Onaka Hiroyasu 尾仲宏康

… Alternative Names

ONAKA Hiroyasu 尾仲宏康

尾仲宏康オナカヒロヤス

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Researcher Number	80315829
Other IDs	https://orcid.org/0000-0003-4536-1881
Affiliation (Current)	2026: 学習院大学, 理学部, 教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 学習院大学, 理学部, 教授 2016 – 2022: 東京大学, 大学院農学生命科学研究科(農学部), 特任教授 2012 – 2016: 東京大学, 農学生命科学研究科, 教授 2012: 東京大学, 大学院・農学生命科学研究科, 特任教授 2010 – 2011: 富山県立大学, 工学部, 准教授 … More 2006: 富山県立大学, 工学部, 講師 2004 – 2005: 富山県立大学, 工学部, 助手 2002 – 2003: 富山県立大学, 工学部・生物工学研究センター, 助手 2000 – 2001: 富山県立大学, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Applied microbiology / Transformative Research Areas, Section (II) / Science and Engineering / 応用微生物学・応用生物化学 / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 38020:Applied microbiology-related Except Principal Investigator Medium-sized Section 37:Biomolecular chemistry and related fields / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 45040:Ecology and environment-related / Science and Engineering / Applied microbiology
Keywords	Principal Investigator 生合成 / 放線菌 / RiPPs / 抗生物質 / 遺伝子 / 二次代謝 / 二次代謝産物 / Streptomyces / インドロカルバゾール / 天然物創薬 … More / 中分子創薬 / ペプチド / 抗生物質生産 / ミコール酸 / 共培養 / 複合培養 / 遺伝子発現 / 微生物 / 遺伝子組換え / バイオテクノロジー / 応用微生物 / rebeccamycin / staurosporine / ラクタゾール / ペプチド系抗生物質 / post-translational / ribosome synthesis / microbiology / biosynthesis / peptide / 天然物 / 創薬 / ミコール酸含有細菌 / 微生物相互作用 / 微生物間相互作用 / 天然物スクリーニング / シグナル伝達 / 醗酵 / チオペプチド / リボソーム合成 / ビオラセイン / 酸化酵素 / 抗ガン物質 / 抗がん物質 / 発酵 / 遺伝学 / Violacein / Saccharothrix / 生合成遺伝子 / レべッカマイシン / Lechevalieria / レベッカマイシン / スタウロスポリン … More Except Principal Investigator 抗真菌薬 / 天然物 / 放線菌 / ビーズ / 脂質 / ペプチド / タンパク質 / 抗体 / ポリカチオン / 細胞膜透過性ペプチド / 相互作用 / 微生物 / 微生物間相互作用 / テルペン / 試験管内リデザイン生合成系 / 擬天然物 / 人工生合成系 / 主鎖修飾型ペプチド / 試験管内リデザイン整合性系 / 代謝解析 / 遺伝子導入 / カルス増殖 / 不定芽 / 不定根 / 組織培養 / クレソン / 環境浄化 / 水生植物 / 植物培養細胞 / 微生物酵素 Less

中分子創薬を目指した特異的結合RiPPs創製への予知生合成Principal Investigator
- Principal Investigator
  
  尾仲宏康
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Gakushuin University
Exploration of Lipid-Binding Natural Products Using Lipid-Immobilized Beads and their Utilization
- Principal Investigator
  
  松森信明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kyushu University
生物活性中高分子の革新的細胞内送達技術による細胞生理機能の制御
- Principal Investigator
  
  濱野吉十
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Fukui Prefectural University
中分子創薬を目指した創薬ターゲット特異的結合RiPPsアナログの創出Principal Investigator
- Principal Investigator
  
  尾仲宏康
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Gakushuin University
Expanding the structural diversity of RiPPs (Ribosomally synthesized and post-translationally modified peptide)Principal Investigator
- Principal Investigator
  
  Onaka Hiroyasu
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Gakushuin University
  The University of Tokyo
Using terpenes as a key to unlock "Black box" of microbial interactions in subseafloor
- Principal Investigator
  
  Ulanova Dana
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 45040:Ecology and environment-related
- Research Institution
  Kochi University
the mode of action in the combined-culture methods that induce potential secondary metabolismPrincipal Investigator
- Principal Investigator
  
  Hiroyasu Onaka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  The University of Tokyo
Synthetic biology of pseudo-natural products by artificial in vitro biosynthesis
- Principal Investigator
  
  菅裕明
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
翻訳系複素環ペプチド生合成遺伝子群の覚醒と新奇抗生物質生産システムへの適応Principal Investigator
- Principal Investigator
  
  尾仲宏康
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Secondary metabolite Screening by combined-culturePrincipal Investigator
- Principal Investigator
  
  Onaka Hiroyasu
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  The University of Tokyo
翻訳系を介した複素環含有ペプチド生合成機構を応用した抗生物質生産システムの構築Principal Investigator
- Principal Investigator
  
  尾仲宏康
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
  Toyama Prefectural University
Characterization of indolocarbazole biosynthetic enzymes; for the application toPrincipal Investigator
- Principal Investigator
  
  ONAKA Hiroyasu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  The University of Tokyo
  Toyama Prefectural University
Expression of microbial enzymes in aquatic plants and their applications for phytoremediation and production of useful chemicals.
- Principal Investigator
  
  KATO Yasuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  Toyama Prefectural University
放線菌由来インドロカルバゾール生合成研究及び新規物質創製への展開Principal Investigator
- Principal Investigator
  
  尾仲宏康
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Toyama Prefectural University
放線菌が生産するインドロカルバゾール化合物の生合成に関する研究Principal Investigator
- Principal Investigator
  
  尾仲宏康
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Toyama Prefectural University
放線菌の生産するスタウロスポリンの生合成に関する研究Principal Investigator
- Principal Investigator
  
  尾仲宏康
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Toyama Prefectural University

[Book] 複合培養による放線菌抗生物質生産の覚醒2016
- Author(s)
  尾仲宏康
- Total Pages
  10
- Publisher
  CMC出版
- Data Source
  KAKENHI-PROJECT-25292046
[Journal Article] SolS-catalyzed sulfoxidation of labionin to solabionin drives antibacterial activity of solabiomycins2023
- Author(s)
  Ijichi Shinta、Hoshino Shotaro、Asamizu Shumpei、Onaka Hiroyasu
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 89 Pages: 129323-129323
- DOI
  10.1016/j.bmcl.2023.129323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04712, KAKENHI-PUBLICLY-23H04543, KAKENHI-PROJECT-22K20566
[Journal Article] Stable Isotope-Guided Metabolomics Reveals Polar-Functionalized Fatty-Acylated RiPPs from <i>Streptomyces</i>2022
- Author(s)
  Asamizu Shumpei、Ijichi Shinta、Hoshino Shotaro、Jo Hansaem、Takahashi Hidenori、Itoh Yuko、Matsumoto Sohkichi、Onaka Hiroyasu
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 17 Issue: 10 Pages: 2936-2944
- DOI
  10.1021/acschembio.2c00601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04712
[Journal Article] Accurate Models of Substrate Preferences of Post-Translational Modification Enzymes from a Combination of mRNA Display and Deep Learning2022
- Author(s)
  Vinogradov Alexander A.、Chang Jun Shi、Onaka Hiroyasu、Goto Yuki、Suga Hiroaki
- Journal Title
  
  ACS Central Science
  
  Volume: 8 Issue: 6 Pages: 814-824
- DOI
  10.1021/acscentsci.2c00223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-21H04712
[Journal Article] De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors2022
- Author(s)
  Vinogradov Alexander A.、Zhang Yue、Hamada Keisuke、Chang Jun Shi、Okada Chikako、Nishimura Hirotaka、Terasaka Naohiro、Goto Yuki、Ogata Kazuhiro、Sengoku Toru、Onaka Hiroyasu、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 44 Pages: 20332-20341
- DOI
  10.1021/jacs.2c07937
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06051, KAKENHI-PROJECT-20H05618, KAKENHI-ORGANIZER-21H05158, KAKENHI-PROJECT-21H04712, KAKENHI-PROJECT-22KF0114, KAKENHI-PLANNED-21H05161
[Journal Article] Longicatenamides A-D, two diastereomeric pairs of cyclic hexapeptides produced by combined-culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B05962021
- Author(s)
  Jiang, Y., Matsumoto, T., Kuranaga, T., Lu, S., Wang, W., Onaka, H., Kakeya, H.
- Journal Title
  
  J. Antibiot.
  
  Volume: - Issue: 5 Pages: 307-316
- DOI
  10.1038/s41429-020-00400-3
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-18H02120, KAKENHI-PROJECT-19H02840
[Journal Article] Amycolapeptins A and B, cyclic nonadepsipeptides produced by combined-culture of Amicolatopsis sp. and Tsukamurella pulmonis2021
- Author(s)
  Pan, C., Kuranaga, T., Cao, X., Suzuki, T., Dohmae, N., Shinzato, N., Onaka, H., Kakeya, H.
- Journal Title
  
  J. Org. Chem.
  
  Volume: 86 Issue: 2 Pages: 1843-1849
- DOI
  10.1021/acs.joc.0c02660
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-18H02120, KAKENHI-PROJECT-19H02840
[Journal Article] Minimal lactazole scaffold for in vitro thiopeptide bioengineering2020
- Author(s)
  Vinogradov Alexander A.、Shimomura Morito、Goto Yuki、Ozaki Taro、Asamizu Shumpei、Sugai Yoshinori、Suga Hiroaki、Onaka Hiroyasu
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 2272-2272
- DOI
  10.1038/s41467-020-16145-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-18K05385, KAKENHI-PROJECT-19K22243, KAKENHI-PLANNED-16H06444, KAKENHI-PROJECT-20H02866
[Journal Article] Promiscuous Enzymes Cooperate at the Substrate Level En Route to Lactazole A2020
- Author(s)
  Vinogradov Alexander A.、Shimomura Morito、Kano Naokazu、Goto Yuki、Onaka Hiroyasu、Suga Hiroaki
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 142 Issue: 32 Pages: 13886-13897
- DOI
  10.1021/jacs.0c05541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H05618, KAKENHI-PROJECT-19K22243, KAKENHI-PLANNED-16H06444, KAKENHI-PROJECT-20H02866
[Journal Article] Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines2019
- Author(s)
  Ozaki Taro、Sugiyama Ryosuke、Shimomura Morito、Nishimura Shinichi、Asamizu Shumpei、Katsuyama Yohei、Kakeya Hideaki、Onaka Hiroyasu
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Issue: 9 Pages: 2370-2378
- DOI
  10.1039/c8ob02846j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05385, KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-18H02120, KAKENHI-PROJECT-17K19233, KAKENHI-PLANNED-16H06444
[Journal Article] Chemical Interactions of Cryptic Actinomycete Metabolite 5‐Alkyl‐1,2,3,4‐tetrahydroquinolines through Aggregate Formation2019
- Author(s)
  Sugiyama Ryosuke、Nakatani Takahiro、Nishimura Shinichi、Takenaka Kei、Ozaki Taro、Asamizu Shumpei、Onaka Hiroyasu、Kakeya Hideaki
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 58 Issue: 38 Pages: 13486-13491
- DOI
  10.1002/anie.201905970
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05385, KAKENHI-PROJECT-18K06717, KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-18H02120, KAKENHI-PROJECT-19H02840
[Journal Article] Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria2018
- Author(s)
  Hoshino Shotaro、Onaka Hiroyasu、Abe Ikuro
- Journal Title
  
  Journal of Industrial Microbiology & Biotechnology
  
  Volume: 46 Issue: 3-4 Pages: 363-374
- DOI
  10.1007/s10295-018-2100-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02120, KAKENHI-PROJECT-16J01117, KAKENHI-PLANNED-16H06443
[Journal Article] Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium2018
- Author(s)
  Hoshino Shotaro、Ozeki Masahiro、Awakawa Takayoshi、Morita Hiroyuki、Onaka Hiroyasu、Abe Ikuro
- Journal Title
  
  Journal of Natural Products
  
  Volume: 81 Issue: 9 Pages: 2106-2110
- DOI
  10.1021/acs.jnatprod.8b00261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KT0095, KAKENHI-PUBLICLY-17H05435, KAKENHI-PROJECT-18H02120, KAKENHI-PROJECT-17H04763, KAKENHI-PROJECT-16J01117
[Journal Article] Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo2017
- Author(s)
  Ozaki, T., Yamashita, K., Goto, Y., Shimomura, M., Hayashi, S., Asamizu, S., Sugai, Y., Ikeda, H., Suga, H., Onaka, H.
- Journal Title
  
  Nat. Commun.
  
  Volume: 8 Issue: 1 Pages: 14207-14207
- DOI
  10.1038/ncomms14207
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06447, KAKENHI-PLANNED-16H06444
[Journal Article] 複合培養による放線菌抗生物質生産の覚醒2016
- Author(s)
  尾仲宏康
- Journal Title
  
  バイオインダストリー
  
  Volume: 3 Pages: 4-10
- Data Source
  KAKENHI-PROJECT-25292046
[Journal Article] Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from 　the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis.2016
- Author(s)
  Sugiyama R, Nishimura S, Ozaki T, Asamizu S, Onaka H, Kakeya H.
- Journal Title
  
  Angew Chem Int Ed Engl.
  
  Volume: 55(35) Issue: 35 Pages: 10278-10282
- DOI
  10.1002/anie.201604126
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-25702048, KAKENHI-PROJECT-15K14721, KAKENHI-PROJECT-16K18673
[Journal Article] Insights into the Biosynthesis of Dehydroalanines in Goadsporin2016
- Author(s)
  Taro Ozaki, Yukari Kurokawa, Shohei Hayashi, Naoya Oku, Shumpei Asamizu, Yasuhiro Igarashi, Hiroyasu Onaka
- Journal Title
  
  Chembiochem
  
  Volume: 17 Issue: 3 Pages: 218-223
- DOI
  10.1002/cbic.201500541
- NAID
  120006313535
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26850043, KAKENHI-PROJECT-26850044, KAKENHI-PROJECT-25292046
[Journal Article] 5-Alkyl-1,2,3,4-tetrahydroquinolines, New Membrane-Interacting Lipophilic Metabolites Produced by Combined Culture of Streptomyces nigrescens and Tsukamurella pulmonis.2015
- Author(s)
  Sugiyama R, Nishimura S, Ozaki T, Asamizu S, Onaka H, Kakeya H.
- Journal Title
  
  Org Lett.
  
  Volume: 印刷中 Issue: 8 Pages: 1918-1921
- DOI
  10.1021/acs.orglett.5b00607
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-25702048, KAKENHI-PUBLICLY-26102726, KAKENHI-PROJECT-26850044, KAKENHI-PROJECT-15K14721
[Journal Article] Niizalactams A-C, multicyclic macrolactams isolated from combined culture of Streptomyces with mycolic acid-containing bacterium2015
- Author(s)
  S. Hoshino, M. Okada, T. Wakimoto, H. Zhang, F. Hayashi, H. Onaka, I. Abe
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 78 Issue: 12 Pages: 3011-3017
- DOI
  10.1021/acs.jnatprod.5b00804
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-15H03112, KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-24688011
[Journal Article] ゲノムマイニングによる休眠型新規チオペプチド天然物・ラクタゾールの発見2015
- Author(s)
  尾仲宏康
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 2 Pages: 126127-126127
- Data Source
  KAKENHI-PUBLICLY-25108707
[Journal Article] Chojalactones A-C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium.2015
- Author(s)
  Hoshino S, Wakimoto T, Onaka H, Abe I.
- Journal Title
  
  Org Lett.
  
  Volume: 印刷中 Issue: 6 Pages: 1501-1504
- DOI
  10.1021/acs.orglett.5b00385
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-15K12740, KAKENHI-PROJECT-15H03112
[Journal Article] Mycolic acid-containing bacteria activate heterologous secondary metabolite expression in Streptomyces lividans.2015
- Author(s)
  Onaka H, Ozaki T, Mori Y, Izawa M, Hayashi S, Asamizu S.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 印刷中 Issue: 9 Pages: 594-597
- DOI
  10.1038/ja.2015.31
- NAID
  120005844159
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-26850044
[Journal Article] Genome Mining Reveals a Minimum Gene Set for the Biosynthesis of 32-Membered Macrocyclic Thiopeptides Lactazoles2014
- Author(s)
  S. Hayashi, T. Ozaki, S. Asamizu, H. Ikeda, S. Omura, N. Oku, Y. Igarashi, H. Tomoda, H. Onaka
- Journal Title
  
  Chem. Biol.
  
  Volume: ２１ Issue: 5 Pages: 679-688
- DOI
  10.1016/j.chembiol.2014.03.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22108006, KAKENHI-PUBLICLY-25108707
[Journal Article] Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823.2014
- Author(s)
  S. Hoshino, L. Zhang, T. Awakawa, T. Wakimoto, H. Onaka, I. Abe
- Journal Title
  
  J. Antibiot.
  
  Volume: 67 Issue: 5 Pages: 1-3
- DOI
  10.1038/ja.2014.147
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25108705, KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-25560399
[Journal Article] Coupling Reaction of Indolepyruvic Acid by StaD and Its Product: Implications for Biosynthesis of Indolocarbazole and Violacein2012
- Author(s)
  *Nagano, S.(3) Hino, T., (他5名)
- Journal Title
  
  ChemBioChem
  
  Volume: 13 Issue: 17 Pages: 2495-2500
- DOI
  10.1002/cbic.201200535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310137, KAKENHI-PROJECT-22580089
[Journal Article] Characterization and Functional Modification of StaC and RebC, Which Are Involved in the Pyrrole Oxidation of Indolocarbazole Biosynthesis2011
- Author(s)
  *Nagano, S.(6)(他4名)
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 75 Issue: 11 Pages: 2184-2193
- DOI
  10.1271/bbb.110474
- NAID
  10030396835
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310137, KAKENHI-PROJECT-22580089
[Journal Article] Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds2006
- Author(s)
  Hiroyasu Onaka
- Journal Title
  
  Actinomycetologica 20
  
  Pages: 62-71
- NAID
  10018284132
- Data Source
  KAKENHI-PROJECT-17780063
[Journal Article] Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.2005
- Author(s)
  Hiroyasu Onaka
- Journal Title
  
  Bioscience, Biotechnology and Biochemistry 69
  
  Pages: 1753-1759
- NAID
  130000030213
- Data Source
  KAKENHI-PROJECT-17780063
[Patent] 化合物ライブラリー及び化合物ライブラリーの製造方法2018
- Inventor(s)
  菅　裕明,後藤　佑樹,尾仲　宏康,ヴィノグラドフ　アレクサンダー
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 新規作用機序の抗生物質創製に向けたGoadsporin構造活性相関の研究2025
- Author(s)
  伊地知新太、星野翔太郎、Vinogradov Alexander A.、後藤佑樹、菅裕明、尾仲宏康
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PUBLICLY-23H04548
[Presentation] 新規作用機序の抗生物質創製に向けたGoadsporin構造活性相関の研究2025
- Author(s)
  星野千優、星野翔太郎、尾仲宏康
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PROJECT-21H04712
[Presentation] 中分子創薬を目指した創薬ターゲット特異的結合RiPPsアナログの創出2025
- Author(s)
  尾仲宏康
- Organizer
  「予知生合成科学」第5回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-23H04548
[Presentation] Actinomadura sp. RD004911と近縁な株に保存されているVLP生合成遺伝子クラスター2025
- Author(s)
  小牧久幸、星野翔太郎、尾仲宏康
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PROJECT-21H04712
[Presentation] RiPPsアナログを用いた中分子創薬2024
- Author(s)
  尾仲宏康
- Organizer
  日本農芸化学会2024年度大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-23H04548
[Presentation] RiPPsアナログを用いた中分子創薬2024
- Author(s)
  4.尾仲宏康
- Organizer
  日本農芸化学会2024年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04712
[Presentation] Unnatural thiopeptide production using RIPP biosynthetic machinery.2024
- Author(s)
  H. Onaka
- Organizer
  5th European Conference on Natural Products,
- Data Source
  KAKENHI-PROJECT-21H04712
[Presentation] Unnatural thiopeptide drug development using RIPP biosynthetic machinery.2024
- Author(s)
  H. Onaka
- Organizer
  US/Japan Seminar on Natural Product Biosynthesis.
- Invited
- Data Source
  KAKENHI-PROJECT-21H04712
[Presentation] 新規作用機序の抗生物質創製に向けたGoadsporin構造活性相関の研究2024
- Author(s)
  星野千優, 星野翔太郎, 尾仲宏康
- Organizer
  2024年度日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-21H04712
[Presentation] Unnatural thiopeptide production using RIPP biosynthetic machinery.2024
- Author(s)
  H. Onaka
- Organizer
  3rd Japanese-German Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-21H04712
[Presentation] Unnatural thiopeptide production using RIPP biosynthetic machinery.2024
- Author(s)
  H. Onaka
- Organizer
  The 2nd Taiwan-Japan Bilateral Symposium on Natural Products Biosynthesis,
- Invited
- Data Source
  KAKENHI-PROJECT-21H04712
[Presentation] Unnatural thiopeptide design using RIPPs biosynthetic machinery2023
- Author(s)
  H. Onaka.
- Organizer
  3rd Japan-Switzerland-Germany Workshop on Biocatalysis and Bioprocess Development.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04712
[Presentation] 中分子創薬を目指したターゲット特異的結合RiPPsアナログの創出2023
- Author(s)
  尾仲宏康
- Organizer
  学術変革領域研究(A)予知生合成科学第二回公開シンポジウム
- Data Source
  KAKENHI-PUBLICLY-23H04548
[Presentation] 放線菌と土壌細菌との相互作用2021
- Author(s)
  浅水俊平、尾仲宏康
- Organizer
  日本農芸化学会2021年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02120
[Presentation] 複合培養におけるStreptomyces coelicolorのRED生産遅延に関与するTetR型転写制御因子の解析2021
- Author(s)
  LEI YUKUN、浅水俊平、石塚匠、栁澤昌臣、大野豊、佐藤勝也、尾仲宏康
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18H02120
[Presentation] RNA-seq解析に基づいた複合培養における二次代謝活性化機構の解析2021
- Author(s)
  木田優士、浅水俊平、尾仲宏康
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18H02120
[Presentation] Introduction2020
- Author(s)
  H. Onaka
- Organizer
  The 5th A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02120
[Presentation] リホゾーム翻訳型ペプチドの生合成の多様性2019
- Author(s)
  尾仲宏康
- Organizer
  第8回食品薬学シンポジウムシンポジウム②【天然薬物学研究のこれから】
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 微生物相互作用と「ものづくり」～東京大学微生物潜在酵素（天野エンザイム）寄付講座の歩み～2019
- Author(s)
  尾仲宏康
- Organizer
  天野エンザイム社内講演会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 複合培養における赤色色素生産非応答性変異株の解析2019
- Author(s)
  石塚匠、浅水俊平、栁澤昌臣、佐藤勝也、尾仲宏康
- Organizer
  2019年度日本農芸化学会
- Data Source
  KAKENHI-PROJECT-18H02120
[Presentation] Introduction2019
- Author(s)
  Hiroyasu Onaka
- Organizer
  The 4th A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 物理的接触が介在する放線菌二次代謝誘導2019
- Author(s)
  尾仲宏康
- Organizer
  環境バイオテクノロジー学会2019年度大会年会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] Combined-culture: co-culture with MACB induced potential secondary metabolism in actinomycetes2019
- Author(s)
  Hiroyasu Onaka
- Organizer
  ISCE 2019 Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] GNAT superfamily enzyme plays a key role in the biosynthesis of polyketide/peptide hybrid lipopeptides2019
- Author(s)
  Hiroyasu Onaka
- Organizer
  1st Japan-Germany-Switzerland Workshop for Enzyme Technology and Bioprocess Development
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] Combined-culture: co-culture with MACB induced potential secondary metabolism in actinomycetes2019
- Author(s)
  Hiroyasu Onaka
- Organizer
  Guest lecture at Gadjah Mada University, Yogyakarta, Indonesia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] Combined-culture: Potential secondary metabolism is promoted by co-culture with mycolic acid containing bacteria2019
- Author(s)
  H Onaka
- Organizer
  2nd China-Japan Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] Combined-culture: Potential secondary metabolism is promoted by co-culture with mycolic acid containing bacteria2019
- Author(s)
  Hiroyasu Onaka
- Organizer
  2nd China-Japan Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02120
[Presentation] RiPPs型生合成リデザインによる迅速多様な中分子創薬に向けた修飾ペプチド創製手法2019
- Author(s)
  尾仲宏康
- Organizer
  2019年度日本農芸化学会シンポジウム生合成マシナリからリデザインへ
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 複合培養：物理的接触を利用した放線菌抗生物質生産手法2019
- Author(s)
  尾仲宏康
- Organizer
  早稲田大学理工学術院セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 物理的接触が引き起こす放線菌抗生物質生産2019
- Author(s)
  尾仲宏康
- Organizer
  微生物ウィーク2019 シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] In vitro reconstitution of RiPPs biosynthesis coupled by in vitrotranslation and post-translation modifications2018
- Author(s)
  H Onaka
- Organizer
  3rd Europian Conference on Natural Products, DECHEMA
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] Combined-culture: potential secondary metabolism is promoted by co-culture with mycolic acid containing bacteria2018
- Author(s)
  H Onaka
- Organizer
  The Japanese-German Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] Combined-culture: Physical contact with mycolic acid containing bacteria promotes potential secondary metabolism of actinomycetes2018
- Author(s)
  H Onaka
- Organizer
  OSU seminar, Oregon Sttes University
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 微生物による「ものづくり」のイノベーション：微生物の潜在能力発掘・応用のための新手法の開発と実践2018
- Author(s)
  尾仲宏康
- Organizer
  (公財）発酵研究所第12回助成研究報告会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 微生物を用いたものづくり　～抗生物質をワンポット試験管内反応でつくる～2018
- Author(s)
  尾仲宏康
- Organizer
  ライフサイエンス技術部会反応分科会講演会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 微生物を用いたものづくり　～抗生物質をワンポット試験管内反応でつくる～2018
- Author(s)
  尾仲宏康
- Organizer
  東京大学大学院農学生命科学研究科微生物潜在機能探索寄付講座最終報告会および記念講演会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 複合培養法による休眠遺伝子の効率的な覚醒をめざして2018
- Author(s)
  尾仲宏康
- Organizer
  バイオインダストリー協会 “未来へのバイオ技術” 勉強会「微生物・覚醒」
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] Combined-culture: potential secondary metabolism is promoted by co-culture with mycolic acid containing bacteria2018
- Author(s)
  Hiroyasu Onaka
- Organizer
  The Japanese-German Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02120
[Presentation] RiPPs biosynthesis by in vitro reconstitution system2018
- Author(s)
  H Onaka
- Organizer
  The 3rd A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 中分子創薬に向けたRiPPs型生合成機構による迅速多様な修飾ペプチド創製手法2017
- Author(s)
  尾仲宏康
- Organizer
  2018年度日本農芸化学会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 天然ペプチド生合成系を利用した新規ペプチド薬剤の開発2017
- Author(s)
  尾仲宏康
- Organizer
  低・中分子創薬推進プラットフォーム特別講演
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 複合培養、微生物コミュニケーションを利用した天然物探索法2017
- Author(s)
  尾仲宏康
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] In vitro reconstitution of RiPPs biosynthesis by translational-coupled post-translational modification2017
- Author(s)
  H Onaka
- Organizer
  ASP meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 無細胞翻訳系と翻訳後修飾反応を介したRiPPs試験管内完全合成2017
- Author(s)
  尾仲宏康
- Organizer
  東大薬学部特別講演会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] マイクロファクトリー:微生物によるものづくり、酒から薬まで2017
- Author(s)
  尾仲宏康
- Organizer
  石川県立大学セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] Dissection of Goadsporin Biosynthesis by in vitro Reconstitution Leading to Designer Analogs Expressed in vivo2017
- Author(s)
  H Onaka
- Organizer
  18th International Symposium on the Biology of Actinomycetes Workshop 1-1
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] RiPPs biosynthesis by in vitro translation-coupled post-translational modification2017
- Author(s)
  尾仲宏康
- Organizer
  1st China-Japan Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] マイクロファクトリー:微生物によるものづくり、酒から薬まで2017
- Author(s)
  尾仲宏康
- Organizer
  田産研第26回バイオテクノロジー教室講演会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] RiPPs (ribosomally synthesized and post-translationally modified peptides) biosynthesis coupled by in vitro translation and post-translation modifications2017
- Author(s)
  H Onaka
- Organizer
  19th German-Japanese workshop on enzyme technology, Rostock
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 多段階連続酵素反応によるペプチド系抗生物質の試験管内完全合成と翻訳後修飾酵素群の基質認識の解明2017
- Author(s)
  尾仲宏康
- Organizer
  第18回酵素応用シンポジウム研究奨励賞受賞講演
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 無細胞翻訳系と翻訳後修飾反応を介したRiPPs試験管内完全合成2017
- Author(s)
  尾仲宏康
- Organizer
  石川県立大学セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] In vitro reconstitution of RiPPs biosynthesis by translational-coupled post-translational modification2017
- Author(s)
  H Onaka
- Organizer
  9th US-JAPAN seminar on the biosynthesis of natural products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] 放線菌における潜在的二次代謝能の覚醒による新規抗生物質探索手法の確立及びその作用機構の解明2016
- Author(s)
  尾仲宏康
- Organizer
  住木梅澤記念賞受賞講演
- Place of Presentation
  学士会館（東京都千代田区）
- Year and Date
  2016-10-18
- Invited
- Data Source
  KAKENHI-PLANNED-16H06444
[Presentation] Streptomyces davawensis JCM 4913 において新規亜硝酸生合成経路を用いて生合成される二次代謝産物の同定2016
- Author(s)
  萩原亮太、勝山陽平、菅井佳宣、尾仲宏康、大西康夫
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] RNA-seqによるミコール酸含有細菌に対するStreptomyces coelicolor A3(2)の応答解析2016
- Author(s)
  佐々木槇子、浅水俊平、尾崎太郎、宮本憲二、尾仲宏康
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 微生物が有する休眠抗生物質生産系の活性化2015
- Author(s)
  尾仲宏康
- Organizer
  第38回分子生物学会年会・第88回生化学会大会合同大会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2015-12-04
- Invited
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 複合培養における放線菌二次代謝の誘導要因の探索2015
- Author(s)
  浅水俊平、尾崎太郎、佐藤勝也、尾仲宏康
- Organizer
  日本農芸化学会大会2015年度一般講演
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 共生にもとづく微生物潜在機能の発掘2015
- Author(s)
  尾仲宏康
- Organizer
  日本農芸化学会大会2015年度大会シンポジウム
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-29
- Invited
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] Streptomyces sp. TP-A0584由来ランチペプチド系化合物のゲノムマイニングによる同定2015
- Author(s)
  小野拓人、江畑一真、浅水俊平、尾崎太郎、尾仲宏康
- Organizer
  日本農芸化学会大会2015年度一般講演
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PUBLICLY-25108707
[Presentation] Combined-culture: the new method for secondary metabolism activation in actinomycetes2015
- Author(s)
  Hiroyasu Onaka
- Organizer
  Pacifichem 2015
- Place of Presentation
  ホノルル(米国)
- Year and Date
  2015-12-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 翻訳系複素環ペプチド生合成遺伝子群の覚醒と新奇抗生物質生産システムへの適応2014
- Author(s)
  尾仲宏康
- Organizer
  第7回生合成マシナリー公開シンポジウム
- Place of Presentation
  東京工業大学
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PUBLICLY-25108707
[Presentation] 翻訳系複素環ペプチド生合成遺伝子群の覚醒と新奇抗生物質生産システムへの適応2014
- Author(s)
  尾仲宏康
- Organizer
  第8回生合成マシナリー公開シンポジウム
- Place of Presentation
  東京大学薬学部大講堂
- Year and Date
  2014-12-05
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108707
[Presentation] 複合培養法：共培養を利用した放線菌からの天然物探索2014
- Author(s)
  尾仲宏康
- Organizer
  第７回北陸合同バイオシンポジウムin 越中八尾
- Place of Presentation
  富山市
- Year and Date
  2014-11-29
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 複合培養法：細胞間接触による二次代謝活性化を利用した天然物探索2014
- Author(s)
  尾仲宏康
- Organizer
  第20回天然薬物の開発と応用シンポジウム
- Place of Presentation
  東京大学弥生講堂
- Year and Date
  2014-11-05
- Invited
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] ゲノム探索が明らかにした新規32員環チオペプチド、ラクタゾールの構造と生合成2014
- Author(s)
  30.林昌平、尾﨑太郎、浅水俊平、尾仲宏康
- Organizer
  第５６回天然有機化合物討論会
- Place of Presentation
  高知市
- Year and Date
  2014-10-15
- Data Source
  KAKENHI-PUBLICLY-25108707
[Presentation] ミコール酸含有微生物との複合培養による Streptomyces属放線菌由来新規生物活性物質の探索2014
- Author(s)
  星野翔太郎、張驪駻、淡川孝義、脇本敏幸、尾仲宏康、阿部郁朗
- Organizer
  第20回天然薬物の開発と応用シンポジウム
- Place of Presentation
  東京大学弥生講堂
- Year and Date
  2014-11-05
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 異属細菌による放線菌二次代謝産物の誘導2014
- Author(s)
  浅水俊平、尾仲宏康
- Organizer
  日本農芸化学会関東支部例会
- Place of Presentation
  東京大学弥生講堂
- Year and Date
  2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] ミコール酸含有微生物との複合培養を用いたStreptomyces属放線菌由来新規生物活性物質の探索2014
- Author(s)
  星野翔太郎、張驪駻、淡川孝義、脇本敏幸、尾仲宏康、阿部郁朗
- Organizer
  東京大学生物生産工学研究センターシンポジウム
- Place of Presentation
  東京大学弥生講堂
- Year and Date
  2014-12-08
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] Combined induction: a fermentation method for heterologous secondary metabolite production in Streptomyces2013
- Author(s)
  Hiroyasu Onaka
- Organizer
  12. 1st European Conference on Natural Products: Research and Application
- Place of Presentation
  Frunkfurt　(Germany)
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 複合培養に応答するgodAプロモーター領域の解析2013
- Author(s)
  浅水俊平, 小野拓人, 林昌平, 尾﨑太郎, 尾仲宏康
- Organizer
  2013年度（第28回）日本放線菌学会大会
- Place of Presentation
  メルパルクホール（広島県）
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 翻訳系複素環ペプチド生合成遺伝子群の覚醒と新奇抗生物質生産システムへの適応2013
- Author(s)
  尾仲宏康
- Organizer
  生合成マシナリー第5回公開シンポジウム
- Place of Presentation
  北海道大学（北海道）
- Data Source
  KAKENHI-PUBLICLY-25108707
[Presentation] 微生物間相互作用が誘発する抗生物質生産機構2012
- Author(s)
  尾仲宏康
- Organizer
  AKPS共同研究報告会
- Place of Presentation
  北里大学薬学部コンベンションホール、東京
- Year and Date
  2012-12-13
- Invited
- Data Source
  KAKENHI-PUBLICLY-23108519
[Presentation] 放線菌二次代謝生合成の解明と活性化手法2012
- Author(s)
  尾仲宏康
- Organizer
  東京大学大学院農学生命科学研究科微生物潜在機能探索寄付講座開設記念シンポジウム「微生物機能の多様性」～東京大学のさまざまな部局における微生物研究～
- Place of Presentation
  東京大学弥生講堂、東京
- Year and Date
  2012-11-28
- Invited
- Data Source
  KAKENHI-PUBLICLY-23108519
[Presentation] Characterization of indolocarbazole biosynthetic enzymes in Streptomyces sp.TP-A02742011
- Author(s)
  尾仲宏康
- Organizer
  16th Japanese-German Workshop on Enzyme Technology
- Place of Presentation
  富山国際会議場
- Year and Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-22580089
[Presentation] 翻訳系を介した複素環含有ペプチド生合成機構を応用した抗生物質生産システムの構築2011
- Author(s)
  尾仲宏康
- Organizer
  文科省科研費補助金新学術領域研究「生合成マシナリー:生物活性物質構造多様性創出システムの解明と制御」第3回公開シンポジウム
- Place of Presentation
  東京大学農学部中島董一郎記念ホール
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PUBLICLY-23108519
[Presentation] 放線菌由来インドロカルバゾール生合成酵素群の反応機構2011
- Author(s)
  尾仲宏康
- Organizer
  酵素工学研究会講演会
- Place of Presentation
  酵素工学研究会
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-22580089
[Presentation] Biosynthesis and genetic engineering of goadsporin, a ribosomal synthesized oxazole and thiazole containing peptide (TOPs) produced by Streptomyces sp.TP-A05842011
- Author(s)
  Hiroyasu Onaka
- Organizer
  ESF-EMBO Symposium, Synthetic Biology of Antibiotic Production
- Place of Presentation
  Sant Feliu de Guixols, Spain
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PUBLICLY-23108519
[Presentation] 翻訳系を介した複素環含有ペプチド生合成機構を応用した抗生物質生産システムの構築2011
- Author(s)
  尾仲宏康
- Organizer
  文科省科研費補助金新学術領域研究「生合成マシナリー:生物活性物質構造多様性創出システムの解明と制御」第2回公開シンポジウム
- Place of Presentation
  東京大学山上会館
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PUBLICLY-23108519
[Presentation] 放線菌由来ヘテロ環含有抗生物質の生合成に関する分子生物学的研究2010
- Author(s)
  尾仲宏康
- Organizer
  日本農芸化学会中部支部会例会(20年度日本農芸化学奨励賞受賞講演)
- Place of Presentation
  静岡市
- Year and Date
  2010-05-30
- Data Source
  KAKENHI-PROJECT-22580089
[Presentation] 放線菌由来ヘテロ環含有抗生物質の生合成に関する分子生物学的研究2010
- Author(s)
  尾仲宏康
- Organizer
  日本農芸化学会中部支部会例会
- Place of Presentation
  静岡市
- Year and Date
  2010-05-30
- Data Source
  KAKENHI-PROJECT-22580089
[Presentation] 翻訳系複素環ペプチド生合成遺伝子群の覚醒と新奇抗生物質生産システムへの適応
- Author(s)
  尾仲宏康
- Organizer
  生合成マシナリー第6回公開シンポジウム
- Place of Presentation
  千葉大学（千葉県）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25108707
[Presentation] Combined induction: effective fermentation procedure for heterologous secondary metabolite production in actinomycetes
- Author(s)
  Hiroyasu Onaka, Yukiko Mori, Masumi Izawa, Shohei Hayashi
- Organizer
  12th International Symposium on the Genetics of Industrial Microorganisms
- Place of Presentation
  Cancun (Mexico)
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 放線菌における潜在的抗生物質生産能力の覚醒技術
- Author(s)
  尾仲宏康
- Organizer
  発酵と代謝研究会シンポジウム「放線菌によるヒト･動物医薬と農薬への貢献－探索と選抜、機能解析から新規開拓へ－」
- Place of Presentation
  東京大学（東京都）
- Invited
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 複合培養を用いたStreptomyces属放線菌由来新規二次代謝産物の探索
- Author(s)
  星野翔太郎、張驪駻、淡川孝義、脇本敏幸、尾仲宏康、阿部郁朗
- Organizer
  日本薬学会第135年会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 5-Alkyl-1,2,3,4-tetrahydroquinolines, membrane-interacting lipophilic metabolites, found in combined-culture of Streptomyces sp. HEK616 and Tsukamurella pulmonis
- Author(s)
  Ryosuke Sugiyama, Shinichi Nishimura, Taro Ozaki, Hiroyasu Onaka and Hideaki Kakeya
- Organizer
  Natural Product Discovery and Development in the Post Genomic Era
- Place of Presentation
  SanDiego（アメリカ）
- Year and Date
  2015-01-11 – 2015-01-14
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] "Combined culture" and "combined induction": Activation of sleeping enzymatic genes involved in the secondary metabolism of actinomycetes
- Author(s)
  Hiroyasu Onaka
- Organizer
  17th German-Japanese Workshop on Enzyme Technology
- Place of Presentation
  Hamburg (Germany)
- Invited
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 微生物同士の接触刺激による抗生物質生産機
- Author(s)
  尾仲宏康
- Organizer
  第21回農芸化学Frontiersシンポジウム
- Place of Presentation
  デュープレックスホテル（茨城県）
- Invited
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] Genome mining reveals a minimum gene set for the biosynthesis of lactazoles, novel 32-membered macrocyclic thiopeptides
- Author(s)
  37.Shohei Hayashi, Taro Ozaki, Shumpei Asamizu, Hiroyasu Onaka
- Organizer
  Natural Product Discovery and Development in the Post Genomic Era
- Place of Presentation
  SanDiego
- Year and Date
  2015-01-11 – 2015-01-15
- Data Source
  KAKENHI-PUBLICLY-25108707
[Presentation] ミコール酸含有微生物との複合培養を用いた、放線菌Streptomyces属由来新規生物活性物質の探索
- Author(s)
  星野翔太郎、張驪駻、淡川孝義、脇本敏幸、尾仲宏康、阿部郁朗
- Organizer
  日本生薬学会第61回年会
- Place of Presentation
  福岡大学
- Year and Date
  2014-09-13 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] ミコール酸含有細菌との複合培養を用いた、Streptomyces属放線菌由来新規生物活性物質の探索
- Author(s)
  星野翔太郎、張驪駻、淡川孝義、脇本敏幸、尾仲宏康、阿部郁朗
- Organizer
  第4回 CSJ化学フェスタ2014
- Place of Presentation
  江戸川区
- Year and Date
  2014-10-14 – 2014-10-16
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] Combined induction: a fermentation method for heterologous secondary metabolite production in Streptomyces
- Author(s)
  Hiroyasu Onaka, Shumpei Asamizu, Taro Ozaki
- Organizer
  17th International symposium on biology of actinomycetes
- Place of Presentation
  Kusadasi, Turkey
- Year and Date
  2014-10-08 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] ミコール酸含有微生物Tsukamurella pulmonisとの複合培養による、放線菌Streptomyces属由来新規生物活性物質の探索
- Author(s)
  星野翔太郎、張驪駻、淡川孝義、脇本敏幸、尾仲宏康、阿部郁朗
- Organizer
  第29回日本放線菌学会大会
- Place of Presentation
  つくば市
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 複合培養を利用した新規テトラヒドロキノリン類の単離とその生合成に関する研究
- Author(s)
  尾崎太郎、杉山龍介、西村慎一、浅水俊平、掛谷秀昭、尾仲宏康
- Organizer
  第29回日本放線菌学会大会
- Place of Presentation
  つくば市
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] 死細胞は放線菌の二次代謝を複合培養において誘導しない
- Author(s)
  浅水俊平、尾崎太郎、尾仲宏康
- Organizer
  第29回日本放線菌学会大会
- Place of Presentation
  つくば市
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-25292046
[Presentation] Secondary metabolites induction by mycolic acid-containing bacteria in Streptomyces
- Author(s)
  Shumpei Asamizu, Taro Ozaki, Hiroyasu Onaka
- Organizer
  Natural Product Discovery and Development in the Post Genomic Era
- Place of Presentation
  SanDiego（アメリカ）
- Year and Date
  2015-01-11 – 2015-01-14
- Data Source
  KAKENHI-PROJECT-25292046

1. KATO Yasuo (20254237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. OGITA Shinjiro (50363875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KAWAKAMI Tomonori (10249146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Ulanova Dana (70610129)

# of Collaborated Projects: 1 results

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5. 宮本憲二 (60360111)

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# of Collaborated Products: 1 results
6. 菅裕明 (00361668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 後藤佑樹 (70570604)

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8. 諸野祐樹 (30421845)

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9. 若松泰介 (60597938)

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10. 濱野吉十 (50372834)

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11. 谷口浩二 (20627020)

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12. 山中一也 (30756870)

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13. 松森信明 (50314357)

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14. WAKIMOTO Toshiyuki

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# of Collaborated Products: 2 results
15. AWAKAWA Takayoshi

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16. OZAKI Taro

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17. 掛谷秀昭

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18. 池田治生

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19. 永野真吾

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20. 浅水俊平

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21. 緒方一博

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22. 浜田恵輔

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23. 仙石徹

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Onaka Hiroyasu 尾仲 宏康

ONAKA Hiroyasu 尾仲 宏康

尾仲 宏康 オナカ ヒロヤス

Research Projects

Research Products

Co-Researchers

中分子創薬を目指した特異的結合RiPPs創製への予知生合成Principal Investigator

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Exploration of Lipid-Binding Natural Products Using Lipid-Immobilized Beads and their Utilization

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生物活性中高分子の革新的細胞内送達技術による細胞生理機能の制御

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中分子創薬を目指した創薬ターゲット特異的結合RiPPsアナログの創出Principal Investigator

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Expanding the structural diversity of RiPPs (Ribosomally synthesized and post-translationally modified peptide)Principal Investigator

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Using terpenes as a key to unlock "Black box" of microbial interactions in subseafloor

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the mode of action in the combined-culture methods that induce potential secondary metabolismPrincipal Investigator

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Synthetic biology of pseudo-natural products by artificial in vitro biosynthesis

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翻訳系複素環ペプチド生合成遺伝子群の覚醒と新奇抗生物質生産システムへの適応Principal Investigator

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Secondary metabolite Screening by combined-culturePrincipal Investigator

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翻訳系を介した複素環含有ペプチド生合成機構を応用した抗生物質生産システムの構築Principal Investigator

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Characterization of indolocarbazole biosynthetic enzymes; for the application toPrincipal Investigator

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Expression of microbial enzymes in aquatic plants and their applications for phytoremediation and production of useful chemicals.

Principal Investigator

Onaka Hiroyasu 尾仲宏康

ONAKA Hiroyasu 尾仲宏康

尾仲宏康オナカヒロヤス