TSURU Akio 都留秋雄

… Alternative Names

都留秋雄ツルアキオ

ISURU Akio 都留秋雄

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Researcher Number	80273861
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Affiliation (Current)	2025: 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教
Affiliation (based on the past Project Information) *help	2018 – 2019: 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 2016 – 2017: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 2006 – 2012: Nara Institute of Science and Technology, Department of Cell Biology, Assistant Professor 2006: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 2005: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助手 … More 2002 – 2004: NAIST, Res. & Edu. Ctr for Genet. Inf., Instructor, 遺伝子教育研究センター, 助手 2001: 奈良先端科学技術大学院大学, 遺伝子教育センター, 助手 1995 – 1996: 奈良先端科学技術大学院大学, 遺伝子教育研究センター, 助手 Less
Review Section/Research Field	Principal Investigator Cell biology Except Principal Investigator Biological Sciences / Applied biochemistry / Cell biology / Cell biology
Keywords	Principal Investigator Unfolded protein response / BiP / GRP78 / IRE1 / Kar2 / ER stress / センシング / ストレス応答 / 小胞体 / kar2 / 小胞体ストレス … More Except Principal Investigator … More 小胞体ストレス / 小胞体 / UPR / ストレス応答 / ストレス / BiP / スプライシング / RNA / IRE1 / 糖尿病 / シグナル伝達 / シャペロン / 分子シャペロン / インスリン / ER stress / ストレスセンサー / Bip / HSP70 / ノックアウトマウス / 構造異常蛋白質 / Ire1 / 翻訳停止 / 特殊スプライシング / プロインスリン / 品質管理 / 翻訳休止 / リボソーム / 寄生虫 / 膵島β細胞 / インスリン分泌 / ムチン産生 / ムチン / 寄生虫感染 / 動物 / 情報伝達 / 細胞応答 / splicing / stress response / molecular chaperon / ER / Stress / ストレス対応 / stress-sensing / quality control of proteins / chaperone / DnaJ / XBP1 / GFP / 小胞体シャペロン / unfolded protein response / 転写調節 / ストレス感知 / タンパク質の品質管理 / transport vesicle / Unfolded Protein Response / 28srRNA / マイクロアレイ / 輸送小胞 / Tubulin / Microtubule / HSE / yeast / Stress Response / 核の配分 / Green Fluorescent Protein / Ssalp / hsp70 / チューブリン / 微小管 / 熱応答エレメント(HSE) / 酵母 / HSP40 / 蛋白質品質管理 / Hsp40 / 転写翻訳調節 / タンパク質品質管理 Less

Elucidation of the mechanism of physiological ER stress response required for the homeostasis of cell and whole body
- Principal Investigator
  
  Kohno Kenji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied biochemistry
- Research Institution
  Nara Institute of Science and Technology
The molecular mechanism of ER stress response and the pathophysiology of ER stress disorders
- Principal Investigator
  
  Kohno Kenji
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Applied biochemistry
- Research Institution
  Nara Institute of Science and Technology
Analyses of the physiological roles of unfolded protein response
- Principal Investigator
  
  KOHNO Kenji
- Project Period (FY)
  2007 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
ストレス応答性RNaseであるIre1と標的RNAのユニークな動態
- Principal Investigator
  
  木俣行雄
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
In vivo functions of the endoribonuclease Ire1
- Principal Investigator
  
  KIMATA Yukio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Nara Institute of Science and Technology
小胞体ストレス応答性RNaseであるIre1と標的RNAのユニークな動態
- Principal Investigator
  
  KIMATA Yukio
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
ER Stress-sensing system and Analyses of its signal transduction mechanism.
- Principal Investigator
  
  KOHNO Kenji
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Institute of Science and Technology
Sensing mechanism of IRE1 to abnormal proteinsPrincipal Investigator
- Principal Investigator
  
  TSURU Akio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Nara Institute of Science and Technology
Functional analyses of ER stress sensor proteins
- Principal Investigator
  
  KOHNO Kenji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
Functional analyzes of molecular chaperons concerning on protein translocation across the ER membrane
- Principal Investigator
  
  KOHNO Kenji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Nara Institute of Science and Technology

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2008

All Journal Article Presentation

[Journal Article] Identification of the physiological substrates of PDIp, a pancreas-specific protein-disulfide isomerase family member2018
- Author(s)
  Fujimoto Takushi、Nakamura Orie、Saito Michiko、Tsuru Akio、Matsumoto Masaki、Kohno Kenji、Inaba Kenji、Kadokura Hiroshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 48 Pages: 18421-18433
- DOI
  10.1074/jbc.ra118.003694
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05534, KAKENHI-PUBLICLY-17H06011, KAKENHI-PROJECT-17H01468, KAKENHI-PROJECT-18H03978, KAKENHI-PROJECT-16H04730, KAKENHI-PROJECT-15K07381, KAKENHI-PROJECT-17K19606, KAKENHI-PLANNED-26116005
[Journal Article] Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway.2016
- Author(s)
  Tsuru, A.*, Imai, Y.*, Saito, M.*, and Kohno, K.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 24217-24217
- DOI
  10.1038/srep24217
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430090, KAKENHI-PROJECT-24228002, KAKENHI-PLANNED-26116006
[Journal Article] 小胞体ストレスと炎症性腸疾患2014
- Author(s)
  都留秋雄、河野憲二
- Journal Title
  
  実験医学
  
  Volume: 32 Pages: 2221-2225
- Data Source
  KAKENHI-PROJECT-24228002
[Journal Article] Negative feedback by IRE1β optimizes mucin production in goblet cells.2013
- Author(s)
  Tsuru, Akio
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 110 Issue: 8 Pages: 2864-2869
- DOI
  10.1073/pnas.1212484110
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058010, KAKENHI-PROJECT-23500496, KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-24580141, KAKENHI-PUBLICLY-24113702
[Journal Article] Negative feedback by IRE1β optimizes mucin production in goblet cells2013
- Author(s)
  Tsuru, A., Fujimoto, N., Takahashi, S.,Saito, M., Nakamura, D., Iwano, M., Iwawaki, T., Kadokura, H., Ron, D., Kohno, K
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 110 Pages: 2864-2869
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058010
[Journal Article] Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue.2013
- Author(s)
  Kadokura, H., Saito, M., Tsuru, A., Hosoda, A., Iwawaki, T., Inaba, K., & Kohno, K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 440 Issue: 2 Pages: 245-250
- DOI
  10.1016/j.bbrc.2013.09.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500496, KAKENHI-PUBLICLY-24113702, KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24580141
[Journal Article] A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins2012
- Author(s)
  Sopha, P., Kadokura, H., Yamamoto, Y.H., Takeuchi, M., Saito, M., Tsuru, A., Kohno, K
- Journal Title
  
  Cell Struct. Funct
  
  Volume: 37 Pages: 177-187
- NAID
  130004137586
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058010
[Journal Article] Mammalian ER stress sensor IRE1β specifically down-regulates the synthesis of secretory pathway proteins2011
- Author(s)
  Nakamura, D., Tsuru, A., Ikegami, K., Imagawa, Y., Fujimoto, N., Kohno, K.
- Journal Title
  
  FEBS Lett
  
  Volume: 585 Pages: 133-138
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058010
[Journal Article] RNase domains determine the functional difference between IRE1a and IRE1b2008
- Author(s)
  Imagawa, Y., Hosoda, A., Sasaka, S.,Tsuru, A., Kohno, K
- Journal Title
  
  FEBS Lett
  
  Volume: 582 Pages: 656-660
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19058010
[Presentation] Requirement of ER stress response for nematode expulsion through mature mucin production by IRE1β specific pathway.2018
- Author(s)
  Akio Tsuru
- Organizer
  International Symposium; Proteins: From the cradle to the grave
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01468
[Presentation] 小胞体ストレスセンサーIRE1βの活性化においてリン酸化が果たす複数の役割2017
- Author(s)
  都留秋雄,　坪山恭之,　大澤祐介, 河野憲二
- Organizer
  生命科学系学会合同年次大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-24228002
[Presentation] ムチン産生に関る小胞体ストレスセンサーIRE1βはIRE1αとは異なるリン酸化制御を受ける2017
- Author(s)
  都留秋雄,　坪山恭之,　大澤祐介,　河野憲二
- Organizer
  第12回小胞体ストレス研究会
- Data Source
  KAKENHI-PROJECT-17H01468
[Presentation] 小胞体ストレスセンサーIRE1βの活性化においてリン酸化が果たす複数の役割2017
- Author(s)
  都留秋雄,　坪山恭之,　大澤祐介, 河野憲二
- Organizer
  生命科学系学会合同年次大会（ConBio2017)
- Data Source
  KAKENHI-PROJECT-17H01468
[Presentation] ムチン産生に関わる小胞体ストレスセンサーIRE1βはIRE1αとは異なるリン酸化制御を受ける2017
- Author(s)
  都留秋雄,　坪山恭之,　大澤祐介,　河野憲二
- Organizer
  第12回小胞体ストレス研究会
- Data Source
  KAKENHI-PROJECT-24228002
[Presentation] 膵特異的に発現するPDIファミリータンパク質(PDIp)の生理的な機能の解析2016
- Author(s)
  藤本拓志, 斉藤美知子, 都留秋雄, 松本雅紀, 河野憲二, 稲葉謙次, 門倉広
- Organizer
  第８９回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-24228002
[Presentation] ERdj5(JPDI)基質候補タンパク質のマウス個体組織からの網羅的同定2015
- Author(s)
  門倉広、斉藤美知子、都留秋雄，稲葉謙次、河野憲二
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂（奈良県・奈良市）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-24228002
[Presentation] PERK-ATF4 branch of the unfolded protein response is required for the full activation of IRE1a-XBP1 signaling2015
- Author(s)
  Akio Tsuru, Yasutaka Imai, Michiko Saito, Kenji Kohno
- Organizer
  FASEB Science Research Conferences
- Place of Presentation
  Saxtons River, VT (USA)
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24228002
[Presentation] 膵臓特異的に発現しているPDIファミリータンパク質(PDIp)の生理的な機能の解析2015
- Author(s)
  藤本拓志，斉藤美知子、都留秋雄，松本雅記，河野憲二，稲葉謙次，門倉広
- Organizer
  BMB2015（日本分子生物学会・日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートピアホテル（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-24228002
[Presentation] 膵特異的に発現するPDIファミリータンパク質(PDIp)の生理的機能の解析2015
- Author(s)
  藤本拓志、斎藤美知子、都留秋雄、河野憲二、稲葉謙次、門倉広
- Organizer
  第67回日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀（東京都・江戸川区）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-24228002
[Presentation] Roles of IRE1b in gastrointestinal nematode expulsion2013
- Author(s)
  Tomoko Komatsu, Akio Tsuru, Koubun Yasuda, Sayo Takahashi, Tomohiro Yoshimoto, Kenji Nakanishi, Kenji Kohno
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  ウインクあいち（愛知県産業労働センター）・愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-24228002
[Presentation] 腸管寄生虫排除における小胞体ストレス応答の生理的役割2013
- Author(s)
  小松朋子, 都留秋雄, ○ 河野憲二
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜・神奈川県横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-24228002
[Presentation] Negative feedback by IRE1β optimizes mucin production in goblet cells2012
- Author(s)
  Akio Tsuru, Michiko Saito, Megumi Iwano, Takao Iwawaki, David Ron, Kenji Kohno
- Organizer
  Cold Spring Harbor Meeting: Molecular Chaperones and Stress Response
- Place of Presentation
  Cold Spring Harbor, USA
- Year and Date
  2012-05-04
- Data Source
  KAKENHI-PLANNED-19058010
[Presentation] The ER stress sensor IRE1β down-regulates MUC2 mRNA to optimize mucin production2010
- Author(s)
  Akio Tsuru
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  ホテル日航奈良
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PLANNED-19058010
[Presentation] The ER stress sensor IRE1β down-regulates MUC2 mRNA to optimize mucin production2010
- Author(s)
  都留秋雄
- Organizer
  BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会・合同大会)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PLANNED-19058010
[Presentation] IRE1beta is a key molecule for ER quality control in goblet cells2008
- Author(s)
  Akio Tsuru, Kenji Kohno
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PLANNED-19058010

1. KOHNO Kenji (50142005)

# of Collaborated Projects: 10 results

# of Collaborated Products: 18 results
2. KIMATA Yukio (60263448)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. SAITO Michiko (40379558)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. TERADA Kazutoyo (00253724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YANAGITANI Kota (70614775)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KADOKURA Hiroshi (70224558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. YAMAMOTO Yohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. OHFURUDONO Miku

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. RON David

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松本雅記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSURU Akio 都留 秋雄

都留 秋雄 ツル アキオ

ISURU Akio 都留 秋雄

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Sensing mechanism of IRE1 to abnormal proteinsPrincipal Investigator

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[Journal Article] Identification of the physiological substrates of PDIp, a pancreas-specific protein-disulfide isomerase family member2018

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[Journal Article] Novel mechanism of enhancing IRE1α-XBP1 signalling via the PERK-ATF4 pathway.2016

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[Journal Article] 小胞体ストレスと炎症性腸疾患2014

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[Journal Article] Negative feedback by IRE1β optimizes mucin production in goblet cells.2013

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[Journal Article] Negative feedback by IRE1β optimizes mucin production in goblet cells2013

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TSURU Akio 都留秋雄

都留秋雄ツルアキオ

ISURU Akio 都留秋雄