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ZAKO Masahiro  雑喉 正泰

ORCIDConnect your ORCID iD *help
Researcher Number 80298596
Other IDs
Affiliation (based on the past Project Information) *help 2010 – 2012: 愛知医科大学, 医学部, 教授
2007: Aichi Medical University, Ophthalmology, Professor
2006: 愛知医科大学, 医学部, 助教授
2003 – 2004: 愛知医科大学, 医学部, 助教授
2001 – 2002: 愛知医科大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Ophthalmology / Ophthalmology
Keywords
Principal Investigator
SPACR / SPACRCAN / ヒアルロン酸 / 視細胞外マトリックス / versican / 網膜接着 / プロテオグリカン / 網膜剥離 / 網膜分化 / Chick … More / Retina / PG-M / MY-174 / Glycoprotein / Sialoprotein / Interphotoreceptor Matrix / FiVerHy versican / interphotoreceptor matrix / hyaluronan / バーシカン / FiVerHy / FiVerHy バーシカン / Proteoglycan / Heparan Sulfate / Chondroitin Sulfate / Hyaluronan / ヘパリン / コンドロイチン硫酸 / ピアルロン酸 / ヘパラン硫酸 / コンドロイチン酸 / 糖蛋白 / シアル酸 / 細胞外マトリックス / TIMP / MMP / 網膜血管内皮細胞 / 網膜色素上皮細胞 / 血液網膜関門 / 血液眼関門 / 毛様体無色素上皮細胞 / マトリックスメタロプロテアーゼ / infliximab / TNF-α / ベーチェット病 / マトリックスメタ ロプロテアーゼ(MMP) / 抗腫瘍壊死因子抗体 / 腫瘍壊死因子 / ぶどう膜炎 / 血液房水関門 Less
  • Research Projects

    (4 results)
  • Research Products

    (47 results)
  • Co-Researchers

    (4 People)
  •  Structural and Functional Evaluation of Blood-Ocular-BarrierPrincipal Investigator

    • Principal Investigator
      ZAKO Masahiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Aichi Medical University
  •  Analysis of useful molecules in interphotoreceptor matrix for retinal detachment treatmentPrincipal Investigator

    • Principal Investigator
      ZAKO Masahiro
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Aichi Medical University
  •  Analysis for the interphotoreceptor matrix molecules.Principal Investigator

    • Principal Investigator
      ZAKO Masahiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Aichi Medical University
  •  Molecular cloning and characterization of chick sialoprotein associated with cones and rods, a developmentally regulated glycoprotein of interphotoreceptor matrixPrincipal Investigator

    • Principal Investigator
      ZAKO Masahiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Aichi Medical University

All 2013 2012 2011 2010 2008 2007 2006 2004 2003 2002 2001 1999 1998 1997 1996 1995 Other

All Journal Article Presentation Book

  • [Book] Chemistry and Biology of Carbohydrates for Health Professionals.2008

    • Author(s)
      Zako M, and Yoneda M.
    • Total Pages
      432
    • Publisher
      ELSEVIER BV
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591940
  • [Book] Functional Glycosaminoglycans in Eye.2008

    • Author(s)
      Zako M, and Yoneda M.
    • Publisher
      ELSEVIER BV(Amsterdam)
    • Data Source
      KAKENHI-PROJECT-18591940
  • [Book] Chemistry and Biology of Hyaluronan (Edited by Garg HG and Hales CA)2004

    • Author(s)
      Zako M, Yoneda M
    • Total Pages
      580
    • Publisher
      ELSEVIER BV(Amsterdam)
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Book] Chemistry and Biology of Hyaluronan2004

    • Author(s)
      Masahiro Zako
    • Total Pages
      605
    • Publisher
      Hari G.Garg and Charles A.Hales (ELSEVIER)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Book] Chemistry and Biology of Carbohydarates for Health professionals.

    • Author(s)
      Zako M, Yoneda M.
    • Publisher
      ELSEVIER BV(Amsterdam)(in press.)
    • Data Source
      KAKENHI-PROJECT-18591940
  • [Journal Article] Infliximab counteracts tumor necrosis factor-α-enhanced induction of matrix metalloproteinases that degrade claudin and occludin in non-pigmented ciliary epithelium.2013

    • Author(s)
      Yamada H, Yoneda M, Inaguma S, Watanabe D, Banno S, Yoshikawa K, Mizutani K, Iwaki M, Zako M.
    • Journal Title

      Biochem Pharmacol

      Volume: in press Issue: 12 Pages: 1770-1782

    • DOI

      10.1016/j.bcp.2013.04.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Comparative analysis of hyaluronan's affinity for antivascular endothelial growth factor agents.2013

    • Author(s)
      Sugita I, Yoneda M, Iwaki M, Zako M.
    • Journal Title

      Ophthalmic Res.

      Volume: 49 Issue: 1 Pages: 43-8

    • DOI

      10.1159/000342975

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Intravitreal Injection of Bevacizumab to Treat a Macular Edema Caused by Leber's Miliary Aneurysm.2012

    • Author(s)
      Takeyama M, Iwaki M, Zako M.
    • Journal Title

      Case Rep Ophthalmol.

      Volume: 3 Issue: 3 Pages: 392-5

    • DOI

      10.1159/000345455

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Choroidal and optic disc metastases from breast cancer and their response to combination pharmacotherapy with tamoxifen, cyclophosphamide hydrate, letrozole, and bevacizumab.2012

    • Author(s)
      Zako M, Takeyama M, Naito E, Mizumoto K, Iwaki M.
    • Journal Title

      J Ocul Pharmacol Ther.

      Volume: 28 Issue: 1 Pages: 89-93

    • DOI

      10.1089/jop.2011.0098

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Trabeculotomy in a Behçet's Disease Patient One Week after Infliximab Administration.2012

    • Author(s)
      Koike A, Handa T, Zako M.
    • Journal Title

      Case Rep Ophthalmol.

      Volume: 3 Issue: 1 Pages: 151-5

    • DOI

      10.1159/000338703

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Long-term remission of ocular and extraocular manifestations in Behcet's disease using infliximab2011

    • Author(s)
      Handa T, Tsunekawa H, Yoneda M, Watanabe D, Mukai T, Yamamura M, Iwaki M, Zako M
    • Journal Title

      Clin Exp Rheumatol

      Volume: 4 Suppl 67

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Cataract Surgery in Behcet's Disease Patients One Week after Infliximab Administration2011

    • Author(s)
      Handa T, Tsunekawa H, Zako M
    • Journal Title

      Case Report Ophthalmol

      Volume: 2 Pages: 176-178

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Efficient penetration into aqueous humor by administration of oral and topical levofloxacin2011

    • Author(s)
      Ishida M, Kataoka T, Niwa K, Iwaki M, Zako M
    • Journal Title

      J Ocul Pharmacol Ther

      Volume: 27 Pages: 247-250

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Infliximab treatment of severe genital ulcers associated with Behcet disease.2010

    • Author(s)
      Kasugai C, Zako M., et.al
    • Journal Title

      J Am Acad Dermatol.

      Volume: VOL.62 Pages: 162-164

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Increase in matrix metalloproteinase-2 level in the chicken retina after laser photocoagulation.2010

    • Author(s)
      Takeyama M, Zako M., et.al
    • Journal Title

      Lasers Surg Med.

      Volume: VOL.42 Pages: 433-441

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Effect of infliximab on tumor necrosis factor-alpha-induced alterations in retinal microvascular endothelial epithelial cells.2010

    • Author(s)
      Li H, Zako M., et.al
    • Journal Title

      J.Ocul Pharmacol Ther.

      Volume: VOL.26 Pages: 549-556

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Journal Article] Versican, fibrillin-1 form a major hyaluronan-binding complex in the ciliary body2008

    • Author(s)
      Ohno-Jinno A, Isogai Z, Yoneda M, Kasai K, Miyaishi O, Inoue Y, Kataoka T, Zhao J, Li H, Takeyama M, Keene K R, Sakai L Y, Kimata K, Iwaki M, Zako M.
    • Journal Title

      Invest Ophthalmol Vis Sci. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591940
  • [Journal Article] Chemistry and Biology of Carbohydrates for Health Professionals. Functional Glycosaminoglycans in Eye.2008

    • Author(s)
      Zako M, Yoneda M.
    • Journal Title

      Edited by Hari G. Garg, Charles A. Hales. ELSEVIER BV(Amsterdam)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591940
  • [Journal Article] Characterization of a motif for specific binding to hyaluronan in chicken SPACR.2008

    • Author(s)
      Zhao J, Yoneda M, Takeyama M, Miyaishi O, Inoue Y, Kataoka T, Ohno-Jinno A, Isogai Z, Kimata K, Iwaki M, Zako M.
    • Journal Title

      J Neurochem. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591940
  • [Journal Article] Versican, a major hyaluronan-binding component in the dermis, loses its hyaluronan-binding ability in solar elastosis.2007

    • Author(s)
      Hasegawa K, Yoneda M, Kuwabara H, Miyaishi O, Itano N, Ohno A, Zako M, Isogai Z.
    • Journal Title

      J Invest Dermatol. 127

      Pages: 1657-63

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591940
  • [Journal Article] Molecular cloning and characterization of chick SPACRCAN.2006

    • Author(s)
      Inoue Y, Yoneda M, Zhao J, Miyashi O, Ohno-Jinnno A, Kataoka T, Isogai Z, Kimata K, Iwaki M, Zako M.
    • Journal Title

      J Bilo Chem. 281

      Pages: 10381-8

    • Data Source
      KAKENHI-PROJECT-18591940
  • [Journal Article] Expression profile of heat shock protein 108 during retinal development in the chick.2006

    • Author(s)
      Zhaio J, Yoneda M, Inoue Y, Kakizaki H, Ohno-Jinno A, Kataoka T, Iwaki M, Zako M.
    • Journal Title

      Neurosci Lerr. 397

    • Data Source
      KAKENHI-PROJECT-18591940
  • [Journal Article] Causes of undercorrection of medial palpebral fissures in blepharoptosis surgery.2004

    • Author(s)
      Kakizaki H, Zako M, Ide A, Mito H, Nakano T, Iwaki M.
    • Journal Title

      Ophthalmic Plastic and Reconstructive Surgery 20・3

      Pages: 198-201

    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor.2004

    • Author(s)
      Deepa SS, Yamada S, Zako M, Goldberger O, Sugahara K.
    • Journal Title

      Journal of Biological Chemistry 279・36

      Pages: 37368-37376

    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Chondroitin sulfate chainson syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurallyand functionallydistinct and cooperate with heparansulfate chainsto bind growth factors, A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor.2004

    • Author(s)
      Deepa SS, Yamada S, Zako M, Goldberger O, Sugahara K.
    • Journal Title

      J Biol Chem 279

      Pages: 37368-37376

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Magnetic resonance imaging of pre- and postoperative lower eyelid states in involutional entropion.2004

    • Author(s)
      Kakizaki H, Zako M, Mito H, Katori N, Iwaki M.
    • Journal Title

      Japanese Journal of Ophthalmology 48・4

      Pages: 364-367

    • NAID

      10013426544

    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] The medial horn and capsulopalpebral fascia in the medial canthus are significant antagonists of the orbicularis oculi muscle for lacrimal drainage.2004

    • Author(s)
      Kakizaki H, Zako M, Nakano T, Asamoto K, Iwaki M.
    • Journal Title

      Ophthalmologica 218・6

      Pages: 419-423

    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Anatomical study of the lower-positioned transverse ligament.2004

    • Author(s)
      Kakizaki H, Zako M, Nakano T, Iwaki M, Mito H.
    • Journal Title

      British Journal of Plastic Surgery 57・4

      Pages: 370-372

    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] A guide to Making a natural eyelid margin curvature in blepharoptosis surgery.2004

    • Author(s)
      Kakizaki H, Zako M, Mito H, Katori N, Iwaki M.
    • Journal Title

      Acta Ophthalmologica Scandinavica 82・2

      Pages: 240-241

    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Syndecan-1 and -4 synthesized simultaneously by mouse mammary gland epithelial cells bear heparan sulfate chains that are apparently structurally indistinguishable2003

    • Author(s)
      Masahiro Zako
    • Journal Title

      J Biol Chem. 278

      Pages: 13561-13569

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Syndecan-1 and -4 synthesized simultaneously by mouse mammary gland epithelial cells bear heparan sulfate chainsthat are apparently structurally indistinguishable.2003

    • Author(s)
      Zako M, Dong J, Goldberger O, Bernfield M, Gallagher JT, Deakin JA.
    • Journal Title

      J Biol Chem. 278

      Pages: 13561-13569

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Molecular cloningand characterization of chicksialoprotein associated with cones and rods, a developmentally regulated glycoprotein of interphotoreceptormatrix.2002

    • Author(s)
      Zako M, Iwaki M, Yoneda M, Miyaishi O, Zhao J, Suzuki Y, Takeuchi M, Miyake G, Ikagawa H, Kimata K.
    • Journal Title

      J Biol Chem. 277

      Pages: 25592-25600

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Structural characterization of heparan sulfate and chondroitin sulfate of syndecan-1 purified from normal murine mammary gland epithelial cells. Common phosphorylation of xylose and differentialsulfation of galactose in the protein linkageregion tetrasaccharide sequence2001

    • Author(s)
      Ueno M, Yamada S, Zako M, Bernfield M, Sugahara K.
    • Journal Title

      J Biol Chem. 276

      Pages: 29134-29140

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Functions of cell surface heparan sulfate proteoglycans1999

    • Author(s)
      Bernfield M, Gotte M, Park PW, Reizes O, Fitzgerald ML, Lincecum J, Zako M.
    • Journal Title

      Annu Rev Biochem 68

      Pages: 729-777

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] The gene structure and promoter sequence of mouse hyaluronan synthase 1.1998

    • Author(s)
      Yamada Y, Itano N, Zako M, Yoshida M, Lenas P, Niimi A, Ueda M, Kimata K.
    • Journal Title

      Biochem J. 330

      Pages: 1223-1227

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Transientexpressionof PG-M/versican, a large chondroitin sulfate proteoglycan in developing chickenretina.1997

    • Author(s)
      Zako M, Shinomura T, Miyaishi O, Iwaki M, Kimata K.
    • Journal Title

      J Neurochem. 69

      Pages: 2155-2161

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Alternative splicing of the unique "PLUS" domain of chicken PG-M/versican is developmentally regulated1997

    • Author(s)
      Zako M, ShinomuraT, Kimata K.
    • Journal Title

      J Biol Chem. 272

      Pages: 9325-9331

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Occurrence of PG-Lb, a leucine-rich small chondroitin/dermatan sulphate proteoglycan in mammalian epiphyseal cartilage : molecular cloningand sequence analysisof the mouse cDNA.1996

    • Author(s)
      Kurita K, Shinomura T, Ujita M, Zako M, Kida D, Iwata H, Kimata K.
    • Journal Title

      Biochem J. 318

      Pages: 909-914

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues.1995

    • Author(s)
      Zako M, Shinomura T, Ujita M, Ito K, Kimata K.
    • Journal Title

      J Biol Chem. 270

      Pages: 3914-3918

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] The gene structure and organization of mouse PG-M, a large chondroitin sulfate proteoglycan. Genomic background for the generation of multiple PG-M transcripts.1995

    • Author(s)
      Shinomura T, Zako M, Ito K, Ujita M, Kimata K.
    • Journal Title

      J Biol Chem. 270

      Pages: 10328-10333

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Multiple forms of mouse PG M, a large chondroitin sulfate proteogly can generated by alternative splicing.1995

    • Author(s)
      Ito K, Shinomura T, Zako M, Ujita M, Kimata K.
    • Journal Title

      270

      Pages: 958-965

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591881
  • [Journal Article] Versican and fibrillin-1 form a major hyaluronan-binding complex in the ciliary body.

    • Author(s)
      Ohno-Jinno A, Isogai Z, Yoneda M, Kasai K, Miyaishi O, Inoue Y, Kataoka T, Zhao J, Li H, Takeyama M, Keene K R, Sakai L Y, Kimata K, Iwaki M, Zako M.
    • Journal Title

      Invest Ophthalmol Vis Sci. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591940
  • [Journal Article] Versican,a major Hyaluronan-Binding Component in the Dermis,Loses its Hymaluronan-Binding Ability in Solar Elastosis.

    • Author(s)
      Hasegawa K, Yoneda M, Kuwabara H, Miyaishi O, Itano N, Ohno A, Zako M, Isogai Z.
    • Journal Title

      J Invest Dermatol. (in press)

    • Data Source
      KAKENHI-PROJECT-18591940
  • [Journal Article] Infliximab counteracts tumor necrosis factor-α-enhanced induction of matrix metalloproteinases that degrade claudin and occludin in non-pigmented ciliary epithelium.

    • Author(s)
      Yamada H, Yoneda M, Inaguma S, Watanabe D, Banno S, Yoshikawa K, Mizutani K, Iwaki M, Zako M.
    • Journal Title

      Biochem Pharmacol.

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-22591953
  • [Presentation] Infliximab attenuates tumornecrosis factor-α-induced alterations in non-pigmented ciliary epithelium.2013

    • Author(s)
      Yamada H, Yoneda M, Inaguma S, Watanabe D, Banno S, Yoshikawa K, Mizutani K, Iwaki M, Zako M.
    • Organizer
      ARVO
    • Place of Presentation
      Seattle
    • Year and Date
      2013-05-05
    • Data Source
      KAKENHI-PROJECT-22591953
  • [Presentation] Moumakubunnkaji no niwatori SPACR to SPACRCAN bunnshi no hatsugenhikaku.2007

    • Author(s)
      Zako M
    • Organizer
      The 111th Annual Meeting of the Japanese Ophthalmological Society.
    • Place of Presentation
      Osaka
    • Year and Date
      2007-04-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591940
  • [Presentation] 網膜分化時のニワトリSPACRとSPACRCAN分子の発現比較2007

    • Author(s)
      雑喉 正泰
    • Organizer
      第111回日本眼科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-19
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591940
  • 1.  YONEDA Masahiko (80201086)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 18 results
  • 2.  IWAKI Masayoshi (10093163)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 3.  KIMATA Koji (10022641)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 4.  MIYAISHI Osamu (60229797)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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