TAKEDA Kozue 武田湖州恵

Researcher Number	80345884
Other IDs
Affiliation (Current)	2025: 中部大学, 生命健康科学部, 准教授
Affiliation (based on the past Project Information) *help	2011 – 2023: 中部大学, 生命健康科学部, 准教授 2013 – 2014: 中部大学, 公私立大学の部局等, 准教授 2006: Chubu University, Life Health Sciences, Associate Professor 2006: 中部大学, 生命健康科学部, 助教授 2005: 中部大学, 生命健康科学研究所, 助教授 2002 – 2003: 名古屋大学, 大学院・医学系研究科, 助手
Review Section/Research Field	Principal Investigator General surgery / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Biological Sciences / Dermatology / Immunology / 広領域 / Risk sciences of radiation and chemicals / Risk sciences of radiation/Chemicals / Laboratory animal science
Keywords	Principal Investigator がん / RET / チロシンキナーゼ / ペプチド / 阻害 Except Principal Investigator RET / CD122 / メラノーマ / CXCR3 / EAE … More / MKK6- / 皮膚 / 井戸水 / ヒ素 / 皮膚癌 / 国際情報交換 / メラノサイト / モデル動物 / CD8 / 制御性T細胞 / グリチルリチン / 十全大補湯 / 細胞傷害性Tリンパ球 / トランスジェニックマウス / CD8^+ T cells / Regulatory T cells / Immune regulation / CD8^+T細胞 / 免疫制御 / negative selection / -mouse / apoptosis / reft / T-lymphocyte / redox / Tyrosine kinase / チロシンキナーゼ / ネガテイブセレクション / -マウス / アポトーシス / ラフト / T細胞 / レドックス / チロシンナーゼ / p21 / LSF / 免疫療法 / DTX3L / RET-マウス / BRAF変異 / 動物モデル / 分子標的療法 / バイオマーカー / エイジング / 加齢性疾患 / 毛髪 / 幹細胞 / 毒性 / 発癌 / 重金属 / 浄化剤 / 飲用水 / 発癌毒性 / 元素 / Placental Growth Factor / 疫学 / バングラデシュ / 国際研究者交流 / 発癌リスク / 飲用井戸水 / 疾患モデル動物 / アメリカ / ドイツ / シンガポール / フランス / 加齢性白髪 / 発症機構 / 加齢 / モデルマウス / 白髪 / 遺伝子改変マウス / インターロイキン(IL)-10 / インターフェロン(IFN)-γ / インターロイキン-10 / T細胞受容体 / MHCクラスI / インターフェロン-γ / IL-2受容体 / CD8陽性 / クルクミン / 漢方 / RETがん遺伝子 / 腫瘍増殖抑制 / 免疫促進 Less

甲状腺癌治療のためのRETキナーゼ阻害ペプチドの開発Principal Investigator
- Principal Investigator
  
  武田湖州恵
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Chubu University
Development of molecular targeted therapy for thyroid cancer using tyrosine kinase inhibition with a novel mechanism of actionPrincipal Investigator
- Principal Investigator
  
  Takeda Kozue
- Project Period (FY)
  2015 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Chubu University
Development of a novel molecular target therapy that can suppress melanoma progression
- Principal Investigator
  
  Masashi Kato
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Nagoya University
Basic researches for analysis of mechanism and development of prediction and prevention on arsenic-mediated skin cancer
- Principal Investigator
  
  Yajima Ichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Nagoya University
Mechanisms of hair graying
- Principal Investigator
  
  IIDA Machiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Nagoya University
  Chubu University
Cancer prevention based on the review for pollution of well drinking water in Asia
- Principal Investigator
  
  Kato Masashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagoya University
Novel mechanism and molecular targeted therapy of thyroid cancerPrincipal Investigator
- Principal Investigator
  
  TAKEDA Kozue
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Chubu University
Development of a model mouse line for hair graying
- Principal Investigator
  
  MASASHI Kato
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Nagoya University
  Chubu University
CD8^+CD122^+制御性T細胞による免疫制御機構の解明
- Principal Investigator
  
  鈴木治彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Clarification of the role of CD8^+CD122^+ regulatory T cells in vivo and development of their clinical applications
- Principal Investigator
  
  SUZUKI Haruhiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Nagoya University
メラノーマ自然発症マウスを用いたCTL免疫誘導促進性抗がん物質の新規探索法の開発
- Principal Investigator
  
  中島泉
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
メラノーマ自然発症トランスジェニックモデルを用いたCTL誘導性抗がん物質の探索
- Principal Investigator
  
  NAKASHIMA Izumi
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Study on redox-linked regulatory mechanism of intracellular signal transduction for differentiation and death of T lymphocytes
- Principal Investigator
  
  NAKASHIMA Izumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  Nagoya University

All 2023 2020 2019 2016 2015 2014 2013 2012 2011 2006 2005

All Journal Article Presentation Patent

[Journal Article] Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action.2020
- Author(s)
  Takeda K, Kawamoto Y, Nagasaki Y, Okuno Y, Goto Y, Iida M, Yajima I, Ohgami N, Kato M.
- Journal Title
  
  Am J Cancer Res.
  
  Volume: 10 Pages: 336-349
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10076
[Journal Article] Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation.2016
- Author(s)
  Kawamoto Y, Ueno Y, Nakahashi E, Obayashi M, Sugihara K, Qiao S, Iida M, Kumasaka MY, Yajima I, Goto Y, Ohgami N, Kato M, Takeda K
- Journal Title
  
  J Nutr Biochem
  
  Volume: 27 Pages: 112-122
- DOI
  10.1016/j.jnutbio.2015.08.025
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460178, KAKENHI-PROJECT-25461717
[Journal Article] Plasma with high electron density and plasma-activated medium for cancer treatment2015
- Author(s)
  H. Tanaka, M. Mizuno, K. Ishikawa, H. Kondo, K. Takeda, H. Hashizume, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Akiyama, S. Maruyama, S. Yamada, Y. Kodera, H. Kaneko, H. Terasaki, H. Hara, T. Adachi, M. Iida, I. Yajima, M. Kato, F. Kikkawa, M. Hori
- Journal Title
  
  Clinical Plasma Medicine
  
  Volume: 3 Issue: 2 Pages: 72-76
- DOI
  10.1016/j.cpme.2015.09.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K13390, KAKENHI-ORGANIZER-24108001, KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-15H05430, KAKENHI-PROJECT-25461717
[Journal Article] Correlated expression levels of endothelin receptor B and Plexin C1 in melanoma2015
- Author(s)
  Kumasaka, M. Y. Yajima, I. Iida, M. Takahashi, H. Inoue, Y. Fukushima, S. Ihn, H. Takeda, K. Naito, Y. Yoshikawa, T. Kato, M.
- Journal Title
  
  Am J Cancer Res
  
  Volume: 5 Pages: 1117-1123
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25340052
[Journal Article] Commentary to Pastore et al (2014): Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors2014
- Author(s)
  K. Takeda, Y. Kawamoto, M. Iida, Y. Omata, C. Zou, M. Kato
- Journal Title
  
  Arch Toxicol
  
  Volume: 88 Issue: 12 Pages: 2319-2320
- DOI
  10.1007/s00204-014-1373-9
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24108002, KAKENHI-PROJECT-24406002, KAKENHI-PROJECT-24591919, KAKENHI-PROJECT-25461717
[Journal Article] Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma.2014
- Author(s)
  Omata Y, Iida M, Yajima I, Takeda K, Ohgami N, Masaru Hori H, Kato M.
- Journal Title
  
  Environ Health Prev Med.
  
  Volume: 19 Issue: 5 Pages: 367-369
- DOI
  10.1007/s12199-014-0399-1
- NAID
  50009312844
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23650241, KAKENHI-PLANNED-24108002, KAKENHI-PROJECT-24406002, KAKENHI-PROJECT-24591919, KAKENHI-PROJECT-25340052, KAKENHI-PROJECT-25461717, KAKENHI-PROJECT-26670525
[Journal Article] Effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice.2014
- Author(s)
  Iida M,Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M.
- Journal Title
  
  Eur J Dermatol
  
  Volume: 24 Issue: 3 Pages: 392-394
- DOI
  10.1684/ejd.2014.2330
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23650241, KAKENHI-PLANNED-24108002, KAKENHI-PROJECT-24406002, KAKENHI-PROJECT-24591919, KAKENHI-PROJECT-25340052, KAKENHI-PROJECT-25461717, KAKENHI-PROJECT-26670525
[Journal Article] RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy.2012
- Author(s)
  Ya manoshita O Kato M
- Journal Title
  
  Dermatol Res Pract.
  
  Volume: 2012 Pages: 354191-354191
- DOI
  10.1155/2012/354191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590558, KAKENHI-PROJECT-22700457, KAKENHI-PROJECT-22780128, KAKENHI-PROJECT-22791041, KAKENHI-PROJECT-23650241
[Journal Article] L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects2011
- Author(s)
  Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, et al
- Journal Title
  
  Toxicol In Vitro, Elsevier
  
  Volume: 25(3) Issue: 3 Pages: 623-629
- DOI
  10.1016/j.tiv.2010.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780128, KAKENHI-PROJECT-22791092, KAKENHI-PROJECT-23650241
[Journal Article] Control of Genetically Designed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions.2011
- Author(s)
  Nakashima, I., Kawamoto, Y., Takeda, K., Kato, M.
- Journal Title
  
  Enzyme Res
  
  Volume: 10 Pages: 896567-896567
- DOI
  10.4061/2011/896567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650241
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.2006
- Author(s)
  Takeda, Kozue
- Journal Title
  
  FEBS Letter 580(3)
  
  Pages: 839-843
- Data Source
  KAKENHI-PROJECT-17047017
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.2006
- Author(s)
  Takeda, Kozue
- Journal Title
  
  FEBS Letter 580(3)
  
  Pages: 839-843
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.2006
- Author(s)
  Takeda, K. et al.
- Journal Title
  
  FEBS letter 580
  
  Pages: 839-843
- Data Source
  KAKENHI-PROJECT-17047017
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities2006
- Author(s)
  Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I
- Journal Title
  
  FEBS Letter 580
  
  Pages: 839-843
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.2006
- Author(s)
  Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I.
- Journal Title
  
  FEBS Letter 580(3)
  
  Pages: 839-843
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities2006
- Author(s)
  Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H. Isobe K, Nakashima I
- Journal Title
  
  FEBS Letter 580
  
  Pages: 839-843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] CD8^+CD122^+ regulatory T cells produce IL-10 to suppress IFN- production and proliferation of CD8^+ cells2005
- Author(s)
  Endharti AT, Rifa'i M, Shi Z, Fukuoka Y, Nakahara Y, Kawamoto Y, Takeda K, Isobe K, Suzuki H
- Journal Title
  
  The Journal of Immunology 175
  
  Pages: 7093-7097
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Journal Article] CD8^+CD122^+ regulatory T cells produce IL-10 to suppress IF N-γ production and proliferation of CD8^+ T cells2005
- Author(s)
  Endharti AT, Rifa'i M, Shi Z, Fu kuoka Y, Nakahara Y, Kawamoto Y, Takeda K, Isobe K, Suzuki H
- Journal Title
  
  The Journal of Immunology 175
  
  Pages: 7093-7097
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390142
[Patent] メラノーマ特異的バイオマーカー及びその利用2015
- Inventor(s)
  加藤昌志、矢嶋伊知朗、武田湖州恵、後藤友二
- Industrial Property Rights Holder
  名古屋大学と中部大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-058692
- Filing Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-26670525
[Patent] メラノーマ特異的バイオマーカー及びその利用2015
- Inventor(s)
  加藤昌志、矢嶋伊知朗、武田湖州恵、後藤友二
- Industrial Property Rights Holder
  名古屋大学と中部大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-058692
- Filing Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-24406002
[Presentation] システインを介したRETキナーゼの活性阻害2023
- Author(s)
  細田稜元、川本善之、武田湖州恵
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K09570
[Presentation] システインを介したRETキナーゼの活性阻害2019
- Author(s)
  武田湖州恵、川本善之、坂川久仁子、川添健司、矢嶋伊知朗、大神信孝、加藤昌志
- Organizer
  第89回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-15K10076
[Presentation] Plasma-mediated modulation of element distribution in skin and skin cancer2013
- Author(s)
  Ichiro YAJIMA, Machiko Iida, Kaoru NAKAGAWA, Hiroki KONDO Mayuko Y. KUMASAKA, Keigo TAKEDA, Masaru HORI, Hiroyuki KANO and Masashi KATO
- Organizer
  ISPlasma2013
- Place of Presentation
  名古屋大学（名古屋市）
- Data Source
  KAKENHI-PROJECT-24406002

1. MASASHI Kato (10281073)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. NAKASHIMA Izumi (40022826)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
3. SUZUKI Haruhiko (90283431)

# of Collaborated Projects: 5 results

# of Collaborated Products: 5 results
4. YAJIMA Ichiro (80469022)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
5. GOTO Yuji (70362522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OHGAMI Nobutaka (80424919)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. KAWAMOTO Yoshiyuki (10410664)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. YAMANOSHITA Osamu (50424924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IIDA Machiko (60465515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. HAYAKAWA Akemi (70412377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SATO Awoi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ISHIKAWA Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. NAKAMURA KAE

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. KANO HIROYUKI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. TAKEDA Keigo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. OMATA Yasuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 田中宏昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKEDA Kozue 武田 湖州恵

Research Projects

Research Products

Co-Researchers

甲状腺癌治療のためのRETキナーゼ阻害ペプチドの開発Principal Investigator

Principal Investigator

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Review Section

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Development of molecular targeted therapy for thyroid cancer using tyrosine kinase inhibition with a novel mechanism of actionPrincipal Investigator

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Novel mechanism and molecular targeted therapy of thyroid cancerPrincipal Investigator

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[Journal Article] Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action.2020

Author(s)

Journal Title

Data Source

[Journal Article] Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation.2016

Author(s)

Journal Title

DOI

TAKEDA Kozue 武田湖州恵