Kaga Naoko 加賀直子

… Alternative Names

加賀直子カガナオコ

KAGA Naoko 加賀直子

Less

Researcher Number	80338342
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 助教 2016 – 2020: 順天堂大学, 医学(系)研究科(研究院), 助教 2004 – 2005: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Applied health science / Structural biochemistry
Keywords	Principal Investigator 非感染性慢性疾患 / メタボロミクス / NCDｓ / 血中代謝物 / 非感染性慢性疾患（NCDs） / DOHaD / メチルドナー / 胎生期低栄養 / 脂質代謝 / 質量分析 … More / 血清メタボローム / 耐糖能異常 / 血中メタボローム解析 / メチルドナー補充 / 低出生体重 / 胎生期低糖質カロリー制限 … More Except Principal Investigator 質量分析 / メタボリック症候群 / 体質と環境 / 非感染性慢性疾患 / 低出生体重 / 先制医療 / 発症前診断 / 低出生体重児 / 高脂肪食 / 低体重児 / キャピラリー電気泳動質量分析 / DOHaD仮説 / 2型糖尿病 / 生活習慣病 / phagocytosis / innate immunity / stable-isotope labeling / mass spectrometry / microdomain / lipidomics / proteomics / 質料分析 / 定量プロテオミクス / 貪食 / 自然免疫 / 安定同位体標識 / マイクロドメイン / リピドミクス / プロテオミクス Less

体質と環境のミスマッチから生じる非感染性慢性疾患(NCDs)発症リスクの機構解明
- Principal Investigator
  
  高ひかり
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Juntendo University
Metabolomics reveals risk factors for the development of diseases in low-birth weight infants for preemptive medicinePrincipal Investigator
- Principal Investigator
  
  Kaga Naoko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Juntendo University
Realization of Preemptive Medicine by elucidating the onset mechanism of diabetes attributed to mismatch between Constitution and Environment
- Principal Investigator
  
  TAKA HIKARI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Juntendo University
Quantitative proteomic and lipidomic analysis of detergent-resistant membrane microdomain involved in signal transduction
- Principal Investigator
  
  YANAGIDA Mitsuaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  JUNTENDO UNIVERSITY

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster2023
- Author(s)
  Yamatoya Kenji、Kurosawa Masaru、Hirose Michiko、Miura Yoshiki、Taka Hikari、Nakano Tomoyuki、Hasegawa Akiko、Kagami Kyosuke、Yoshitake Hiroshi、Goto Kaoru、Ueno Takashi、Fujiwara Hiroshi、Shinkai Yoichi、Kan Frederick W K、Ogura Atsuo、Araki Yoshihiko
- Journal Title
  
  Biology of Reproduction
  
  Volume: 110 Issue: 3 Pages: 465-475
- DOI
  10.1093/biolre/ioad159
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-20K07834, KAKENHI-PROJECT-22K09648, KAKENHI-PROJECT-21K09503, KAKENHI-PROJECT-18KK0256, KAKENHI-PLANNED-19H05758, KAKENHI-PROJECT-23K27096
[Journal Article] Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice2023
- Author(s)
  Kakehi Saori、Tamura Yoshifumi、Ikeda Shin-ichi、Kaga Naoko、Taka Hikari、Nishida Yuya、Kawamori Ryuzo、Watada Hirotaka
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 14
- DOI
  10.3389/fphys.2023.1198390
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-21K11684
[Journal Article] The Effect of Long-Term Inorganic Iodine on Intrathyroidal Iodothyronine Content and Gene Expression in Mice with Graves' Hyperthyroidism2023
- Author(s)
  Uchida Toyoyoshi、Shimamura Mika、Taka Hikari、Kaga Naoko、Miura Yoshiki、Nishida Yuya、Nagayama Yuji、Watada Hirotaka
- Journal Title
  
  Thyroid
  
  Volume: 33 Issue: 3 Pages: 330-337
- DOI
  10.1089/thy.2022.0496
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K09028, KAKENHI-PROJECT-19K11752
[Journal Article] Biochemical characterization of mitochondria from adult worms and plerocercoid larvae of Spirometra mansoni shows mixed populations of anaerobic and aerobic mitochondria2023
- Author(s)
  Takamiya Shinzaburo、Nakamura Takeshi、Tsubokawa Daigo、Tsuji Naotoshi、Fukuda Koichi、Yamasaki Hiroshi、Fujimura Tsutomu、Taka Hikari、Kaga Naoko、Kobayashi-Tanabe Momoko、Matsuda Motoo、Mita Toshihiro
- Journal Title
  
  Parasitology International
  
  Volume: 92 Pages: 102695-102695
- DOI
  10.1016/j.parint.2022.102695
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-21K06996, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-20K05880
[Journal Article] A Comprehensive Analysis of Plasma Cytokines and Metabolites Shows an Association between Galectin-9 and Changes in Peripheral Lymphocyte Subset Percentages Following Coix Seed Consumption2022
- Author(s)
  Suzuki Yoshio、Miyahara Taisei、Jinnouchi Minami、Miura Yoshiki、Taka Hikari、Kaga Naoko、Ohara-Takada Akiko
- Journal Title
  
  Nutrients
  
  Volume: 14 Issue: 9 Pages: 1696-1696
- DOI
  10.3390/nu14091696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-18K07829
[Journal Article] Short-term physical inactivity induces diacylglycerol accumulation and insulin resistance in muscle via lipin1 activation2021
- Author(s)
  Kakehi Saori、Tamura Yoshifumi、Ikeda Shin-ichi、Kaga Naoko、Taka Hikari、Ueno Noriko、Shiuchi Tetsuya、Kubota Atsushi、Sakuraba Keishoku、Kawamori Ryuzo、Watada Hirotaka
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: 321 Issue: 6 Pages: E766-E781
- DOI
  10.1152/ajpendo.00254.2020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09403, KAKENHI-PROJECT-18H03152, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-20K09834, KAKENHI-PROJECT-21K06496, KAKENHI-PROJECT-21K11684, KAKENHI-PROJECT-18K19745
[Journal Article] Nicotine Oral Administration Attenuates DSS-Induced Colitis Through Upregulation of Indole in the Distal Colon and Rectum in Mice2021
- Author(s)
  Nakajima Akihito、Shibuya Tomoyoshi、Sasaki Takashi、Lu Yu Jie、Ishikawa Dai、Haga Keiichi、Takahashi Masahito、Kaga Naoko、Osada Taro、Sato Nobuhiro、Nagahara Akihito
- Journal Title
  
  Frontiers in Medicine
  
  Volume: 8
- DOI
  10.3389/fmed.2021.789037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08657, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-21K08692
[Journal Article] Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis2020
- Author(s)
  Takewaki D, Suda W, Sato W, Takayasu L, Kumar N, Kimura K, Kaga N, Mizuno T, Miyake S, Hattori M, Yamamura T
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 117 Issue: 36 Pages: 22402-22412
- DOI
  10.1073/pnas.2011703117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-18H04045
[Journal Article] Correction: Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-12019
- Author(s)
  Sekihara Kazumasa、Saitoh Kaori、Han Lina、Ciurea Stefan、Yamamoto Shinichi、Kikkawa Mika、Kazuno Saiko、Taka Hikari、Kaga Naoko、Arai Hajime、Miida Takashi、Andreeff Michael、Konopleva Marina、Tabe Yoko
- Journal Title
  
  Oncotarget
  
  Volume: 10 Issue: 63 Pages: 6842-6842
- DOI
  10.18632/oncotarget.27309
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K11752
[Journal Article] A metabolic profile of polyamines in parkinson disease: A promising biomarker2019
- Author(s)
  Saiki Shinji、Sasazawa Yukiko、Fujimaki Motoki、Kamagata Koji、Kaga Naoko、Taka Hikari、Li Yuanzhe、Souma Sanae、Hatano Taku、Imamichi Yoko、Furuya Norihiko、Mori Akio、Oji Yutaka、Ueno Shin‐Ichi、Nojiri Shuko、Miura Yoshiki、Ueno Takashi、Funayama Manabu、Aoki Shigeki、Hattori Nobutaka
- Journal Title
  
  Annals of Neurology
  
  Volume: 86 Issue: 2 Pages: 251-263
- DOI
  10.1002/ana.25516
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0027, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-19K08003, KAKENHI-PROJECT-19K11752, KAKENHI-PROJECT-19K22603, KAKENHI-PROJECT-18H04043, KAKENHI-PROJECT-18H02744, KAKENHI-PROJECT-18K15464
[Journal Article] Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine.2018
- Author(s)
  Tabe Y, Saitoh K, Yang H, Sekihara K, Yamatani K, Ruvolo V, Taka H, Kaga N, Kikkawa M, Arai H, Miida T, Andreeff M, Spagnuolo PA, Konopleva M.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 16837-16837
- DOI
  10.1038/s41598-018-35198-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07424, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-16K19855, KAKENHI-PROJECT-15K08653, KAKENHI-PROJECT-16K01834
[Journal Article] Choline-related metabolites influenced by feeding patterns in preterm and term infants2018
- Author(s)
  Shoji Hiromichi、Taka Hikari、Kaga Naoko、Ikeda Naho、Hisata Ken、Miura Yoshiki、Shimizu Toshiaki
- Journal Title
  
  The Journal of Maternal-Fetal & Neonatal Medicine
  
  Volume: ー Issue: 2 Pages: 1-6
- DOI
  10.1080/14767058.2018.1488165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-20K08194, KAKENHI-PROJECT-17K10192
[Journal Article] Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease.2018
- Author(s)
  Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N.
- Journal Title
  
  Neurology.
  
  Volume: 90 Issue: 5 Pages: 1-8
- DOI
  10.1212/wnl.0000000000004888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-16K09675, KAKENHI-PROJECT-16K09676, KAKENHI-PROJECT-16K09700, KAKENHI-PROJECT-17K07797, KAKENHI-PROJECT-15KK0354, KAKENHI-PROJECT-18K07829, KAKENHI-PROJECT-18H04043
[Journal Article] A pilot study of the effect of human breast milk on urinary metabolome analysis in infants.2017
- Author(s)
  Shoji H, Taka H, Kaga N, Ikeda N, Kitamura T, Miura Y, Shimizu T.
- Journal Title
  
  J Pediatr Endocrinol Metab.
  
  Volume: 30 Issue: 9 Pages: 939-946
- DOI
  10.1515/jpem-2017-0179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-15K09727, KAKENHI-PROJECT-26461643
[Journal Article] Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes.2017
- Author(s)
  Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K.
- Journal Title
  
  Respir Res.
  
  Volume: 18 Issue: 1 Pages: 46-46
- DOI
  10.1186/s12931-017-0529-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-16K15598, KAKENHI-PROJECT-17K10653, KAKENHI-PROJECT-16K15625
[Journal Article] Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1.2017
- Author(s)
  Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y.
- Journal Title
  
  Oncotarget
  
  Volume: in press Issue: 21 Pages: 34552-34564
- DOI
  10.18632/oncotarget.16602
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08653, KAKENHI-PROJECT-16K19855, KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-15K08624
[Journal Article] Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2.2016
- Author(s)
  Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada SS, Giacca A, Kanazawa A, Fujitani Y, Kawamori R, Watada H.
- Journal Title
  
  J Clin Endocrinol Metab.
  
  Volume: 101 Issue: 10 Pages: 3676-3684
- DOI
  10.1210/jc.2016-1650
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01834
[Journal Article] Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids.2016
- Author(s)
  Morales J, Hashimoto M, Williams TA, Hirawake-Mogi H, Makiuchi T, Tsubouchi A, Kaga N, Taka H, Fujimura T, Koike M, Mita T, Bringaud F, Concepcion JL, Hashimoto T, Embley TM, Nara T.
- Journal Title
  
  Proc R Soc B
  
  Volume: 283 Issue: 1830 Pages: 20160520-20160520
- DOI
  10.1098/rspb.2016.0520
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-15K08452, KAKENHI-PROJECT-16K01834, KAKENHI-PROJECT-16K15268
[Presentation] 低出生体重倹約型表現型モデルラットの骨格筋と脂肪組織の解析2022
- Author(s)
  根本崇宏、加賀直子、高ひかり、上野隆
- Organizer
  第95回日本生化学大会　2022年11月9日―11日
- Data Source
  KAKENHI-PROJECT-18K07829
[Presentation] 低出生体重倹約型表現型モデルラットの骨格筋と脂肪組織の解析2022
- Author(s)
  根本崇宏、加賀直子、高ひかり、上野隆
- Organizer
  第95回日本生化学大会
- Data Source
  KAKENHI-PROJECT-19K11752
[Presentation] 出生後母乳を介したメチルドナー補充が低栄養出生仔へ与える影響2019
- Author(s)
  加賀直子,高ひかり、上野隆、三浦芳樹
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K11752
[Presentation] 出生後母乳を介したメチルドナー補充が低栄養出生仔へ与える影響2019
- Author(s)
  加賀直子、高ひかり、上野隆、三浦芳樹、根本崇宏
- Organizer
  第92回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07829
[Presentation] 低出生体重仔への高脂肪食負荷による非感染性慢性疾患（NCDｓ）発症リスクへの影響2018
- Author(s)
  高ひかり、加賀直子、上野隆、三浦芳樹、根本崇宏
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07829
[Presentation] 低出生体重仔への高脂肪食負荷による非感染性慢性疾患（NCDｓ）発症リスクへの影響2018
- Author(s)
  高ひかり、加賀直子、上野隆、三浦芳樹、根本崇宏
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K01834
[Presentation] 低出生体重仔における非感染性慢性疾患発症機序の解明2016
- Author(s)
  加賀　直子、高　ひかり、上野隆、根本崇宏
- Organizer
  第10回メタボロームシンポジウム
- Place of Presentation
  山形県鶴岡市
- Year and Date
  2016-10-19
- Data Source
  KAKENHI-PROJECT-16K01834

1. TAKA HIKARI (60338374)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
2. YANAGIDA Mitsuaki (80365569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. IWABUCHI Kazuhisa (10184897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NEMOTO takahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. FUNAYAMA Manabu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SASAZAWA Yukiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 田部陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 三井田孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 斉木臣二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 上野紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 長田太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 奈良武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 橋本宗明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 坪内暁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. モラレスホルヘ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kaga Naoko 加賀 直子

加賀 直子 カガ ナオコ

KAGA Naoko 加賀 直子

Research Projects

Research Products

Co-Researchers

体質と環境のミスマッチから生じる非感染性慢性疾患(NCDs)発症リスクの機構解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metabolomics reveals risk factors for the development of diseases in low-birth weight infants for preemptive medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Realization of Preemptive Medicine by elucidating the onset mechanism of diabetes attributed to mismatch between Constitution and Environment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitative proteomic and lipidomic analysis of detergent-resistant membrane microdomain involved in signal transduction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Effect of Long-Term Inorganic Iodine on Intrathyroidal Iodothyronine Content and Gene Expression in Mice with Graves' Hyperthyroidism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical characterization of mitochondria from adult worms and plerocercoid larvae of Spirometra mansoni shows mixed populations of anaerobic and aerobic mitochondria2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Comprehensive Analysis of Plasma Cytokines and Metabolites Shows an Association between Galectin-9 and Changes in Peripheral Lymphocyte Subset Percentages Following Coix Seed Consumption2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Short-term physical inactivity induces diacylglycerol accumulation and insulin resistance in muscle via lipin1 activation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nicotine Oral Administration Attenuates DSS-Induced Colitis Through Upregulation of Indole in the Distal Colon and Rectum in Mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correction: Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-12019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A metabolic profile of polyamines in parkinson disease: A promising biomarker2019

Author(s)

Journal Title

DOI

Data Source

Kaga Naoko 加賀直子

加賀直子カガナオコ

KAGA Naoko 加賀直子