TAKAHASHI NAOTO 高橋直人

… Alternative Names

TAKAHASHI Naoto 高橋直人

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Researcher Number	80344753
Other IDs	https://orcid.org/0000-0002-6758-3787
Affiliation (Current)	2024: 秋田大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2024: 秋田大学, 医学系研究科, 教授 2018 – 2021: 秋田大学, 医学系研究科, 教授 2017: 秋田大学, 医学部, 教授 2016: 秋田大学, 医学部血液腎臓膠原病内科, 教授 2014 – 2016: 秋田大学, 医学(系)研究科(研究院), 教授 … More 2015: 秋田大学, 大学院医学系研究科, 教授 2013: 秋田大学, 医学部, 講師 2011 – 2013: 秋田大学, 医学(系)研究科(研究院), 講師 Less
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Medical pharmacy / Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator 慢性骨髄性白血病 / 薬剤耐性 / チロシンキナーゼ阻害薬 / 薬物濃度 / BIM / SNP / 薬物輸送蛋白 / T/Nk細胞プロファイリング / 制御性T細胞 / 薬物トランスポーター … More / NK細胞 / T細胞 / レナリドミド / 治療効果 / 血中濃度 / 多発性骨髄腫 / 骨髄性白血病 / microRNA / Bmi-1 / miR-200c / miRNA / CML … More Except Principal Investigator TDM / 血中濃度 / 分子標的治療薬 / 分子標的抗がん剤 / 赤血球造血 / CASIN / CASIN（阻害剤） / TRL4 / LPS / 好中球 / 造血幹細胞 / Cdc42 / 脱核 / ヒト赤芽球 / 膠原病 / 薬物動態学的相互作用 / イトラコナゾール / エベロリムス / 骨髄移植 / 腎移植 / 薬物動態 / CYP3A5遺伝子多型 / タクロリムス / 抗がん剤 / 個別化治療 / 精密医療 / side population / リンパ腫 / SAHA / マントル細胞リンパ腫 / SP細胞 / Bmi-1 / 皮膚浸潤性T細胞リンパ腫 / ケモカインレセプターCCR6 / 転移浸潤 / 悪性リンパ腫 / metastasis / CCR6 / miR-150 / miR-16 / Side population / CTCL / malignant lymphoma / miRNA / 個別化療法 / 遺伝子多型 Less

TKI抵抗性CMLに対するエキソーム解析とFRET解析の統合による個別化治療の可能性Principal Investigator
- Principal Investigator
  
  高橋直人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Akita University
The mechanism of organelle relocation in human erythroblasts.
- Principal Investigator
  
  Ubukawa Kumi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Akita University
Therapeutic drug management of the novel agents for multiple myelomaPrincipal Investigator
- Principal Investigator
  
  Takahashi Naoto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Akita University
Development of a new treatment strategy using TDM for next generation anticancer drug
- Principal Investigator
  
  Miura Masatomo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Akita University
Do patients taking tacrolimus need to undergo CYP3A5 genotyping along with blood concentration monitoring?
- Principal Investigator
  
  Niioka Takenori
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Akita University
Identification of microRNAs that might be therapeutic target of malignant lymphomas
- Principal Investigator
  
  Tagawa Hiroyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Akita University
Therapeutic drug management of tyrosine kinase inhibitor
- Principal Investigator
  
  MIURA MASATOMO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Akita University
Detection for miRNA dysregulation in CMLPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Naoto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Akita University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011

All Journal Article Presentation Book

[Book] Therapeutic Drug Monitoring of Imatinib for Chronic Myeloid Leukemia Patients. Myeloid Leukemia–Clinical Diagnosis and Treatment2011
- Author(s)
  Takahashi, N and Miura, M
- Publisher
  INTECH, Croatia
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] IL-6 Generated from Human Hematopoietic Stem and Progenitor Cells through TLR4 Signaling Promotes Emergency Granulopoiesis by Regulating Transcription Factor Expression2021
- Author(s)
  Sasaki Yumi、Guo Yong-Mei、Goto Tatsufumi、Ubukawa Kumi、Asanuma Ken、Kobayashi Isuzu、Sawada Kenichi、Wakui Hideki、Takahashi Naoto
- Journal Title
  
  The Journal of Immunology
  
  Volume: 207 Issue: 4 Pages: 1078-1086
- DOI
  10.4049/jimmunol.2100168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08315, KAKENHI-PROJECT-20K17367
[Journal Article] Cdc42 regulates cell polarization and contractile actomyosin rings during terminal differentiation of human erythroblasts2020
- Author(s)
  Ubukawa Kumi、Goto Tatsufumi、Asanuma Ken、Sasaki Yumi、Guo Yong-Mei、Kobayashi Isuzu、Sawada Kenichi、Wakui Hideki、Takahashi Naoto
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 11806-11806
- DOI
  10.1038/s41598-020-68799-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08315
[Journal Article] 1.ATP produced by anaerobic glycolysis is essential for enucleation of human erythroblasts.2019
- Author(s)
  Goto T, Ubukawa K, Kobayashi I, Sugawara K, Asanuma K, Sasaki Y, Guo YM, Takahashi N, Sawada K, Wakui H, Nunomura W.
- Journal Title
  
  Exp Hematol.
  
  Volume: 72
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08315
[Journal Article] Thrombocytopenia Caused by a Tea Beverage of <i>Taxus yunnanensis</i> (Chinese Yew)2019
- Author(s)
  Ubukawa K, Kameoka Y, Guo YM, Nara M, Watanabe A, Fujishima M, Fujishima N, Yoshioka T, Takahashi N.
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 21 Pages: 3153-3156
- DOI
  10.2169/internalmedicine.2967-19
- NAID
  130007740721
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-11-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08315
[Journal Article] The localization of α-synuclein in the process of differentiation of human erythroid cells2018
- Author(s)
  Araki Katsuya、Sugawara Kotomi、Hayakawa Eri H.、Ubukawa Kumi、Kobayashi Isuzu、Wakui Hideki、Takahashi Naoto、Sawada Kenichi、Mochizuki Hideki、Nunomura Wataru
- Journal Title
  
  International Journal of Hematology
  
  Volume: 108 Issue: 2 Pages: 130-138
- DOI
  10.1007/s12185-018-2457-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08315, KAKENHI-PROJECT-18K11135, KAKENHI-PROJECT-16K09716
[Journal Article] Clinical effects of single nucleotide polymorphisms on drug-related genes in Japanese metastatic renal cell carcinoma patients treated with sunitinib.2017
- Author(s)
  Numakura K, Tsuchiya N, Kagaya H, Takahashi M, Tsuruta H, Inoue T, Narita S, Huang M, Satoh S, Niioka T, Miura M, Habuchi T.
- Journal Title
  
  Anticancer Drugs.
  
  Volume: 28(1) Pages: 97-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460188
[Journal Article] Routine therapeutic drug monitoring of tyrosine kinase inhibitors by HPLC-UV or LC-MS/MS methods.2016
- Author(s)
  Miura M, Takahashi N.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 31(1) Issue: 1 Pages: 12-20
- DOI
  10.1016/j.dmpk.2015.09.002
- NAID
  50014431236
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460188
[Journal Article] Therapeutic drug monitoring enables safe and effective lenalidomide therapy in patients with multiple myeloma on hemodialysis2016
- Author(s)
  Takahiro Kobayashi, Takenori Niioka, Masatomo Miura, Naoto Takahashi
- Journal Title
  
  Ann Hematol
  
  Volume: 95(12) Issue: 12 Pages: 2087-2088
- DOI
  10.1007/s00277-016-2809-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461414
[Journal Article] Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma cells.2016
- Author(s)
  Ikeda S, Kitadate A, Ito M, Abe F, Nara M, Watanebe A, Takahashi N, Miyagaki T, Sugaya M, Tagawa H.
- Journal Title
  
  Oncotarget
  
  Volume: in press Issue: 12 Pages: 13563-13574
- DOI
  10.18632/oncotarget.6916
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461405, KAKENHI-PROJECT-16K10146
[Journal Article] MicroRNA-16 mediates the regulation of a senescence-apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas.2016
- Author(s)
  Kitadate A, Ikeda S, Teshima K, Ito M, Toyota I, Hasunuma N, Takahashi N, Miyagaki T, Sugaya M, Tagawa H.
- Journal Title
  
  Oncogene
  
  Volume: in press Issue: 28 Pages: 3692-3704
- DOI
  10.1038/onc.2015.435
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461405, KAKENHI-PROJECT-16K10146
[Journal Article] Therapeutic drug monitoring enables safe and effective lenalidomide therapy in patients with multiple myeloma on hemodialysis.2016
- Author(s)
  Kobayashi T, Niioka T, Miura M, Takahashi N.
- Journal Title
  
  Ann Hematol.
  
  Volume: 95(12) Pages: 2087-2088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460188
[Journal Article] Analysis of clinical characteristics and prognostic factors for angioimmunoblastic T-cell lymphoma.2015
- Author(s)
  Kameoka Y, Takahashi N, Itou S, Kume M, Noji H, Kato Y, Ichikawa Y, Sasaki O, Motegi M, Ishiguro A, Tagawa H, Ishizawa K, Ishida Y, Ichinohasama R, Harigae H, Sawada K.
- Journal Title
  
  Int J Hematol
  
  Volume: 101 Issue: 6 Pages: 536-542
- DOI
  10.1007/s12185-015-1763-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08609, KAKENHI-PROJECT-25461405, KAKENHI-PROJECT-25461431
[Journal Article] Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective tissue disease.2015
- Author(s)
  Togashi M, Niioka T, Komatsuda A, Nara M, Okuyama S, Omokawa A, Abumiya M, Wakui H, Takahashi N, Miura M.
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 71 Issue: 9 Pages: 1091-7
- DOI
  10.1007/s00228-015-1901-4
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460189
[Journal Article] Effects of CYP3A5 polymorphism and the tacrolimus 12?h concentration on tacrolimus-induced acute renal dysfunction in patients with lupus nephritis.2015
- Author(s)
  Niioka T, Komatsuda A, Kato S, Togashi M, Okuyama S, Omokawa A, Nara M, Wakui H, Takahashi N, Miura M.
- Journal Title
  
  Xenobiotica.
  
  Volume: 45 Pages: 1147-53
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460189
[Journal Article] Treatment of multiple myeloma in Akita: features and outcomes in the era of novel agents.2014
- Author(s)
  Shida S, Takahashi N, Niioka T, Kitabayashi A, Kawabata Y, Kume M, Saitoh H, Hatano Y, Ichikawa Y, Kuroki J, Motegi M, Kobayashi T, Kameoka Y, Tagawa H, Fujishima N, Yoshioka T, Hirokawa M, Miura M, Sawada K.
- Journal Title
  
  J Clin Exp Hematop
  
  Volume: 54 Pages: 89-93
- NAID
  130004886480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460188
[Journal Article] A limited sampling model to estimate exposure to lenalidomide in multiple myeloma patients.2014
- Author(s)
  Shida S, Takahashi N, Miura M, Niioka T, Matsumoto M, Hagihara M, Kobayashi T, Abumiya M, Kameoka Y, Fujishima N, Tagawa H, Hirokawa M, Sawada K.
- Journal Title
  
  Ther Drug Monit
  
  Volume: 36 Issue: 4 Pages: 505-9
- DOI
  10.1097/ftd.0000000000000034
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460188
[Journal Article] A Limited Sampling Model to Estimate Exposure to Lenalidomide in Multiple Myeloma Patients.2014
- Author(s)
  Shida S, Takahashi N, Miura M, Niioka T, Matsumoto M, Hagihara M, Kobayashi T, Abumiya M, Kameoka Y, Fujishima N, Tagawa H, Hirokawa M, Sawada K.
- Journal Title
  
  Ther Drug Monit.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Multicenter phase II clinical trial of nilotinib for patients with imatinib-resistant or -intolerant chronic myeloid leukemia from the East Japan CML study group evaluation of molecular response and the efficacy and safety of nilotinib.2014
- Author(s)
  Takahashi N, Miura M, Kuroki J, Mitani K, Kitabayashi A, Sasaki O, Kimura H, Imai K, Tsukamoto N, Noji H, Kondo T, Motegi M, Kato Y, Mita M, Saito H, Yoshida C, Torimoto Y, Kimura T, Wano Y, Nomura J, Yamamoto S, Mayama K, Honma R, Sugawara T, Sato S, Shinagawa A, Abumiya M, Niioka T, Harigae H, Sawada K.
- Journal Title
  
  Biomark Res.
  
  Volume: 20;2(1) Issue: 1 Pages: 2-6
- DOI
  10.1186/2050-7771-2-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590168, KAKENHI-PROJECT-25461431
[Journal Article] Therapeutic drug management of BCR-ABL tyrosine kinase inhibitor for chronic myeloid leukemia patients.2014
- Author(s)
  Miura M, Takahashi N.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 54 Pages: 1720-1729
- NAID
  10031196316
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Bortezomib reduces the tumorigenicity of multiple myeloma via downregulation of upregulated targets in clonogenic side population cells2013
- Author(s)
  Nara M, Teshima K, Watanabe A, Ito M, Iwamoto K, Kitabayashi A, Kume M, Hatano Y, Takahashi N, Iida S, Sawada K, Tagawa H
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- Data Source
  KAKENHI-PROJECT-23591365
[Journal Article] A multicenter clinical study evaluating the confirmed complete molecular response rate in imatinib-treated patients with chronic phase chronic myeloid leukemia by using the international scale of real-time quantitative polymerase chain reaction.2013
- Author(s)
  Shinohara Y, Takahashi N, Nishiwaki K, Hino M, Kashimura M, Wakita H, Hatano Y, Hirasawa A, Nakagawa Y, Itoh K, Masuoka H, Aotsuka N, Matsuura Y, Takahara S, Sano K, Kuroki J, Hata T, Nakamae H, Mugitani A, Nakane T, Miyazaki Y, Niioka T, Miura M, Sawada K.
- Journal Title
  
  Haematologica.
  
  Volume: 98(9) Issue: 9 Pages: 1407-13
- DOI
  10.3324/haematol.2013.085167
- NAID
  120006986100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Bortezomib reduces the tumorigenicity of multiple myeloma via downregulation of upregulated targets in clonogenic side population cells2013
- Author(s)
  Nara M, Teshima K, Watanabe A, Ito M, Iwamoto K, Kitabayashi A, Kume M, Hatano Y, Takahashi N, Iida S, Sawada K, Tagawa H
- Journal Title
  
  PLos One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461405
[Journal Article] Bortezomib reduces the tumorigenicity of multiple myeloma via downregulation of upregulated targets in clonogenic side population cells2013
- Author(s)
  Nara M, Teshima K, Watanabe A, Ito M, Iwamoto K, Kitabayashi A, Kume M, Hatano Y, Takahashi N, Iida S, Sawada K, Tagawa H.
- Journal Title
  
  PLosOne
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591365
[Journal Article] Therapeutic drug management of BCR-ABL tyrosine kinase inhibitor for chronic myeloid leukemia patients2013
- Author(s)
  Miura M, Takahashi N
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: Vol.54 Pages: 1720-1729
- NAID
  10031196316
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Bile acid is important for gastrointestinal absorption of nilotinib.2012
- Author(s)
  Fujimi A, Takahashi N, Miura M, Kanisawa Y, Ono K, Sawada K.
- Journal Title
  
  Eur J Clin Pharmacol.
  
  Volume: 68 Issue: 11 Pages: 1575-6
- DOI
  10.1007/s00228-012-1282-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Pharmacokinetics of nilotinib in imatinib-resistant/intolerant chronic myeloid leukemia patients on hemodialysis for chronic renal failure.2012
- Author(s)
  Onaka T, Takahashi N, Miura M, Yonezawa A, Imada K, Sawada K
- Journal Title
  
  Am J Hematol.
  
  Volume: 87 Issue: 4 Pages: 451-451
- DOI
  10.1002/ajh.23125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Enucleation of human erythroblasts involves non-muscle myosin IIB2012
- Author(s)
  Ubukawa K, Guo YM, Takahashi M, Hirokawa M, Michishita Y, Nara M, Tagawa H, Takahashi N, Komatsuda A, Nunomura W, Takakuwa Y, Sawada K
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 1036-44
- Data Source
  KAKENHI-PROJECT-23591365
[Journal Article] Drug interaction between lenalidomide and itraconazole2012
- Author(s)
  Takahashi N, Miura M, Kameoka Y, Abumiya M, Sawada K
- Journal Title
  
  Am J Hematol
  
  Volume: 87 Issue: 3 Pages: 338-9
- DOI
  10.1002/ajh.22260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients.2012
- Author(s)
  Takahashi N, Miura M, Niioka T, Sawada K.
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 69(4) Pages: 999-1004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Pharmacokinetics of dasatinib for Philadelphia-positive acute lymphocytic leukemia with acquired T315I mutation2012
- Author(s)
  Takahashi N, Miura M, Scott SA, Niioka T, Sawada K
- Journal Title
  
  J Hematol Oncol
  
  Volume: 5 Issue: 1 Pages: 23-23
- DOI
  10.1186/1756-8722-5-23
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] H2-receptor antagonist influences dasatinib pharmacokinetics in a patient with Philadelphia-positive acute lymphoblastic leukemia2012
- Author(s)
  Matsuoka A, Takahashi N, Miura M, Niioka T, Kawakami K, Matsunaga T, Sawada K
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 70(2) Issue: 2 Pages: 351-2
- DOI
  10.1007/s00280-012-1900-4
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients2012
- Author(s)
  Takahashi N, Miura M, Niioka T, Sawada K
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 69(4) Issue: 4 Pages: 999-1004
- DOI
  10.1007/s00280-011-1797-3
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] A synthetic double-stranded RNA, poly I : C, induces a rapid apoptosis of human CD34(+) cells2012
- Author(s)
  Liu J, Guo YM, Hirokawa M, Iwamoto K, Ubukawa K, Michishita Y, Fujishima N, Tagawa H, Takahashi N, Xiao W, Yamashita J, Ohteki T, Sawada K
- Journal Title
  
  Exp Hematol
  
  Volume: 40 Pages: 330-41
- Data Source
  KAKENHI-PROJECT-23591365
[Journal Article] Age-associated alteration ofγδT-cell repertoire and different profiles of activation-induced death of Vδ1 and Vδ2 T cells2011
- Author(s)
  Michishita Y, Hirokawa M, Guo YM, Abe Y, Liu J, Ubukawa K, Fujishima N, Fujishima M, Yoshioka T, Kameoka Y, Saito H, Tagawa H, Takahashi N, Sawada K
- Journal Title
  
  Int J Hematol
  
  Volume: 94 Pages: 230-40
- Data Source
  KAKENHI-PROJECT-23591365
[Journal Article] Drug interaction of (S)-warfarin, and not (R)-warfarin, with itraconazole in a hematopoietic stem cell transplant recipient2011
- Author(s)
  Miura M, Takahashi N, Kanno S, Kato S, Nara M, Itoh M, Saitoh H, Yoshioka T, Kameoka Y, Fujishima N, Tagawa H, Hirokawa M, Sawada K
- Journal Title
  
  Clin Chim Acta
  
  Volume: 9;412 Pages: 2002-6
- Data Source
  KAKENHI-PROJECT-23591365
[Journal Article] The role of microRNA-150 as a tumor suppressor in malignant lymphoma2011
- Author(s)
  Watanabe A, Tagawa H, Yamashita J, Teshima K, NaraM, Iwamoto K, Kume M, Kameoka Y, Takahashi N, Nakagawa T, Shimizu N, Sawada K
- Journal Title
  
  Leukemia
  
  Volume: 25 Pages: 1324-34
- Data Source
  KAKENHI-PROJECT-23591365
[Journal Article] Quantitative determination of imatinib in human plasma with high-performance liquid chromatography and ultraviolet detection2011
- Author(s)
  Miura M, Takahashi N, Sawada K
- Journal Title
  
  J Chromatogr Sci
  
  Volume: 49(5) Pages: 412-5
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Therapeutic drug monitoring of imatinib for chronic myeloid leukemia patients in the chronic phase.2011
- Author(s)
  Takahashi N, Miura M.
- Journal Title
  
  Pharmacology.
  
  Volume: 87(5-6) Pages: 241-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Fatal hemorrhagic pneumonia caused by Stenotrophomanas maltophilia in a patient with non-Hodgkin lymphoma2011
- Author(s)
  Takahashi N, Yoshioka T, Kameoka Y, Tagawa H, Fujishima N, Saitoh H, Hirokawa M, Enomoto K, Sawada K
- Journal Title
  
  J Infect Chemother
  
  Volume: 17 Pages: 858-62
- NAID
  10030226036
- Data Source
  KAKENHI-PROJECT-23591365
[Journal Article] The role of miR-150 in malignant lymphoma2011
- Author(s)
  Waatanabe A, Tagawa H, Takahashi N, et al.
- Journal Title
  
  Leukemia
  
  Volume: 25 Issue: 8 Pages: 1324-34
- DOI
  10.1038/leu.2011.81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591191, KAKENHI-PROJECT-22591025, KAKENHI-PROJECT-23591365, KAKENHI-PROJECT-23701080
[Journal Article] Successful treatment of necrotizing fasciitis in an upper extremity caused by Clostridium perfringens after bone marrow transplantation2011
- Author(s)
  Ito M, Takahashi N, Saitoh H, Shida S, Nagao T, Kume M, Kameoka Y, Tagawa H, Fujishima N, Hirokawa M, Tazawa H, Minato T, Yamada S, Sawada K.
- Journal Title
  
  Intern Med
  
  Volume: 50 Pages: 2213-7
- NAID
  130001087906
- Data Source
  KAKENHI-PROJECT-23591365
[Journal Article] Therapeutic drug monitoring of imatinib for chronic myeloid leukemia patients in the chronic phase2011
- Author(s)
  Takahashi N, Miura M
- Journal Title
  
  Pharmacology
  
  Volume: 87(5-6) Issue: 5-6 Pages: 241-8
- DOI
  10.1159/000324900
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] Quantitative determination of imatinib in human plasma with high-performance liquid chromatography and ultraviolet detection.2011
- Author(s)
  Miura M, Takahashi N, Sawada K.
- Journal Title
  
  J Chromatogr Sci.
  
  Volume: 49(5) Pages: 412-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590168
[Journal Article] False-positive human immunodeficiency virus antibody test and autoimmune hemolytic anemia in a patient with angioimmunoblastic T-cell lymphoma2011
- Author(s)
  Shida S, Takahashi N, Fujishima N, Kameoka Y, Nara M, Fujishima M, Saitoh H, Tagawa H, Hirokawa M, Ichinohasama R, Sawada K
- Journal Title
  
  Intern Med
  
  Volume: 50(20) Pages: 2383-7
- NAID
  130001087753
- Data Source
  KAKENHI-PROJECT-23591365
[Presentation] Cdc42 regulates terminal differentiation in human erythroblasts.2018
- Author(s)
  Goto T, Ubukawa K, Asanuma K, Kobayashi I, Guo YM, Takahashi N, Wakui H, Nunomura W.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08315
[Presentation] ヒト赤芽球の終末分化におけるCdc42の情報伝達経路の解明．2018
- Author(s)
  後藤樹史、鵜生川久美、浅沼研、小林五十鈴、郭永梅、高橋直人、涌井秀樹、布村渉
- Organizer
  第91回日本生化学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08315
[Presentation] 移植非適応未治療多発性骨髄腫患者に対するLd療法およびレナリドミドの至適血漿中濃度の検討2017
- Author(s)
  小林敬宏, 三浦昌朋, 新岡丈典, 鐙屋舞子, 大八木秀明, 篠原良徳, 茂木睦仁, 黒木淳, 西成民夫, 川端良成, 北林淳, 道下吉広, 池田翔, 志田青慈, 吉岡智子, 高橋直人
- Organizer
  日本骨髄腫学会
- Place of Presentation
  東京
- Year and Date
  2017-05-27
- Data Source
  KAKENHI-PROJECT-26461414
[Presentation] INTERRUPTION OF CCL20-CCR6 INTERACTION INHIBITS METASTASIS OF ADVANCED CUTANEOUS T-CELL LYMPHOMA2016
- Author(s)
  Hiroyuki Tagawa, Sho Ikeda1, Akihiro Kitadate, Naoto Takahashi, Makoto Sugaya
- Organizer
  ヨーロッパ血液学会
- Place of Presentation
  コペンハーゲン
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-25461405
[Presentation] MicroRNA-16 Mediates the Regulation of a Senescence-Apoptosis Switch in Cutaneous and other Non-Hodgkin Lymphomas.2016
- Author(s)
  Hiroyuki Tagawa, Akihiro Kitadate, Sho Ikeda, Kazuaki Teshima, Mitsugu Ito, Naoto Takahashi, Tomomitsu Miyagaki, Sugaya Makoto
- Organizer
  2016 Highlights of ASH in Asia.
- Place of Presentation
  risbane Australia
- Year and Date
  2016-03-05
- Data Source
  KAKENHI-PROJECT-25461405
[Presentation] Lenalidomide/dexamethasone salvage therapy for MM with stepwise evaluation for practical dose2016
- Author(s)
  Reiko Watanabe, Hideo Yagi, Jian Hua, Masatomo Miura, Masao Hagihara, Naoto Takahashi, Michihide Tohuhira, Masatiro Kizaki
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460188
[Presentation] Two-year consolidation by Nilotinib might improve the TFR of STIM trial in CML with DMR2016
- Author(s)
  Kaichi Nishiwaki, Naoto Takahashi, Chiaki Nakaseko, Hisashi Wakita, Koji Sano, Chikako Ohwada, Nobuyuki Aotsuka, Jun Kuroki, Hideo Kimura, Hideyoshi Noji, Michihide Tokuhira, Kinuko Mitani, Kazuhisa Fujikawa, Osamu Iwase, Kohshi Ohishi, Fumihiko Kimura, Tetsuya Fukuda, Sakae Tanosaki, Masatomo Miura, Kenichi Sawada
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460188
[Presentation] MicroRNA-16 mediates the regulation of a senescence-apoptosis switch in malignant lymphomas.2016
- Author(s)
  Akihiro Kitadate, Sho Ikeda, Kazuaki Teshima, Mitsugu Ito, Naoto Takahashi, Miyagaki Tomomitsu, Makoto Sugaya, Hiroyuki Tagawa
- Organizer
  Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics.
- Place of Presentation
  Maui, USA
- Year and Date
  2016-02-16
- Data Source
  KAKENHI-PROJECT-25461405
[Presentation] フィラデルフィア染色体陽性慢性骨髄性白血病患者におけるボスチニブの初期と維持期の血中濃度と効果の関係2016
- Author(s)
  鐙屋舞子，新岡丈典，高橋直人，三浦昌朋
- Organizer
  日本医療薬学会第26回年会
- Place of Presentation
  京都
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-26460188
[Presentation] Phosphatidylinositol phosphates profile reveals distinct subtypes of malignant lymphomas.2015
- Author(s)
  阿部史人, 田川博之, 北舘明宏, 池田翔, 奈良美保, 亀岡吉弘, 高橋直人, 佐々木雄彦, 中西広樹
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25461405
[Presentation] Silencing progression of tumor suppressive microRNAs essentially contributes to develop aggressive T-cell lymphoma.2015
- Author(s)
  Akihiro Kitadate, Mitsugu Ito, Sho Ikeda, Kazuaki Teshima, Naoko Hasunuma, Tomomitsu Miyagaki, Sugaya Makoto, Naoto Takahashi, Atsushi Komatuda , Hiroyuki Tagawa
- Organizer
  20th Congress of the European Hematology Association. (Abstract #E1361)
- Place of Presentation
  Vienna, Austla
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-25461405
[Presentation] Correlation of dasatinib pharmacokinetics with clinical response and adverseevents2015
- Author(s)
  Akiko Mita, Masatomo Miura, Takenori Niioka, Maiko Abumiya Takahiro Kobayashi, Saori Takahashi, Yoshihiro Kameoka, Tomoko Yoshioka, Naoto Takahashi
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26460188
[Presentation] MicroRNA-16 Mediates the Regulation of a Senescence-Apoptosis Switch in Cutaneous and other Non-Hodgkin Lymphomas.2015
- Author(s)
  Akihiro Kitadate, Sho Ikeda, Kazuaki Teshima, Mitsugu Ito, Naoto Takahashi, Tomomitsu Miyagaki, Sugaya Makoto, Hiroyuki Tagawa
- Organizer
  57th American Society of Hematology Annual Meeting ＆ Exposition. (Abstarct #468)
- Place of Presentation
  Orland USA
- Year and Date
  2015-12-07
- Data Source
  KAKENHI-PROJECT-25461405
[Presentation] 膠原病患者におけるタクロリムスとイトラコナゾールとの薬物相互作用に及ぼすCYP3A5およびABCB1遺伝子多型の影響2015
- Author(s)
  新岡丈典, 富樫賢, 小松田敦, 奈良瑞穂, 奥山慎, 面川歩, 鐙屋舞子, 涌井秀樹, 高橋直人, 三浦昌朋
- Organizer
  日本医療薬学会第25回年会
- Place of Presentation
  横浜
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-26460189
[Presentation] Influence of CYP3A5 gene polymorphisms on pharmacokinetics of tacrolimus modified-release once-daily after hematopoietic stem cell transplantation.2015
- Author(s)
  Takaya Yamashita, Naohito Fujishima, Masatomo Miura, Takenori Niioka, Maiko Abumiya, Kazuaki Teshima, Kumi Ubukawa, Miho Nara, Masumi Fujishima, Yoshihiro Kameoka, Makoto Hirokawa, Naoto Takahashi
- Organizer
  20th Congress of European Hematology Association
- Place of Presentation
  Vienna
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460189
[Presentation] Tumor-suppressor miR-16 induces senescence and apoptosis in aggressive T-cell lymphomas2015
- Author(s)
  北舘明宏、池田翔、奈良美保、鵜生川久美、渡部敦、藤島真澄、藤島直仁、吉岡智子、亀岡吉弘、高橋直人、宮垣朝光、菅谷誠、田川博之
- Organizer
  第77回日本血液学会学術総会 (演題番号OS-3-131、抄録p424)
- Place of Presentation
  金沢
- Year and Date
  2015-10-18
- Data Source
  KAKENHI-PROJECT-25461405
[Presentation] Pharmacokinetics of bosutinib and its induced-diarrhea in Ph-positive chronic myeloid leukemia2015
- Author(s)
  Maiko Abumiya, Naoto Takahashi, Takenori Niioka, Saori Takahashi, Akiko Mita, Takahiro Kobayashi, Yoshihiro Kameoka, Tomoko Yoshioka, Naohito Fujishima, Hiroyuki Tagawa, Kenichi Sawada, Masatomo Miura
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26460188
[Presentation] Restoration of tumor-suppressive miRNAs induces senescence, apoptosis and metastasis inhibition in aggressive T-cell lymphomas2015
- Author(s)
  北舘明宏、池田翔、伊藤貢、手島和暁、阿部史人、奈良美保、渡部敦、亀岡吉弘、高橋直人、田川博之
- Organizer
  第74回日本癌学会学術総会(演題番号P-3227、抄録p284)
- Place of Presentation
  名古屋
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-25461405
[Presentation] Clarithromycin Elevates the Plasma Concentration of Lenalidomide Via Inhibition of MDR1.2014
- Author(s)
  Naoki Takezako, Masatomo Miura, Akihisa Nagata, Naohiro Sekiguchi, Takenori Niioka, Seiji Shida, Takahiro Kobayashi, Maiko Abumiya, Akiyoshi Miwa, Naoto Takahashi
- Organizer
  56th American Society of Hematology Annual Meeting and Exposition
- Place of Presentation
  サンフランシスコ
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-26460188
[Presentation] レナリドマイドのTDMの有用性～TM-Rev 試験からの報告2014～2014
- Author(s)
  新岡丈典、高橋直人、志田青慈、小林敬宏、鐙屋舞子、澤田賢一、三浦昌朋
- Organizer
  医療薬学フォーラム2014/第22回クリニカルファーマシーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2014-06-28
- Data Source
  KAKENHI-PROJECT-26460188
[Presentation] Blood concentration of lenalidomide would change with the existence of clarithromycin.2014
- Author(s)
  Naoki Takezako, Naohiro Sekiguchi, Akihisa Nagata, Masatomo Miura, Tekenori Niioka, Seiji Shida, Takahiro Kobayashi, Maiko Abumiya, Naoto Takahashi
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-26460188
[Presentation] Pharmacokinetcis of lenalidomide in patients with multiple myeloma on hemodialysis.2014
- Author(s)
  Takahiro Kobayashi, Naoto Takahashi, Masatomo Miura, Ayano Ohara, Yoshihiro Mitishita, Tekenori Niioka, Maiko Abumiya, Seiji Shida, Kumi Ubukawa, Naohito Fujishima, Yoshihiro Kameoka, Hiroyuki Tagawa, Kenichi Sawada
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-26460188
[Presentation] Inter- and intra-individual variability of nilotinib plasma trough concentration in CML patients2013
- Author(s)
  Abumiya M, Miura M, Takahashi N, Niioka T, Sawada K
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590168
[Presentation] Inter- and intra-individual variability of nilotinib plasma trough concentration in CML patients.2013
- Author(s)
  2) Maiko Abumiya, Masatomo Miura, Naoto Takahashi, Takenori Niioka, Kenichi Sawada
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590168
[Presentation] Multicenter Phase II Clinical Trial of Nilotinib for Patients with Imatinib-Resistant or Intolerant CML from the East Japan CML Study Group (EJCML) Trial : Evaluation of Molecular Responses by the BCR-ABL1 Mutational Status and Plasma Trough Concentration of Nilotinib2012
- Author(s)
  Takahashi N, Miura M, et al
- Organizer
  54th American Society of Hematology Annual Meeting and Exposition
- Place of Presentation
  Atlanta
- Data Source
  KAKENHI-PROJECT-23590168
[Presentation] ダサチニブと胃酸分泌抑制剤との相互作用2012
- Author(s)
  三浦昌朋,高橋直人,新岡丈典,澤田賢一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590168
[Presentation] Multicenter phase II clinical trial of Nilotinib for patients with Imatinib-resistance or -intolerant CML from the East Japan CML Study Group (EJCML): Evaluation of molecular response by BCR-ABL1 mutation status and plasma trough concentration of Nilotinib2012
- Author(s)
  Takahashi N, Miura M, Niioka T, et al
- Organizer
  ASH Annual Meeting
- Place of Presentation
  アトランタ
- Data Source
  KAKENHI-PROJECT-23590168
[Presentation] 経口分子標的治療薬の個別化治療2012
- Author(s)
  三浦昌朋,高橋直人
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-23590168
[Presentation] 遺伝子多型情報とTDMに基づいたイマチニブ個別化療法2011
- Author(s)
  三浦　昌朋、高橋　直人
- Organizer
  第28回　日本TDM学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23590168

1. MIURA MASATOMO (30265194)

# of Collaborated Projects: 5 results

# of Collaborated Products: 44 results
2. TAGAWA Hiroyuki (30373492)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
3. TSUCHIYA Norihiko (70282176)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Kagaya Hideaki

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. SATO Kazuhiro (30436191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. Shibata Hiroyuki (60393732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Niioka Takenori (20722276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. SATOH Shigeru (80187195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Ubukawa Kumi (70646554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 横山和明 (00647498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大場雄介 (30333503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Abumiya Maiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
13. ICHINOHASAMA Ryo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 鵜生川久美

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
15. 石澤賢一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI NAOTO 高橋 直人

TAKAHASHI Naoto 高橋 直人

Research Projects

Research Products

Co-Researchers

TKI抵抗性CMLに対するエキソーム解析とFRET解析の統合による個別化治療の可能性Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

The mechanism of organelle relocation in human erythroblasts.

Principal Investigator

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Review Section

Research Institution

Therapeutic drug management of the novel agents for multiple myelomaPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Development of a new treatment strategy using TDM for next generation anticancer drug

Principal Investigator

Project Period (FY)

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Research Institution

Do patients taking tacrolimus need to undergo CYP3A5 genotyping along with blood concentration monitoring?

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of microRNAs that might be therapeutic target of malignant lymphomas

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic drug management of tyrosine kinase inhibitor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Detection for miRNA dysregulation in CMLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Therapeutic Drug Monitoring of Imatinib for Chronic Myeloid Leukemia Patients. Myeloid Leukemia–Clinical Diagnosis and Treatment2011

Author(s)

Publisher

Data Source

[Journal Article] IL-6 Generated from Human Hematopoietic Stem and Progenitor Cells through TLR4 Signaling Promotes Emergency Granulopoiesis by Regulating Transcription Factor Expression2021

Author(s)

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DOI

Data Source

[Journal Article] Cdc42 regulates cell polarization and contractile actomyosin rings during terminal differentiation of human erythroblasts2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 1.ATP produced by anaerobic glycolysis is essential for enucleation of human erythroblasts.2019

Author(s)

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Data Source

[Journal Article] Thrombocytopenia Caused by a Tea Beverage of <i>Taxus yunnanensis</i> (Chinese Yew)2019

Author(s)

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DOI

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Data Source

TAKAHASHI NAOTO 高橋直人

TAKAHASHI Naoto 高橋直人