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AKIYAMA Masahiro  秋山 昌広

ORCIDConnect your ORCID iD *help
Researcher Number 80273837
Other IDs
Affiliation *help 2018 : 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授
2013 – 2017 : 奈良先端科学技術大学院大学, バイオサイエンス研究科, 准教授
1999 – 2001 : Nara Institute of Science and Technology, Grad. Sch. of Biol. Sci., Associate Professor, バイオサイエンス研究科, 助教授
1996 – 1997 : 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教授
Review Section/Research Field
Principal Investigator
Molecular biology / Molecular biology / Basic Section 43050:Genome biology-related
Except Principal Investigator
Molecular biology
Keywords
Principal Investigator
複製フォーク / 突然変異 / DNA複製フォーク / DNAポリメラーゼ / バイパスDNA合成 / DNA組換え酵素 / 自然突然変異 / bypass DNA synthesis / translesion DNA replication / DNA複製速度 … More / 複製装置 / REV3遺伝子 / replication fork / DNAポリメラーゼ・ゼータ / DNA損傷応答 / mutation / スライディングクランプ / 一分子解析 / SOS応答 / チミン飢餓死 / 枯草菌 / DNA damages / 損傷乗り越えDNA複製 / DNA複製 / REV3 gene / ミスマッチ修復 / 分子マシナリー / DNA組み換え酵素 / 染色体高次構造 / アフリカツメガエル / DNA複製阻害 / チェックポイント / アフリカツメガエル卵母細胞 / ゲノム不安定性 / DNA polymerase zeta / レプリソーム / Xenopus / DNA損傷 / DNAコーミング … More
Except Principal Investigator
DNA修復 / DNA複製 / 蛋白質リン酸化 / DNA replication / 複製開始点結合因子 / 発がん物質 / クロマチン集合 / 細胞周期 / 誤りがち修復 / SOS repair / DNA polymerase / S期 / S期導入因子 / 染色体構造 / DNA repair / SOS response / SOS応答 / PCNA / Error-pronerepair / PCNA結合タンパク質 / Mutagen / E2F-1 / SOS修復 / ライセンシング因子 / 変異原 / MCM / Carciniogen / ORC / DNAメチル転移酵素 / DNAポリメラーゼ Less
  • Research Projects

    (6results)
  • Research Products

    (23results)
  • Co-Researchers

    (16People)
  •  A role of genome dynamics in dramatic cell death caused by thymine synthesis inhibitorsPrincipal InvestigatorOngoing

    • Principal Investigator
      秋山 昌広
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43050:Genome biology-related
    • Research Institution
      Nara Institute of Science and Technology
  •  Study of mechanisms that decrease speed of replication fork progression in DNA damage responsePrincipal Investigator

    • Principal Investigator
      Akiyama Masahiro
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      Nara Institute of Science and Technology
  •  Biochemical studies of eukaryotic DNA polymerase zeta functioning in bypass DNA synthesisPrincipal Investigator

    • Principal Investigator
      AKIYAMA Masahiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
  •  Molecular mechanisms of mutagenesis caused by transletion DNA synthesis

    • Principal Investigator
      MAKI Hisaji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Molecular biology
    • Research Institution
      Nara Institute of Science and Technology
  •  ミスマッチ認識および修復過程の生化学的研究Principal Investigator

    • Principal Investigator
      秋山 昌広
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nara Institute of Science and Technology
  •  p21によるPCNAの機能制御と細胞のがん化

    • Principal Investigator
      釣本 敏樹
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nara Institute of Science and Technology

All 2016 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Replication fork progression is paused in two large chromosomal zones flanking the DNA replication origin in Escherichia coli2016

    • Author(s)
      Masahiro Tatsumi Akiyama, Taku Oshima, Onuma Chumsakul, Shu Ishikawa and Hisaji Mak
    • Journal Title

      Genes to Cells

      Volume : 21 Pages : 907-914

    • DOI
      10.1111/gtc.12388
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-26450090
  • [Journal Article] Recombinase and translesion DNA polymerase decrease the speed of replication fork progression during the DNA damage response in Escherichia coli cells2015

    • Author(s)
      Tan K.W., Pham M.T., Furukohri A, Maki H. and Akiyama T.M.
    • Journal Title

      Nucleic Acids Research

      Volume : 43 Pages : 1715-1725

    • DOI
      10.1093/nar/gkv044
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-25840009
  • [Journal Article] DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts2014

    • Author(s)
      Ikeda M, Furukohri A, Philippin G, Loechler E, Akiyama MT, Katayama T, Fuchs RP, Maki H.
    • Journal Title

      Nucleic Acids Research

      Volume : 42 Pages : 8461-8472

    • DOI
      10.1093/nar/gku547
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-25840009
  • [Journal Article] A single-molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerase III is a major determinant of fork speed2013

    • Author(s)
      Pham M.T., Tan K.W., Sakumura Y., Okumura K., Maki H. and Akiyama T.M.
    • Journal Title

      Molecular Microbiology

      Volume : 90 Pages : 584-596

    • DOI
      10.1111/mmi.12386
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009
  • [Presentation] Replication profiles in Escherichia coli cells2016

    • Author(s)
      Masahiro Tatsumi Akiyama
    • Organizer
      3R International Symposium
    • Place of Presentation
      ホテル一畑(島根県島根市)
    • Year and Date
      2016-11-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌の複製フォークの動態プロファイリング2016

    • Author(s)
      秋山昌広
    • Organizer
      日本遺伝学会第88回大会(三島大会)
    • Place of Presentation
      日本大学(静岡県三島市)
    • Year and Date
      2016-09-09
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] recAまたはdinB遺伝子の過剰発現による複製フォーク速度の低下2015

    • Author(s)
      Tan Kang Wei、Pham Minh Tuan、古郡麻子、真木寿治、秋山昌広
    • Organizer
      日本遺伝学会・第87回大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-09-25
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] DNA損傷応答による複製マシナリーの進行速度の低下2015

    • Author(s)
      Tan Kang Wei、Pam Minh Tuan、古郡麻子、真木壽治、秋山昌広
    • Organizer
      第12回21世紀大腸菌研究会
    • Place of Presentation
      琵琶湖グランドホテル(滋賀県大津市)
    • Year and Date
      2015-06-04
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌損傷乗り越え型DNA Polymerase IVの複製フォークにおける役割2015

    • Author(s)
      古郡麻子、池田美央、秋山昌広、片山勉、Robert P. Fuchs、真木壽治
    • Organizer
      第12回21世紀大腸菌研究会
    • Place of Presentation
      琵琶湖グランドホテル(滋賀県大津市)
    • Year and Date
      2015-06-04
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌のrecAまたはdinB遺伝子の過剰発現による複製フォーク進行の遅延2015

    • Author(s)
      Tan Kang Wei、Pham Minh Tuan、古郡麻子、真木寿治、秋山昌広
    • Organizer
      第38回・日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌の栄養環境が酸化DNA損傷と活性酸素種に与える影響2015

    • Author(s)
      布瀬翔平、Tom Conrad、安藤さやか、豊本奈美江、中村葵、秋山昌広、真木壽治
    • Organizer
      日本遺伝学会・第87回大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-09-26
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌細胞のDNA複製フォーク速度の単分子解析2013

    • Author(s)
      Pham Minh Tuan、Tan Kang Wei、作村諭一、奥村克純、真木寿治、秋山昌広
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      慶應義塾大学日吉キャンパス、横浜市
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌細胞におけるDNA複製フォークの進行速度に関する一分子解析2013

    • Author(s)
      秋山昌広
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド、神戸市
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌細胞における複製フォークの進行速度に関する一分子解析2013

    • Author(s)
      Pham Minh Tuan、Tan Kang Wei、作村諭一、奥村克純、真木寿治、秋山昌広
    • Organizer
      第22回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      ホテルニュー水戸屋、仙台市
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌細胞のDNA複製フォーク速度の単分子解析2013

    • Author(s)
      Pham Minh Tuan、Tan Kang Wei、作村諭一、奥村克純、真木寿治、秋山昌広
    • Organizer
      第10回21世紀大腸菌研究会
    • Place of Presentation
      ラフォーレ修善寺、伊豆市
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] DNA polymerase III is a major determinant of replication fork speed in Escherichia coli cells2013

    • Author(s)
      Tuan Minh Pham, Kang Wei Tan, Yuichi Sakumura, Katsuzumi Okumura, Hisaji Maki and Masahiro Tatsumi Akiyama
    • Organizer
      日本遺伝学会第85回大会
    • Place of Presentation
      慶應義塾大学日吉キャンパス、横浜市
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] Escherichia coli DNA polymerase IV mediates quick recpovery of repliaction forks stalled at N2-dG adducts.

    • Author(s)
      Furukohri, A., Ikead, M., Akiyama, M., Katayama, T., Fuchs R.P., and Maki, H.
    • Organizer
      The 9th 3R International Symposium
    • Place of Presentation
      御殿場高原ホテル(静岡県、御殿場市)
    • Year and Date
      2014-11-11 – 2014-11-21
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] A single molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerae III is a major determinant of fork speed

    • Author(s)
      Pham, TM., Tan, K.W., Sakumura, Y., Okumura,K., Furukohri, A., Maki, H.,and Akiyama, T.M.
    • Organizer
      The 9th 3R International Symposium
    • Place of Presentation
      御殿場高原ホテル(静岡県、御殿場市)
    • Year and Date
      2014-11-11 – 2014-11-21
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] Escherichia coli DNA polymerase IV mediates quick recpovery of repliaction forks stalled at N2-dG adducts

    • Author(s)
      Furukohri, A., Ikead, M., Akiyama, M., Katayama, T., Fuchs R.P., and Maki, H.
    • Organizer
      DNA polymerases: Biology, Diseases and Biomediacal Appliatiuon Conference 2014
    • Place of Presentation
      Robinson collage (Cambridge, England)
    • Year and Date
      2014-08-31 – 2014-09-04
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] A single molecule approach to DNA replication in Escherichia coli cells demonstrated that DNA polymerae III is a major determinant of fork speed

    • Author(s)
      Pham, TM., Tan, K.W., Sakumura, Y., Okumura,K., Furukohri, A., Maki, H.,and Akiyama, T.M.
    • Organizer
      DNA polymerases: Biology, Diseases and Biomediacal Appliatiuon Conference 2014
    • Place of Presentation
      Robinson collage (Cambridge, England)
    • Year and Date
      2014-08-31 – 2014-09-04
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌のSOS応答による複製フォークの進行速度の低下

    • Author(s)
      Tang Kang Wei、Pham Minh Tuan、古郡麻子、奥村克純、真木寿治、秋山昌広
    • Organizer
      第37回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌損傷乗り越え型 DNA Polymerase IV の複製フォークにおける役割

    • Author(s)
      古郡麻子、池田美央、西川義人、秋山昌広、片山 勉、Robert P. Fuchs、真木寿治
    • Organizer
      日本遺伝学会 第86回大会
    • Place of Presentation
      長浜バイオ大学(滋賀県、長浜市)
    • Year and Date
      2014-09-17 – 2014-09-19
    • Data Source
      KAKENHI-PROJECT-25440009
  • [Presentation] 大腸菌のSOS応答による複製フォーク速度の減速

    • Author(s)
      Tang Kang Wei、Pham Minh Tuan、古郡麻子、真木寿治、秋山昌広
    • Organizer
      日本遺伝学会 第86回大会
    • Place of Presentation
      長浜バイオ大学(滋賀県、長浜市)
    • Year and Date
      2014-09-17 – 2014-09-19
    • Data Source
      KAKENHI-PROJECT-25440009
  • 1.  Maki Hisaji (20199649)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 20results
  • 2.  Katayama Tsutomu (70264059)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 5results
  • 3.  UMEZU Keiko (20223612)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 4.  釣本 敏樹 (30163885)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 5.  小布施 力史 (00273855)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 6.  藤田 雅俊 (30270713)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 7.  大谷 清 (30201974)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 8.  村上 洋太 (20260622)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 9.  正井 久雄 (40229349)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 10.  加藤 順也 (00273839)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 11.  関 峰秋 (40304167)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 12.  大島 拓 (50346318)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 1results
  • 13.  松本 吉博
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 14.  FUCHS Robert
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 15.  ISHIKAWA Shu
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 16.  FURUKOHRI Asako
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results

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