Igarashi Hideki 五十嵐秀樹

… Alternative Names

IGARASHI Hideki 五十嵐秀樹

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Researcher Number	80333970
Affiliation (Current)	2025: 山形大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2016 – 2018: 山形大学, 医学部, 講師 2008 – 2015: Yamagata University, 医学部, 助教 2006: 山形大, 医学部, 助手 2004 – 2005: 国立大学法人山形大学, 医学部, 助手 2003 – 2005: 山形大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology
Keywords	Principal Investigator マウス / 加齢 / 若返り / 小胞体ストレス / 加齢卵 / ATP / カルシウム / Salubrinal / 小胞体 / ミトコンドリア … More / salburinal / salubrinal / BiP / tunicamycin / thapsigargin / マウス卵 / 生殖医学 / 卵 / Ca^<2+>オシレーション … More Except Principal Investigator ミトコンドリア / 卵の加齢 / エストロゲン / Akt / PC12 / estrogen / IGF-1 / EGF / FRET / GFP / 分子生理学 / イオンチャネル / 子宮平滑筋 / 不妊症 / アポトーシス / 加齢マウス / エストロゲン受容体 / TFAM / Parkin / LC3 / マイトファジー / Potasium channel / Calcium channel / Pregnancy / Smooth muscle cells / Ion channels / Kチャネル / カルシウムチャネル / 妊娠 / telomerase / apoptosis / β-Amyloid / Alzheimer / raloxifene / 神経突起 / 黄体ホルモン / 神経細胞 / テロメラーゼ / ベータアミロイド / アルツハイマー病 / ラロキシフェン / growth factor / selective estrogen receptor modulator (SERM) / SERM / 成長因子 / 選択的エストロゲン受容体モジュレーター(SERM) / Molecular physiology / Ion channel / Myometrium / ピルビン酸脱水素酵素 / カルニチン / 脂肪酸 / ベータ酸化 / リピドミクス / 酸化ストレス / メタボローム / カルシウムオシレーション / 細胞内カルシウム / ATP / 細胞内カルシウム制御機構 / オートファジー / メタボロミクス / 共焦点レーザー顕微鏡 / 蛍光顕微鏡 / AF-2ドメイン / 変異遺伝子 / 転写制御 / GFPキメラ蛋白 / 核内分布 / シグナル伝達 / 欠失変異 / インスリン様増殖因子(IGF)-1 / 上皮成長因子(EGF) Less

Development of a new treatment for the deterioration of egg quality by aging based on mitochondrial quality control
- Principal Investigator
  
  Takahashi Toshifumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fukushima Medical University
Therapeutic strategy for reproductive aged women by regulation of oxidative stress and endoprasmic reticulum stressPrincipal Investigator
- Principal Investigator
  
  IGARASHI Hideki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Development of treatment strategy for age-related decline in oocyte quality by analyzing lipid metabolism
- Principal Investigator
  
  Takahashi Toshifumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Molecular mechanism of aging-related decline in oocyte quality: a study of metabolomics and autophagy
- Principal Investigator
  
  TAKAHASHI Toshifumi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Study of rejuvenation of aged oocyte "Aim at the establishment of the strategy of a new fertility treatment"Principal Investigator
- Principal Investigator
  
  IGARASHI Hideki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
卵の質の改善を目的とした体細胞ミトコンドリア自家移植法の開発Principal Investigator
- Principal Investigator
  
  五十嵐秀樹
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Study ofion channels involved in uterine smooth muscle cells contraction by using molecular physiological approach
- Principal Investigator
  
  TAKAHASHI Toshifumi, 手塚尚広
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
リガンド依存性・非依存性のエストロゲン受容体活性化と核内分布変化を可視化する試み
- Principal Investigator
  
  KURACHI Hirohisa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Anti-apoptotic effect of SERM on the amyloid-β-induced apoptosis in PC12
- Principal Investigator
  
  TAKAHASHI Kazuhiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
加齢マウスモデルを用いた卵の若返りに関する研究Principal Investigator
- Principal Investigator
  
  五十嵐秀樹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
Crosstalk between estrogen receptor and transcriptional factors in the presence of SERM
- Principal Investigator
  
  KOJIMAHARA Takanobu, 高橋俊文
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
DYNAMICS OF ION CHANNEL EXPRESSION IN PREGNANT RAT MYOMETRIUM : ANALYSIS MOLECULAR PHYSIOLOGICAL
- Principal Investigator
  
  TEZUKA Naohiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University

All 2017 2016 2015 2011 2010 2008 2005 Other

All Journal Article Presentation

[Journal Article] Poor embryo development in post-ovulatory in vivo-aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenation.2016
- Author(s)
  Igarashi H, Takahashi T, Abe H, Nakano H, Nakajima O, Nagase S
- Journal Title
  
  Human Reproduction
  
  Volume: 31 Issue: 10 Pages: 2331-2338
- DOI
  10.1093/humrep/dew203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462474, KAKENHI-PROJECT-16K11080, KAKENHI-PROJECT-16H03189
[Journal Article] Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies2015
- Author(s)
  Igarashi, Hideki Takahashi, Toshifumi Nagase, Satoru
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 14 Issue: 4 Pages: 159-169
- DOI
  10.1007/s12522-015-0209-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462474
[Journal Article] Cellular and molecular mechanisms of various types of oocyteaging2011
- Author(s)
  Takahashi T, Igarashi H, Amita M, Hara S, Kurachi H.
- Journal Title
  
  Reprod Med Biol
  
  Volume: 10 Issue: 4 Pages: 239-249
- DOI
  10.1007/s12522-011-0099-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591815
[Journal Article] Usefulness of Bezafibrate for Ovulation Induction in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome Patients with Dyslipidemia : A Prospective Pilot study of Seven Cases.2010
- Author(s)
  Hara S, Takahashi T, Amita M, Igarashi H, Kurachi H
- Journal Title
  
  Gynecol Obstet Invest. 16
  
  Pages: 166-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591905
[Journal Article] Roles of prostagrandins during oocytes maturation : lessons from knockout mice.2010
- Author(s)
  Takahashi T, Igarashi H, Amita M, Hara S, Kurachi H
- Journal Title
  
  J Mamm Ova Res 27
  
  Pages: 11-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591905
[Journal Article] Usefulness of Bezafibrate for Ovulation Induction in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome Patients with Dyslipidemia : A Prospective Pilot Study of Seven Cases.2010
- Author(s)
  Shuichiro Hara, Toshifumi Takahashi, Mitsuyoshi Amita, Hideki Igarashi, Hirohisa Kurachi
- Journal Title
  
  Gynecol Obstet Invest.
  
  Volume: 70 Pages: 166-172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591905
[Journal Article] Aged Mouse Oocytes Fail to Readjust Intracellular Adenosine Triphosphates at Fertilization2005
- Author(s)
  Hideki Igarashi et al.
- Journal Title
  
  Biology of Reproduction (in press)
- Data Source
  KAKENHI-PROJECT-15790875
[Journal Article] Aged Mouse Oocytes Fail to Readjust Intracellular Adenosine Triphosphates at Fertilization2005
- Author(s)
  Hideki Igarashi
- Journal Title
  
  Biology of Reproduction 72
  
  Pages: 1256-1261
- Data Source
  KAKENHI-PROJECT-17791102
[Journal Article] Growth factors change nuclear distribution of estrogen receptor-α via mitogen-activated protein kinase or phosphatidylinositol 3-kinase cascade in a human breast cancer cell line.2005
- Author(s)
  Takahashi T, Ohmichi M, Kawagoe J, Ohshima C, Doshida M, Ohta T, Saitoh M, Mori-Abe A, Du B, Igarashi H, Takahashi K, Kurachi H
- Journal Title
  
  Endocrinology 146(9)
  
  Pages: 4082-4089
- Data Source
  KAKENHI-PROJECT-16659444
[Journal Article] Molecular mechanism of poor embryo development in postovulatory aged oocytes
- Author(s)
  Takahashi T, Igarashi H, Amita M, Hara S, Koki M, Kurachi H.
- Journal Title
  
  Mini review
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591815
[Presentation] Mitochondrial transfer from somatic cells is not sufficient for rejuvenation of postovulatory in vivo-aged mouse oocytes2017
- Author(s)
  Igarashi H, Takahashi T, Abe H, Nakano H, Nakajima O, Nagase S, Kyono K
- Organizer
  The 7th Congress of Asia Pacific Initiative on Reproduction
- Place of Presentation
  Kuala Lumpur, Malaysia, Kuala Lumpur Convention Centre
- Year and Date
  2017-03-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462474
[Presentation] MITOCHONDRIAL TRANSFER FROM SOMATIC CELLS IS NOT SUFFICIENT FOR REJUVENATION OF POSTOVULATORY IN VIVOAGED MOUSE OOCYTES2017
- Author(s)
  Igarashi H, Takahashi T, Abe H, Nakano H, Nakajima O, Nagase S, Kyono K
- Organizer
  The 7th Congress of the Asia Pacific Initiative on Reproduction
- Place of Presentation
  Kuala Lumpur Convention Center, Kuala Lumpur, Malaysia
- Year and Date
  2017-03-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11080
[Presentation] 卵加齢メカニズムの新しい概念:マウス卵の加齢に小胞体ストレスが関与する2011
- Author(s)
  五十嵐秀樹、網田光善、原周一郎、堤誠司、高橋俊文、倉智博久
- Organizer
  第63回日本産科婦人科学会
- Place of Presentation
  リーガロイヤルホテル大阪および大阪国際会議場(大阪市)
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22591815
[Presentation] 卵の加齢メカニズムにおける小胞体ストレスの関与についての検討2011
- Author(s)
  五十嵐秀樹、高橋俊文、原周一郎、松尾幸城、倉智博久
- Organizer
  第56回日本生殖医学会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-22591815
[Presentation] マウス加齢卵における卵の質の改善を目的としたミトコンドリア移植の試み.2008
- Author(s)
  五十嵐秀樹、高橋俊文、網田光善、倉智博久
- Organizer
  第49回日本哺乳動物卵子学会
- Place of Presentation
  名古屋
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-20591905
[Presentation] マウス加齢卵におけるミトコンドリア機能の評価とミトコンドリア移植の試み2008
- Author(s)
  五十嵐秀樹、高橋俊文、網田光善、倉智博久
- Organizer
  第53回日本生殖医学会総会・学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-20591905
[Presentation] Impact of endoplasmic reticulum stress on the postovulatory aging of the mouse oocyte
- Author(s)
  H. Igarashi, T. Takahashi, M. Amita, A. Hasegawa
- Organizer
  ASRM 2014
- Place of Presentation
  Hawaii Convention Center (Honolulu, Hawaii)
- Year and Date
  2014-10-18 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-26462474

1. TAKAHASHI Toshifumi (20302292)

# of Collaborated Projects: 9 results

# of Collaborated Products: 14 results
2. KURACHI Hirohisa (40153366)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
3. TSUTSUMI Seiji (50323168)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TAKAHASHI Kazuhiro (20292427)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. AMITA Mitsuyoshi (30420061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. TEZUKA Naohiro (60261690)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KOJIMAHARA Takanobu (20344806)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. HARA Shuichiro (10436230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MATSUO Koki (90594317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ABE Akiko (30359567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中原健次 (80250934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大道正英 (10283764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 菅沼亮太 (30528211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Igarashi Hideki 五十嵐 秀樹

IGARASHI Hideki 五十嵐 秀樹

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Therapeutic strategy for reproductive aged women by regulation of oxidative stress and endoprasmic reticulum stressPrincipal Investigator

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Study of rejuvenation of aged oocyte "Aim at the establishment of the strategy of a new fertility treatment"Principal Investigator

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卵の質の改善を目的とした体細胞ミトコンドリア自家移植法の開発Principal Investigator

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加齢マウスモデルを用いた卵の若返りに関する研究Principal Investigator

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[Journal Article] Poor embryo development in post-ovulatory in vivo-aged mouse oocytes is associated with mitochondrial dysfunction, but mitochondrial transfer from somatic cells is not sufficient for rejuvenation.2016

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[Journal Article] Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies2015

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[Journal Article] Cellular and molecular mechanisms of various types of oocyteaging2011

Igarashi Hideki 五十嵐秀樹

IGARASHI Hideki 五十嵐秀樹