kobayashi michiyo 小林美智代

… Alternative Names

Michiyo Kobayashi 小林美智代

KOBAYASHI Michiyo 小林美智代

小林美智代コバヤシミチヨ

Less

Researcher Number	80316265
Other IDs
Affiliation (Current)	2025: 奥羽大学, 歯学部, 講師
Affiliation (based on the past Project Information) *help	2025: 奥羽大学, 歯学部, 講師 2016 – 2023: 奥羽大学, 歯学部, 講師 2013: 北海道大学, 理学部, その他 2013: 北海道大学, 理学部, 特任助教 2012 – 2013: 北海道大学, その他部局等, その他 … More 2011 – 2012: 北海道大学, 創成研究機構, 特任助教 2010 – 2011: 北海道医療大学, 歯学部, 助教 2006 – 2008: Health Sciences University of Hokkaido, 歯学部, 助教 2005 – 2008: 北海道医療大学, 歯学部, 助手 2003: 北海道医療大学, 歯学部, 助手 2002: 北海道医療大学, 歯学部・口腔衛生学講座, 助手 2001: 北海道医療大学, 歯学部・口腔衛生学, 助手 2000: 北海道医療大学, 歯学部, 助手 Less
Review Section/Research Field	Principal Investigator Pathobiological dentistry/Dental radiology / Basic Section 59040:Nutrition science and health science-related / 矯正・小児・社会系歯学 / Basic Section 57060:Surgical dentistry-related / Eating habits Except Principal Investigator Basic Section 57080:Social dentistry-related / Basic Section 57060:Surgical dentistry-related / Surgical dentistry / Orthodontic/Pediatric dentistry / Pathobiological dentistry/Dental radiology
Keywords	Principal Investigator Osteoprotegerin / RANKL / 血管内皮細胞 / osteoprotegerin / Candida albicans / 炎症 / 感染 / 免疫 / Porphyromonas gingivalis / ラクトフェリン … More / ACE2 / TMPRSS2 / SARS-CoV-2 / candida albicans / RANK / 日和見感染症 / Endothelial cells / Integrin αvβ / 細胞死 / インテグリン / トロンビン / 炎症性サイトカイン / オステオプロテゲリン / OPG / HUVEC / MCP-1 / IL-8 / endothelial cells / protease / chemokines … More Except Principal Investigator 血管内皮細胞 / インテグリン / SARS-CoV-2 / インターフェロンλ / poly(I:C) / ラクトフェリン / 幹細胞マーカー / ヒト口腔癌癌細胞株 / RNA編集酵素 / ADAR1 / 上皮ー間葉転換 / スフェロイド形成細胞 / 上皮ー間葉転換誘導 / RNA編集酵素ADAR1 / スフェロイド形成 / 癌幹細胞 / 上皮間葉移行関連分子 / 腫瘍抑制 / MMP-9 / 浸潤性 / 口腔扁平上皮癌細胞 / miRNA制御 / 自然免疫分子 / 血管新生制御機構 / ヒトカセリシジン / hCAP18 / LL-37 / 抗菌ペプチド / 抗腫瘍効果 / 自然免疫 / カセリシジン / 血管新生 / IL-6 / オステオプロテグリン(OPG) / TNFα / 伸展刺激 / マトリックス / オステオプロテゲリン / Gingipain / Osteprotegerin / Porphyromonas gingivalis / Osteoprotegerin Less

SARS-CoV-2変異株の侵入様式に着眼したラクトフェリンによる新規感染予防法の基礎検討Principal Investigator
- Principal Investigator
  
  小林美智代
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Ohu University
免疫系に働きかけるラクトフェリン機能発現の解明と高齢者ウイルス感染制御への展開
- Principal Investigator
  
  廣瀬公治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Ohu University
ラクトフェリンと自然免疫受容体に着目したSARS-CoV-2感染制御機構の解明Principal Investigator
- Principal Investigator
  
  小林美智代
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Ohu University
Targeting therapy of oral cancer stem cell renewal by RNA editing enzyme
- Principal Investigator
  
  Okumura Kazuhiko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Health Sciences University of Hokkaido
RANK/RANKL/OPG signaling upregulates IL-10 -regulated anti-inflammatory response during Candida albicans InfectionPrincipal Investigator
- Principal Investigator
  
  Kobayashi Michiyo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Ohu University
An increase in serum osteoprotegerin is a marker of the onset of Candida albicans infection and may contribute to endothelial cell dysfunctionPrincipal Investigator
- Principal Investigator
  
  Michiyo Kobayashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Ohu University
同位体顕微鏡を用いた機能性食品の新しい腸管機能評価法の開発Principal Investigator
- Principal Investigator
  
  小林美智代
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Hokkaido University
Study of miRNA regulatory systems of antitumor effects by human cathelicidin.
- Principal Investigator
  
  OKUMURA Kazuhiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Health Sciences University of Hokkaido
Characterization of osteoprotegerin-induced signaling in human endothelial cellsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Michiyo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Hokkaido University
  Health Sciences University of Hokkaido
Study of mechanical tensile stress effects on the synthesis of osteoprotegerin in microvascular endothelium
- Principal Investigator
  
  ISOGAI Emiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  Health Sciences University of Hokkaido
promotes proliferation and migration of human microvascular endothelial cellsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Michiyo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Health Sciences University of Hokkaido
歯周病における血管内皮細胞の骨吸収防御機構の解析
- Principal Investigator
  
  CHIBA Itsuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Health Sciences University of Hokkaido
歯周病原細菌が産生するプロテアーゼの血管内皮細胞障害に関する研究Principal Investigator
- Principal Investigator
  
  小林美智代
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  矯正・小児・社会系歯学
- Research Institution
  Health Sciences University of Hokkaido
歯周病原性細菌のヒト冠状動脈内皮細胞に対する病原性機構の解明Principal Investigator
- Principal Investigator
  
  小林美智代
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  矯正・小児・社会系歯学
- Research Institution
  Health Sciences University of Hokkaido

All 2024 2023 2022 2020 2018 2016 2011 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Bovine lactoferrin suppresses the cathepsin-dependent pathway of SARS-CoV-2 entry in?vitro2024
- Author(s)
  Kobayashi-Sakamoto Michiyo、Maeda Toyonobu、Yusa Junko、Shimada Takahisa、Tani Hideki、Kato Yasumasa、Hirose Kimiharu
- Journal Title
  
  International Dairy Journal
  
  Volume: 148 Pages: 105805-105805
- DOI
  10.1016/j.idairyj.2023.105805
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09929, KAKENHI-PROJECT-22K10344, KAKENHI-PROJECT-22K11783, KAKENHI-PROJECT-18K09642, KAKENHI-PROJECT-19K10074
[Journal Article] Lactoferrin as a Possible Preventive and Therapeutic Agent Against SARS-CoV-2 Infection2023
- Author(s)
  Kobayashi-Sakamoto M, Maeda T, Yusa J, Tani H, Kato Y, Hirose K
- Journal Title
  
  Journal of Disaster Research
  
  Volume: 18 Issue: 1 Pages: 27-33
- DOI
  10.20965/jdr.2023.p0027
- ISSN
  1881-2473, 1883-8030
- Year and Date
  2023-01-20
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10074, KAKENHI-PROJECT-22K09929, KAKENHI-PROJECT-22K10344, KAKENHI-PROJECT-22K11783
[Journal Article] Bovine lactoferrin increases the poly(I:C)-induced antiviral response in vitro2022
- Author(s)
  Kobayashi-Sakamoto M, Maeda T, Kimura M, Yusa J, Ito H, Tani H, Kato Y, Hirose K
- Journal Title
  
  Biochemistry and Cell Biology
  
  Volume: 100 Issue: 4 Pages: 338-348
- DOI
  10.1139/bcb-2021-0342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10074, KAKENHI-PROJECT-22K09929, KAKENHI-PROJECT-22K10344, KAKENHI-PROJECT-22K11783
[Journal Article] RANK-RANKL signaling upregulates Il-10 mRNA expression in mucosal Candida infection in vivo2020
- Author(s)
  Kobayashi-Sakamoto Michiyo、Maeda Toyonobu、Yusa Junko、Kato Yasumasa、Kiyoura Yusuke
- Journal Title
  
  Microbial Pathogenesis
  
  Volume: 149 Pages: 104285-104285
- DOI
  10.1016/j.micpath.2020.104285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09642, KAKENHI-PROJECT-19K10074, KAKENHI-PROJECT-19K10343
[Journal Article] Gastrointestinal colonisation and systemic spread of Candida albicans in mice treated with antibiotics and prednisolone.2018
- Author(s)
  Kobayashi-Sakamoto M, Tamai R, Isogai E, Kiyoura Y.
- Journal Title
  
  Microb Pathog.
  
  Volume: 117 Pages: 191-199
- DOI
  10.1016/j.micpath.2018.02.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11516
[Journal Article] 磯貝恵美子、秋葉敬斎、岡翔太、堀初弘、磯貝浩、小林美智代、奥村一彦2011
- Author(s)
  磯貝恵美子、秋葉敬斎、岡翔太、堀初弘、磯貝浩、小林美智代、奥村一彦
- Journal Title
  
  マダニデフェンシンの中腸由来細菌に対する抗菌活性、無菌生物
  
  Volume: 41 Pages: 113-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592938
[Journal Article] Anti-cell-associated glucosyltransferase immunoglobulin Y suppression of salivary mutans streptococci in healthy young adults2011
- Author(s)
  Nguyen SV, Icatlo FC Jr, Nakano T.Isogai E, Hirose K, Mizugai H, Kobayashi-Sakamoto M, Isogai H, Chiba I.
- Journal Title
  
  The Journal of the American Dental Association
  
  Volume: 142 Pages: 943-949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592097
[Journal Article] マダニデフェンシンの中腸由来細菌に対する抗菌活性2011
- Author(s)
  磯貝恵美子、秋葉敬斎、岡　翔太、堀　初弘、磯貝　浩、小林美智代、奥村一彦
- Journal Title
  
  無菌生物
  
  Volume: 41 Pages: 113-116
- NAID
  10029976308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592938
[Journal Article] マダニデフェンシンの中腸由来細菌に対する抗菌活性2011
- Author(s)
  磯貝恵美子、秋葉敬斉、関翔太、堀初弘、磯貝浩、小林美智代、奥村一彦
- Journal Title
  
  Journal of Germfree Life and Gnotobiology
  
  Volume: 41 Pages: 113-116
- NAID
  10029976308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592097
[Journal Article] Anti-glucosyltransferase IgY suppresses salivary mutans streptococci in volunteers2011
- Author(s)
  Nguyen SV., Icatlo FC Jr., Nakano T., Isogai E, Hirose K., Mizugai H., Kobayashi- SakamotoM ., IsgaiH , ChibaI
- Journal Title
  
  The Journal of the American Dental Association
  
  Volume: 142(8) Pages: 943-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592097
[Journal Article] Osteoprotegerin induces cytoskeletal reorganization and activates FAK, Src, and ERK signaling in endothelial cells.2010
- Author(s)
  Kobayashi-Sakamoto M, Isogai E, Holen I.
- Journal Title
  
  European Journal of Haematology
  
  Volume: 85(1) Pages: 26-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592097
[Journal Article] Osteoprotegerin induces cytoskeletal reorganization and activates FAK, Src, and ERK signaling in endothelial cells2010
- Author(s)
  Kobayashi -SakamotoM , IsogaiE. , Holen .I
- Journal Title
  
  European Journal of Haematology
  
  Volume: 85(1) Issue: 1 Pages: 26-35
- DOI
  10.1111/j.1600-0609.2010.01446.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592097
[Journal Article] Antimicrobial activity of three tick defensins and four mammalian cathelicidin-derived synthetic peptides against Lyme disease spirochetes and bacteria isolated from the midgut2009
- Author(s)
  Isogai, E., Isogai, H., Takahashi, K., Kobayashi-Sakamoto, M. & Okumura, K.
- Journal Title
  
  Exp Appl Acarol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592364
[Journal Article] Role of alpha(v) integrin in osteoprotegrin-induced endothelial cell migration and proliferation2008
- Author(s)
  Kobayashi-Sakamoto M
- Journal Title
  
  Microvasc Res 76
  
  Pages: 139-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592364
[Journal Article] Role of alphav integrin in osteoprotegerin-induced endothelial cell migration and proliferation2008
- Author(s)
  Kobayashi-Sakamoto, M., Isogai, E., Hirose, K. & Chiba, I.
- Journal Title
  
  Microvasc Res 76
  
  Pages: 139-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592364
[Journal Article] 歯科病院環境の真菌学的検討-病院環境におけるStachybotrys chartarum, Aspergillus niger, Chaetomium funicolaの分離2007
- Author(s)
  磯貝恵美子、小林美智代、奥村一彦、磯貝浩、榑林陽一、林俊治
- Journal Title
  
  環境感染 22(4)
  
  Pages: 260-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592364
[Journal Article] 歯科病院環境の真菌学的検討-病院環境におけるStachybotrys chartarum,Aspergillus niger,Chaetolmium funicolaの分離2007
- Author(s)
  磯貝恵美子, 小林美千代, 奥村一彦, 磯貝浩, 榑林陽一, 林俊治
- Journal Title
  
  環境汚染 22(4)
  
  Pages: 260-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592064
[Journal Article] 「研究成果報告書概要(欧文)」より2006
- Author(s)
  Kobayashi-Sakamoto M, Hirose K, Nishikata M, Isogai E, Chiba I
- Journal Title
  
  Osteoprotegerin protects endothelial cells against apoptotic cell death induced by Porphyromonas gingivalis cysteine proteinases, FEMS Microbiology Letters 264
  
  Pages: 238-245
- Data Source
  KAKENHI-PROJECT-18592064
[Journal Article] Osteoprotegerin protects endothelial cells against apoptotic cell death induced by Porphyromonas gingivalis cysteine proteinases.2006
- Author(s)
  Kobayashi-Sakamoto M, Hirose K, Nishikata M, Isogai E, Chiba I
- Journal Title
  
  FEMS Microbiology Letters 264
  
  Pages: 238-245
- Data Source
  KAKENHI-PROJECT-17659594
[Journal Article] Osteoprotegerin protects endothelial cells against apoptotic cell death induced by Porphyromonas gingivalis cysteine proteinaases.2006
- Author(s)
  Kobayashi-Sakamoto M, Hirose K, Nishikata M, Isogai E & Chiba I.
- Journal Title
  
  FEMS Microbiology Letters 264
  
  Pages: 238-245
- Data Source
  KAKENHI-PROJECT-18592064
[Journal Article] Osteoprotegerin protects endothelial cells against apoptotic cell death induced by Porphyromonas gingivalis cysteine proteinases2006
- Author(s)
  Kobayashi-Sakamoto M, Hirose K, Nishikata M, Isogai E, Chiba I
- Journal Title
  
  FEMS Microbiology Letters 264
  
  Pages: 238-245
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592064
[Presentation] ラクトフェリンによるSARS-CoV-2疑似ウイルス感染抑制の検討2023
- Author(s)
  小林美智代, 前田豊信, 遊佐淳子, 加藤靖正, 廣瀬公治
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K10344
[Presentation] 小腸様細胞株Caco-2におけるウシラクトフェリンの抗ウイルス作用解析2023
- Author(s)
  小林美智代、廣瀬公治
- Organizer
  第72回日本口腔衛生学会学術大会
- Data Source
  KAKENHI-PROJECT-22K10344
[Presentation] ラクトフェリンのSARS-CoV-2疑似ウイルス感染抑制は宿主細胞のTMPRSS2発現に依存する2023
- Author(s)
  小林美智代、前田豊信、遊佐淳子、谷英樹、加藤靖正、広瀬公治
- Organizer
  第12回東北口腔衛生学会・総会
- Data Source
  KAKENHI-PROJECT-22K10344
[Presentation] ラクトフェリンによるSARS-CoV-2疑似ウイルス感染抑制の検討2023
- Author(s)
  小林美智代, 前田豊信, 遊佐淳子, 加藤靖正, 廣瀬公治
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-22K11783
[Presentation] 小腸様細胞株Caco-2におけるウシラクトフェリンの抗ウイルス作用解析2023
- Author(s)
  小林美智代、廣瀬公治
- Organizer
  第72回日本口腔衛生学会学術大会
- Data Source
  KAKENHI-PROJECT-22K11783
[Presentation] ラクトフェリンのSARS-CoV-2疑似ウイルス感染抑制は宿主細胞のTMPRSS2発現に依存する2023
- Author(s)
  小林美智代、前田豊信、遊佐淳子、谷英樹、加藤靖正、広瀬公治
- Organizer
  第12回東北口腔衛生学会・総会
- Data Source
  KAKENHI-PROJECT-22K11783
[Presentation] In vitroにおけるラクトフェリン抗ウイルス作用の解析2022
- Author(s)
  小林美智代 , 前田豊信 , 遊佐淳子 , 加藤靖正 , 廣瀬公治
- Organizer
  第71回奥羽大学歯学会
- Data Source
  KAKENHI-PROJECT-22K10344
[Presentation] ラクトフェリンのヒト小腸様細胞株Caco-2に対する抗ウイルス作用の解析2022
- Author(s)
  小林美智代、前田豊信、谷英樹、加藤靖正、廣瀬公治
- Organizer
  第11回東北口腔衛生学会総会
- Data Source
  KAKENHI-PROJECT-22K11783
[Presentation] ラクトフェリンのヒト小腸様細胞株Caco-2に対する抗ウイルス作用の解析2022
- Author(s)
  小林美智代 , 前田豊信 , 谷英樹 , 加藤靖正 , 廣瀬公治
- Organizer
  第11回東北口腔衛生学会総会
- Data Source
  KAKENHI-PROJECT-22K10344
[Presentation] In vitroにおけるラクトフェリン抗ウイルス作用の解析2022
- Author(s)
  小林美智代、前田豊信、遊佐淳子、加藤靖正、廣瀬公治
- Organizer
  第71回奥羽大学歯学会
- Data Source
  KAKENHI-PROJECT-22K11783
[Presentation] 口腔カンジダ症モデルマウスにおけるCandida albicans の消化管定着と腎臓への移行2018
- Author(s)
  小林美智代、磯貝恵美子
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K11516
[Presentation] 口腔カンジダ症モデルマウスにおけるCandida albicansの腎臓への移行と血中マーカーの探索2018
- Author(s)
  小林美智代
- Organizer
  第62回日本医真菌学会・総会
- Data Source
  KAKENHI-PROJECT-16K11516
[Presentation] 口腔カンジタ症モデルマウスにおけるCandida albicans の全身臓器への移行2016
- Author(s)
  小林美智代　玉井利代子　清浦有祐
- Organizer
  第25回日本口腔感染症学会総会学術大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-16K11516
[Presentation] Cathelicidin antimicrobial peptide, LL-37 has proangiogenic and angiostatic activity in human microvascular endothelial cells.2011
- Author(s)
  Okumura K, Kobayashi-Sakamoto M, Taira H, Isogai E, Isogai H.
- Organizer
  International Union of Microbiological Societies (IUMS) 2011 Congress　XIII International Congress of Bacteriology and Applied Microbiology
- Place of Presentation
  Sapporo convention center, Hokkaido, Japan.
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] トロンビンは血管内皮細胞においてオステオプロテゲリンの産生を誘導する2011
- Author(s)
  小林美智代,広瀬公治,千葉逸朗
- Organizer
  第60回日本口腔衛生学会総会
- Place of Presentation
  日本大学松戸歯学部(松戸)
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] トロンビンは血管内皮細胞においてオステオプロテゲリンの産生を誘導する2011
- Author(s)
  小林美智代磯貝恵美子,瀬公治,.奥村一彦、千葉逸朗
- Organizer
  第32回日本炎症再生医学会
- Place of Presentation
  国立京都国際会館(京都)
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] Thrombin induces osteopritegrin production via phosphatidylinositol 3-kinase pathway in human microvascular endothelial cells.2011
- Author(s)
  Kobayashi-Sakamoto M, Isogai E, Hirose K, Okumura K, Holen I, Chiba I.
- Organizer
  10th World Congress on Inflammation
- Place of Presentation
  Palais des Congres, Paris, France
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] Thrombin induces osteoprotegerin production via the phosphatidylinositol 3-kinase pathway in human microvascular endothelial cells2011
- Author(s)
  Michiyo Kobayashi-sakamoto
- Organizer
  10th World Congress on Inflammation
- Place of Presentation
  France, Paris, Palais des Congres
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] トロンビンは血管内皮細胞においてオステオプロテゲリンの産生を誘導する2011
- Author(s)
  小林美智代
- Organizer
  第60回日本口腔衛生学会
- Place of Presentation
  千葉県、松戸市、日本大学松戸歯学部
- Year and Date
  2011-10-09
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] トロンビンは血管内皮細胞においてオステオプロテゲリンの産生を誘導する2011
- Author(s)
  小林美智代、磯貝恵美子、廣瀬公治、奥村一彦、千葉逸朗
- Organizer
  第32回日本炎症・再生医学会
- Place of Presentation
  国立京都国際会館、京都
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] Thrombin induces osteopritegrin production via phosphatidylinositol 3-kinase pathway in human microvascular endothelial cells2011
- Author(s)
  Kobayashi-Sakamoto M, Isogai E, Hirose K, Okumura K, Holen I, Chiba I
- Organizer
  10th World Congress on Inflammation
- Place of Presentation
  Palais des Congres, Paris, France
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] LL-37 induces angiostatic activity through FPRL1 in microvascular endothelial cells.2011
- Author(s)
  Okumura K, Sawada T, Kobayashi-Sakamoto M, Taira H, Isogai E, Isogai H.
- Organizer
  45th Meeting of the Continental European Division (CED) of IADR
- Place of Presentation
  Semmelweis University Theoretical Building, Budapest, Hungary
- Data Source
  KAKENHI-PROJECT-23592938
[Presentation] 血管内皮細胞におけるオステオプロテゲリンの役割とその作用機序の解明2010
- Author(s)
  小林美智代
- Organizer
  日本炎症再生医学会
- Place of Presentation
  京王プラザホテル(東京)
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] A Human Cathelicidin hCAP18 Inhibits Tube Formation in Endothelial Cells2010
- Author(s)
  Okumura K., Sawada N., Isogai E., Kobayashi-Sakamoto M.,Taira H., Shibata T., and Isogai H
- Organizer
  International and American Association for Dental Research
- Place of Presentation
  Centre de Convencions Internacional Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] Inhibition of angiogenesis and cell proliferation by royal jelly2010
- Author(s)
  Kobayashi D., Kobayashi-Sakamoto M., Isogai E., Hirose K., Holen .I. Chiba I
- Organizer
  International and American Association for Dental Research
- Place of Presentation
  Centre de Convencions Internacional Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] Characterization of osteoprotegerin-induced signalinguman in human endothelial cells2010
- Author(s)
  Michiyo Kobayashi-sakamoto
- Organizer
  International and American Association for Dental Research.
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2010-07-17
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] 血管内皮細胞におけるオステオプロテゲリンの役割とその作用機序の解明2010
- Author(s)
  小林美智代,磯貝恵美子,広瀬公治
- Organizer
  第31回日本炎症再生医学会
- Place of Presentation
  京王プラザホテル(東京)(2010)
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] inhibition of angiogenesis and cell proliferation by royal jelly2010
- Author(s)
  Daiji Kobayashi
- Organizer
  International and American Association for Dental Research.
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2010-07-17
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] Characterization of osteoprotegerin-induced signalinguman in human endothelial cells2010
- Author(s)
  Kobayashi-Sakamoto M., Isogai E.,Hirose K., Holen I., Chiba I
- Organizer
  International and American Association for Dental Research
- Place of Presentation
  Centre de Convencions Internacional Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-22592097
[Presentation] Osteoprotegerin-mediated cytoskeletal reorganization in microvascular endothelium2009
- Author(s)
  Kobayashi-Sakamoto M, Isogai, E, Hirose, K, Reid P, Chiba I, and Holen I
- Organizer
  IADR/AADR/CADR 87th General Session and Exhibition
- Place of Presentation
  Miami,USA
- Data Source
  KAKENHI-PROJECT-19592364
[Presentation] Role of αV integrin in osteoprotegerin-induced endothelial cell migration and proliferation2009
- Author(s)
  小林美智代
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19592364
[Presentation] Osteoprotegerin promotes proliferation and migration of human microvascular endothelial cells2008
- Author(s)
  小林美智代, 磯貝恵美子
- Organizer
  第57回日本口腔衛生学会総会,
- Place of Presentation
  大宮
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-19592364
[Presentation] Pathogenesis of skin lesions in Lyme disese2008
- Author(s)
  Isogai E, Isogai H, Takahashi K, Kobayashi-Sakamoto M,
- Organizer
  11^<th> International Conference on Lyme Borreliosis and other tick-borne diseases
- Place of Presentation
  Irvine, USA
- Data Source
  KAKENHI-PROJECT-19592364
[Presentation] Savage PBFunctional properties of cationic antimicrobial compounds on the neutrophils and endothelial cells2008
- Author(s)
  Isogai E ,Isogai H, Okumura K, Kobayashi-Salkamoto M, Kaneko F, Ohgami K, Ohno S
- Organizer
  13^<th> Int Conf for Behcet's disease
- Place of Presentation
  Klagenfult
- Data Source
  KAKENHI-PROJECT-19592364
[Presentation] Osteoprotegerin promotes proliferation and migration of human microvascular endothelial cells2008
- Author(s)
  小林美智代
- Organizer
  第57回日本口腔衛生学会総会
- Place of Presentation
  大宮
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-19592364
[Presentation] Osteoprotegerin promotes integrin αvβ3-dependnent endothelial cell migration2007
- Author(s)
  Kobayashi-Sakamoto M, Isogai E, Hirose K, Chiba I,
- Place of Presentation
  Glasgow, UK
- Data Source
  KAKENHI-PROJECT-19592364

1. ISOGAI Emiko (80113570)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
2. OKUMURA Kazuhiko (60194510)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. CHIBA Itsuo (50250460)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. HIROSE Kimiharu (10218836)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ARAKAWA Toshiya (40306254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 細川洋一郎 (70173599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 坂本直哉 (30466429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 谷英樹 (20397706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 前田豊信 (10382756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
10. Tamai Riyoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. Kiyoura Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 広瀬公治

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
13. 加藤靖正

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

kobayashi michiyo 小林 美智代

Michiyo Kobayashi 小林 美智代

KOBAYASHI Michiyo 小林 美智代

小林 美智代 コバヤシ ミチヨ

Research Projects

Research Products

Co-Researchers

SARS-CoV-2変異株の侵入様式に着眼したラクトフェリンによる新規感染予防法の基礎検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫系に働きかけるラクトフェリン機能発現の解明と高齢者ウイルス感染制御への展開

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ラクトフェリンと自然免疫受容体に着目したSARS-CoV-2感染制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting therapy of oral cancer stem cell renewal by RNA editing enzyme

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RANK/RANKL/OPG signaling upregulates IL-10 -regulated anti-inflammatory response during Candida albicans InfectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

An increase in serum osteoprotegerin is a marker of the onset of Candida albicans infection and may contribute to endothelial cell dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

同位体顕微鏡を用いた機能性食品の新しい腸管機能評価法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of miRNA regulatory systems of antitumor effects by human cathelicidin.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of osteoprotegerin-induced signaling in human endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of mechanical tensile stress effects on the synthesis of osteoprotegerin in microvascular endothelium

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

promotes proliferation and migration of human microvascular endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

歯周病における血管内皮細胞の骨吸収防御機構の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

歯周病原細菌が産生するプロテアーゼの血管内皮細胞障害に関する研究Principal Investigator

kobayashi michiyo 小林美智代

Michiyo Kobayashi 小林美智代

KOBAYASHI Michiyo 小林美智代

小林美智代コバヤシミチヨ