Nagafuchi Hiroko 永渕裕子

… Alternative Names

NAGAFUCHI Hiroko 永渕裕子

永渊裕子ナガフチヒロコ

永渕裕子ナガフチヒロコ

Less

Researcher Number	80278001
Other IDs
External Links
Affiliation (Current)	2025: 聖マリアンナ医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2022: 聖マリアンナ医科大学, 医学部, 講師 2015: 聖マリアンナ医科大学, 医学部, 講師 2004 – 2005: 聖マリアンナ医科大学, 医学部, 講師 2001: St. Marianna University School of Medicine, Departments of Internal Medicine, Assistant Professor, 医学部, 助手 1998 – 2000: 聖マリアンナ医科大学, 難病治療研究センター, 助手 1996: 聖マリアンナ医科大学, 難病治療研究センター, 助手
Review Section/Research Field	Principal Investigator 内科学一般 / Basic Section 54020:Connective tissue disease and allergy-related / 膠原病・アレルギー・感染症内科学 Except Principal Investigator 内科学一般 / Collagenous pathology/Allergology / Neurology
Keywords	Principal Investigator 関節リウマチ / プロラクチン / 滑膜細胞 / 神経ペプチド / 神経・免疫・内分泌軸 / 全身性エリテマトーデス / 滑膜炎症 / 骨吸収 / Interleukin-34 / 線維芽細胞様滑膜細胞 … More / IL-34 / neuropeptide / luslin-growth factor / growth hormone / prolactin / neuroendocrine immune system / systemic lupus erythematosus / rheumatoid arthritis / インスリン成長因子 / 成長ホルモン / 滑膜浸潤リンパ球 / ブロモクリプチン / ホルモル / 慢性関節リウマチ / チロシンリン酸化 / オリゴクロナリティー / CD4+CD28+T細胞 / CD4+CD28-T細胞 … More Except Principal Investigator 全身性エリテマトーデス / JAK2-STAT5 / CREB / RAG / X染色体 / 自己反応性T細胞 / 慢性関節リウマチ / アポトーシス / MPO-ANCA / バイオマーカー / 血管炎 / アポリポタンパク / ペプチドミクス / ANCA関連血管炎 / prolactin / endorophin / encephalin / Rheumatoid athritis / プロラクチン / エンドロフィン / エンケファリン / apoptosis / Receptor editing / B lymphocytes / anti-DNA antibody / SLE / 抗CD40抗体 / EBウイルス / B細胞株 / 抗DNA抗体 / レセプターエディティング / Bリンパ球 / 興DNA交代 / mosaicism / X chromosome / autoreactive T cells / systemic lupus erythematosus / モザイク現象 / キメラ / メタロプロテイネース / 炎症性サイトカイン / 細胞増殖 / 滑膜細胞 / 遺伝子 / Jun-D / インターフェロンγ / Tリンパ球 / 免疫系細胞 / 神経細胞 / 神経成長因子 Less

Could IL-34, which is involved in inflammation and bone resorption, be a target molecule for the treatment of rheumatoid arthritis?Principal Investigator
- Principal Investigator
  
  NAGAFUCHI Hiroko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  St. Marianna University School of Medicine
Basic analysis of clinical significance of novel vasculitis biomarkers identified by a peptidomic approach
- Principal Investigator
  
  Ozaki Shoichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  St. Marianna University School of Medicine
Therapeutic strategy for autoimmune disease at the neuroendocrine-immune interfacePrincipal Investigator
- Principal Investigator
  
  NAGAFUCHI Hiroko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  St.Marianna University School of Medicine
全身性エリテマトーデスの発症のメカニズムと女性のX染色体キメリズム
- Principal Investigator
  
  高井憲治
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内科学一般
- Research Institution
  St. Marianna University School of Medicine
Analysis of RAG expression in antibody-secreting B cell of SLE patients
- Principal Investigator
  
  SUZUKI Noboru
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  St. Marianna University School of Medicine
Development of novel therapeutic strategies for rheumatoid arthritis based on the neuro - endocrine-immune axis
- Principal Investigator
  
  TAKENO Mitsuhiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  St. Marianna University School of Medicine
慢性関節リウマチの関節滑膜局所の病態形成における神経・免疫・内分泌軸の関与Principal Investigator
- Principal Investigator
  
  永渕裕子
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  St. Marianna University School of Medicine
Jun-D遺伝子導入による慢性関節リウマチの治療に関する基礎的研究
- Principal Investigator
  
  SAKANE Tusyoshi
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内科学一般
- Research Institution
  St. Marianna University School of Medicine
X-chromosome inactivation mosaicism is implicated in the emergence of autoreactive T cells in patients with systemic lupus erythematosus
- Principal Investigator
  
  SAKANE Tusyoshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  St. Marianna University School of Medicine
神経成長因子(NGF)による免疫応答調節機構の解析
- Principal Investigator
  
  上田裕司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  St. Marianna University School of Medicine
全身性エリテマトーデス(SLE)患者末梢血T細胞における情報伝達機構の解析Principal Investigator
- Principal Investigator
  
  永渕裕子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  St. Marianna University School of Medicine

All 2022 2021 2019 2015 2014 2005

All Journal Article Presentation

[Journal Article] Reasons for discontinuation of methotrexate in the treatment of rheumatoid arthritis and challenges of methotrexate resumption: a single-center, retrospective study2022
- Author(s)
  Hiroko Nagafuchi, Yutaka Goto, Tomofumi Kiyokawa, Kimito Kawahata
- Journal Title
  
  Egyptian Rheumatology and Rehabilitation
  
  Volume: － Issue: 1
- DOI
  10.1186/s43166-022-00162-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08420, KAKENHI-PROJECT-20K08785
[Journal Article] Pregnancy outcomes in patients with rheumatoid arthritis who discontinue methotrexate treatment to conceive2021
- Author(s)
  Nagafuchi Hiroko、Goto Yutaka、Kiyokawa Tomofumi、Ooka Seido、Kawahata Kimito
- Journal Title
  
  Clinical Rheumatology
  
  Volume: 41 Issue: 3 Pages: 669-675
- DOI
  10.1007/s10067-021-05985-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08420, KAKENHI-PROJECT-20K08785
[Journal Article] Rheumatoid arthritis relapse in patients with other iatrogenic immunodeficiency-associated lymphoproliferative disorders and its treatment2021
- Author(s)
  Nagafuchi Hiroko、Goto Yutaka、Suzuki Shotaro、Sakurai Keiichi、Imamura Mitsuru、Suzuki Takeshi、Yamasaki Yoshioki、Shibata Tomohiko、Kawahata Kimito
- Journal Title
  
  Modern Rheumatology
  
  Volume: 31 Issue: 6 Pages: 1087-1093
- DOI
  10.1080/14397595.2021.1879367
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08420, KAKENHI-PROJECT-20K08785
[Journal Article] Clinical subsets associated with different anti-aminoacyl transter RNA synthetase antibodies and their association with coexisting anti-Ro52.2015
- Author(s)
  Yamasaki Y, Satoh M, Mizushima M, Okazaki T, Nagafuchi H, Ooka S, Shibata T, Nakano H, Ogawa H, Azuma K, Maeda A, Tonooka K, Ito H, Takakuwa Y, Inoue M, Kiyokawa T, Tsuchida K, Matsushita H, Mikage H, Murakami Y, Jason Y. F. Chan, Ozaki S, Yamada H.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 1 Issue: 3 Pages: 403-9
- DOI
  10.3109/14397595.2015.1091155
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461489, KAKENHI-PROJECT-15K08790
[Journal Article] Assessment of the Birmingham vasculitis activity score in patients with MPO-ANCA-associated vasculitis: sub-analysis from a study by the Japanese Study Group for MPO-ANCA-associated vasculitis.2014
- Author(s)
  Yumura W, Kobayashi S, Suka M, Hayashi T, Ito S, Nagafuchi H, Yamada H, Ozaki S.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 24(2) Pages: 304-309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461489
[Journal Article] Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis.2014
- Author(s)
  Sato T, Yamano Y, Tomaru U, Shimizu Y, Ando H, Okazaki T, Nagafuchi H, Shimizu J, Ozaki S, Miyazawa T, Yudoh K, Oka H, Suzuki N.
- Journal Title
  
  Mod Rheumatol. 2014 Jan;:
  
  Volume: 24(1) Pages: 129-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461489
[Journal Article] Comparison of phenotype and outcome in microscopic polyangiitis between Europe and Japan.2014
- Author(s)
  Furuta, S., Chaudhry, AN., Hamano, Y., Fujimoto, S., Nagafuchi, H., Makino, H., Matsuo, S., Ozaki, S., Endo, T., Muso, E., Ito, C., Kusano, E., Yamagata, M., Ikeda, K., Kashiwakuma, D., Iwamoto, I., Westman, K. and Jayne, D.
- Journal Title
  
  J Rheumatol.
  
  Volume: 41(2) Issue: 2 Pages: 325-33
- DOI
  10.3899/jrheum.130602
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23510244, KAKENHI-PROJECT-25293195, KAKENHI-PROJECT-25461217, KAKENHI-PROJECT-25461489, KAKENHI-PROJECT-25670408, KAKENHI-PROJECT-26305029
[Journal Article] Long-term safety and efficacy of rituximab in 7 Japanese patients with ANCA-associated vasculitis.2014
- Author(s)
  Nagafuchi H., Atsumi T., Hatta K., Muso E., Takeno M., Yamada H., Ozaki S.:
- Journal Title
  
  Mod Rheumatol
  
  Volume: 15 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461489
[Journal Article] Expressive expression of Txk, a member of Tec family tyrosine kinases, contributes to excessive Th1 cytokine production by T lymphocytes in patients with Behcet's disease2005
- Author(s)
  Nagafuchi H, et al.
- Journal Title
  
  Clin Exp Immunol 139(2)
  
  Pages: 363-370
- Data Source
  KAKENHI-PROJECT-16590999
[Journal Article] Expressive expression of Txk, a member of Tec family tyrosine kinases, contributes to excessive Th1 cytokine production by T lymphocytes in patients with Behcet's disease.2005
- Author(s)
  Nagafuchi H, et al.
- Journal Title
  
  Clin Exp Immunol 139(2)
  
  Pages: 363-370
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590999
[Presentation] 関節リウマチの病態形成におけるIL-34の役割2019
- Author(s)
  永渕裕子
- Organizer
  日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-18K08420
[Presentation] 関節リウマチの病態形成におけるIL-34の役割2019
- Author(s)
  永渕裕子、尾崎承一、川畑仁人
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K08420

1. TAKENO Mitsuhiro (50236494)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. SAKANE Tusyoshi (40127519)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SUZUKI Noboru (40235982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Ozaki Shoichi (00231233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KUROKAWA Manae (90301598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 上田裕司 (00223470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 高井憲治 (60121167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHMOTO Yasukazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 尾崎信弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 濱野慶朋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagafuchi Hiroko 永渕 裕子

NAGAFUCHI Hiroko 永渕 裕子

永渊 裕子 ナガフチ ヒロコ

永渕 裕子 ナガフチ ヒロコ

Research Projects

Research Products

Co-Researchers

Could IL-34, which is involved in inflammation and bone resorption, be a target molecule for the treatment of rheumatoid arthritis?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic analysis of clinical significance of novel vasculitis biomarkers identified by a peptidomic approach

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic strategy for autoimmune disease at the neuroendocrine-immune interfacePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

全身性エリテマトーデスの発症のメカニズムと女性のX染色体キメリズム

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of RAG expression in antibody-secreting B cell of SLE patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic strategies for rheumatoid arthritis based on the neuro - endocrine-immune axis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

慢性関節リウマチの関節滑膜局所の病態形成における神経・免疫・内分泌軸の関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Jun-D遺伝子導入による慢性関節リウマチの治療に関する基礎的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

X-chromosome inactivation mosaicism is implicated in the emergence of autoreactive T cells in patients with systemic lupus erythematosus

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経成長因子(NGF)による免疫応答調節機構の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

全身性エリテマトーデス(SLE)患者末梢血T細胞における情報伝達機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Reasons for discontinuation of methotrexate in the treatment of rheumatoid arthritis and challenges of methotrexate resumption: a single-center, retrospective study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pregnancy outcomes in patients with rheumatoid arthritis who discontinue methotrexate treatment to conceive2021

Author(s)

Nagafuchi Hiroko 永渕裕子

NAGAFUCHI Hiroko 永渕裕子

永渊裕子ナガフチヒロコ

永渕裕子ナガフチヒロコ