Hisahara Shin 久原真

… Alternative Names

久原真ヒサハラシン

HISAHARA Shin 久原真

HISAKARA Shin 久原真

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Researcher Number	80336403
Other IDs
External Links
Affiliation (Current)	2025: 札幌医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 札幌医科大学, 医学部, 教授 2022 – 2023: 札幌医科大学, 医学部, 教授 2018 – 2019: 札幌医科大学, 医学部, 准教授 2017: 札幌医科大学, 医学部, 講師 2009 – 2011: Sapporo Medical University, 医学部, 助教 2001 – 2004: Sapporo Medical University, Assistant Professor, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Nerve anatomy/Neuropathology / Neurology / Neuroscience in general Except Principal Investigator Basic Section 52020:Neurology-related / 応用薬理学・医療系薬学 / General pharmacology / General pharmacology / Biological Sciences
Keywords	Principal Investigator 分化 / SIRTファミリー / ヒストン脱アセチル化酵素 / 分化転換 / アルツハイマー病 / 炎症性サイトカイン / アルツハイマー型認知症 / グリア細胞 / 血管内皮細胞 / 骨髄間葉系幹細胞 … More / 周皮細胞 / 前駆細胞 / 多発性硬化症 / 初代培養 / マイクロRNA / 変性 / オリゴデンドロサイト / 細胞死 / 酸化ストレス / パーキンソン病 / 神経分子病態学 / sirtinol / splitomicin / neurosphere assay / Sir(silent information regulator) / Subventricular zone / 増殖 / Neuroshere assay / 神経幹細胞 / Sir2α(SIRT1) / ヒストン脱アセチル酵素 … More Except Principal Investigator 脳 / CA3 / AQP4 / brain / ATP sensitive K^+ channel / K^+ channel / synaptophysin / シナプス / ATP感受性Kチャネル / Kチャネル / 精巣 / 分化 / 神経幹細胞 / 脱アセチル化酵素 / 多発性硬化症 / ミクログリア / エクソソーム / herbimycin / glia / laminine / water channel / ATP感受性カリウムチャネル / チャネル / カリウム / ポリリジン / 網膜 / PDZドメイン / マウス / 一次培養細胞 / モルモット / ラミニン / Kir4.1 / アストロサイト / 浮腫 / cDNA / チロシンリン酸化 / ミュラー細胞 / グリア / カリウムチャネル / 水チャネル / Parkinson disease / dopamine neuron / substantia nigra / sulfonylurea receptor / 海馬 / テルチアピン / PC12 / SUR / Parkinson病 / ドーパミン細胞 / 黒質 / スルフォニル尿素受容体(SUR) / 胎児 / ニコチンアミド / オリゴデンドロサイト / 神経細胞 / Sir2α / aldolase / helicase / NAD / subventricular zone / GFP / 上衣細胞 / 核局在シグナル / 老化 / ヒストン Less

アストロサイトより放出される細胞外小胞の脱髄疾患モデルにおける解析Principal Investigator
- Principal Investigator
  
  久原真
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Sapporo Medical University
Role of microglia-derived exosomes in the neurodegeneration of multiple sclerosis.
- Principal Investigator
  
  岩原直敏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Sapporo Medical University
周皮細胞のアルツハイマー病モデルにおける分化転換の解析Principal Investigator
- Principal Investigator
  
  久原真
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Sapporo Medical University
Analysis of microRNA in oligodendrocyte degenerationPrincipal Investigator
- Principal Investigator
  
  Hisahara Shin
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Sapporo Medical University
Functional analysis of histone deacetylase SIRT in the pathophysiology of neurodegenerative disordersPrincipal Investigator
- Principal Investigator
  
  HISAHARA Shin
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Sapporo Medical University
老化と体内時計
- Principal Investigator
  
  堀尾嘉幸
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University
神経細胞増殖・分化におけるヒストン脱アセチル化酵素Sirの役割Principal Investigator
- Principal Investigator
  
  久原真
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Sapporo Medical University
脳Sirの老化、寿命における分子機能解析
- Principal Investigator
  
  HORIO Yoshiyuk
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Investigation for the roles of ions in the differentiation, structure and death in cells
- Principal Investigator
  
  HORIO Yoshiyuk
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University
Mechanism of water transport; Elucidation of brain edema and development of treatment.
- Principal Investigator
  
  HORIO Yoshiyuki
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  SAPPORO MEDICAL UNIVERSITY

All 2023 2022 2020 2019 2018 2017 2012 2011 2010 2009 2005 2004 2003

All Journal Article Presentation Book

[Book] Animal Models of Parkinson's Disease Induced by Toxins and Genetic Manipulation2012
- Author(s)
  Shin Hisahara, Shun Shimohama
- Publisher
  In Tech
- Data Source
  KAKENHI-PROJECT-21591096
[Book] Mechanisms in Parkinson's Disease-Models and Treatments2011
- Author(s)
  Shin Hisahara and Shun Shimohama
- Total Pages
  28
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Cerebral Tuberculoma Diagnosed by Nested Polymerase Chain Reaction of a Formalin-fixed Paraffin-embedded Brain Biopsy Sample2023
- Author(s)
  Yamamoto Morihiro、Manabe Tatsuo、Yokokawa Kazuki、Tsuzaka Kazuhumi、Yamada Minoru、Miyanaga Rei、Saito Taro、Yamamoto Daisuke、Matsumura Akihiro、Suzuki Syuuichirou、Hisahara Shin
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 12 Pages: 1827-1833
- DOI
  10.2169/internalmedicine.0356-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-06-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07541
[Journal Article] Transthyretin Variant Amyloidosis with a <i>TTR</i> A97D (p.A117D) Mutation Manifesting Remarkable Asymmetric Neuropathy2023
- Author(s)
  Ikeda Kazuna、Yamamoto Daisuke、Usui Keiko、Takeuchi Hiroki、Oka Nobuyuki、Katoh Nagaaki、Yazaki Masahide、Kametani Fuyuki、Nishino Ichizo、Hisahara Shin
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 15 Pages: 2261-2266
- DOI
  10.2169/internalmedicine.0798-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-08-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06884, KAKENHI-PROJECT-22K07541
[Journal Article] Occurrence of Autoimmune Encephalitis in a Patient with Hepatocellular Carcinoma after Atezolizumab and Bevacizumab Combination Therapy: A Case Study2023
- Author(s)
  Osuga Takahiro、Miyanishi Koji、Ito Ryo、Tanaka Shingo、Kubo Tomohiro、Hamaguchi Kota、Ohnuma Hiroyuki、Murase Kazuyuki、Takada Kohichi、Yamamoto Morihiro、Manabe Tatsuo、Hisahara Shin、Kato Junji
- Journal Title
  
  Kanzo
  
  Volume: 64 Issue: 11 Pages: 559-566
- DOI
  10.2957/kanzo.64.559
- ISSN
  0451-4203, 1881-3593
- Year and Date
  2023-11-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08011, KAKENHI-PROJECT-22K07541
[Journal Article] Activation of SIRT1 promotes membrane resealing via cortactin2022
- Author(s)
  Iwahara Naotoshi、Azekami Kuya、Hosoda Ryusuke、Nojima Iyori、Hisahara Shin、Kuno Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 15328-15328
- DOI
  10.1038/s41598-022-19136-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07541, KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-21K15629
[Journal Article] Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination2022
- Author(s)
  Tanemoto Masanobu、Oda Ryosuke、Toyama Yuichiro、Shizukawa Hirohiko、Yokokawa Kazuki、Saito Taro、Suzuki Syuuichirou、Matsumura Akihiro、Hisahara Shin
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 23 Pages: 3605-3609
- DOI
  10.2169/internalmedicine.0404-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-12-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07541
[Journal Article] Ubiquitin-dependent rapid degradation conceals a cell-protective function of cytoplasmic SIRT3 against oxidative stress2022
- Author(s)
  Hayashi Takashi、Matsushita Takashi、Hisahara Shin、Iwahara Naotoshi、Kuno Atsushi、Kunimoto Risa、Hosoda Ryusuke、Tanno Masaya、Shimohama Shun、Horio Yoshiyuki
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 171 Issue: 2 Pages: 201-213
- DOI
  10.1093/jb/mvab119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07541
[Journal Article] Case Series and Review of the Literature2022
- Author(s)
  Nagano Nobutaka、Muranaka Atsuko、Nishikawa Ryo、Ohwada Wataru、Kouzu Hidemichi、Kamiyama Naoyuki、Fujito Takefumi、Mochizuki Atsushi、Nagahara Daigo、Nakanishi Mitsuhiro、Ohkubo Yukiko、Hisahara Shin、Nakao Satoshi、Katoh Nagaaki、Ishikawa Aki、Sakurai Akihiro、Yano Toshiyuki
- Journal Title
  
  Int. Heart J.
  
  Volume: 63 Issue: 1 Pages: 168-175
- DOI
  10.1536/ihj.21-336
- NAID
  130008145711
- ISSN
  1349-2365, 1349-3299
- Year and Date
  2022-01-29
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08544, KAKENHI-PROJECT-22K07541
[Journal Article] Severe Mononeuritis Multiplex due to Rheumatoid Vasculitis in Rheumatoid Arthritis in Sustained Clinical Remission for Decades2020
- Author(s)
  Tanemoto Masanobu、Hisahara Shin、Hirose Bungo、Ikeda Kazuna、Matsushita Takashi、Suzuki Shuichiro、Manabe Tatsuo、Imai Tomihiro、Shimohama Shun
- Journal Title
  
  Intern. Med.
  
  Volume: 59 Issue: 5 Pages: 705-710
- DOI
  10.2169/internalmedicine.3866-19
- NAID
  130007804520
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2020-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07099
[Journal Article] CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.2019
- Author(s)
  Fujikura M, Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Manabe T, Matsushita T, Suzuki S, Shimohama S.
- Journal Title
  
  J Alzheimers Dis.
  
  Volume: 68 Issue: 1 Pages: 323-337
- DOI
  10.3233/jad-180904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress2019
- Author(s)
  Yokokawa Kazuki、Iwahara Naotoshi、Hisahara Shin、Emoto Miho C.、Saito Taro、Suzuki Hiromi、Manabe Tatsuo、Matsumura Akihiro、Matsushita Takashi、Suzuki Syuuichirou、Kawamata Jun、Sato-Akaba Hideo、Fujii Hirotada G.、Shimohama Shun
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 72 Issue: 3 Pages: 867-884
- DOI
  10.3233/jad-190817
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease2019
- Author(s)
  Saito Taro、Hisahara Shin、Iwahara Naotoshi、Emoto Miho C.、Yokokawa Kazuki、Suzuki Hiromi、Manabe Tatsuo、Matsumura Akihiro、Suzuki Syuuichirou、Matsushita Takashi、Kawamata Jun、Sato-Akaba Hideo、Fujii Hirotada G.、Shimohama Shun
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 145 Pages: 20-32
- DOI
  10.1016/j.freeradbiomed.2019.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07920, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-17K16388
[Journal Article] Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy.2019
- Author(s)
  Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S, Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S.
- Journal Title
  
  Journal of Alzheimer's disease
  
  Volume: 67 Issue: 3 Pages: 1079-1087
- DOI
  10.3233/jad-180985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19776, KAKENHI-PROJECT-16H05279, KAKENHI-PROJECT-16K10291, KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-17K16388
[Journal Article] Fingolimod induces BAFF and expands circulating transitional B cells without activating memory B cells and plasma cells in multiple sclerosis2018
- Author(s)
  Miyazaki Yusei、Niino Masaaki、Takahashi Eri、Suzuki Masako、Mizuno Masanori、Hisahara Shin、Fukazawa Toshiyuki、Amino Itaru、Nakano Fumihito、Nakamura Masakazu、Akimoto Sachiko、Minami Naoya、Fujiki Naoto、Doi Shizuki、Shimohama Shun、Terayama Yasuo、Kikuchi Seiji
- Journal Title
  
  Clinical Immunology
  
  Volume: 187 Pages: 95-101
- DOI
  10.1016/j.clim.2017.10.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07099, KAKENHI-PROJECT-16H05279
[Journal Article] Dopamine Receptors and Parkinson's Disease2011
- Author(s)
  Shin Hisahara, Shun Shimohama
- Journal Title
  
  International Journal of Medicinal Chemistry
  
  Volume: 2011 Pages: 1-16
- DOI
  10.1155/2011/403039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Relationship between dysphagia and depressive states in patients with Parkinson's disease2011
- Author(s)
  Meng Han, Hirofumi Ohnishi, Michio Nonaka, Rika Yamauchi, Takayoshi Hozuki, Takashi Hayashi, Masaki Saitoh, Shin Hisahara, Tomihiro Imai, Shun Shimohama, Mitsuru Mori
- Journal Title
  
  Parkinson's Disease & Related Disorders
  
  Volume: 17 Pages: 437-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Toxin-Induced and Genetic Animal Models of Parkinson's Disease2011
- Author(s)
  Shin Hisahara, Shun Shimohama
- Journal Title
  
  Parkinson's Disease
  
  Volume: 2011 Pages: 951709-951709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Toxin-Induced and Genetic Animal Models of Parkinson's Disease2011
- Author(s)
  Shin Hisahara and Shun Shimohama
- Journal Title
  
  Parkinson's Disease
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Dopamine Receptors and Parkinson's Disease2011
- Author(s)
  Shin Hisahara and Shun Shimohama
- Journal Title
  
  International Journal of Medicinal Chemistry
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Correlation of bite force with excitation-contraction coupling time of the masseter in myasthenia gravis2010
- Author(s)
  Tsuda E, Imai T, Hozuki T, Yamauchi R, Saitoh M, Hisahara S, Yoshikawa H, Motomur M, Shimohama S
- Journal Title
  
  Clin Neurophysiol
  
  Volume: 121 Pages: 1051-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K(2) in corticosteroid-treated patients : a pilot study2010
- Author(s)
  Hozuki T, Imai T, Tsuda E, Matsumura A, Yamamoto D, Toyoshima T, Suzuki S, Yamauchi R, Hayashi T, Hisahara S, Shimohama S
- Journal Title
  
  Intern Med
  
  Volume: 49 Pages: 371-6
- NAID
  130000251679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure2010
- Author(s)
  Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K and Horio Y
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Pages: 8375-8382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591096
[Journal Article] NAD dependent histone deacetylase SIRT12005
- Author(s)
  Hisahara S, Chiba S, Matsumoto H, Horio Y
- Journal Title
  
  J.Pharmacol.Sci. in press
- Data Source
  KAKENHI-PROJECT-15659062
[Journal Article] NAD-dependent histone deacetylase SIRT1 (Sir2α)2005
- Author(s)
  Shin Hisahara, Susumu Chiba, Hiroyuki Matsumoto, Yoshiyuki Horio
- Journal Title
  
  J.Pharmacol.Sci. (in press)
- Data Source
  KAKENHI-PROJECT-15700261
[Journal Article] Histone deacetylase Sir2α affects proliferation and differentiation of Neural stem cells2004
- Author(s)
  Yoshiyuki Horio, Shin Hisahara, Jun sakamoto
- Journal Title
  
  J.Pharmacol.Sci. 94,suppl.1
  
  Pages: 49-49
- Data Source
  KAKENHI-PROJECT-15700261
[Journal Article] SIR2の分子機能解析2003
- Author(s)
  堀尾嘉幸, 久原真, 坂本淳
- Journal Title
  
  日本薬理学雑誌 122巻補完1号
  
  Pages: 30-32
- NAID
  10018622274
- Data Source
  KAKENHI-PROJECT-15700261
[Journal Article] Sir2の分子機能解析2003
- Author(s)
  堀尾嘉幸, 久原真, 坂本淳
- Journal Title
  
  日薬理誌 122
  
  Pages: 30-32
- NAID
  10018622274
- Data Source
  KAKENHI-PROJECT-15659062
[Journal Article] Caspase-mediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination2003
- Author(s)
  Shin Hisahara, Hideyuki Okano, Masayuki Miura
- Journal Title
  
  Neurosci.Res. 46(4)
  
  Pages: 387-397
- NAID
  10016206932
- Data Source
  KAKENHI-PROJECT-15700261
[Presentation] 発症早期の自己免疫性てんかんの臨床的特徴の検討2023
- Author(s)
  種本真将, 横川和樹, 齋藤太郎, 岩原直敏, 松村晃寛, 鈴木秀一郎, 山本彬広, 外山祐一郎, 古山裕康, 溝渕雅広, 佐光一也, 久原真
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 筋萎縮性側索硬化症(ALS)の進行・予後を予測する因子の検討2023
- Author(s)
  池田和奈, 横川和樹, 岩原直敏, 鈴木秀一郎, 久原真
- Organizer
  第41回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 細胞外小胞からみた多発性硬化症2023
- Author(s)
  岩原直敏, 村岡賢, 久原真
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] クリニカルパス導入による多職種連携への影響　看護師の視点から2023
- Author(s)
  五十嵐瑞姫, 織田采佳, 館脇誠佳, 佐藤由佳子, 鈴木秀一郎, 久原真
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 多系統萎縮症新診断基準の有用性の検討2023
- Author(s)
  市之川萌奈美, 松島理明, 工藤彰彦, 佐久嶋研, 西本尚樹, 澤田潤, 松岡健, 南尚哉, 佐光一也, 武井麻子, 久原真, 佐藤典宏, 佐々木秀直, 矢部一郎
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 当院における抗MOG抗体関連疾患の治療経験2023
- Author(s)
  舩越匠, 池田和奈, 岩原直敏, 鈴木秀一郎, 久原真, 廣田亮介
- Organizer
  第41回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] パーキンソン病薬剤調整パス後の転機悪化症例における要因分析2023
- Author(s)
  鈴木秀一郎,池田和奈, 横川和樹, 岩原直敏, 館脇誠佳, 畑中陽子, 佐藤由佳子, 柏木悠里, 安田圭佑, 久原真
- Organizer
  第41回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 多発性硬化症を対象とした脳脊髄液由来細胞外小胞のプロテオーム解析2023
- Author(s)
  岩原直敏, 齋藤太郎, 村岡賢, 久原真
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 当院脳神経内科における外来初診患者動向の実態調査2023
- Author(s)
  宮永怜, 鈴木秀一郎, 横川和樹, 齋藤太郎, 岩原直敏, 松村晃寛, 久原真
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 抗体陰性重症筋無力症と診断した患者の診断精度や臨床経過の検討2023
- Author(s)
  横川和樹, 山田稔, 齋藤太郎, 岩原直敏, 松村晃寛, 鈴木秀一郎, 久原真
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 神経筋疾患の問題症例　亜急性に進行した小脳性運動失調症と脱髄性ニューロパチーの一例2023
- Author(s)
  河田由香, 池田和奈, 山田稔, 齋藤太郎, 津田玲子, 鈴木秀一郎, 緒方英紀, 磯部紀子, 久原真
- Organizer
  第53回日本臨床神経生理学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 炎症性脱髄疾患における細胞外小胞プロテオーム解析2022
- Author(s)
  岩原直敏, 村岡賢, 齋藤太郎, 久原真
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 松島理明, 佐久嶋研, 金谷泰宏, 西本尚樹, 澤田潤, 松岡健, 久原真, 上杉春雄, 南尚哉, 佐光一也, 武井麻子, 玉腰暁子, 佐藤典宏, 佐々木秀直2022
- Author(s)
  松島理明, 佐久嶋研, 金谷泰宏, 西本尚樹, 澤田潤, 松岡健, 久原真, 上杉春雄, 南尚哉, 佐光一也, 武井麻子, 玉腰暁子, 佐藤典宏, 佐々木秀直
- Organizer
  第63回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] mRNA SARS-CoV-2ワクチン接種後に発症した抗 SRP 抗体陽性ミオパチーの1 例2022
- Author(s)
  種本真将，鈴木秀一郎，松村晃寛，横川和樹，久原真，静川裕彦
- Organizer
  第40回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 脳神経内科外来のパーキンソン病患者における便秘の有訴者数と臨床像2022
- Author(s)
  鈴木秀一郎，河田由香，種本真将，池田和奈，横川和樹，松村晃寛，久原真
- Organizer
  第40回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07541
[Presentation] 神経変性疾患に対する脳血流123I-IMP-SPECTにおけるCIScore解析の検証2019
- Author(s)
  松村晃寛, 浅沼治, 横川和樹, 齋藤太郎, 藤倉舞, 岩原直敏, 眞部建郎, 津田玲子, 山本大輔, 松下隆司, 鈴木秀一郎, 臼井桂子, 齊藤正樹, 久原真, 川又純, 今井富裕, 下濱俊
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Deacetylase SIRT1 and SIRT2 regulate cytoskeleton-related molecules in oligodendrocyte cell lines2019
- Author(s)
  Shin Hisahara， Naotoshi Iwahara， Tatsuo Manabe， Mai Fujikura， Taro Saito， Kazuki Yokokawa， Takashi Matsushita， Akihiro Matsumura， Syuuichirou Suzuki， Jun Kawamata， Shun Shimohama
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Time course of intranigral invasion of immunocytes in 6-OHDA-induced Parkinson's disease rat model2019
- Author(s)
  鈴木秀一郎, 鈴木紘美, 齋藤太郎, 横川和樹, 藤倉舞, 真部健郎, 岩原直敏, 松下隆司, 松村晃寛, 久原真, 川又純, 下濱俊
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Rat Bone Marrow-derived MSCs Attenuate Oxidative Stress and Neuroinflammation in APP/PS1 mice2019
- Author(s)
  横川和樹, 岩原直敏, 江本美穂, 久原真, 齋藤太郎, 藤倉舞, 真部建郎, 松下隆司, 松村晃寛, 鈴木秀一郎, 川又純, 藤井博匡, 下濱俊
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Effectiveness of galantamine treatment in normal cognition phase of APPswe/PS1dE9 mice2019
- Author(s)
  齋藤太郎, 横川和樹, 藤倉舞, 眞部建郎, 岩原直敏, 久原真, 松村晃寛, 鈴木秀一郎, 松下隆司, 川又純, 鈴木紘美, 江本美穂, 藤井博匡, 下濱俊
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Involvement of SIRTs in the morphological change of human oligodendrocyte cell lines2018
- Author(s)
  Shin Hisahara， Naotoshi Iwahara， Tatsuo Manabe， Mai Fujikura， Taro Saito， Kazukia Yokokawa， Naoki Gamo， Takashi Matsushita， Matsumura Akihiro， Syuuichirou Suzuki， Jun Kawamata， Shun Shimohama
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Deacetylase SIRTs regulate differentiation of oligodendrocyte and modulate distribution of oligodendrocyte-specific cytoskeleton-related molecules2017
- Author(s)
  Shin Hisahara, Naotoshi Iwahara, Tatsuo Manabe, Mai Fujikura, Taro Saito, Kazuki Yokokawa, Akihiro Matsumura, Syuuichirou Suzuki, Jun Kawamata, Shun Shimohama
- Organizer
  23rd Annual Meeting of World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07099
[Presentation] Resver atrolによる神経系細胞における酸化ストレス耐性の検討2010
- Author(s)
  久原真、堀尾嘉幸、下濱俊
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21591096
[Presentation] Resveratrolによる神経系細胞における酸化ストレス耐性の検討2010
- Author(s)
  久原真、堀尾嘉幸、下濱俊
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21591096
[Presentation] 培養神経幹細胞における分化特性とヒストン脱アセチル化酵素SIRT1の関与2009
- Author(s)
  久原真、堀尾嘉幸、下濱俊
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21591096
[Presentation] Histone deacetylase SIRT1 modulates neuronal differentiation2009
- Author(s)
  S. Hisahara, M. Tanno, S. Shimohama, M. Sato, Y. Horio
- Organizer
  Annual Meeting of Society for Neuroscience
- Place of Presentation
  アメリカ合衆国・シカゴ
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21591096

1. HORIO Yoshiyuk (30181530)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
2. SAKAMOTO Jun (40336392)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. HATTA Shinnichi (60094223)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TAKEMURA Haruo (20106462)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. MIYAMOTO Atsushi (50166196)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. SHIMOHAMA Shun (60235687)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
7. 岩原直敏 (00613085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 村岡賢 (50582681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 齋藤太郎 (60718063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. INUZUKA Eiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 藤井博匡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 江本美穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Hisahara Shin 久原 真

久原 真 ヒサハラ シン

HISAHARA Shin 久原 真

HISAKARA Shin 久原 真

Research Projects

Research Products

Co-Researchers

アストロサイトより放出される細胞外小胞の脱髄疾患モデルにおける解析Principal Investigator

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Role of microglia-derived exosomes in the neurodegeneration of multiple sclerosis.

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周皮細胞のアルツハイマー病モデルにおける分化転換の解析Principal Investigator

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Analysis of microRNA in oligodendrocyte degenerationPrincipal Investigator

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Functional analysis of histone deacetylase SIRT in the pathophysiology of neurodegenerative disordersPrincipal Investigator

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老化と体内時計

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神経細胞増殖・分化におけるヒストン脱アセチル化酵素Sirの役割Principal Investigator

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脳Sirの老化、寿命における分子機能解析

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Investigation for the roles of ions in the differentiation, structure and death in cells

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Mechanism of water transport; Elucidation of brain edema and development of treatment.

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[Book] Animal Models of Parkinson's Disease Induced by Toxins and Genetic Manipulation2012

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[Book] Mechanisms in Parkinson's Disease-Models and Treatments2011

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[Journal Article] Cerebral Tuberculoma Diagnosed by Nested Polymerase Chain Reaction of a Formalin-fixed Paraffin-embedded Brain Biopsy Sample2023

Author(s)

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DOI

Hisahara Shin 久原真

久原真ヒサハラシン

HISAHARA Shin 久原真

HISAKARA Shin 久原真