression in DNA damage responsePrincipal Investigator
- Principal Investigator
  
  Akiyama Masahiro
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Nara Institute of Science and Technology
Biochemical studies of eukaryotic DNA polymerase zeta functioning in bypass DNA synthesisPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Masahiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
Molecular mechanisms of mutagenesis caused by transletion DNA synthesis
- Principal Investigator
  
  MAKI Hisaji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Molecular biology
- Research Institution
  Nara Institute of Science and Technology
ミスマッチ認識および修復過程の生化学的研究Principal Investigator
- Principal Investigator
  
  秋山昌広
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nara Institute of Science and Technology
p21によるPCNAの機能制御と細胞のがん化
- Principal Investigator
  
  釣本敏樹
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nara Institute of Science and Technology

All 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Replication fork progression is paused in two large chromosomal zones flanking the DNA replication origin in Escherichia coli2016
- Author(s)
  Masahiro Tatsumi Akiyama, Taku Oshima, Onuma Chumsakul, Shu Ishikawa and Hisaji Mak
- Journal Title
  
  Genes to Cells
  
  Volume : 21 Pages : 907-914
- DOI
  10.1111/gtc.12388
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-26450090
[Journal Article] Recombinase and translesion DNA polymerase decrease the speed of replication fork progression during the DNA damage response in Escherichia coli cells2015
- Author(s)
  Tan K.W., Pham M.T., Furukohri A, Maki H. and Akiyama T.M.
- Journal Title
  
  Nucleic Acids Research
  
  Volume : 43 Pages : 1715-1725
- DOI
  10.1093/nar/gkv044
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-25840009
[Journal Article] DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts2014
- Author(s)
  Ikeda M, Furukohri A, Philippin G, Loechler E, Akiyama MT, Katayama T, Fuchs RP, Maki H.
- Journal Title
  
  Nucleic Acids Research
  
  Volume : 42 Pages : 8461-8472
- DOI
  10.1093/nar/gku547
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-25840009
[Journal Article] A single-molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerase III is a major determinant of fork speed2013
- Author(s)
  Pham M.T., Tan K.W., Sakumura Y., Okumura K., Maki H. and Akiyama T.M.
- Journal Title
  
  Molecular Microbiology
  
  Volume : 90 Pages : 584-596
- DOI
  10.1111/mmi.12386
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009
[Presentation] Replication profiles in Escherichia coli cells2016
- Author(s)
  Masahiro Tatsumi Akiyama
- Organizer
  3R International Symposium
- Place of Presentation
  ホテル一畑（島根県島根市）
- Year and Date
  2016-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌の複製フォークの動態プロファイリング2016
- Author(s)
  秋山昌広
- Organizer
  日本遺伝学会第88回大会(三島大会)
- Place of Presentation
  日本大学（静岡県三島市）
- Year and Date
  2016-09-09
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] recAまたはdinB遺伝子の過剰発現による複製フォーク速度の低下2015
- Author(s)
  Tan Kang Wei、Pham Minh Tuan、古郡麻子、真木寿治、秋山昌広
- Organizer
  日本遺伝学会・第87回大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] DNA損傷応答による複製マシナリーの進行速度の低下2015
- Author(s)
  Tan Kang Wei、Pam Minh Tuan、古郡麻子、真木壽治、秋山昌広
- Organizer
  第12回21世紀大腸菌研究会
- Place of Presentation
  琵琶湖グランドホテル（滋賀県大津市）
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌損傷乗り越え型DNA Polymerase IVの複製フォークにおける役割2015
- Author(s)
  古郡麻子、池田美央、秋山昌広、片山勉、Robert P. Fuchs、真木壽治
- Organizer
  第12回21世紀大腸菌研究会
- Place of Presentation
  琵琶湖グランドホテル（滋賀県大津市）
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌のrecAまたはdinB遺伝子の過剰発現による複製フォーク進行の遅延2015
- Author(s)
  Tan Kang Wei、Pham Minh Tuan、古郡麻子、真木寿治、秋山昌広
- Organizer
  第38回・日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌の栄養環境が酸化ＤＮＡ損傷と活性酸素種に与える影響2015
- Author(s)
  布瀬翔平、Tom Conrad、安藤さやか、豊本奈美江、中村葵、秋山昌広、真木壽治
- Organizer
  日本遺伝学会・第87回大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌細胞のDNA複製フォーク速度の単分子解析2013
- Author(s)
  Pham Minh Tuan、Tan Kang Wei、作村諭一、奥村克純、真木寿治、秋山昌広
- Organizer
  日本遺伝学会第85回大会
- Place of Presentation
  慶應義塾大学日吉キャンパス、横浜市
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌細胞におけるDNA複製フォークの進行速度に関する一分子解析2013
- Author(s)
  秋山昌広
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド、神戸市
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌細胞における複製フォークの進行速度に関する一分子解析2013
- Author(s)
  Pham Minh Tuan、Tan Kang Wei、作村諭一、奥村克純、真木寿治、秋山昌広
- Organizer
  第22回DNA複製･組換え･修復ワークショップ
- Place of Presentation
  ホテルニュー水戸屋、仙台市
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌細胞のDNA複製フォーク速度の単分子解析2013
- Author(s)
  Pham Minh Tuan、Tan Kang Wei、作村諭一、奥村克純、真木寿治、秋山昌広
- Organizer
  第10回21世紀大腸菌研究会
- Place of Presentation
  ラフォーレ修善寺、伊豆市
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] DNA polymerase III is a major determinant of replication fork speed in Escherichia coli cells2013
- Author(s)
  Tuan Minh Pham, Kang Wei Tan, Yuichi Sakumura, Katsuzumi Okumura, Hisaji Maki and Masahiro Tatsumi Akiyama
- Organizer
  日本遺伝学会第85回大会
- Place of Presentation
  慶應義塾大学日吉キャンパス、横浜市
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] Escherichia coli DNA polymerase IV mediates quick recpovery of repliaction forks stalled at N2-dG adducts.
- Author(s)
  Furukohri, A., Ikead, M., Akiyama, M., Katayama, T., Fuchs R.P., and Maki, H.
- Organizer
  The 9th 3R International Symposium
- Place of Presentation
  御殿場高原ホテル（静岡県、御殿場市）
- Year and Date
  2014-11-11 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] A single molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerae III is a major determinant of fork speed
- Author(s)
  Pham, TM., Tan, K.W., Sakumura, Y., Okumura,K., Furukohri, A., Maki, H.,and Akiyama, T.M.
- Organizer
  The 9th 3R International Symposium
- Place of Presentation
  御殿場高原ホテル（静岡県、御殿場市）
- Year and Date
  2014-11-11 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] Escherichia coli DNA polymerase IV mediates quick recpovery of repliaction forks stalled at N2-dG adducts
- Author(s)
  Furukohri, A., Ikead, M., Akiyama, M., Katayama, T., Fuchs R.P., and Maki, H.
- Organizer
  DNA polymerases: Biology, Diseases and Biomediacal Appliatiuon Conference 2014
- Place of Presentation
  Robinson collage (Cambridge, England)
- Year and Date
  2014-08-31 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] A single molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerae III is a major determinant of fork speed
- Author(s)
  Pham, TM., Tan, K.W., Sakumura, Y., Okumura,K., Furukohri, A., Maki, H.,and Akiyama, T.M.
- Organizer
  DNA polymerases: Biology, Diseases and Biomediacal Appliatiuon Conference 2014
- Place of Presentation
  Robinson collage (Cambridge, England)
- Year and Date
  2014-08-31 – 2014-09-04
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌のSOS応答による複製フォークの進行速度の低下
- Author(s)
  Tang Kang Wei、Pham Minh Tuan、古郡麻子、奥村克純、真木寿治、秋山昌広
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌損傷乗り越え型 DNA Polymerase IV の複製フォークにおける役割
- Author(s)
  古郡麻子、池田美央、西川義人、秋山昌広、片山　勉、Robert P. Fuchs、真木寿治
- Organizer
  日本遺伝学会第86回大会
- Place of Presentation
  長浜バイオ大学（滋賀県、長浜市）
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-25440009
[Presentation] 大腸菌のSOS応答による複製フォーク速度の減速
- Author(s)
  Tang Kang Wei、Pham Minh Tuan、古郡麻子、真木寿治、秋山昌広
- Organizer
  日本遺伝学会第86回大会
- Place of Presentation
  長浜バイオ大学（滋賀県、長浜市）
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-25440009

1. Maki Hisaji (20199649)

# of Collaborated Projects : 2results

# of Collaborated Products : 20results
2. Katayama Tsutomu (70264059)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
3. UMEZU Keiko (20223612)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
4. 釣本敏樹 (30163885)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. 小布施力史 (00273855)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. 藤田雅俊 (30270713)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. 大谷清 (30201974)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. 村上洋太 (20260622)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. 正井久雄 (40229349)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. 加藤順也 (00273839)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. 関峰秋 (40304167)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. 大島拓 (50346318)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
13. 松本吉博

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. FUCHS Robert

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. ISHIKAWA Shu

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
16. FURUKOHRI Asako

# of Collaborated Projects : 0results

# of Collaborated Products : 2results

AKIYAMA Masahiro 秋山 昌広

Research Projects

Research Products

Co-Researchers

A role of genome dynamics in dramatic cell death caused by thymine synthesis inhibitorsPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of mechanisms that decrease speed of replication fork progression in DNA damage responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biochemical studies of eukaryotic DNA polymerase zeta functioning in bypass DNA synthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of mutagenesis caused by transletion DNA synthesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ミスマッチ認識および修復過程の生化学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

p21によるPCNAの機能制御と細胞のがん化

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Replication fork progression is paused in two large chromosomal zones flanking the DNA replication origin in Escherichia coli2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recombinase and translesion DNA polymerase decrease the speed of replication fork progression during the DNA damage response in Escherichia coli cells2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A single-molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerase III is a major determinant of fork speed2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Replication profiles in Escherichia coli cells2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 大腸菌の複製フォークの動態プロファイリング2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] recAまたはdinB遺伝子の過剰発現による複製フォーク速度の低下2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] DNA損傷応答による複製マシナリーの進行速度の低下2015

Author(s)

Organizer

Place of Presentation

AKIYAMA Masahiro 秋山昌広