OKADA TAROU 岡田太郎

… Alternative Names

Okada Taro 岡田太郎

OKADA Tarou 岡田太郎

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Researcher Number	80304088
Other IDs	https://orcid.org/0000-0001-5183-9402
Affiliation (Current)	2026: 神戸大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 神戸大学, 医学研究科, 准教授 2016 – 2020: 神戸大学, 医学研究科, 准教授 2014 – 2015: 神戸大学, 大学院医学研究科, 准教授 2012 – 2015: 神戸大学, 医学(系)研究科(研究院), 准教授 2011 – 2012: 神戸大学, 大学院・医学研究科, 准教授 … More 2008 – 2011: 神戸大学, 医学研究科, 准教授 2008: 神戸大学, 大学院・医学研究科, 准教授 2007: Kobe University, Graduate School of Medicine, Associate Professor 2006: 神戸大学, 医学系研究科, 助教授 2005: 神戸大学, 大学院医学系研究科, 助教授 2002 – 2004: 神戸大学, 大学院・医学系研究科, 講師 2001: 神戸大学, 大学院・医学系研究科, 助手 1998 – 2000: 神戸大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 44010:Cell biology-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / General medical chemistry / Functional biochemistry Except Principal Investigator Respiratory organ internal medicine / General medical chemistry / Pathological medical chemistry / Biological Sciences / Basic Section 49010:Pathological biochemistry-related … More / Medium-sized Section 48:Biomedical structure and function and related fields / Pathological medical chemistry / General medical chemistry / Functional biochemistry Less
Keywords	Principal Investigator スフィンゴ脂質 / パーキンソン病 / スフィンゴシン１リン酸 / スフィンゴシン１－リン酸 / スフィンゴシン1-リン酸 / スフィンゴシンキナーゼ / S1P / S1P受容体 / α－シヌクレイン / エクソソーム … More / シグナル伝達 / Gqタンパク質 / 神経変性疾患 / カテプシンD / 逆行性輸送 / カゼインキナーゼ / レトログレード輸送 / シヌクレイノパチー / リソソーム / αシヌクレイン / パルミトイル化 / スフィンゴシン１－リン酸受容体 / ガングリオシド / スフィンゴシン１リン酸受容体 / 神経伝達物質放出 / スフィンゴシン1リン酸 … More Except Principal Investigator スフィンゴシンキナーゼ / スフィンゴシン1リン酸 / 細胞内情報伝達 / S1P / エキソソーム / S1P受容体 / スフィンゴシン・キナーゼ / コリン燐脂質 / ADP-リボシル化因子 / G_<M2>アクチベーター / ホスホリパーゼD / パーキンソン病 / 気管支喘息 / 神経伝達物質 / グルタミン酸 / 海馬 / エンドソーム / マクロピノサイトーシス / ホスホイノシタイド / レビー小体 / αシヌクレイン / スフィンゴシン１燐酸 / 後期エンドソーム / LBPA / リゾビスフォスファチジン酸 / スフィンゴシン１リン酸 / bronchial asthma / lung fibroblast / sphingosine kinase / sphingosine 1-phosphate / 急性喘息モデル / 線維芽細胞 / ADP-ribosvlation factor / G-protein / G_<M2> activator / Phospholipase D / Signal transduction / 癌微細環境 / Met / 治療 / 気道リモデリング / 気道炎症 / 国際情報交換 / マウス / 卵白アルブミン / 樹状細胞 / IL-33 / IL-25 / TSLP / JTE013 / 喘息 / スフィンゴシン1リン酸受容体 / スフィンゴシン1燐酸(SIP) / GABA / 分子病態学 / goblet cells / IL-13 / ERK / mucin / Shingosine kinase / SlP受容体 / Sphingosine kinase / 粘液産生 / スフィンゴシン / 苔状線維 / 自発放出 / 核移行シグナル / 核排出シグナル / 生理活性 / 生体分子 / 脂質 / 酵素 / シグナル伝達 / イノシトール燐脂質 / スフィンゴシン1燐酸 / スフィンゴ脂質 / 小胞輸送 / 酵母ツーハイブリッド法 / PXドメイン / RPK118 / 初期エンドソーム / ADP―リボシル化因子 / ホスファチジルイノシトール4,5二リン酸 / ホスファチジルコリン / プロテイン・キナーゼC / ADPリボシル化因子 Less

Novel mechanism of lesion propagation by extracellular alpha-synuclein in synucleinopathies.Principal Investigator
- Principal Investigator
  
  Okada Taro
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kobe University
Involvement of S1P receptor signaling and exosome release on Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  Okada Taro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Kobe University
Analysis on pathogenesis of Parkinson's disease through S1P signaling
- Principal Investigator
  
  Nakamura Shun-ichi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Kobe University
Analysis of molecular mechanism underlying S1P signal-mediated exosome release
- Principal Investigator
  
  Nakamura Shun-ichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kobe University
Inhibition of S1P receptor signal transduction by extracellular alpha-synucleinPrincipal Investigator
- Principal Investigator
  
  OKADA TARO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kobe University
Studies on the coupling mechanism between lysobisphosphatidic acid (LBPA) and S1P signaling
- Principal Investigator
  
  Nakamura Shun-ichi
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Regulation of cancer malignancy through the cargo sorting into exosomes
- Principal Investigator
  
  NAKAMURA Shun-ichi
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
S1P receptors on neuronal cells as a target of medicine for epilepsyPrincipal Investigator
- Principal Investigator
  
  OKADA Taro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kobe University
Role of sphingolipids in the respiratory immune system
- Principal Investigator
  
  NISHIMURA Yoshihiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kobe University
Mechanism underlying the regulation of brain function through sphingosine kinase/S1P signaling
- Principal Investigator
  
  NAKAMURA Shunichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
The role of sphingosine kinases on the formation of neural network in dentate granule cells of hippocampusPrincipal Investigator
- Principal Investigator
  
  OKADA Taro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
The control of airway mucus secretion via sphingosine signals
- Principal Investigator
  
  NISHIMURA Yoshihiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kobe University
スフィンゴ脂質による神経伝達物質放出機構の解析
- Principal Investigator
  
  中村俊一
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Studies on the mechanism of nucleo/cytoplasmic shuttling of sphingosine kinase
- Principal Investigator
  
  NAKAMURA Shunichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
Research of sphingosine kinase modification in acute lung injury
- Principal Investigator
  
  NISHIMURA Yoshihiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kobe University
スフィンゴシン1リン酸に結合する核内受容体の同定Principal Investigator
- Principal Investigator
  
  岡田太郎
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
エンドソーム形成の分子メカニズムの解析
- Principal Investigator
  
  中村俊一
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
低分子G蛋白質ARF依存性ホスホリパーゼDの活性化機構の解析
- Principal Investigator
  
  NAKAMURA Shunichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Studies on the mechanism of activation of phospholipase D
- Principal Investigator
  
  NAKAMURA Shun-ichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
G_<M2>アクチベーターによるホスホリパーゼDの活性化機構に関する研究
- Principal Investigator
  
  中村俊一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University

[Book] 細胞工学2015
- Author(s)
  梶本武利、岡田太郎、中村俊一
- Total Pages
  5
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-24590112
[Book] 細胞内外で機能するスフィンゴシン1リン酸(S1P)の役割2012
- Author(s)
  岡田太郎、中村俊一
- Publisher
  生化学
- Data Source
  KAKENHI-PROJECT-21590309
[Journal Article] Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells2024
- Author(s)
  Nishida Susumu、Matovelo Shubi Ambwene、Kajimoto Taketoshi、Nakamura Shun‐ichi、Okada Taro
- Journal Title
  
  Genes to Cells
  
  Volume: 29 Issue: 3 Pages: 207-216
- DOI
  10.1111/gtc.13093
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06360, KAKENHI-PROJECT-20K07289, KAKENHI-PROJECT-22K06206
[Journal Article] Involvement of sphingosine 1-phosphate signaling in insulin-like growth factor-II/mannose 6-phosphate receptor trafficking from endosome to the trans-Golgi network2024
- Author(s)
  Nishida Susumu、Matovelo Shubi Ambwene、Kajimoto Taketoshi、Nakamura Shun-ichi、Okada Taro
- Journal Title
  
  Communications Biology
  
  Volume: 7 Issue: 1 Pages: 1182-1182
- DOI
  10.1038/s42003-024-06828-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06206, KAKENHI-PROJECT-23K06360
[Journal Article] Identification of novel OCRL isoforms associated with phenotypic differences between Dent disease-2 and Lowe syndrome2021
- Author(s)
  Sakakibara Nana、Ijuin Takeshi、Horinouchi Tomoko
- Journal Title
  
  Nephrology Dialysis Transplantation
  
  Volume: 37 Issue: 2 Pages: 262-270
- DOI
  10.1093/ndt/gfab274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15864, KAKENHI-PROJECT-22K06206
[Journal Article] Involvement of Receptor-Mediated S1P Signaling in EGF-Induced Macropinocytosis in COS7 Cells2020
- Author(s)
  Shubi Ambwene Matovelo, Lifang Zhang, Nesma Nabil Ibrahim Mohamed, Taketoshi Kajimoto, Takeshi Ijuin, Taro Okada, Shun-Ichi Nakamura
- Journal Title
  
  Kobe J Med Sci
  
  Volume: 66
- NAID
  120006975791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06657
[Journal Article] Involvement of receptor-mediated S1P signaling in EGF-induced macropinocytosis in COS7 cells2020
- Author(s)
  Matovelo Shubi Ambwene, Zhang Lifang, Mohamed Nesma Nabil Ibrahim, Kajimoto Taketoshi, Ijuin Takeshi, Okada Taro, Nakamura Shun-ichi
- Journal Title
  
  Kobe J Med Sci.
  
  Volume: 66
- NAID
  120006975791
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02623
[Journal Article] Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter2019
- Author(s)
  Kajimoto Taketoshi、Caliman Alisha D.、Tobias Irene S.、Okada Taro、Pilo Caila A.、Van An-Angela N.、Andrew McCammon J.、Nakamura Shun-ichi、Newton Alexandra C.
- Journal Title
  
  Science Signaling
  
  Volume: 12 Issue: 562
- DOI
  10.1126/scisignal.aat6662
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08594, KAKENHI-PROJECT-15KK0307, KAKENHI-PROJECT-18K06657, KAKENHI-PROJECT-18H02623, KAKENHI-PROJECT-18K19430
[Journal Article] Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G protein signaling.2018
- Author(s)
  Badawy SMM, Okada T, Kajimoto T, Hirase M, Matovelo SA, Nakamura S, Yoshida D, Ijuin T, Nakamura SI.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: in press Issue: 21 Pages: 8208-8216
- DOI
  10.1074/jbc.ra118.001986
- NAID
  120006554634
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08585, KAKENHI-PROJECT-15K07930, KAKENHI-PROJECT-17K08594, KAKENHI-PROJECT-18K06657, KAKENHI-PROJECT-18K19430, KAKENHI-PROJECT-18H02623
[Journal Article] Involvement of Gβγ subunits of Gi protein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes2018
- Author(s)
  Kajimoto, T., Mohamed, N.N.I., Badawy, S.M.M., Matovelo, S.A., Hirase, M., Nakamura, S., Yoshida, D., Okada, T., Ijuin, T., Nakamura, S.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 1 Pages: 245-253
- DOI
  10.1074/jbc.m117.808733
- NAID
  120006554633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08594, KAKENHI-PROJECT-15K07930
[Journal Article] Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells2018
- Author(s)
  Mohamed Nesma Nabil Ibrahim, Okada Taro, Kajimoto Taketoshi, Nakamura Shun-ichi
- Journal Title
  
  Kobe J Med Sci.
  
  Volume: 25;63(4)
- NAID
  120006471054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02623
[Journal Article] DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling2017
- Author(s)
  Badawy SMM, Okada T, Kajimoto T, Ijuin T, Nakamura SI.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 16552-16552
- DOI
  10.1038/s41598-017-16457-4
- NAID
  120006380402
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08585, KAKENHI-PROJECT-17K08594, KAKENHI-PROJECT-15K07930
[Journal Article] Extracellular α-synuclein induces sphingosine 1-phosphate receptor subtype 1 uncoupled from inhibitory G-protein leaving β-arrestin signal intact.2017
- Author(s)
  Zhang L, Okada T, Badawy SM, Hirai C, Kajimoto T, Nakamura SI.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 44248-44248
- DOI
  10.1038/srep44248
- NAID
  120006380401
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460341, KAKENHI-PROJECT-15K07930
[Journal Article] Impairment of PDGF-induced chemotaxis by extracellular α-synuclein through selective inhibition of Rac1 activation2016
- Author(s)
  Okada, T., Hirai, C., Badawy, S., Zhang, L., Kajimoto, T., Nakamura, SI.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 37810-37810
- DOI
  10.1038/srep37810
- NAID
  120005898707
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460341, KAKENHI-PROJECT-15K07930
[Journal Article] High expression of Mcl-1L via the MEK-ERK-phospho-STAT3 (Ser727) pathway protects melanocytes and melanoma from UVB-induced apoptosis.2016
- Author(s)
  Fukumoto-T, Iwasaki-T, Okada-T, Hashimoto-T, Moon-Y, Sakaguchi-M, Fukami-Y, Nishigori-C, Oka-M.
- Journal Title
  
  Genes Cells.
  
  Volume: 21 Issue: 2 Pages: 185-199
- DOI
  10.1111/gtc.12330
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07930, KAKENHI-PROJECT-15K19689, KAKENHI-PROJECT-26461692
[Journal Article] エキソソームの形成機構2015
- Author(s)
  梶本武利、岡田太郎、中村俊一
- Journal Title
  
  細胞工学
  
  Volume: ３４ Pages: 168-173
- Data Source
  KAKENHI-PROJECT-15K15066
[Journal Article] エキソソームの形成機構2015
- Author(s)
  梶本武利、岡田太郎、中村俊一
- Journal Title
  
  細胞工学
  
  Volume: 34 Pages: 168-173
- Data Source
  KAKENHI-PROJECT-26670158
[Journal Article] Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein2014
- Author(s)
  Jesko, H., Okada, T., Strosznajder, R. P., & Nakamura, S.
- Journal Title
  
  Folia Neuropathol.
  
  Volume: 52 Pages: 70-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670158
[Journal Article] Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein.2014
- Author(s)
  Jesko H, Okada T, Strosznajder RP, Nakamura S.
- Journal Title
  
  Folia Neuropathol
  
  Volume: 52 Pages: 70-78
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590112
[Journal Article] Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes.2013
- Author(s)
  Taketoshi Kajimoto, Taro Okada, Satoshi Miya, Lifang Zhang, Shun-ichi Nakamura
- Journal Title
  
  Nature Communications
  
  Volume: 4:2712 Issue: 1 Pages: 1-13
- DOI
  10.1038/ncomms3712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790293, KAKENHI-PROJECT-24590112
[Journal Article] 細胞内外で機能するスフィンゴシン1リン酸(S1P)の役割2012
- Author(s)
  岡田太郎、中村俊一
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 92-101
- NAID
  10030346307
- Data Source
  KAKENHI-PROJECT-22390053
[Journal Article] Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus2010
- Author(s)
  Kanno T, Nishizaki T, Proia RL, Kajimoto T, Jahangeer S, Okada T, Nakamura S
- Journal Title
  
  Neuroscience
  
  Volume: 29 Pages: 973-80
- Data Source
  KAKENHI-PROJECT-21590309
[Journal Article] Sphingosine kinase 1 regulates mucin production via ERK phosphorylation2010
- Author(s)
  Kono Y, Nishiuma T, Okada T, Kobayashi K, Funada Y, Kotani Y, Jahangeer S, Nakamura S, Nishimura Y
- Journal Title
  
  Pulm Pharmacol Ther
  
  Volume: 23(1) Pages: 36-42
- NAID
  120003290046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590965
[Journal Article] Sphingosine kinase 1 regulates mucin production via ERK phosphorylation2010
- Author(s)
  Kono Y, Nishiuma T, Okada T, Kobayashi K, Funada Y, Kotani Y, Jahangeer S, Nakamura S, Nishimura Y
- Journal Title
  
  Pulm Pharmacol Ther
  
  Volume: 23 Pages: 36-42
- NAID
  120003290046
- Data Source
  KAKENHI-PROJECT-21590309
[Journal Article] Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus.2010
- Author(s)
  Kanno, T., Nishizaki, T., Proia, R. L., Kajimoto, T., Jahangeer, S., Okada, T., & Nakamura, S.
- Journal Title
  
  Neurosci
  
  Volume: 171 Pages: 973-980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390053
[Journal Article] Sphingosine kinase 1 regulates mucin production via ERK phosphorylation2010
- Author(s)
  Kono, Y., Nishiuma, T., Okada, T., Kobayashi, K., Funada, Y., Kotari, Y., Jahangeer, S., Nakamura S., Nishimura Y.
- Journal Title
  
  Pulm.Pharmacol.Ther.
  
  Volume: 23 Pages: 36-42
- NAID
  120003290046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390053
[Journal Article] Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus2010
- Author(s)
  Kanno, T., Nishizaki, T., Proia, L., Kajimoto, T., Jahangeer, S., Okada., T., Nakamura, S
- Journal Title
  
  Neuroscience
  
  Volume: 171 Pages: 7-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390053
[Journal Article] Sphingosine kinase 1 regulates mucin production via ERK phosphorylation2010
- Author(s)
  Kono, Y., Nishiuma, T., Okada, T., Kobayashi, K., Funada, Y., Kotani, Y., Jahangeer, S., Nakamura, S., Nishimura, Y.
- Journal Title
  
  Pulm.Pharmacol.Ther. 23
  
  Pages: 36-42
- NAID
  120003290046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20022026
[Journal Article] Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system2009
- Author(s)
  Okada, T., Kajimoto, T., Jahangeer, S., Nakamura, S.
- Journal Title
  
  Cell. Signal 21
  
  Pages: 7-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590309
[Journal Article] Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system2009
- Author(s)
  Okada T, Kajimoto T, Jahangeer S, Nakamura S
- Journal Title
  
  Cell Signal
  
  Volume: 21 Pages: 7-13
- Data Source
  KAKENHI-PROJECT-21590309
[Journal Article] Roles of extracellular and intracellular sphingosine 1-phosphate in cell migration2009
- Author(s)
  Yu H, Okada T, Kobayashi M, Abo-Elmatty DM, Jahangeer S, Nakamura S
- Journal Title
  
  Genes Cells
  
  Volume: 14 Pages: 597-605
- Data Source
  KAKENHI-PROJECT-21590309
[Journal Article] CtBP1/BARS is an activator of phospholipase D1 necessary for agonist-induced macropinocytosis2009
- Author(s)
  Haga, Y., Miwa, N., Jahangeer, S., Okada, T., Nakamura, S.
- Journal Title
  
  EMBO J. 28
  
  Pages: 1197-1207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20022026
[Journal Article] Roles of extracellular and intracellular sphingosine 1-phosphate in cell migration2009
- Author(s)
  Yu, H., Okada, T., Kobayashi, M., Abo-Elmatty, D.M., Jahangeer, S., Nakamura, S.
- Journal Title
  
  Genes Cells 14
  
  Pages: 597-605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20022026
[Journal Article] Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system2009
- Author(s)
  Okada, T., Kajimoto, T., Jahangeer, S., & Nakamura, S.
- Journal Title
  
  Cell. Signal. 21
  
  Pages: 7-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20022026
[Journal Article] CtBP1/BARS is an activator of phospholipase D1 necessary for agonist-induced macropinocytosis2009
- Author(s)
  Haga Y, Miwa N, Jahangeer S, Okada T, Nakamura S
- Journal Title
  
  EMBO J
  
  Volume: 28 Pages: 1197-207
- Data Source
  KAKENHI-PROJECT-21590309
[Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model2008
- Author(s)
  Nishiuma, T, Nishimura, Y, Okada, T, Kuramoto, E, Kotani, Y, Jahangeer, S, Nakamura, S
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model2008
- Author(s)
  Nishiuma, T., Nishimura, Y., Okada, T., Kuramoto, E., Kotani, Y., Jahangeer, S., & Nakamura, S.
- Journal Title
  
  Am. J. Physiol. Lung Cell. Mo1. Physiol. 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590309
[Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model2008
- Author(s)
  Nishiuma, T., Nishimura, Y., Okada, T., Kuramoto, E., Kotani, Y., Jahangeer, S., Nakamura, S.
- Journal Title
  
  Am. J. Physiol. Lung Cell. Mol. Physiol. 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590309
[Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.2008
- Author(s)
  Nishiuma T, Nishimura Y, Okada T, Kuramoto E, Kotani Y, Jahangeer S, Nakamura S
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590848
[Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model2008
- Author(s)
  Nishiuma, T., Nishimura, Y., Okada, T., Kuramoto, E., Kotani, Y., Jahan geer, S., & Nakamura, S.
- Journal Title
  
  Am. J. Physiol. Lung Cell. Mol. Physiol. 294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20022026
[Journal Article] Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons2007
- Author(s)
  Kajimoto, T., Okada, T., Yu, F., Goparaju, S. K., Jahangeer, S., Nakamura. S.
- Journal Title
  
  Mol. Cell. Biol. 27
  
  Pages: 3429-3440
- NAID
  10024355377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590309
[Journal Article] Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons2007
- Author(s)
  Kajimoto, T., Okada, Y., Yu, H., Goparaju, S., Jahangeer, S. & Nakamura, S.
- Journal Title
  
  Mol. Cell. Biol. 27
  
  Pages: 3429-3440
- NAID
  10024355377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590309
[Journal Article] Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF{beta}12007
- Author(s)
  Kono, Y., Nishiuma, T., Nishimura, Y., Kotani, Y., Okada, T., Nakamura, S., Yokoyama M.
- Journal Title
  
  Am. J. Respir. Cell. Mol. Biol. 37
  
  Pages: 395-404
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590309
[Journal Article] Requirement of phospholipase D for ilimaquinone-induced Golgi membrane fragmentation2007
- Author(s)
  Sonoda, H., Okada, T., Jahangeer, S., and Nakamura, S.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 34085-34092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590309
[Journal Article] Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta12007
- Author(s)
  Kono, Y, Nishiuma, T, Nishimura, Y, Kotani, Y, Okada, T, Nakamura, S, Yokoyama, M
- Journal Title
  
  Am J Respir Cell Mol Biol 37
  
  Pages: 395-404
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Journal Article] Requirement of phospholipase D for ilimaquinone-induced Golgi membrane fragmentation2007
- Author(s)
  Sonoda, H., Okada, T., Jahangeer, S., Nakamura, S.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 34085-34092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590309
[Journal Article] Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta12007
- Author(s)
  Kono Y, Nishiuma T, Nishimura Y, Kotani Y, Okada T, Nakamura S, Yokoyama M.
- Journal Title
  
  Am J Respir Cell Mol Biol 37
  
  Pages: 395-404
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590848
[Journal Article] Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 22007
- Author(s)
  Ding, G., Sonoda, H., Yu, H., Kajimoto, T., Goparaju, S. K., Jahangeer, S., Okada, T., Nakamura, S.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 27493-27502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590309
[Journal Article] Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 22007
- Author(s)
  Ding G, Sonoda H, Yu H, Kajimoto T, Goparaju SK, Jahangeer S, Okada T, Nakamura S.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 27493-27502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590309
[Journal Article] Involvement of N-terminal-extended form of sphingosine kinase 2 in Serum-dependent regulation of cell proliferation and apoptosis2005
- Author(s)
  岡田太郎
- Journal Title
  
  The Journal of Biological Chemistry 280
  
  Pages: 36318-36325
- Data Source
  KAKENHI-PROJECT-16770098
[Presentation] S1P 受容体タイプ３－Ｇｑ－カゼインキナーゼ系によるレトログレード輸送およびリソソーム機能の制御2025
- Author(s)
  岡田太郎
- Organizer
  第１８回スフィンゴテラピィ研究会
- Data Source
  KAKENHI-PROJECT-22K06206
[Presentation] SphK1/S1P受容体系はエンドソームからTGNへのCI-M6PRの逆行輸送に寄与することでライソゾーム酵素Cathepsin Dの活性を制御する2023
- Author(s)
  西田晋，中村俊一，岡田太郎
- Organizer
  第９６回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06206
[Presentation] 細胞外α-シヌクレインによるスフィンゴシン-1-リン酸受容体の阻害とその影響2022
- Author(s)
  岡田太郎
- Organizer
  第15回セラミド研究会・第１６回スフィンゴテラピィ研究会合同学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06206
[Presentation] Regulation of multivesicular body maturation by S1P signaling2013
- Author(s)
  Nakamura, S., Kajimoto, T., Miya, S., Zhang, L., and Okada, T.
- Organizer
  8th Sphingo-therapy conference
- Place of Presentation
  Yamanakaonsen-Kajikaso Royal Hotel
- Invited
- Data Source
  KAKENHI-PROJECT-24590112
[Presentation] Sphingolipid signaling and neuronal function2011
- Author(s)
  Nakamura, S., Fukai, E., Miya, S., Jesko, H., & Okada, T.
- Organizer
  52nd International Conference onthe Bioscience of Lipids
- Place of Presentation
  Warsaw, Poland
- Year and Date
  2011-09-02
- Data Source
  KAKENHI-PROJECT-22390053
[Presentation] Sphingolipid signaling and neuronal function2011
- Author(s)
  Nakamura, S., Fukai, E., Miya, S., Jesko, H., Okada, T.
- Organizer
  52^<nd> International Conference on the Bioscience of Lipids
- Place of Presentation
  ワルシャワ(ポーランド)(招待講演)
- Year and Date
  2011-08-03
- Data Source
  KAKENHI-PROJECT-22390053
[Presentation] Nakamura, S., Fukai, E., Jesko, H., & Okada, T.2010
- Author(s)
  Nakamura, S., Fukai, E., Jesko, H., & Okada, T.
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22390053
[Presentation] スフィンゴシン1リン酸による神経伝達物質放出の調節2009
- Author(s)
  中村俊一、岡田太郎
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20022026
[Presentation] Sphingosine 1-phosphate in physiology and pathology in the brain2009
- Author(s)
  Nakamura, S. and Okada, T.
- Organizer
  9th International Congress of the Polish Neuroscience Society in Warsow
- Place of Presentation
  Poland
- Data Source
  KAKENHI-PROJECT-21590309
[Presentation] スフィンゴシンキナーゼ2によるエキソソーム放出の調節2008
- Author(s)
  中村俊一、岡田太郎
- Organizer
  第3回スフィンゴテラピィ(STC)研究会
- Place of Presentation
  大山(鳥取)
- Year and Date
  2008-04-18
- Data Source
  KAKENHI-PROJECT-20022026
[Presentation] スフィンゴシンキナーゼ2によるエキソソーム放出の調節2008
- Author(s)
  中村俊一, 岡田太郎
- Organizer
  第3回スフィンゴテラピイ(STC)研究会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-19590309
[Presentation] スフィンゴシンキナーゼ2によるエキソソーム放出の調節2008
- Author(s)
  中村俊一, 岡田太郎
- Organizer
  第3回スフィンゴテラピィ(STC)研究会
- Place of Presentation
  大山(鳥取)
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19590309
[Presentation] Sphingosine Kinase(SPHK)1 Regulates Differentiation of Lung Fibroblasts Mediated by Transforming Growth Factor (TGF) beta12007
- Author(s)
  Kono Y, Nishiuma T, Nishimura Y, Okada T, Kobayashi K, Funada Y, Kotani Y, Nakamura S, Yokoyama M
- Organizer
  米国胸部疾患学会(American Thoracic Society)
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2007-05-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Presentation] Effect of sphingosine kinase on IL-13 induced goblet cell metaplasia2007
- Author(s)
  Kono, Y, Nishiuma, T, Nishimura, Y, Okada, T, Kobayashi, K, Funada, Y, Kotani, Y, Nakamura, S, Yokoyama, M
- Organizer
  Asian Pacific Society of Respirology
- Place of Presentation
  Gold Coast, Australia
- Year and Date
  2007-12-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Presentation] Sphingosine Kinase(SPHK)1 Regulates Differentiation of Lung Fibroblasts Mediated by Transforming Growth Factor(TGF)betal2007
- Author(s)
  Kono, Y, Nishiuma, T, Nishimura, Y, Okada, T, Kobayashi, K, Funada, Y, Kotani, Y, Nakamura, S, Yokoyama, M
- Organizer
  American Thoracic Society
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2007-05-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590848
[Presentation] Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes
- Author(s)
  梶本武利、岡田太郎、宮聡志、張麗芳、中村俊一
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26670158

1. NAKAMURA Shunichi (40155833)

# of Collaborated Projects: 11 results

# of Collaborated Products: 32 results
2. MIWA Noriko (50202354)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KAJIMOTO Taketoshi (00509953)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
4. NISHIMURA Yoshihiro (20291453)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
5. JAHANGEER Saleem (80314475)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
6. KOTANI Yoshikazu (90403287)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
7. KOBAYASHI Kazuyuki (50403275)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. NISHIUMA Teruaki (10379414)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
9. 伊集院壮 (00361626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
10. FUNADA Yasuhiro (60437465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. HIRATA Kenichi (20283880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 榊原菜々

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKADA TAROU 岡田 太郎

Okada Taro 岡田 太郎

OKADA Tarou 岡田 太郎

Research Projects

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Co-Researchers

Novel mechanism of lesion propagation by extracellular alpha-synuclein in synucleinopathies.Principal Investigator

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Involvement of S1P receptor signaling and exosome release on Parkinson's diseasePrincipal Investigator

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Inhibition of S1P receptor signal transduction by extracellular alpha-synucleinPrincipal Investigator

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S1P receptors on neuronal cells as a target of medicine for epilepsyPrincipal Investigator

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The role of sphingosine kinases on the formation of neural network in dentate granule cells of hippocampusPrincipal Investigator

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OKADA TAROU 岡田太郎

Okada Taro 岡田太郎

OKADA Tarou 岡田太郎