HIRANO Mayumi 平野真弓

Researcher Number	80336031
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2017: 九州大学, 医学研究院, 助教 2015: 九州大学, 大学院医学研究院, 助教 2011 – 2015: 九州大学, 医学(系)研究科(研究院), 助教 2013: 九州大学, 大学院医学研究院, 助教 2008 – 2010: Kyushu University, 大学院・医学研究院, 助教 2006: Kyushu University, Graduate School of Medical Sciences, Research Associate, 大学院医学研究院, 助手 2002 – 2005: 九州大学, 大学院・医学研究院, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Cardiovascular medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Applied pharmacology
Keywords	Principal Investigator 血管内皮細胞 / 内皮細胞 / ミオシン軽鎖リン酸化 / Rac1 / growth arrest / transcription activity / promoter region / cell-cell contact / 転写活性 / 脱感作障害 … More / バリアー機能障害 / トロンビン受容体 / 血管透過性 / トロンビン / 血管平滑筋細胞 / アクチンストレスファイバー / Rhoキナーゼ / 血管病 / 凝固因子XI / 血管バリアー機能障害 / プロテイナーゼ活性化型受容体１ / 肺高血圧症 / アクチン / 内皮バリアー障害 / プロテイナーゼ活性化型受容体(PAR1) / small G protein / p27^<Kip1> / Vascular endothelial cells / アポトーシス / Kip1遺伝子 / 低分子量G蛋白質 / KIP^1遺伝子 / 細胞間接触 / p27^<Kip1> gene / vascular endothelial cells / 増殖停止 / プロモーター領域 / p27^<Kip1>遺伝子 / 細胞間接着 / 受容体発現亢進 / アクチン繊維束 / 平滑筋細胞A7r5 / 動脈硬化 / 平滑筋細胞 / 脱感作 / 受容体 / ミオシン軽鎖リン酸 / 細胞質Ca^<2+>濃度 / G蛋白質 / Rhaキナーゼ / プロテイナーゼ活性化型受容体 / 内皮細胞の透過性 / 分子血管病態学 … More Except Principal Investigator 受容体 / トロンビン / シグナル伝達 / 血管平滑筋細胞 / 血管内皮細胞 / VASCULAR DISEASES / NITRIC OXIDE / VASCULAR TONE / VASCULAR SMOOTH MUSCLE / VASCULAR ENDOTHELIAL CELLS / RECEPTOR / PROTEINASE / THROMBIN / 増殖 / プロテアーゼ / 平滑筋 / 血管 / 血管スパズム / 発現 / プラスミン / 血管病 / 一酸化窒素 / 血管トーヌス / プロテイナーゼ / 脳血管攣縮 / 酸化ストレス / 蛋白質リン酸化反応 / 不可逆的活性 / 受容体脱感作機構 / トロンビン受容体 / 平滑筋細胞 / 活性酸素 / 蛋白質リン酸化 / 細胞内カルシウムシグナル / ミオシン軽鎖リン酸化 / 内皮バリアー機能 / 脱感作障害 / 肺高血圧症 / 受容体拮抗薬 / モデル動物 / 肺高血圧 Less

Elucidation of the molecular mechanism underlying the vascular dysfunction mediated by proteinase-activated receptor 1Principal Investigator
- Principal Investigator
  
  Hirano Mayumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyushu University
Development of innovative and ultimate strategies for the treatment of cerebral vasospams with thrombin receptor as a therapeutic target
- Principal Investigator
  
  Hirano Katsuya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Kagawa University
Development of new therapeutic strategies for the treatment of atherosclerosis based on the elucidation of molecular mechanisms underlying dysregulation of signaling activity of thrombin receptorPrincipal Investigator
- Principal Investigator
  
  HIRANO Mayumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Elucidation of roles of proteinase-activated receptor in pulmonary hypertension and development of new therapeutic strategies
- Principal Investigator
  
  HIRANO Katsuya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Role of endothelial proteinase-activated receptors in the early phase of the development of vascular lesions.Principal Investigator
- Principal Investigator
  
  HIRANO Mayumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Role of proteinase-activated receptors in the dysregulation of vascular tone and the enhancement of the proliferative state in vascular lesions
- Principal Investigator
  
  HIRANO Katsuya
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERCITY
Elucidation of the Intracellular Signaling Networks Involved in the Proliferation and Functional Differentiation Induced by Cell-cell Contact in Vascular Endothelial Cells.Principal Investigator
- Principal Investigator
  
  HIRANO Mayumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Elucidation of the Intracellular Signal Networks Involved in the Growth Arrest induced by Cell-cell Contact in Vascular Endothelial CellsPrincipal Investigator
- Principal Investigator
  
  HIRANO Mayumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University

[Book] Diagnosis treatment of pulmonary hypertension - From bench to bedside2016
- Author(s)
  Hirano K
- Publisher
  The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension
- Data Source
  KAKENHI-PROJECT-26670271
[Journal Article] Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption.2016
- Author(s)
  Hirano M, Hirano K
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 20989-20989
- DOI
  10.1038/srep20989
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09159, KAKENHI-PROJECT-26670271
[Journal Article] プロテイナーゼ活性化型受容体の血管生物学2016
- Author(s)
  平野勝也
- Journal Title
  
  医学のあゆみ
  
  Volume: 256 Pages: 489-494
- Data Source
  KAKENHI-PROJECT-26670271
[Journal Article] 血管平滑筋機能とカルシウム2015
- Author(s)
  平野勝也
- Journal Title
  
  CLINICAL CALCIUM
  
  Volume: 25 Pages: 59-69
- Data Source
  KAKENHI-PROJECT-26670271
[Journal Article] 脳血管攣縮における細胞膜受容体の活性制御異常：トロンビン受容体PAR1の役割2014
- Author(s)
  平野勝也
- Journal Title
  
  血管
  
  Volume: 37 Pages: 125-134
- Data Source
  KAKENHI-PROJECT-26670271
[Journal Article] プロテイナーゼ活性化型受容体を標的とした肺高血圧治療の可能性2014
- Author(s)
  平野勝也
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 163 (4) Pages: 182-186
- Data Source
  KAKENHI-PROJECT-23591104
[Journal Article] 肺高血圧症の薬物治療の最前線:序文2014
- Author(s)
  平野勝也、渡邉裕司
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 143 (4) Pages: 163-164
- Data Source
  KAKENHI-PROJECT-23591104
[Journal Article] トロンビン受容体を標的とした脳血管攣縮予防2014
- Author(s)
  平野勝也、平野真弓
- Journal Title
  
  日本臨牀(増刊号5：最新臨床脳卒中学上)
  
  Volume: 72 Pages: 433-437
- Data Source
  KAKENHI-PROJECT-26670271
[Journal Article] トロンビン受容体を標的とした脳血管攣縮予防2014
- Author(s)
  平野勝也、平野真弓
- Journal Title
  
  日本臨牀72
  
  Volume: 増刊号5 Pages: 433-437
- Data Source
  KAKENHI-PROJECT-24591118
[Journal Article] Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility.2013
- Author(s)
  Saito T, Hirano M, Ide T, Ichiki T, Koibuchi N, Sunagawa K, Hirano K.
- Journal Title
  
  Circulation.
  
  Volume: 127 Issue: 1 Pages: 104-114
- DOI
  10.1161/circulationaha.112.135608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23220013, KAKENHI-PROJECT-23591104, KAKENHI-PROJECT-24591118, KAKENHI-PROJECT-25281024
[Journal Article] Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid hemorrhage.2011
- Author(s)
  Kameda K, Kikkawa Y, Hirano M, Matsuo S, Sasaki T, Hirano K
- Journal Title
  
  Br J Pharmacol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590883
[Journal Article] トロンビン受容体拮抗薬2011
- Author(s)
  平野勝也
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 138 (6) Pages: 258-259
- NAID
  10030455891
- Data Source
  KAKENHI-PROJECT-23591104
[Journal Article] Involvement of reactive oxygen species in the thrombin-induced pulmonary vasoconstriction.2010
- Author(s)
  Maki J, Hirano M, Hoka S, Kanaide H, Hirano K
- Journal Title
  
  Am J Resp Crit Care Med 182
  
  Pages: 1435-1444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590883
[Journal Article] Impaired Feedback regulation of the receptor activity and the myofilament Ca^<2+> sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage.2010
- Author(s)
  Kikkawa Y, Kameda K, Hirano M, Sasaki T, Hirano K
- Journal Title
  
  J Cerb Blood Flow Metab 30
  
  Pages: 1637-1650
- NAID
  120005227174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590883
[Journal Article] Current perspective on the role of the thrombin receptor in cerebral vasospasm after subarachnoid hemorrhage.2010
- Author(s)
  Hirano K, et al
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 114 Pages: 127-133
- NAID
  10027746316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590883
[Journal Article] Up-regulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortas.2010
- Author(s)
  Aman M, Hirano M, Kanaide H, Hirano K
- Journal Title
  
  J Vase Res 47
  
  Pages: 494-506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590883
[Journal Article] Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca^<2+>-sensitivity and induces vasoconstriction in porcine pulmonary arteries.2010
- Author(s)
  Maki J, Hirano M, Hoka S, Kanaide H, Hirano K
- Journal Title
  
  Br J Pharmacol 159
  
  Pages: 919-927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590883
[Journal Article] Enhanced contractile response of the basilar artery to platelet-derived growth factor in subarachnoid hemorrhage.2009
- Author(s)
  Maeda Y, Hirano K, Hirano M, Kikkawa Y, Kameda K, Sasaki T, Kanaide H
- Journal Title
  
  Stroke 40
  
  Pages: 591-596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590883
[Journal Article] Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca^<2+> influx in vascular endothelial cells.2009
- Author(s)
  Hirano K, Hirano M, Hanada A
- Journal Title
  
  J Cell Biochem 108
  
  Pages: 499-507
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590883
[Journal Article] Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery.2007
- Author(s)
  Fujiyoshi T, Hirano K, Hirano M, Nishimura J, Takahashi S, Kanaide H
- Journal Title
  
  Arterioscler Thromb Vasc Biol 27
  
  Pages: 949-954
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] The roles of proteinase-activated receptors in the vascular physiology and pathophysiology.2007
- Author(s)
  Hirano K
- Journal Title
  
  Arterioscler Thromb Vasc Biol 27
  
  Pages: 27-36
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] The roles of proteinase-activated receptors in the vascular physiology and pathophysiology2007
- Author(s)
  Hirano K
- Journal Title
  
  Arterioscler Thromb Vase Biol 27
  
  Pages: 27-36
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Involvement of Na^+-Ca^2+ exchanger in cAMP-mediatpd relaxation in mice aorta : Evaluation using transgenic mice2007
- Author(s)
  Karashima E, Nishimura J, Iwamoto T, Hirano K, Hirano M, Kita S, Harada M, Kanaide H
- Journal Title
  
  Br J Pharmacol (in press)
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery2007
- Author(s)
  Fujiyoshi T, Hirano K, Hirano M, Nishimura J, Takahashi S, Kanaide H
- Journal Title
  
  Arterioscler Thromb Vase Biol (in press)
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Plasmin induces endothelium-dependent nitric oxide- mediated relaxation in the porcine coronary artery.2007
- Author(s)
  Fujiyoshi T, Hirano K, Hirano M, Nishimura J, Takahashi S, Kanaide H
- Journal Title
  
  Arterioscler Thromb Vasc Biol 27
  
  Pages: 949-954
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Distinct Ca^<2+> requirement for NO production between proteinase-activated receptor 1 and 4 (PAR_1 and PAR_4) in vascular endothelial cells.2007
- Author(s)
  Hirano K, Nomoto N, Hirano M, Momota F, Hanada A, Kanaide H
- Journal Title
  
  J Pharmacol Exp Ther (印刷中)
- NAID
  120000984880
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Involvement of G_<i/o>in the PAR-4-induced NO production in endothelial cells.2006
- Author(s)
  Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H
- Journal Title
  
  Biochem Biophys Res Commun 342
  
  Pages: 365-371
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Involvement of Gi_i/o in the PAR-4-induced NO production in endothelial cells2006
- Author(s)
  Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H
- Journal Title
  
  Biochem Biophys Res Commun 342
  
  Pages: 365-371
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Involvement of G_<i/o> in the PAR-4-induced NO production in endothelial cells2006
- Author(s)
  Momota F, Hirano K, Hirano M, Nishimura J, Hideo Kanaide
- Journal Title
  
  Biochem Biophys Res Commun (in press)
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Involvement of Gi/o in the PAR-4-induced NO production in endothelial cells.2006
- Author(s)
  Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H:
- Journal Title
  
  Biochem Biophys Res Commun 342
  
  Pages: 365-371
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury.2006
- Author(s)
  Fukunaga R, Hirano K, Hirano M, Niiro N, Nishimura J, Maehara Y, Kanaide H
- Journal Title
  
  Am J Physiol Heart Circ Physiol 291
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Involvement of G_<i/o> in the PAR-4-induced NO production in endothelial cells.2006
- Author(s)
  Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H
- Journal Title
  
  Biochem Biophys Res Commun 342
  
  Pages: 365-371
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Involvement of Gi/o in the PAR-4-induced NO production in endothelial cells.2006
- Author(s)
  Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H
- Journal Title
  
  Biochem Biophys Res Commun 342
  
  Pages: 365-371
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Involvement of Gi/o in the PAR-4-induced NO production in endothelial cells.2006
- Author(s)
  Momota F, Hirano K, Hirano M, Nishimura J, Kanaide H
- Journal Title
  
  Biochemical and Biophysical Research Communications (In press)
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury2006
- Author(s)
  Fukunaga R, Hirano K, Hirano M, Niiro N, Nishimura J, Maehara Y, Kanaide H
- Journal Title
  
  Am J Physiol Heart Circ Physiol 291
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits2006
- Author(s)
  Furuyama T, Komori K, Shimokawa H, Matsumoto Y, Uwatoku T, Hirano K, Maehara Y
- Journal Title
  
  J Vase Surg
  
  Pages: 1249-1256
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Enhancement of trypsin-induced contraction by in vivo treatment with 17β-estradiol and progesterone in rat myometrium2005
- Author(s)
  Aman M, Hirano K, Nishimura J, Nakano H, Kanaide H
- Journal Title
  
  British Journal of Pharmacology 146
  
  Pages: 425-434
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery2005
- Author(s)
  Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H:
- Journal Title
  
  Cir Res 96
  
  Pages: 1014-1021
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery2005
- Author(s)
  Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H
- Journal Title
  
  Circulation Research 96
  
  Pages: 1014-1021
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Contractile properties of the cultured vascular smooth muscle cells : The crucial role played by RhoA in the regulation of contractility2005
- Author(s)
  Bi D, Nishimura J, Niiro N, Hirano K, Kanaide H
- Journal Title
  
  Circulation Research 96
  
  Pages: 890-897
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Rac1 regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells.2005
- Author(s)
  Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H
- Journal Title
  
  Arterioscler Thromb Vasc Biol 25
  
  Pages: 1506-1511
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Physiology and pathophy siology of proteinase-activated receptors (PARs) : Regulation o the expression of PARs2005
- Author(s)
  Hirano K, Yufu T, Hirano M, Nishimura J, Kanaide H:
- Journal Title
  
  J Pharmacol Sci 97
  
  Pages: 31-37
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Rac1 regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells2005
- Author(s)
  Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H
- Journal Title
  
  Arteriosclerosis, Thrombosis and Vascular Biology 25
  
  Pages: 1506-1511
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery2005
- Author(s)
  Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H
- Journal Title
  
  Circ Res 96
  
  Pages: 1014-1021
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Racl regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells.2005
- Author(s)
  Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H:
- Journal Title
  
  Arterioscler Thromb Vasc Biol 25
  
  Pages: 1506-1511
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Physiology and pathophysiology of proteinase-activated receptors (PARs) : Regulation of the expression of PARs2005
- Author(s)
  Hirano K, Yufu T, Hirano M, Nishimura J, Kanaide H
- Journal Title
  
  J Pharmacol Sci 97
  
  Pages: 31-37
- NAID
  10025725089
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery2005
- Author(s)
  Shiga N, Hirano K, Hirano M, Nishimura J, Nawata H, Kanaide H
- Journal Title
  
  Circulation Research 96
  
  Pages: 1014-1021
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Racl regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells.2005
- Author(s)
  Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H
- Journal Title
  
  Arterioscler Thromb Vasc Biol 25
  
  Pages: 1506-1511
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Rac1 regulation of the surface expression of PAR1 and responsiveness to thrombin in vascular smooth muscle cells.2005
- Author(s)
  Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H
- Journal Title
  
  Arterioscler Thromb Vasc Biol 25
  
  Pages: 1506-1511
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Inactivation of protease- activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells2004
- Author(s)
  Nakayama T, Hirano K, Hirano M, Nishimura J, Kuga H, Nakamura K, Takahashi S, Kanaide H
- Journal Title
  
  Biochem Pharmacol 68
  
  Pages: 23-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells2004
- Author(s)
  Hirano K, Hirano M, Nishimura J, Kanaide H
- Journal Title
  
  FEBS Lett 570
  
  Pages: 149-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Regulation of myosin phosphorylation and myofilament Ca^<2+> sensitivity in vascular smooth muscle2004
- Author(s)
  Hirano K, Hirano M, Kanaide H:
- Journal Title
  
  J Smooth Muscl Res 40
  
  Pages: 219-236
- NAID
  110002950110
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells2004
- Author(s)
  Koga M, Hirano K, Hirano M, Nishimura J, Kanaide H
- Journal Title
  
  Biochem Biophys Res Commun 324
  
  Pages: 321-325
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells2004
- Author(s)
  Koga M, Hirano K, Hirano M, Nishimura J, Kanaide H
- Journal Title
  
  Biochemical and Biophysical Research Communications 324
  
  Pages: 321-325
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells2004
- Author(s)
  Hirano K, Hirano M, Nishimura J, Kanaide H:
- Journal Title
  
  FEBS Lett 570
  
  Pages: 149-154
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Facilitation of proteasomal degradation of p27^<Kip1> by N-terminal cleavage, and their sequence requirements2004
- Author(s)
  Hirano K, Ihara E, Hirano M, Nishimura J, Nawata H, Kanaide H
- Journal Title
  
  FEBS Lett 574
  
  Pages: 111-115
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells2004
- Author(s)
  Nakayama T, Hirano (co-1^<st>author), Hirano M, Nishimura J, Kuga H, Nakamura K, Takahashi S, Kanaide H:
- Journal Title
  
  Biochem Pharmacol 68
  
  Pages: 23-32
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Facilitation of proteasomal degradation of p27^<Kip1> by N-terminal cleavage, and their sequence requirements2004
- Author(s)
  Hirano K, Ihara E, Hirano M, Nishimura J, Nawata H, Kanaide H
- Journal Title
  
  FEBS Letters 574
  
  Pages: 111-115
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells2004
- Author(s)
  Koga M, Hirano K, Hirano M, Nishimura J, Kanaide H:
- Journal Title
  
  Biochem Biophys Res Commun 324
  
  Pages: 321-325
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca^<2+> sensitivity in an intact coronary artery2004
- Author(s)
  Hirano K, Derkach DN, Hirano M, Nishimura J, Takahashi S, Kanaide H
- Journal Title
  
  Arteriosclerosis, Thrombosis and Vascular Biology 24
  
  Pages: 464-469
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca^<2+> sensitivity in an intact coronary artery2004
- Author(s)
  Hirano K, Derkach DN, Hirano M, Nishimura J, Takahashi S, Kanaide H:
- Journal Title
  
  Arterioscier Thromb Vasc Biol 24
  
  Pages: 464-469
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Regulation of myosin phosphorylation and myofilament Ca^<2+> sensitivity in vascular smooth muscle2004
- Author(s)
  Hirano K, Hirano M, Kanaide H
- Journal Title
  
  J Smooth Muscl Res 40
  
  Pages: 219-236
- NAID
  110002950110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells2004
- Author(s)
  Hirano K, Hirano M, Nishimura J, Kanaide H
- Journal Title
  
  FEBS Letters 570
  
  Pages: 149-154
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Facilitation of proteasomal degradation of p27^<Kip1> by N-terminal cleavage, and their sequence requirements2004
- Author(s)
  Hirano K, Ihara E, Hirano M, Nishimura J, Nawata H, Kanaide H:
- Journal Title
  
  FEBS Lett 574
  
  Pages: 111-115
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca^<2+> sensitivity in an intact coronary artery2004
- Author(s)
  Hirano K, Derkach DN, Hirano M, Nishimura J, Takahashi S, Kanaide H
- Journal Title
  
  Arterioscler Thromb Vasc Biol 24
  
  Pages: 464-469
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590695
[Journal Article] Distinct Ca^<2+> requirement for NO production between proteinase-activated receptor 1 and 4 (PAR_1 and PAR_4) in vascular endothelial cells.
- Author(s)
  Hirano K, Nomoto N, Hirano M, Momota F, Hanada A, Kanaide H
- Journal Title
  
  J Pharmacol Exp Ther (in press)
- NAID
  120000984880
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Journal Article] Novel dual endothelin receptor antagonist macitentan reverses severe pulmonary arterial hypertension in rats
- Author(s)
  Kunita-Takanezawa M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Oka M, Sunagawa K
- Journal Title
  
  J Cardiovasc Pharmacol
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-23591104
[Patent] トロンビン受容体アンタゴニストを有効成分とする肺高血圧症の予防治療剤2013
- Inventor(s)
  平野勝也、阿部弘太郎、平野真弓
- Industrial Property Rights Holder
  九州大学、エーザイ・アール・アンド・ディー・マネジメント株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2013-09-18
- Overseas
- Data Source
  KAKENHI-PROJECT-23591104
[Patent] トロンビン受容体アンタゴニストを有効成分とする肺高血圧症の予防治療剤2012
- Inventor(s)
  平野勝也、阿部弘太郎、平野真弓
- Industrial Property Rights Holder
  エーザイ・アール・アンド・ディー・マネジメント株式会社、九州大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-23591104
[Patent] トロンビン受容体アンタゴニストを有効成分とする肺高血圧症の予防治療剤2012
- Inventor(s)
  平野勝也、阿部弘太郎、平野真弓
- Industrial Property Rights Holder
  エーザイ・アール・アンド・ディー・マネジメント株式会社、九州大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-09-20
- Overseas
- Data Source
  KAKENHI-PROJECT-23591104
[Patent] トロンビン受容体アンタゴニストを有効成分とする肺高血圧症の予防治療剤2012
- Inventor(s)
  平野勝也、阿部弘太郎、平野真弓
- Industrial Property Rights Holder
  九州大学・エーザイ株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-23591104
[Patent] トロンビン受容体アンタゴニストを有効成分とする肺高血圧症の予防治療剤2012
- Inventor(s)
  平野勝也、阿部弘太郎、平野真弓
- Industrial Property Rights Holder
  エーザイ・アール・アンド・ディー・マネジメント株式会社、九州大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-09-20
- Overseas
- Data Source
  KAKENHI-PROJECT-23591104
[Patent] トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤2005
- Inventor(s)
  平野勝也他4名
- Industrial Property Rights Holder
  九州大学, エーザイ株式会社
- Filing Date
  2005-03-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590744
[Patent] トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤2005
- Inventor(s)
  平野勝也, 前田善久, 佐々木富男, 金出英夫, 甲斐康稔
- Industrial Property Rights Holder
  九州大学, エーザイ株式会社
- Filing Date
  2005-09-02
- Data Source
  KAKENHI-PROJECT-17590744
[Presentation] Rho-Rhoキナーゼ経路がトロンビンによる内皮バリアー障害の初期事象である細胞辺縁部アクチン繊維束形成に関わる2018
- Author(s)
  平野真弓、平野勝也
- Organizer
  第47回日本心脈管作動物質学会年会
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] 実験的肺高血圧症に対するプロテイナーゼ活性化型受容体1（PAR1）拮抗薬の治療的効果2017
- Author(s)
  平野勝也、桑原志実、田中真理子、阿部弘太郎、平野真弓
- Organizer
  第59回日本平滑筋学会総会
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] トロンビン受容体PAR1の阻害は肺高血圧症の病態形成を抑制する2017
- Author(s)
  平野勝也、桑原志実、田中真理子、阿部弘太郎、平野真弓
- Organizer
  第132回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] Involvement of Rho-Rho kinase pathway in peripheral actin filament formation, an initial event during thrombin-induced endothelial barrier disruption.2017
- Author(s)
  Hirano M, Hirano K.
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  浜松
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] Increased contractile effects of thrombin in pulmonary artery of monocrotaline-induced pulmonary hypertension2016
- Author(s)
  Hirano K, Kuwabara Y, Abe K, Hirano M
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] Increased expression of thrombin receptor, PAR1 is a new therapeutic target for pulmonary hypertension2016
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] Peripheral actin bundle formation due to myosin light chain di-phosphorylation proceeds stress fiber formation during thrombin-induced endothelial barrier disruption2016
- Author(s)
  Hirano K, Hirano M.
- Organizer
  第33回国際心臓研究学会日本部会総会
- Place of Presentation
  東京
- Year and Date
  2016-12-16
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] モノクロタリン誘発肺高血圧モデルにおけるトロンビン受容体PAR1の肺動脈収縮作用の亢進2016
- Author(s)
  平野勝也、桑原志実、阿部弘太郎、平野真弓
- Organizer
  第58回日本平滑筋学会総会
- Place of Presentation
  仙台
- Year and Date
  2016-08-17
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] pecific and increased expression of thrombin receptor PAR1 in pulmonary artery plays a key role in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats.2016
- Author(s)
  Kuwabara Y, Tanaka M, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K.
- Organizer
  American Heart Association Scientific Session 2016
- Place of Presentation
  New Orleans, LO, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] モノクロタリン誘発肺高血圧症におけるトロンビン受容体PAR1の発現亢進とトロンビンの肺動脈収縮作用の増強2016
- Author(s)
  平野勝也、桑原志実、阿部弘太郎、平野真弓
- Organizer
  第129回日本薬理学会近畿部会
- Place of Presentation
  広島
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] Vascular intrinsic circadian rhythm of myosin phosphatase activity2016
- Author(s)
  平野勝也
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  北海道札幌市
- Year and Date
  2016-03-22
- Invited
- Data Source
  KAKENHI-PROJECT-26670271
[Presentation] Mechanism for impaired desensitization irreversible activation of thrombin receptor in vascular smooth muscle2015
- Author(s)
  Hirano K, Hanada A, Hirano M
- Organizer
  HAKATA Cardiovascular Conference 2015
- Place of Presentation
  福岡県福岡市
- Year and Date
  2015-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670271
[Presentation] 内皮バリアー障害におけるミオシン軽鎖２リン酸化の特異的役割2015
- Author(s)
  平野勝也、平野真弓
- Organizer
  第57回日本平滑筋学会
- Place of Presentation
  宇部
- Year and Date
  2015-08-26
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] Proteinase-activated receptor 1 antagonist inhibited the progression of monocrotaline induced pulmonary hypertension in rats2015
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K
- Organizer
  American Heart Association Scientific Session
- Place of Presentation
  2015Orlando, FL, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] モノクロタリン誘発肺高血圧モデルにおける肺動脈のトロンビンに対する収縮反応性の亢進2015
- Author(s)
  平野勝也、桑原志実、阿部弘太郎、平野真弓
- Organizer
  第57回日本平滑筋学会
- Place of Presentation
  宇部
- Year and Date
  2015-08-26
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] 内皮バリアー障害の初期事象としてのミオシン2リン酸化の特異的役割2015
- Author(s)
  平野勝也、平野真弓
- Organizer
  生理研研究会2015心臓・血管系の包括的な機能統合研究
- Place of Presentation
  岡崎
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] 肺高血圧病態におけるトロンビン誘発大動脈収縮反応の増強2015
- Author(s)
  平野勝也、桑原志実、阿部弘太郎、平野真弓
- Organizer
  第67回日本薬理学会西南部会
- Place of Presentation
  下関
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] 内皮バリアー障害におけるミオシン軽鎖２リン酸化の特異的役割2015
- Author(s)
  平野勝也、平野真弓
- Organizer
  第57回日本平滑筋学会
- Place of Presentation
  山口県宇部市
- Year and Date
  2015-08-25
- Invited
- Data Source
  KAKENHI-PROJECT-26670271
[Presentation] トロンビン受容体PAR1拮抗薬は肺高血圧の病態形成を抑制する2015
- Author(s)
  桑原志実、阿部弘太郎、平野真弓、廣岡良隆、砂川賢二、平野勝也
- Organizer
  第3回肺高血圧学会・第4回肺循環学会合同学術集会
- Place of Presentation
  東京
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-15K09159
[Presentation] Distinct role of mono- and di-phosphorylation of myosin light chain (MLC) in thrombin-induced endothelial barrier disruption2014
- Author(s)
  Hirano K, Hirano M
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京(Circ J. 2014;78 (Suppl I): OJ-065)
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] 内皮バリアー障害の初期事象としての細胞辺縁部のミオシン軽鎖2リン酸化とアクチン線維束形成の役割2014
- Author(s)
  平野真弓、平野勝也
- Organizer
  第６７回日本薬理学会西南部会
- Place of Presentation
  北九州市
- Year and Date
  2014-11-23
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] トロンビンが引き起こす内皮バリアー障害におけるミオシン軽鎖の1リン酸化と2リン酸化の役割2014
- Author(s)
  Mayumi Hirano, Katsuya Hirano
- Organizer
  第８７回　日本薬理学会年会
- Place of Presentation
  仙台、宮城県
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Role of mono- and di-phosphorylation of myosin light chain in thrombin-induced endothelial barrier disruption2014
- Author(s)
  Hirano M, Hirano K
- Organizer
  第87回日本薬理学会
- Place of Presentation
  仙台(J Pharmacol Sci 124 (Suppl 1): 160P, 2014)
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role in thrombin-induced endothelial barrier disruption2014
- Author(s)
  Hirano K, Hirano M
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Oxidative Stress and ERK Cause Impaired Desensitization and Irreversible Activation of Thrombin Receptor PAR1 after Subarachnoid Hemorrhage (SAH)2014
- Author(s)
  Katsuya Hirano, Mayumi Hirano
- Organizer
  第７８回　日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role in thrombin-induced endothelial barrier disruption2014
- Author(s)
  Katsuya Hirano, Mayumi Hirano
- Organizer
  第91回日本生理学会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Preventive effects of thrombin receptor antagonist on hemodynamic parameters and histological findings in monocrotaline-induced pulmonary hypertension rats2014
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Hirano K, Sunagawa K
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京(Circ J. 2014;78 (Suppl I): PE-306)
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] A new endothelin receptor antagonist macitentan prevents endothelin-1-induced contraction in intrapulmonary arteries in rats with severe pulmonary arterial hypertension2013
- Author(s)
  Kunita M, Abe K, Hirooka Y, Hirano K, Sunagawa K
- Organizer
  35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
- Place of Presentation
  Osaka, Japan
- Year and Date
  2013-07-05
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Myosin light chain di-phosphorylation at sub-membranous region plays a critical role during thrombin-induced barrier disruption in vascular endothelial cells2013
- Author(s)
  Hirano M, Hirano K
- Organizer
  International Symposium on Regulatory Circuits in Cell Motility, honoring Dave Hartshorne
- Place of Presentation
  Philadelphia, PA, USA
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Critical role of Rho-kinase-mediated subjunctional di-phosphorylation of myosin light chain (MLC) in thrombin-induced disruption of endothelial barrier2013
- Author(s)
  Hirano K, Hirano M
- Organizer
  Circ J 77 (Suppl I): I-1198
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] トロンビン受容体を標的とした新たな肺高血圧治療ストラテジーの確立Vascular Biology Innovation2013
- Author(s)
  阿部弘太郎、平野勝也
- Organizer
  第8回研究発表会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Crucial role of proteinase-activated receptor 1 in the development of monocrotaline induced pulmonary arterial hypertension in rats.2013
- Author(s)
  55. Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K
- Organizer
  American Heart Association Scientific Session, 2013
- Place of Presentation
  Dallas, Texas, USA
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] A New Endothelin Receptor Antagonist Macitentan is a Potent Vasodilator in Intrapulmonary Arteries in Rats with Severe Pulmonary Hypertension2013
- Author(s)
  Kunita M, Abe K, Hirano K, Sunagawa K, Hirooka Y
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] A new endothelin receptor antagonist macitentan is a potent vasodilator in intrapulmonary arteries in rats with severe pulmonary hypertension2013
- Author(s)
  Kunita M, Abe K, Hirano K, Sunagawa K, Hirooka Y
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜(Circ J 77 (Suppl I): I-2275, 2013)
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Critical Role of Rho-kinase-mediated Subjunctional Di-phosphorylation of Myosin Light Chain (MLC) in Thrombin-induced Disruption of Endothelial Barrier2013
- Author(s)
  Katsuya Hirano, Mayumi Hirano
- Organizer
  第 77 回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] A New Strategy for Treatment of Pulmonary Hypertension with Thrombin Receptor as a Therapeutic Target2013
- Author(s)
  平野勝也
- Organizer
  第86回日本薬理学会年会シンポジウム「肺高血圧症の薬物治療の最前線」
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] A novel endothelin receptor antagonist, macitentan markedly improved severe pulmonary arterial hypertension in rats by a nearly complete blockade of endothelin receptors2013
- Author(s)
  Kunita M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Oka M, Sunagawa K
- Organizer
  American Heart Association Scientific Session
- Place of Presentation
  Dallas, TX, USA(Circulation 128: A11237, 2013)
- Year and Date
  2013-11-17
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Di-phosphorylation of myosin light chain and actin fiber formation in the submembranous region at inter-endothelial junction play a crucial role in thrombin-induced endothelial barrier disruption2013
- Author(s)
  Hirano M, Hirano K
- Organizer
  American Heart Association Scientific Session
- Place of Presentation
  Dallas, TX, USA
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Rho Kinase-mediated Di-phosphorylation of Myosin Light Chain in the Sub-membranous Regions and Circumferential Actomyosin Contraction Mediate Thrombin-induced Barrier Disruption in Vascular Endothelial Cells2013
- Author(s)
  Mayumi Hirano, Akiko Hanada, Katsuya Hirano
- Organizer
  International Stroke Conference 2013
- Place of Presentation
  ホノルル、米国
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] 血管平滑筋細胞トロンビン受容体の脱感作障害のメカニズム2013
- Author(s)
  平野真弓、平野勝也
- Organizer
  第55回日本平滑筋学会総会
- Place of Presentation
  旭川、北海道
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Chronic administration of proteinase- activated receptor 1 (PAR1) antagonist attenuated monocrotaline-induced pulmonary hypertension in rats2013
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Hirano K, Sunagawa K
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜(Circ J 77 (Suppl I): I-684, 2013)
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Rho kinase-mediated di-phosphorylation of myosin light chain in the sub-membranous regions and circumferential actomyosin contraction mediate thrombin-induced barrier disruption in vascular endothelial cells2013
- Author(s)
  Hirano M, Hanada A, Hirano K
- Organizer
  American Heart Association, International Stroke Conference 2013
- Place of Presentation
  Hololulu, HI, USA(Stroke 44 (2): AWP438, 2013)
- Year and Date
  2013-02-06
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Di-phosphorylation of myosin light chain and actin fiber formation in the submembranous region at inter- endothelial junction play a crucial role in thrombin-induced endothelial barrier disruption2013
- Author(s)
  Hirano M, Hirano K
- Organizer
  American Heart Association Scientific Session
- Place of Presentation
  Dallas, TX, USA(Circulation 128:A12861, 2013)
- Year and Date
  2013-11-18
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] 新薬マシテンタンは肺高血圧モデルラットの病態進行を抑制する2013
- Author(s)
  國田睦、阿部弘太郎、廣岡良隆、桑原志実、平野勝也、砂川賢二
- Organizer
  第1回日本肺高血圧学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Oxidative stress and extracellular signal-regulated protein kinase (ERK) are responsible for impaired desensitization and irreversible activation of thrombin receptor in vascular smooth muscle, which underlie cerebral vasospasm.2013
- Author(s)
  Hirano K, Hanada A, Hirano M
- Organizer
  American Heart Association Scientific Session
- Place of Presentation
  Dallas, TX, USA
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Chronic Administration of Proteinase-Activated Receptor 1 (PAR1) Antagonist Attenuated Monocrotaline-Induced Pulmonary Hypertension in Rats.2013
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Hirano K, Sunagawa K
- Organizer
  第77回日本循環器学会学術集会 Featured Research Session: Pulmonary Circulation
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] A new strategy for treatment of pulmonary hypertension with thrombin receptor as a therapeutic target2013
- Author(s)
  Hirano K
- Organizer
  第86回日本薬理学会年会シンポジウム
- Place of Presentation
  福岡(オーガナイザー:平野勝也、渡邉裕司)
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Di-phosphorylation of myosin light chain and actin fiber formation in the submembranous region at inter-endothelial junction play a crucial role in thrombin-induced endothelial barrier disruption.2013
- Author(s)
  56. Hirano M, Hirano K
- Organizer
  American Heart Association Scientific Session, 2013
- Place of Presentation
  Dallas, Texas, USA
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] トロンビン受容体拮抗薬はモノクロタリン誘発肺高血圧を抑制する2013
- Author(s)
  桑原志実、阿部弘太郎、平野真弓、廣岡良隆、平野勝也、砂川賢二
- Organizer
  第1回日本肺高血圧学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Crucial role of proteinase-activated receptor 1 in the development of monocrotaline induced pulmonary arterial hypertension in rats2013
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K
- Organizer
  American Heart Association Scientific Session
- Place of Presentation
  Dallas, TX, USA(Circulation 128: A16487, 2013)
- Year and Date
  2013-11-18
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] 血管平滑筋細胞トロンビン受容体の脱感作障害のメカニズム2013
- Author(s)
  平野真弓、平野勝也
- Organizer
  第55回日本平滑筋学会総会
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] モノクロタリン誘発肺高血圧に対するトロンビン受容体拮抗薬の予防効果2013
- Author(s)
  平野勝也、桑原志実、平野真弓、阿部弘太郎
- Organizer
  第2回Integrated Pulmonary Circulation Research–III (iPUC-III)
- Place of Presentation
  東京
- Year and Date
  2013-06-22
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] くも膜下出血後脳血管攣縮におけるプロテイナーゼ活性化型受容体1の役割2013
- Author(s)
  平野勝也
- Organizer
  第29回スパズムシンポジウム
- Place of Presentation
  東京(特別講演)
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Myosin light chain di-phosphorylation at sub-membranous region plays a critical role during thrombin-induced barrier disruption in vascular endothelial cells.2013
- Author(s)
  Hirano M, Hirano K
- Organizer
  International Symposium on Regulatory circuits in cell motility
- Place of Presentation
  Philadelphia, PA, USA
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] 肺高血圧症におけるトロンビン受容体の役割と新たな治療標的としての可能性2012
- Author(s)
  平野勝也
- Organizer
  PHサミット2012シンポジウム「CTEPHの病因・診断・治療」
- Place of Presentation
  岡山
- Year and Date
  2012-07-28
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] 肺高血圧症におけるトロンビン受容体の役割と新たな治療標的としての可能性2012
- Author(s)
  平野勝也
- Organizer
  PHサミット2012　シンポジウム「CTEPHの病因・診断・治療」
- Place of Presentation
  岡山
- Invited
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Contribution of Rho-kinase and oxidative stress to the thrombin- induced pulmonary vasoconstriction2012
- Author(s)
  Hirano K, Hirano M
- Organizer
  第29回国際心臓研究学会日本部会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] 血管平滑筋細胞におけるトロンビン受容体の脱感作障害にExtracellular signal-regulated kinase (ERK) が重要な役割を果たす2012
- Author(s)
  平野真弓、花田亜希子、平野勝也
- Organizer
  第65回日本薬理学会西南部会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Di-phosphorylation of myosin light chain (MLC) in the sub-membranous region plays an important role in the thrombin-induced barrier dysfunction in endothelial cells2012
- Author(s)
  Hirano M, Hirano K
- Organizer
  第29回国際心臓研究学会日本部会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Oxidative Stress and Rho-associated Coiled-coil Protein Kinase (ROCK)-mediated Double Phosphorylation of Myosin Light Chain in the Submembranous Region Plays a Key Role in Thrombin-induced Barrier Dysfunction in Vascular Endothelial Cells2012
- Author(s)
  Mayumi Hirano, Akiko Hanada, Katsuya Hirano
- Organizer
  American Heart Association Scientific Sessions2012 米国心臓協会学術集会
- Place of Presentation
  ロサンゼルス、米国
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Rho kinase-mediated di-phosphorylation of myosin light chain in the subjunctional regions plays a critical role in thrombin-induced endothelial barrier dysfunction2012
- Author(s)
  Hirano M, Hanada A, Hirano K
- Organizer
  第85回日本薬理学会
- Place of Presentation
  京都(J Pharmacol Sci 118 (Suppl 1): 245P, 2012)
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Potential of Thrombin Receptor as a New Therapeutic Target for Treatment of Pulmonary Hypertension2012
- Author(s)
  平野勝也
- Organizer
  第29回国際心臓研究学会日本部会総会Special Symposium: Pulmonary hypertension and RV failure
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Potential of Thrombin Receptor as a New Therapeutic Target for Treatment of Pulmonary Hypertension2012
- Author(s)
  Hirano K, Abe K
- Organizer
  第29回国際心臓研究学会日本部会総会
- Place of Presentation
  福岡
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Ca^<2+>-independent di-phosphorylation of myosin light chain by Rho-associated coiled-coil protein kinase (ROCK) in the subjunctional regions of cell-cell contact mediates thrombin-induced barrier dysfunction in vascular endothelial cells2011
- Author(s)
  Hirano M, Hanada A, Hirano K
- Organizer
  American Heart Association, Scientific Sessions 2011
- Place of Presentation
  Orlando, FL, USA(Circulation 124 (21): A9614, 2011)
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Thrombin causes barrier dysfunction via two distinct signal transduction pathways in vascular endothelial cells2011
- Author(s)
  平野真弓、平野勝也
- Organizer
  第84回日本薬理学会年会(誌上開催)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] トロンビンが引き起こす内皮透過性亢進には細胞膜直下におけるミオシン軽鎖の2リン酸化が重要な役割を果たす2011
- Author(s)
  平野勝也、平野真弓、花田亜希子
- Organizer
  第64回日本薬理学会西南部会
- Place of Presentation
  福岡(日本薬理学雑誌139 (3): 38P, 2011)
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Thrombin causes barrier dysfunction via two distinct signal transduction pathways in vascular endothelial cells2011
- Author(s)
  平野真弓
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜(誌上開催)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] Differential regulation of the thrombin- induced mono- and di-phosphorylation of myosin light chain in vascular endothelial cells内皮細胞においてトロンビンが引き起こすミオシン軽鎖の1リン酸化と2リン酸化は異なる制御を受ける2010
- Author(s)
  平野真弓、平野勝也
- Organizer
  第83回日本薬理学会年
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] Differential regulation of the thrombin-induced mono-and di-phosphorylation of myosin light chain in vascular endothelial cells2010
- Author(s)
  平野真弓
- Organizer
  第83回日本薬理学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] Involvement of two signaling pathways in the thrombin-induced barrier dysfunction in vascular endothelial cells.2010
- Author(s)
  平野真弓、花田亜希子、平野勝也
- Organizer
  第63回日本薬理学会西南部会(合同開催第20回日韓薬理学合同セミナー)
- Place of Presentation
  鹿児島
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] Involvement of two signaling pathways in the thrombin-induced barrier dysfunction in vascular endothelial cells2010
- Author(s)
  平野真弓
- Organizer
  第63回日本薬理学会西南部会(合同開催;第20回日韓薬理学合同セミナー)
- Place of Presentation
  鹿児島
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] A new method for analyzing myosin light chain phosphorylation with a Phos-tag^<TM> technology.2009
- Author(s)
  平野真弓、平野勝也
- Organizer
  Phos-tag^<TM>技術を用いたミオシン軽鎖リン酸化の新たな定量解析法第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] A new method for analyzing myosin light chain phosphorylation with a Phos-tag^<TM> technology2009
- Author(s)
  平野真弓, 平野勝也
- Organizer
  第82会日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] Phos-tag^<TM> SDS-PAGE analysis revealed differential requirement of Ca^<2+> source for the thrombin-induced mono- and di-phosphorylation of myosin light chain in vascular endothelial cells.2009
- Author(s)
  平野真弓, 平野勝也
- Organizer
  International symposium of smooth muscle research "Post-genomic advances in the physiology of smooth muscle", Satellite Symposium of the International Union of Physiological Society World Congress 2009
- Place of Presentation
  名古屋
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] Phos-tag^<TM> SDS-PAGE analysis revealed differential requirement of Ca^<2+> source for the thrombin-induced mono- and di-phosphorylation of myosin light chain in vascular endothelial cells2009
- Author(s)
  平野真弓
- Organizer
  Satellite Symposium of the IUPS2009 Post-genomic Advances in the Physiology of Smooth Muscle
- Place of Presentation
  名古屋
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] Involvement of STIM1 in PAR1・mediated Ca^<2+> influx and NO production in vascular endothelial cells.2009
- Author(s)
  平野勝也, 花田亜希子, 平野真弓
- Organizer
  第82会日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] トロンビンが引き起こす血管内皮細胞のCa^<2+>流入におけるSTIM1の関与トランスポーターワークショップIN福岡2008
- Author(s)
  平野真弓、平野勝也
- Place of Presentation
  福岡
- Year and Date
  2008-11-02
- Data Source
  KAKENHI-PROJECT-20590883
[Presentation] Ca2+-independent di-phosphorylation of myosin light chain by rho-associated coiled-coil protein kinase (ROCK) in the subjunctional regions of cell-cell contact mediates thrombin-induced barrier dysfunction in vascular endothelial cells
- Author(s)
  Hirano M, Hanada A, Hirano K
- Organizer
  Scientific Sessions 2011 of the American Heart Association
- Place of Presentation
  米国フロリダ州オーランド
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role as an initial event during endothelial barrier disruption.
- Author(s)
  Hirano M, Hirano K
- Organizer
  11th International Symposium on Resistant Artery
- Place of Presentation
  Banff, AB, Canada
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Rho kinase-mediated di-phosphorylation of myosin light chain in the subjunctional regions plays a critical role in thrombin-induced endothelial barrier dysfunction.
- Author(s)
  Hirano M, Hanada A, Hirano K
- Organizer
  第８５回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] Sub-junctional di-phosphorylation of regulatory myosin light chain plays a critical role during thrombin-induced endothelial barrier dysfunction.
- Author(s)
  Hirano K, Hirano M
- Organizer
  18th International Vascular Biology Meeting
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Vascular intrinsic biological clock in the regulation of myofilament calcium sensitivity
- Author(s)
  Hirano K
- Organizer
  11th International Symposium on Resistant Artery
- Place of Presentation
  Banff, AB, Canada
- Year and Date
  2014-09-07 – 2014-09-11
- Invited
- Data Source
  KAKENHI-PROJECT-26670271
[Presentation] トロンビンが引き起こす内皮透過性亢進には細胞膜直下におけるミオシン軽鎖の2リン酸化が重要な役割を果たす
- Author(s)
  平野勝也、平野真弓、花田亜希子
- Organizer
  第６４回日本薬理学会西南部会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591104
[Presentation] The protective role of bone morphogenetic protein receptor II against thrombin-induced endothelial barrier dysfunction
- Author(s)
  Rahmawati A, Hirano M, Chishaki A, Hirano K
- Organizer
  第４４回日本心脈管作動物質学会
- Place of Presentation
  高松
- Year and Date
  2015-02-06 – 2015-02-07
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Inhibition of increased thrombin receptor activity attenuated monocrotaline-induced pulmonary hypertension in rats.
- Author(s)
  Kuwabara Y, Abe K, Hirano M, Hirooka Y, Hirano K, Sunagawa K
- Organizer
  American Heart Association Scientific Session 2014
- Place of Presentation
  Chicago, IL, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] 細胞辺縁部に局在するミオシン軽鎖２リン酸化とアクチン繊維束形成が内皮細胞バリアー障害の初期事象として重要な役割を果たす
- Author(s)
  平野真弓、平野勝也
- Organizer
  第４４回日本心脈管作動物質学会
- Place of Presentation
  高松
- Year and Date
  2015-02-06 – 2015-02-07
- Data Source
  KAKENHI-PROJECT-24591118
[Presentation] Mechanism for impaired desensitization and irreversible activation of thrombin receptor in vascular smooth muscle
- Author(s)
  Hirano K, Hanada A, Hirano M
- Organizer
  HAKATA Cardiovascular Conference 2015
- Place of Presentation
  福岡市
- Year and Date
  2015-05-29 – 2015-05-30
- Data Source
  KAKENHI-PROJECT-26670271

1. HIRANO Katsuya (80291516)

# of Collaborated Projects: 8 results

# of Collaborated Products: 153 results
2. ABE Kohtaro (20588107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
3. ODA Yoshinao (70291515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Kobayashi Sei (80225515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 砂川賢二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 井手友美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIRANO Mayumi 平野 真弓

Research Projects

Research Products

Co-Researchers

Elucidation of the molecular mechanism underlying the vascular dysfunction mediated by proteinase-activated receptor 1Principal Investigator

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Development of innovative and ultimate strategies for the treatment of cerebral vasospams with thrombin receptor as a therapeutic target

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Development of new therapeutic strategies for the treatment of atherosclerosis based on the elucidation of molecular mechanisms underlying dysregulation of signaling activity of thrombin receptorPrincipal Investigator

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Elucidation of roles of proteinase-activated receptor in pulmonary hypertension and development of new therapeutic strategies

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Role of endothelial proteinase-activated receptors in the early phase of the development of vascular lesions.Principal Investigator

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Role of proteinase-activated receptors in the dysregulation of vascular tone and the enhancement of the proliferative state in vascular lesions

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Elucidation of the Intracellular Signaling Networks Involved in the Proliferation and Functional Differentiation Induced by Cell-cell Contact in Vascular Endothelial Cells.Principal Investigator

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Elucidation of the Intracellular Signal Networks Involved in the Growth Arrest induced by Cell-cell Contact in Vascular Endothelial CellsPrincipal Investigator

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[Book] Diagnosis treatment of pulmonary hypertension - From bench to bedside2016

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[Journal Article] Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption.2016

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[Journal Article] プロテイナーゼ活性化型受容体の血管生物学2016

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[Journal Article] 血管平滑筋機能とカルシウム2015

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[Journal Article] 脳血管攣縮における細胞膜受容体の活性制御異常：トロンビン受容体PAR1の役割2014

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[Journal Article] プロテイナーゼ活性化型受容体を標的とした肺高血圧治療の可能性2014

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[Journal Article] 肺高血圧症の薬物治療の最前線:序文2014

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HIRANO Mayumi 平野真弓