Asoda Seiji 莇生田整治

… Alternative Names

ASODA Seiji 莇生田整治

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Researcher Number	80296706
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2025: 慶應義塾大学, 医学部(信濃町), 講師 2016 – 2023: 慶應義塾大学, 医学部(信濃町), 講師 2012 – 2015: 慶應義塾大学, 医学部, 講師 2010 – 2011: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Pathobiological dentistry/Dental radiology Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 57040:Regenerative dentistry and dental engineering-related / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator CD44 / 口腔扁平上皮癌 / EMT / CD44v / スルファサラジン / 遺伝子変異 / 遺伝子パネル検査 / 口腔 / トランスレーショナルリサーチ / 癌 … More / CD140a / CD326 / SpCC / グルタチオン / 腫瘍生物学 / 実験腫瘍学 … More Except Principal Investigator PDXモデル / CD44v / 口腔癌 / 自動停止 / 切削抵抗 / サイナスリフト / 歯科インプラント / 薬剤スクリーニング / TBK1 / YAP / セロトニン / 分化誘導療法 / 扁平上皮癌 / HTR7 / CD44ｖ / PDXマウスモデル / 口腔がん / 口腔扁平上皮癌 Less

口腔癌のエクソソームとCD47スプライシングアイソフォームによる免疫逃避の解明Principal Investigator
- Principal Investigator
  
  莇生田整治
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Keio University
Development of dental implant drill with bone quality change detection mechanism
- Principal Investigator
  
  河奈裕正
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Kanagawa Dental College
PDXモデルを用いた局所進行・再発転移口腔癌に対する新たな治療戦略の考案
- Principal Investigator
  
  吉川桃子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Keio University
セロトニンシグナルを標的とした扁平上皮癌分化誘導療法の開発
- Principal Investigator
  
  岡崎章悟
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Nihon University
Actionable遺伝子変異に基づく新たな口腔扁平上皮癌治療戦略の開発Principal Investigator
- Principal Investigator
  
  莇生田整治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Keio University
Characterization of CD44v-positive oral cancer stem cells using PDX model and establishment of novel drug therapy
- Principal Investigator
  
  Yoshikawa Momoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Keio University
Identification of targetable genetic mutations and establishment of personalized therapy in standard therapy-resistant oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Asoda Seiji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Keio University
Development of novel treatment targeting cancer stromal cells in standard treatment-resistant oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Asoda Seiji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Keio University
Treatment sensitivity evaluation of oral squamous cell carcinoma based on the expression of a functional cancer stem cell marker CD44vPrincipal Investigator
- Principal Investigator
  
  Asoda Seiji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Keio University
New classification of oral squamous cell carcinoma based on the molecular expression profile controlling the epithelial mesenchymal transition and stem cell-like characteristicsPrincipal Investigator
- Principal Investigator
  
  ASODA Seiji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Keio University

All 2024 2023 2022 2020 2019 2018 2015 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells2018
- Author(s)
  Ouchi T.、Morikawa S.、Shibata S.、Takahashi M.、Yoshikawa M.、Soma T.、Miyashita H.、Muraoka W.、Kameyama K.、Kawana H.、Arima Y.、Saya H.、Okano H.、Nakagawa T.、Asoda S.
- Journal Title
  
  J Dent Res
  
  Volume: ー Issue: 7 Pages: 779-786
- DOI
  10.1177/0022034518759278
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20613, KAKENHI-PROJECT-16K11521
[Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013
- Author(s)
  Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
- Journal Title
  
  Cancer Res
  
  Volume: 73(6) Issue: 6 Pages: 1855-1866
- DOI
  10.1158/0008-5472.can-12-3609-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592100, KAKENHI-PROJECT-23659941, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24591912, KAKENHI-PROJECT-24592965, KAKENHI-PROJECT-24791713, KAKENHI-PROJECT-24792194, KAKENHI-PROJECT-25293344, KAKENHI-PROJECT-25870730, KAKENHI-PLANNED-22130007
[Journal Article] 抗VEGFモノクロナール抗体ベバシズマブの関与が疑われた顎骨壊死の1例2011
- Author(s)
  安居孝純, 鬼澤勝弘, 兵藤朋子, 岩崎良太郎, 莇生田整治, 河奈裕正
- Journal Title
  
  日本口腔科学会雑誌
  
  Volume: 60(1) Pages: 16-22
- NAID
  10030270787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592100
[Journal Article] Burkitt's lymphoma in a patient presenting with inferior alveolar nerve hypoesthesia in the absence of a regional tumor : A case report and review of the literature2010
- Author(s)
  Chika Niizato, Seiji Asoda, Daisuke Araki, Kentaro Sugiyama, Shin Usuda, Taneaki Nakagawa, Hiromasa Kawana
- Journal Title
  
  Asian Journal of Oral and Maxillofacial Surgery
  
  Volume: 22(3) Pages: 180-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592100
[Presentation] 口腔癌薬物療法の現在と未来　最新ガイドラインに学ぶ！口腔癌薬物療法戦略2024
- Author(s)
  莇生田整治
- Organizer
  第42回日本口腔腫瘍学会総会
- Data Source
  KAKENHI-PROJECT-22K10200
[Presentation] 骨質変化検出機構を備えた歯科インプラント用ドリルの開発2023
- Author(s)
  野崎貴裕、莇生田整治、河奈裕正
- Organizer
  生活生命支援医療福祉工学系学会連合大会2023（LIFE2023）
- Data Source
  KAKENHI-PROJECT-23K09226
[Presentation] FOXA1 suppresses oral cancer progression through inhibiting p38 activation induced by lipid-derived aldehydes2022
- Author(s)
  岡崎章悟, 吉川桃子, 相馬智也, 莇生田整治, 今井健一, 後飯塚僚, 佐谷秀行, 永野修
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K10200
[Presentation] 口腔扁平上皮癌におけるFOXA1の発現低下は腫瘍成長とxCT依存性を促進する2022
- Author(s)
  岡﨑章悟、中島由梨佳、吉川桃子、相馬智也、莇生田整治、今井健一、後飯塚僚、佐谷秀行、永野修
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07157
[Presentation] FOXA1 suppresses oral cancer progression through inhibiting p38 activation induced by lipid-derived aldehydes2022
- Author(s)
  岡崎章悟、吉川桃子、相馬智也、莇生田整治、今井健一、後飯塚僚、佐谷秀行、永野修
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K10344
[Presentation] FOXA1 suppresses oral cancer progression through inhibiting p38 activation induced by lipid-derived aldehydes2022
- Author(s)
  岡崎章悟、吉川桃子、相馬智也、莇生田整治、今井健一、後飯塚、佐谷秀行、永野修
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07157
[Presentation] FOXA1 suppresses oral cancer progression through inhibiting p38 activation induced by lipid-derived aldehydes2022
- Author(s)
  岡崎章悟, 吉川桃子, 相馬智也, 莇生田整治, 今井健一, 後飯塚僚, 佐谷秀行, 永野修
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K10103
[Presentation] 紡錘細胞癌における間葉系幹細胞の同定とPDGFRα阻害薬を用いた細胞死の誘導2020
- Author(s)
  黄地健仁, 森川暁, 高橋萌, 吉川桃子, 相馬智也, 宮下英高, 河奈裕正, 中川種昭, 莇生田整治
- Organizer
  第74回　日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K10344
[Presentation] 舌に発生した紡錘細胞癌は間葉系幹細胞の性質をもつ2019
- Author(s)
  吉川桃子、黄地健仁、森川暁、高橋萌、相馬智也、宮下英高、河奈裕正、佐谷秀行、中川種昭、莇生田整治
- Organizer
  第64回　日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19K10344
[Presentation] 口腔に発生した再発紡錘細胞癌における間葉系幹細胞の同定2019
- Author(s)
  吉川桃子、黄地健仁、森川暁、芝田晋介、高橋萌、相馬智也、宮下英高、村岡渡、亀山香織、河奈裕正、有馬好美、佐谷秀行、岡野栄之、中川種昭、莇生田整治
- Organizer
  第43回　日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-19K10344
[Presentation] セツキシマブ耐性口腔扁平上皮癌細胞に対する治療の可能性2015
- Author(s)
  吉川桃子, 莇生田整治, 森川暁, 宮下英高, 臼田慎, 河奈裕正, 中川種昭, 佐谷秀行, 永野修
- Organizer
  第33回日本口腔腫瘍学会総会
- Place of Presentation
  奈良
- Year and Date
  2015-01-30
- Data Source
  KAKENHI-PROJECT-25462930
[Presentation] 口腔癌細胞の腫瘍形成におけるCD44v-xCTの機能的役割2013
- Author(s)
  吉川桃子, 永野修, 莇生田整治, 中川種昭, 河奈裕正, 佐谷秀行
- Organizer
  第31回日本口腔腫瘍学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22592100
[Presentation] xCT シスチントランスポーターの阻害はCD44 バリアント陽性扁平上皮癌細胞の生体内における拡大を抑制する.2012
- Author(s)
  吉川桃子, 永野修, 土橋賢治, 莇生田整治, 中川種昭, 佐谷秀行
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22592100
[Presentation] 口腔扁平上皮癌に対するCDDP/S-1併用術前化学療法の検討-CDDP/5-FU療法との比較-2010
- Author(s)
  莇生田整治, 臼田慎, 他
- Organizer
  第34回日本頭頸部癌学会
- Place of Presentation
  東京
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-22592100
[Presentation] xCT標的治療はCD44v陽性口腔扁平上皮癌細胞を選択的に死滅させる
- Author(s)
  吉川桃子, 莇生田整治, 河奈裕正, 中川種昭, 佐谷秀行
- Organizer
  第58回（社）日本口腔外科学会総会, 福岡, 2013.10.
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25462930
[Presentation] xCT inhibition depletes CD44v-expressing squamous cell carcinoma cells that are resistant to EGFR-targeted therapy
- Author(s)
  Momoko Yoshikawa, Osamu Nagano, Kenji Tsuchihashi, Seiji Asoda, Hiromasa Kawana, Taneaki Nakagawa, Hideyuki Saya
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25462930

1. YOSHIKAWA Momoko (50570967)

# of Collaborated Projects: 8 results

# of Collaborated Products: 15 results
2. SAYA Hideyuki (80264282)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
3. 岡崎章悟 (20784044)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. 森川暁 (00424169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. 黄地健仁 (30803564)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. 小澤宏之 (30327621)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. EINAGA YASUAKI (00322066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 相馬智也 (10624637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 河奈裕正 (50224803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 野崎貴裕 (20734479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Asoda Seiji 莇生田 整治

ASODA Seiji 莇生田 整治

Research Projects

Research Products

Co-Researchers

口腔癌のエクソソームとCD47スプライシングアイソフォームによる免疫逃避の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of dental implant drill with bone quality change detection mechanism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PDXモデルを用いた局所進行・再発転移口腔癌に対する新たな治療戦略の考案

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

セロトニンシグナルを標的とした扁平上皮癌分化誘導療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Actionable遺伝子変異に基づく新たな口腔扁平上皮癌治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of CD44v-positive oral cancer stem cells using PDX model and establishment of novel drug therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of targetable genetic mutations and establishment of personalized therapy in standard therapy-resistant oral squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel treatment targeting cancer stromal cells in standard treatment-resistant oral squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Treatment sensitivity evaluation of oral squamous cell carcinoma based on the expression of a functional cancer stem cell marker CD44vPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New classification of oral squamous cell carcinoma based on the molecular expression profile controlling the epithelial mesenchymal transition and stem cell-like characteristicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 抗VEGFモノクロナール抗体ベバシズマブの関与が疑われた顎骨壊死の1例2011

Author(s)

Journal Title

NAID

Data Source

Asoda Seiji 莇生田整治

ASODA Seiji 莇生田整治

[Presentation] 口腔癌薬物療法の現在と未来　最新ガイドラインに学ぶ！口腔癌薬物療法戦略2024