YAMASHITA Yasuko 山下康子

Researcher Number	80291532
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2012: 長崎大学, 医歯薬学総合研究科, 講師 2010 – 2011: 長崎大学, 大学院・医歯薬学総合研究科, 講師 2002 – 2004: Nagasaki University Postgraduate School of Biomedical Sciences, Lecturer, 大学院・医歯薬学総合研究科, 講師 1997 – 2001: 長崎大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology Except Principal Investigator General pharmacology / General pharmacology / 環境影響評価(含放射線生物学) / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator MCP-1 / BLOOD BRAIN BARRIER / ET_B RECEPTOR / ASTROCYTES / MICROGLIA / ISCHEMIA-RELATED NEURONAL DEATH / SHRSP / 虚血性神経細胞死 / アストロサイト / ミクログリア / 虚血性脳神経細胞死 … More Except Principal Investigator … More TCDD / pentosan polysulfate / anti-dementia drug / 抗痴呆薬 / BBB in vitro再構築系 / 脳毛細血管内皮細胞 / 血液脳関門(BBB) / locomotor activity / 運動活性 / ラット脳 / GABA_BR1d / GABA_BR1c / ノニルフェノール / 中枢神経機能 / conformation diseaase / Alzheimer disease / prion disease / heparin / blood-brain barrier(BBB) / コンフォメーション病 / アルツハイマー病 / プリオン病 / ヘパリン誘導体 / ペントサン / 血液脳関門 / brain capillary endothelial cells / hippocampus CA1 neurons / GP8 cell / ischemia-related neuronal death / BBB in vitro model / blood-brain barrier (BBB) / petosan polysulfate / 血液脳関門 in vitro 再構築薬 / Pentosem polysulfate / 海馬CA1錐体神経細胞 / BBB in vitro 再構築系 / 海馬CA1錐体神経細胞死 / 虚血性神経細胞死 / central nervous system / open-field test / learning and memory / i. c. v. injection / nonylphenol / environmental endocrine disruptors / 飲水量 / 摂食量 / ビスフェノールA / オープンフィールド / 学習・記憶 / 脳室内投与 / in vitro model of the BBB / brain capillary endothelial cell / pericytes / Drug-transport to brain / astrocytes / Blood-Brain Barrier / BBBキット / ペリサイト(周囲細胞) / 薬物脳内移行 / アストロサイト / water intake / food consumption / communication box / blood brain barrier / rat brain / stress / 飲水 / 摂食 / コミュニケーションボックス / 血液-脳関門 / 環境ストレス / G protein-gated inwardly rectifying K^+ channel (GIRK) / GABA_B receptor / synaptophysin / dopamine release / rat brain mRNA / Xenopus oocyte / プロテインキナーゼC / 開口放出 / 神経終末 / γ-アミノ酪酸(GABA) / ドパミン / GIRK / GABA_BRIC / G蛋白質依存性内向き整流K^+チャネル(GIRK) / GABA_B受容体 / シナプトフィジン / ドパミン遊離 / ラット脳mRNA / アフリカツメガエル卵母細胞 / エストロゲン受容体 / エストロゲン活性 / 情動 / 一般活動性 / ビスフェノール A / 学習記憶 / 周産期曝露 / 植物エストロゲン / 内分泌撹乱化学物質 / 内分泌かく乱物質 Less

エストロゲン活性を有する内分泌撹乱化学物質類の学習記憶能に及ぼす影響評価
- Principal Investigator
  
  YAMASHITA Kimihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagasaki University
Experimental-therapeutic potency of pentosan pofysulfate as an anti-prion and anti-dementia drug
- Principal Investigator
  
  NIWA Masami
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Nagasaki University
Pentosan polysulfate strenghens blood-brain barrier functions : A possible role of anti-dementia drug
- Principal Investigator
  
  MASAMI Niwa
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  NAGASAKI UNIVERSITY
ANALYSIS OF MULTIFUNCTION OF MICROGLIA IN THE ISCHEMIA-RELATED NEURONAL DEATHPrincipal Investigator
- Principal Investigator
  
  SAKURAI Yasuko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  NAGASAKI UNIVERSITY
In vitro model of the blood-brain barrier
- Principal Investigator
  
  NIWA Masami
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  NAGASAKI UNIVERSITY
Effects of environmental endocrine disrupters on learning, memory and emotional behavior in the function of central nervous system
- Principal Investigator
  
  YAMASHITA Kimihiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Nagasaki University
Effects of environmental stresses on the permeability of blood brain barrier
- Principal Investigator
  
  YAMASHITA Kimihiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Department of Environmental Conservation, Faculty of Environmental Studies, Nagasaki University
Study on regulatory molecules involved in neurotransmitter release in Xenopus oocytes injected with mRNA
- Principal Investigator
  
  TANIYAMA Kohtaro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Nagasaki University

All 2013 2012 2011 2010 2003

All Journal Article Presentation

[Journal Article] Involvement of 5-hydroxytryptamine_4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia2003
- Author(s)
  Sakurai-Yamashita Y
- Journal Title
  
  Brain Res 973
  
  Pages: 92-98
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390081
[Journal Article] 脳卒中と薬2003
- Author(s)
  山下康子
- Journal Title
  
  脳21 6
  
  Pages: 79-84
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390081
[Journal Article] Involvement of 5-hydroxytryptamine_4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia.2003
- Author(s)
  Sakurai-Yamashita Y et al.
- Journal Title
  
  Brain Ras 973
  
  Pages: 92-98
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390081
[Journal Article] Cerebral stroke and drugs.2003
- Author(s)
  S-Yamashita et al.
- Journal Title
  
  Brain 21 6
  
  Pages: 79-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390081
[Presentation] Effects of perinatal exposure to nonlphenol on the function of central nervous system in male rat offsprings2013
- Author(s)
  Kimihiro Yamashita
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡福岡国際会議場
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] Effects of perinatal exposure to nonylphenol on the function of central nervous system in male rat offsprings2013
- Author(s)
  Kimihiro Yamashita
- Organizer
  第86回　日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] トリブチルスズのラット学習記憶に及ぼす影響評価2012
- Author(s)
  山下樹三裕
- Organizer
  環境ホルモン学会第15回研究発表会
- Place of Presentation
  東京大学　山上会館
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] Effects of perinatal exposure to bisphenol A on the function of central nervous system in male rat offsprings2012
- Author(s)
  Kimihiro Yamashita
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都国立京都国際会館
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] トリブチルスズのラット学習記憶に及ぼす影響評価2012
- Author(s)
  山下樹三裕
- Place of Presentation
  東京東京大学山上会館
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] Effects of perinatal exposure to bisphenol A on the function of central nervous system in male rat offsprings2012
- Author(s)
  山下樹三裕
- Organizer
  日本薬理学会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] 含エストロゲン活性環境ホルモンの海馬内微量注入が雄性ラットの学習記憶に及ぼす影響2011
- Author(s)
  山下樹三裕
- Place of Presentation
  横浜パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] ビスフェノール A周産期曝露が雄性ラットの学習記憶に及ぼす影響2011
- Author(s)
  山下樹三裕
- Place of Presentation
  東京東京大学山上会館
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] 含エストロゲン活性環境ホルモンの海馬内微量注入が雄性ラットの学習記憶に及ぼす影響2011
- Author(s)
  山下樹三裕
- Organizer
  日本薬理学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] ビスフェノールA周産期曝露が雄性ラットの学習記憶に及ぼす影響2011
- Author(s)
  山下樹三裕
- Organizer
  環境ホルモン学会
- Place of Presentation
  東京大学山上会館
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] ビスフェノール Aの海馬内微量注入が雄性ラットの学習記憶に及ぼす影響についての研究2010
- Author(s)
  山下樹三裕
- Place of Presentation
  東京東京大学山上会館
- Data Source
  KAKENHI-PROJECT-22510069
[Presentation] ビスフェノールAの海馬内微量注入が雌性ラットの学習記憶に及ぼす影響についての研究2010
- Author(s)
  山下樹三裕
- Organizer
  環境ホルモン学会
- Place of Presentation
  東京大学山上会館
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-22510069

1. NIWA Masami (20136641)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. YAMASHITA Kimihiro (50192399)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
3. TANIYAMA Kohtaro (70030898)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KATAOKA Yasufumi (70136513)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKAOKA Ryota (50325635)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KAIBARA Muneshige (40274633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KATAMINE Shigeru (40161062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NISHIDA Noriyuki (40333520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ABRAHAM Sandor (60315231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMADA Ryo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. DELI Maria

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMASHITA Yasuko 山下 康子

Research Projects

Research Products

Co-Researchers

エストロゲン活性を有する内分泌撹乱化学物質類の学習記憶能に及ぼす影響評価

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental-therapeutic potency of pentosan pofysulfate as an anti-prion and anti-dementia drug

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pentosan polysulfate strenghens blood-brain barrier functions : A possible role of anti-dementia drug

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ANALYSIS OF MULTIFUNCTION OF MICROGLIA IN THE ISCHEMIA-RELATED NEURONAL DEATHPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vitro model of the blood-brain barrier

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of environmental endocrine disrupters on learning, memory and emotional behavior in the function of central nervous system

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Effects of environmental stresses on the permeability of blood brain barrier

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on regulatory molecules involved in neurotransmitter release in Xenopus oocytes injected with mRNA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Involvement of 5-hydroxytryptamine_4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] 脳卒中と薬2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Involvement of 5-hydroxytryptamine_4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cerebral stroke and drugs.2003

Author(s)

Journal Title

Description

Data Source

[Presentation] Effects of perinatal exposure to nonlphenol on the function of central nervous system in male rat offsprings2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Effects of perinatal exposure to nonylphenol on the function of central nervous system in male rat offsprings2013

Author(s)

Organizer

Place of Presentation

YAMASHITA Yasuko 山下康子