Isse Toyohi 一瀬豊日

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ISSE Toyohi 一瀬豊日

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Researcher Number	80341494
Other IDs
External Links
Affiliation (Current)	2025: 産業医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2008 – 2014: University of Occupational and Environmental Health, Japan, 医学部, 准教授 2006 – 2007: University of Occupational and Environmental Health, Japan, School of Medicine, Assistant professor, 医学部, 講師 2001 – 2005: 産業医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Hygiene and public health / Risk sciences of radiation/Chemicals / Hygiene / Hygiene Except Principal Investigator Hygiene / Hygiene
Keywords	Principal Investigator アセトアルデヒド / 毒性 / 診療科目 / 勤務地選択 / 医師のキャリアパス / 空間統計学 / 医師偏在 / 保健医療行政 / 蛋白質付加体 / ミトコンドリアゲノム … More / 蛋白付加体 / ゲノム付加体 / ミトコンドリア / アルデヒド / 健康影響 / 発がん性 / トキシコロジー / 付加体 / 亜鉛 / アクロレイン / アセトアルデヒト / ノックアウトマウス / アルデヒド脱水素酵素 / 視床下部 / 遺伝子発現 / マイクロアレイ法 / 遺伝子多型 / エタノール / アルコール嗜好性 / アルデヒド脱水素酵素2 … More Except Principal Investigator CytochromeP450 2E1 / tumor marker / CytochromeP450 / lung cancer / esophageal cancer / Knock out mouse / ALDH2 / p53 / CytochromeP450 2A6 / 食道癌 / Cytochrome P450 2E1 / 遺伝子多型 / アルコール / ノックアウトマウス / アルデヒド脱水素酵素 / Survival / Smoking / Lung cancer / Prevention / CytochromeP450 1A1 / 生存率 / 喫煙 / 肺癌 / 肺癌予防 / Environmental Chemicals / Ethanol / Acetaldehyde / Alcohol preference / Genetic Polymorphism / Alcohol / Knockout mice / Acetaldehyde dehydrogenase / 内因性オピオイド / エタノール嗜好性 / 環境中化学物質 / アセトアルデヒド / アルコール嗜好性 / Cytochrome P450 / 扁平上皮癌 / 皮膚癌 / 癌 / Aldh2欠損マウス / 環境中毒 / SDS-PAGE / 蛋白質付加体 / 質量分析 / プロテオミクス / 蛋白付加体 / IgG / IgE / 環境化学物質 / 共有結合 / 免疫グロブリン / アレルギー / 化学物質 / 感作 / 環境 Less

GEOSTATIC AND CARRIER ANALYSIS OF PHYSICIAN IN JAPANPrincipal Investigator
- Principal Investigator
  
  ISSE Toyohi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hygiene and public health
- Research Institution
  University of Occupational and Environmental Health, Japan
Elucidation of the development mechanism of the alcohol and aceta l dehyde-induced squamous-cell-carcinoma by using A/dh2 deficient mice.
- Principal Investigator
  
  OZAKI Shinichi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  University of Occupational and Environmental Health, Japan
Mitochondrial genome/protein toxicity mechanism of aldehyde.Principal Investigator
- Principal Investigator
  
  ISSE Toyohi
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  University of Occupational and Environmental Health, Japan
Development of specific immunoglobulin against environmental sensitizing chemicals and actual survey on sensitizing status
- Principal Investigator
  
  KAWAMOTO Toshihiro
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  University of Occupational and Environmental Health, Japan
アルデヒド脱水素酵素2欠損マウスを用いた吸入毒性感受性の研究Principal Investigator
- Principal Investigator
  
  一瀬豊日
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hygiene
- Research Institution
  University of Occupational and Environmental Health, Japan
Detection of the cytochrome P450 enzyme in lung cancer may be useful for cancer screening
- Principal Investigator
  
  OYAMA Tsunehiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  University of Occupational and Environmental Health, Japan
Study of the mechanism of alcohol-induced organ disorders, including esophageal cancer, using aldehyde dehydrogenase 2 (ALDH2) knock-out mice.
- Principal Investigator
  
  KAWAMOTO Toshihiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  University of Occupational and Environmental Health, Japan
アセトアルデヒド脱水素酵素欠損マウスを用いた行動・神経毒性の遺伝子発現変化の解析Principal Investigator
- Principal Investigator
  
  一瀬豊日
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hygiene
- Research Institution
  University of Occupational and Environmental Health, Japan
CYP2A6 and CYP2E1 immunoreactivities in bronchial epithelial cells affected by smoking in non-small cell lung cancer patients.
- Principal Investigator
  
  OYAMA Tsunehiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  University of Occupational and Environmental Health
A study about individual sensitivity to environmental chemicals using acetaldehyde dehydrogenase 2 knockout mice
- Principal Investigator
  
  KAWAMOTO Toshihiro
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  University of Occupational and Environmental Health

All 2014 2012 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation Book

[Book] Enzymology and Molecular Biology of Carbonyl Metabolism-12.(Weiner, H., Plapp, B., Lindahl, R., Maser, E. (Eds), Actalodehyde elimination changes in transgenic mice lacking aldehyde dehydrogenase 2 activity.)2006
- Author(s)
  Isse T, Oyama T, Matsuno K, Kitagawa K, Ogawa M, Kinaga T, Suzuki-Narai R, Yamaguchi T, Uchiyama I, Kawamoto T
- Publisher
  Purdue University Press
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] 医師・歯科医師・薬剤師調査を基にした医師過剰状態の定量指標の検討2014
- Author(s)
  一瀬豊日, 中村早人, 蜂須賀研二
- Journal Title
  
  日本衛生学雑誌
  
  Volume: 69 Pages: 209-209
- Data Source
  KAKENHI-PROJECT-25670328
[Journal Article] 平成24年までの医師歯科医師薬剤師調査より捉えた産業医数と業務内容の変化2014
- Author(s)
  一瀬豊日, 中村早人, 蜂須賀研二
- Journal Title
  
  産業衛生学雑誌
  
  Volume: 56 Pages: 510-510
- Data Source
  KAKENHI-PROJECT-25670328
[Journal Article] The effect of ethanol on the formation of N^<2-> ethylidene-dG adducts in mice: implications for alcohol-related carcinogenicity of the oral cavity and esophagus2012
- Author(s)
  Yu H-S, Oyama T, Matsuda T, Isse T, Yamaguchi T, Tanaka M, Tsuji M, Kawamoto T
- Journal Title
  
  Biomarkers
  
  Volume: 17 Issue: 3 Pages: 269-274
- DOI
  10.3109/1354750x.2012.666675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590620, KAKENHI-PROJECT-22510036, KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-24390159
[Journal Article] Effects and Action Mechanisms of Korean Pear(Pyrus pyrifolia cv. Shingo) on Alcohol Detoxification2012
- Author(s)
  Lee HS, Isse T, Kawamoto T, Woo HS, Kim AK, Park JY, Yang M.
- Journal Title
  
  Phytother Res
  
  Volume: 17 Issue: 11 Pages: 269-274
- DOI
  10.1002/ptr.4630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006, KAKENHI-PROJECT-22510036
[Journal Article] The effect of ethanol on the formation of N((2))-ethylidene-dG adducts in mice : implications for alcohol-related carcinogenicity of the oral cavity and esophagus.2012
- Author(s)
  Yu HS, Oyama T, Matsuda T, Isse T, Yamaguchi T, Tanaka M, Tsuji M, Kawamoto T.
- Journal Title
  
  Biomarkers
  
  Volume: 17巻 Pages: 269-274
- URL
  http://informahealthcare.com/doi/abs/10.3109/1354750X.2012.666675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Aldehyde Dehydrogenase-2 Deficiency Aggravates Cardiac Dysfunction Elicited by Endoplasmic Reticulum Stress Induction2012
- Author(s)
  Liao J, Sun A, Xie Y, Isse T, Kawamoto T, Zou Y, Ge J.
- Journal Title
  
  Mol Med
  
  Volume: (in press) Issue: 5 Pages: 785-793
- DOI
  10.2119/molmed.2011.00466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice2011
- Author(s)
  Shimizu Y, Sakai A, Menuki K, Mori T, Isse T, Oyama T, Kawamoto T, Nakamura T.
- Journal Title
  
  Bone
  
  Volume: 48巻 Pages: 1075-1086
- URL
  http://www.sciencedirect.com/science/article/pii/S8756328211000123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice(Aldh2-/-)2010
- Author(s)
  Oyama T, Nagayoshi H, Matsuda T, Oka M, Isse T, Yu HS, Pham TT, Tanaka M, Kagawa N, Kaneko K, Kawamoto T.
- Journal Title
  
  Front Biosci(Elite Ed)
  
  Volume: 1巻 Pages: 1344-1354
- URL
  http://www.bioscience.org/2010/V2E/af/194/fulltext.htm
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice (Aldh2^<-/->).2010
- Author(s)
  Oyama T, Nagayoshi H, Matsuda T, Oka M, Isse T, Yu HS, Pham TTP, Tanaka M, Kagawa N, Kaneko K, Kawamoto T
- Journal Title
  
  Front Biosci (Elite Ed) 2
  
  Pages: 1344-1354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590620
[Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice (Aldh2^<-/->)2010
- Author(s)
  Oyama T, Nagayoshi H, Matsuda T, Oka M, Isse T, Yu HS, Pham TTP, Tanaka M, Kagawa N, Kaneko K, Kawamoto T
- Journal Title
  
  Front Biosci (Elite Ed)
  
  Volume: 2 Pages: 1344-1354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590620
[Journal Article] Formation of acetaldehyde-derived DNA adducts due to alcohol exposure.2010
- Author(s)
  Yu HS, Oyama T, Isse T, Kitagawa K, Pham TT, Tanaka M, Kawamoto T.
- Journal Title
  
  Chem Biol Interact
  
  Volume: 188巻 Pages: 367-375
- URL
  http://www.sciencedirect.com/science/article/pii/S0009279710005259
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Formation of acetaldehyde-derived DNA adducts due to alcohol exposure.2010
- Author(s)
  Yu HS, Oyama T, Isse T, Kitagawa K, Pham TT, Tanaka M, Kawamoto T.
- Journal Title
  
  Chem Biol Interact. 188巻
  
  Pages: 367-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Formation of acetaldehyde-derived DNA adducts due to alcohol exposure.2010
- Author(s)
  Yu HS, Oyama T, Isse T, et al
- Journal Title
  
  Chem Biol Interact.
  
  Volume: 188 Pages: 367-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice(Aldh2-/-).2010
- Author(s)
  Oyama T, Nagayoshi H, Matsuda T, Oka M, Isse T, Yu HS, Pham TT, Tanaka M, Kagawa N, Kaneko K, Kawamoto T.
- Journal Title
  
  Front Biosci. 2巻
  
  Pages: 1344-1354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models2009
- Author(s)
  Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K, Ijiri I, Kinoshita H.
- Journal Title
  
  Brain Res
  
  Volume: 1295巻 Pages: 37-43
- URL
  http://www.sciencedirect.com/science/article/pii/S0006899309015935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Ethanol metabolism in ALDH2 knockout mice I Blood acetate levels2009
- Author(s)
  Ameno K, Wang W., Jamal M, Toyohi I, Kawamoto T, Kitagawa K, Nakayama K-I, Ijiri I, Kinoshita H
- Journal Title
  
  Legal Medicine 11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mices2009
- Author(s)
  Yu H-S, Oyama T, Isse T, Kitagawa K, Ogawa M, Pham TTP, Kawamoto T
- Journal Title
  
  Toxicology Mechanisms and Methods 19
  
  Pages: 535-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Characteristics of aldehyde dehydrogenase 2(Aldh2) knockout mice2009
- Author(s)
  Yu HS, Oyama T, Isse T, Kitakawa K, Ogawa M, Pham TT, Kawamoto T.
- Journal Title
  
  Toxicol Mech Methods
  
  Volume: 19巻 Pages: 535-540
- URL
  http://informahealthcare.com/doi/abs/10.3109/15376510903401708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficinet mice models.2009
- Author(s)
  Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K-I, Ijiri I, Kinoshita H
- Journal Title
  
  Brain Research 1295
  
  Pages: 37-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals2009
- Author(s)
  Pham TT, Oyama T, Isse T, Kawamoto T.
- Journal Title
  
  Arch Environ Contam Toxicol 1295
  
  Pages: 427-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals2009
- Author(s)
  Pham TT, Oyama T, Isse T, Kawamoto T
- Journal Title
  
  Arch Environ Contam Toxicol
  
  Volume: 57巻 Pages: 427-436
- URL
  http://www.springerlink.com/content/u8qh1q2366445482/?MUD=MPEpub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals.2009
- Author(s)
  Pham TTP, Oyama T, Isse T, Kawamoto T
- Journal Title
  
  Archives of Environmental Contamination and Toxicology. 57
  
  Pages: 427-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] ダイオードアレイ検出器高速液体クロマトグラフィーを用いた感作性化学物質による蛋白付加体形成の簡易検査法2009
- Author(s)
  一瀬豊日、Pham TTP、小山倫浩、荻野景規、川本俊弘
- Journal Title
  
  日本予防医学会雑誌 4
  
  Pages: 23-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice.2009
- Author(s)
  Yu H-S, Oyama T, Isse T, Kitagawa K, Ogawa M, Pham TTP, Kawamoto T.
- Journal Title
  
  Toxicology Mechanisms and Methods 19(9)
  
  Pages: 535-540
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of A1dh2-deficient mice models2009
- Author(s)
  Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K, Ijiri I, Kinoshita H.
- Journal Title
  
  Brain Res. 1295
  
  Pages: 37-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals.2009
- Author(s)
  Pham TT, Oyama T, Isse T, Kawamoto T.
- Journal Title
  
  Arch Environ Contam Toxicol 1295巻
  
  Pages: 427-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models.2009
- Author(s)
  Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K, Ijiri I, Kinoshita H.
- Journal Title
  
  Brain Res. 1295巻
  
  Pages: 37-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals2009
- Author(s)
  Pham TTP, Oyama T, Isse T, Kawamoto T
- Journal Title
  
  Application of tryptophan fluorescence to assess sensitizing potentials of chemicals 57
  
  Pages: 427-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Characteristics of aldehyde dehydrogenase 2(Aldh2)knockout mice.2009
- Author(s)
  Yu HS, Oyama T, Isse T, Kitakawa K, Ogawa M, Pham TT, Kawamoto T.
- Journal Title
  
  Toxicol Mech Methods. 19巻
  
  Pages: 535-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Characteristics of aldehyde dehydrogenase 2(A1dh2) knockout mice2009
- Author(s)
  Yu HS, Oyama T, Isse T, Kitakawa K, Ogawa M, Pham TT, Kawamoto T.
- Journal Title
  
  Toxicol Mech Methods. 19
  
  Pages: 535-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficinet mice models2009
- Author(s)
  Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K-I, Ijiri I, Kinoshita H
- Journal Title
  
  Brain Research 1295
  
  Pages: 37-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice2008
- Author(s)
  Matsumoto A, Kawamoto T, Mutoh F, Isse T, Oyama T, Kitagawa K, Nakayama KI, Ichiba M
- Journal Title
  
  Pharmacogenet Genomics
  
  Volume: 18巻 Pages: 847-852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Effects of 5-week ethanol feeding on the liver of aldehyde dehydorgenase 2 knockout mice.2008
- Author(s)
  Matsumoto A, Kawamoto T, Mutoh F, Isse T, Oyama T, Kitagawa K, Nakayama K-I. Ichiba M.
- Journal Title
  
  Pharmacogenetics and Genomices 18
  
  Pages: 847-852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde2008
- Author(s)
  Kunugita N, Isse T, Oyama T, Kitagawa K, Ogawa M, Yamaguchi T, Kinaga T, Kawamoto T.
- Journal Title
  
  J Toxicol Sci 33
  
  Pages: 31-36
- NAID
  110006596029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Expression of Cytochrome P450 in non-small cell lung cancer2008
- Author(s)
  Oyama T, Sugio K, Isse T, Matsumoto A, Nose N, Uramoto H, Nozoe T, Morita M, Kagawa N, Osaki T, Muto M, Yasumoto K, Kawamoto T
- Journal Title
  
  Front Biosci
  
  Volume: 13 Pages: 5787-5793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590620
[Journal Article] Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice2008
- Author(s)
  Matsumoto A, Kawamoto T, Mutoh F, Isse T, Oyama T, Kitagawa K, Nakayama KI, Ichiba M.
- Journal Title
  
  Pharmacogenet Genomics 18
  
  Pages: 47-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice.2008
- Author(s)
  Matsumoto A, Kawamoto T, Mutoh F, Isse T, Oyama T, Kitagawa K, Nakayama KI, Ichiba M.
- Journal Title
  
  Pharmacogenet Genomics. 18巻
  
  Pages: 47-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Effects of 5-week ethanol feeding on the liver of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice.2008
- Author(s)
  Matsumoto A, Kawamoto T, Mutoh F, Isse T, Oyama T, Kitagawa K, Nakayama KI, Ichiba M
- Journal Title
  
  Pharmacogenet Genom
  
  Volume: 18 Issue: 10 Pages: 847-852
- DOI
  10.1097/fpc.0b013e328307a0a9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590620
[Journal Article] Expression of Cytochrome P450 in non-small cell lung cancer.2008
- Author(s)
  Oyama T, Sugio K, Isse T, Matsumoto A, Nose N, Uramoto H, Nozoe T, Morita M, Kagawa N, Osaki T, Muto M, Yasumoto K, Kawamoto T
- Journal Title
  
  Front Biosci 13
  
  Pages: 5787-5793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590620
[Journal Article] Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde.2008
- Author(s)
  Kunugita N, Isse T, Oyama T, Kitagawa K, Ogawa M, Yamaguchi T, Kinaga T, Kawamoto T.
- Journal Title
  
  J Toxicol Sci. 33巻
  
  Pages: 31-36
- NAID
  110006596029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20681006
[Journal Article] Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in A ldh2 knockout mice exposed to acetaldehyde2008
- Author(s)
  Kunugita N, Isse T, Oyama T, Kitagawa K, Ogawa M, Yamaguchi T, Kinaga T, Kawamoto T
- Journal Title
  
  J Toxicol Sci
  
  Volume: 33 Pages: 31-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590620
[Journal Article] 指定感作性物質の国際比較2007
- Author(s)
  村上朋絵、小山倫浩、一瀬豊日、奈良井理恵、金岡麻希、PHAN Thi Thu Phuong、川本俊弘
- Journal Title
  
  産業医科大学雑誌 29(3)
  
  Pages: 303-388
- NAID
  110006381797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice2007
- Author(s)
  Oyama T, Isse T, Ogawa M, Muto M, Uchiyama I, Kawamoto T
- Journal Title
  
  Frontiers in Bioscience 12
  
  Pages: 1927-1934
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice.2007
- Author(s)
  Oyama T, Isse T, Ogawa M, Muto M, Uchiyama I, Kawamoto T
- Journal Title
  
  Frontiers in Bioscience 12
  
  Pages: 1927-1934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] International comparison of criteria for evaluating sensitization of PRTR-designated chemical substances2007
- Author(s)
  Murakami T, Oyama T, Isse T, Ogawa M, Sugio T, Kawamoto T
- Journal Title
  
  Environmental Health and Preventive Medicine 12(2) (in press)
- NAID
  110006243383
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] International comparison of criteria for evaluating sensitization of PRTR-designated chemical substances2007
- Author(s)
  Murakami T, Oyama T, Isse T, Ogawa M, Sugie T, Kawamoto T
- Journal Title
  
  Environmental Health and Preventive Medicine 56-65
  
  Pages: 12-12
- NAID
  110006243383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Uchiyama I. : Effects of lifestyle on urinary 1-hydroxypyrene concentration2007
- Author(s)
  Kawamoto T, Yang M, Kim Y-D, Kim H, Oyama T, Isse T, Matsuno K, Katoh T, Uchiyama I
- Journal Title
  
  Journal of Occupational Health 183-189
  
  Pages: 49-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype.2007
- Author(s)
  Ogawa M, Oyama T, Isse T, Saito K, Tomigahara Y, Endo Y, Kawamoto T
- Journal Title
  
  Toxicol Lett. 168(2)
  
  Pages: 148-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] 飲酒により生じるタンパク質付加体と臓器障害2007
- Author(s)
  一瀬豊日、北川恭子、松野康二、松田知成、小山倫浩川本俊弘
- Journal Title
  
  日本アルコール精神医学雑誌 14
  
  Pages: 3-9
- NAID
  40016137824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790387
[Journal Article] 飲酒により生じるタンパク質付加体と臓器障害2007
- Author(s)
  一瀬豊日、小山倫浩、PHAM Thi Thu Phoung、川本俊弘
- Journal Title
  
  日本予防医学会雑誌 2
  
  Pages: 9-12
- NAID
  40016137824
- Data Source
  KAKENHI-PROJECT-18790387
[Journal Article] Effects of lifestyle on urinary 1-hydroxypyrene concentration.2007
- Author(s)
  Kawamoto T, Yang M, Kim Y-D, Kim H, Oyama T, Isse T, Matsuno K, Katoh T, Uchiyama I
- Journal Title
  
  Journal of Occupational Health 49(3)
  
  Pages: 183-189
- NAID
  110006278712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] International comparison of criteria for evaluating sensitization of PRTR-designated chemical substances.2007
- Author(s)
  Murakami T, Oyama T, Isse T, Ogawa M, Sugie T, Kawamoto T
- Journal Title
  
  Environmental Health and Preventive Medicine 12(2)
  
  Pages: 56-65
- NAID
  110006243383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Urinary 8-Hydoxydeoxyguanosine (8-OHdG) and Plasma Malondialdehyde (MDA) Levels in Aldh2 knock-out mice under acetaldehyde exposure2006
- Author(s)
  Ogawa M, Isse T, Oyama T, Kunugita N, Yamaguchi T, Kinaga T, Narai R, Kim H, Uchiyama I, Kawamoto T
- Journal Title
  
  Industrial Health 44
  
  Pages: 179-183
- NAID
  40007169620
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Hemoglobin adducts as a marker of exposure to chemical substances, especially PRTR class I designated chemical substances2006
- Author(s)
  Ogawa M, Oyama T, Isse T, Yamaguchi T, Murakami T, Endo Y, Kawamoto T
- Journal Title
  
  Journal of Occupational Health 48(5)
  
  Pages: 314-328
- NAID
  110004821575
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Hemoglobin adducts as a marker of exposure to chemical substances, especially PRTR class I designated chemical substances.2006
- Author(s)
  Ogawa M, Oyama T, Isse T, Yamaguchi T, Murakami T, Endo Y, Kawamoto T
- Journal Title
  
  Journal of Occupational Health. 48
  
  Pages: 314-328
- NAID
  110004821575
- Data Source
  KAKENHI-PROJECT-18390187
[Journal Article] Paired acuta inhalation test reveals that aldehyde toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-type mice.2005
- Author(s)
  Isse T, et al.
- Journal Title
  
  J Toxicol Sci 30
  
  Pages: 329-337
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590527
[Journal Article] Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain and liver after ethanol gavages.2005
- Author(s)
  Isse T, et al.
- Journal Title
  
  Alcohol Clin Exp Res 29
  
  Pages: 1959-1964
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590527
[Journal Article] Paired acute inhalation test reveals that aldehyde toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-type mice.2005
- Author(s)
  Isse T, et al.
- Journal Title
  
  J Toxicol Sci 30
  
  Pages: 329-337
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590527
[Journal Article] Aldehyde dehydrogenase 2 activity affects symptoms produced by an intraperitoneal acetaldehyde injection, but not acetaldehyde lethality.2005
- Author(s)
  Isse T, et al.
- Journal Title
  
  J Toxicol Sci 30
  
  Pages: 315-328
- NAID
  110002978309
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590527
[Presentation] 医師・歯科医師・薬剤師調査を基にした医師過剰状態の定量指標の検討2014
- Author(s)
  一瀬豊日、中村早人、蜂須賀研二
- Organizer
  第87回日本衛生学会学術総会
- Place of Presentation
  岡山（岡山コンベンションセンター）
- Data Source
  KAKENHI-PROJECT-25670328
[Presentation] 平成24年までの医師歯科医師薬剤師調査より捉えた産業医数と業務内容の変化2014
- Author(s)
  一瀬豊日、中村早人、蜂須賀研二
- Organizer
  第84回日本産業衛生学会学術総会
- Place of Presentation
  岡山（岡山コンベンションセンター）
- Data Source
  KAKENHI-PROJECT-25670328
[Presentation] エタノール摂取による症状とアルデヒド脱水素酵素(ALDH)2多型の影響2010
- Author(s)
  一瀬豊日
- Organizer
  平成22年度アルコール・薬物依存関連学会合同学術総会
- Place of Presentation
  リーガロイヤルホテル小倉(北九州)
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-20681006
[Presentation] エタノール摂取による症状とアルデヒド脱水素酵素(ALDH) 2多型の影響2010
- Author(s)
  一瀬豊日
- Organizer
  平成22年度アルコール・薬物依存関連学会合同学術総会
- Place of Presentation
  リーガロイヤルホテル小倉(北九州)
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-20681006
[Presentation] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals2009
- Author(s)
  Pham TTP, Oyama T, Isse T, Kawamoto T
- Organizer
  48^<th> Annual Meeting of Society of Toxicology
- Place of Presentation
  Baltimore (USA)
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice (Special Lecture)2009
- Author(s)
  Yu H-S, Oyama T, Isse T, Kitakawa K, Ogawa M, Pham TTP, Kawamoto T
- Organizer
  The 12^<th> International Symposium of Society for the Aldh2 Knockout Mouse Research
- Place of Presentation
  産業医科大学(Kitakyushu, Japan)
- Year and Date
  2009-10-05
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals (Special Lecture)2009
- Author(s)
  Pham TTP, Oyama T, Isse T, Kawamoto T
- Organizer
  The 12^<th> International Symposium of Society for the Aldh2 Knockout Mouse Research
- Place of Presentation
  産業医科大学(Kitakyushu, Japan)
- Year and Date
  2009-10-05
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals2009
- Author(s)
  Pham TTP, Oyama T, Isse T, Kawamoto T
- Organizer
  48th Annual Meeting of Society of Toxicology.
- Place of Presentation
  Baltimore, MA. USA.
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] Covalent bindings of environiental sensitizing chemicals to human serum albumin2008
- Author(s)
  Kawaioto T, Pham TTP, Isse T, Oyama T, Matsuno K
- Organizer
  The 2nd East Asia Conference of the International Society for Environmental Epidemiology
- Place of Presentation
  Jeju (Korea)
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] Covalent bindings of environmental sensitizing chemicals to human serum albumin.2008
- Author(s)
  Kawamoto T, Pham TTP, Isse T, Oyama T, Matsuno K
- Organizer
  The 2nd East Asia Conference of the International Society for Environmental Epidemiology.
- Place of Presentation
  Lotte Hotel Jeju, Korea
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] Aneletrophoretic study on covalent bidings of sensitizing chemical substances to albumin.2008
- Author(s)
  Kawamoto T, Oyama T, Isse T, Pham TTP
- Organizer
  47th Annual Meeting of Society of Toxicology. Seattle
- Place of Presentation
  WA. USA.
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] An electrophoretic study on covalent bindings of sensitizing chemical substances to albumin2008
- Author(s)
  Kawamoto T, Oyama T, Isse T, Pham TTP
- Organizer
  47^<th> Annual Meeting of Society of Toxicology. Seattle Annual Meeting of Society of Toxicology. Seattle
- Place of Presentation
  Seattle, USA, Mar
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] ダイオートアレイ検出器液体クロマトグラフィーによる感作性化学物質判定法2008
- Author(s)
  一瀬豊日、小山倫浩、Pham Thi Thu PHoung、荻野景規、川本俊弘
- Organizer
  第6回日本予防医学会学術総会
- Place of Presentation
  東京医科大学病院(東京都新宿区)
- Data Source
  KAKENHI-PROJECT-20681006
[Presentation] Aldh2 transgenic knockout mice dislike alcohol drinking and receive severer acetaldehyde toxicity2007
- Author(s)
  Isse T
- Organizer
  11th Congress of the European Society for Biomedical Research on Alcoholism
- Place of Presentation
  Berlin
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] Covalent bindings of environmental chemicals and albumin: An analysis by electrophoresis.2007
- Author(s)
  Kawamoto T, Yamaguchi T, Pham TTP, Isse T, Oyama T, Matsuno K
- Organizer
  XI International Congress of Toxicology. Montreal
- Place of Presentation
  Canada.
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] 遺伝子多型による毒性の差を検出する簡易濃度固定急性吸入毒性試験;アルデヒド脱水素酵素2ノックアウトマウス(Aldh2-/-)を用いた検討2007
- Author(s)
  一瀬豊日
- Organizer
  第34回日本トキシコロジー学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] Hemoglobin adduct as exposure markers of chemical substances.2006
- Author(s)
  Ogawa M, Oyama T, Isse T, Murakami T, Yamaguchi T, Kinaga T, Kawamoto T
- Organizer
  The 45th Annual Meeting of Society of Toxicology.
- Place of Presentation
  San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-18390187
[Presentation] Chemical substances which each country evaluates to produce sensitization.2006
- Author(s)
  Murakami T, Oyama T, Isse T, Narai R, Kinaga T, Ogawa M, Yamaguchi T, Kawamoto T
- Organizer
  The 45th Annual Meeting of Society of Toxicology.
- Place of Presentation
  San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-18390187

1. OYAMA Tsunehiro (00309965)

# of Collaborated Projects: 6 results

# of Collaborated Products: 37 results
2. KAWAMOTO Toshihiro (60177748)

# of Collaborated Projects: 6 results

# of Collaborated Products: 39 results
3. MATSUMOTO Akiko (10330979)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OZAKI Shinichi (70412632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. GOTOH Akinobu (70283885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KITAGAWA Kyoko (20299605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUGIO Kenji (70235927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松野康二 (40131940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

Isse Toyohi 一瀬 豊日

ISSE Toyohi 一瀬 豊日

Research Projects

Research Products

Co-Researchers

GEOSTATIC AND CARRIER ANALYSIS OF PHYSICIAN IN JAPANPrincipal Investigator

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Elucidation of the development mechanism of the alcohol and aceta l dehyde-induced squamous-cell-carcinoma by using A/dh2 deficient mice.

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Mitochondrial genome/protein toxicity mechanism of aldehyde.Principal Investigator

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Development of specific immunoglobulin against environmental sensitizing chemicals and actual survey on sensitizing status

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アルデヒド脱水素酵素2欠損マウスを用いた吸入毒性感受性の研究Principal Investigator

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Detection of the cytochrome P450 enzyme in lung cancer may be useful for cancer screening

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Study of the mechanism of alcohol-induced organ disorders, including esophageal cancer, using aldehyde dehydrogenase 2 (ALDH2) knock-out mice.

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アセトアルデヒド脱水素酵素欠損マウスを用いた行動・神経毒性の遺伝子発現変化の解析Principal Investigator

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CYP2A6 and CYP2E1 immunoreactivities in bronchial epithelial cells affected by smoking in non-small cell lung cancer patients.

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A study about individual sensitivity to environmental chemicals using acetaldehyde dehydrogenase 2 knockout mice

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[Book] Enzymology and Molecular Biology of Carbonyl Metabolism-12.(Weiner, H., Plapp, B., Lindahl, R., Maser, E. (Eds), Actalodehyde elimination changes in transgenic mice lacking aldehyde dehydrogenase 2 activity.)2006

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[Journal Article] 医師・歯科医師・薬剤師調査を基にした医師過剰状態の定量指標の検討2014

Author(s)

Journal Title

Data Source

[Journal Article] 平成24年までの医師歯科医師薬剤師調査より捉えた産業医数と業務内容の変化2014

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Data Source

[Journal Article] The effect of ethanol on the formation of N^<2-> ethylidene-dG adducts in mice: implications for alcohol-related carcinogenicity of the oral cavity and esophagus2012

Author(s)

Journal Title

Isse Toyohi 一瀬豊日

ISSE Toyohi 一瀬豊日