Kojima Misaki 小島美咲

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KOJIMA Misaki 小島美咲

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Researcher Number	80355742
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2021: 国立研究開発法人農業・食品産業技術総合研究機構, 畜産研究部門, シニア特別研究員 2017 – 2018: 国立研究開発法人農業・食品産業技術総合研究機構, 畜産研究部門, 主席研究員 2015: 独立行政法人農業生物資源研究所, 家畜ゲノム研究ユニット, 上級研究員 2010 – 2012: 独立行政法人農業生物資源研究所, 家畜ゲノム研究ユニット, 上級研究員
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Medical pharmacy Except Principal Investigator Integrative animal science / Laboratory animal science
Keywords	Principal Investigator 転写因子 / 性差 / 肝臓 / 薬物代謝酵素 / アンドロゲン / 異物代謝酵素 / BCL6 / Cytochrome P450 / 薬物トランスポーター / CYP4A … More / CYP2C33 / IGF1 / 遺伝子発現 / 腎臓 / CUX2 / GHR-KOブタ / 成長ホルモン受容体欠損ブタ / 成長ホルモン / 薬物輸送体 / 臓器選択性 / 品種間差 / CYP1A2 / CYP1A1 / 常染色体性優性遺伝 / アンドロゲン濃度 / PGC-1α / Cyp7a1 / IL-1 / 構成的発現 / 第II相薬物代謝酵素 / ブタ / 優性遺伝 / 系統差 / CYP … More Except Principal Investigator β-細胞 / 性差 / β細胞 / 遺伝解析 / 疾患モデル動物 / エキソームシークエンス / コンジェニックマウス / QTL / インスリン低下 / DDD系統 / Ayアリル / β細胞喪失 / QTLマッピング / モデルマウス / 2型糖尿病 / NASH / 動物モデル / NASHモデル Less

Analysis of androgen-dependent gene expression of drug metabolizing enzymes using GHR-KO pigsPrincipal Investigator
- Principal Investigator
  
  Kojima Misaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  National Agriculture and Food Research Organization
Genetic and pathophysiologic analyses of type 2 diabetes mellitus in newly established mouse model DDD-Ay
- Principal Investigator
  
  Suto Jun-ichi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Integrative animal science
- Research Institution
  National Agriculture and Food Research Organization
Development of a novel animal model of hepatocellular carcinoma with nonalcoholic steatohepatitis
- Principal Investigator
  
  Aiura Koichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Keio University
Inhibitory effect of androgen on the constitutive gene expression of hepatic drug metabolizing enzymes and its mechanismPrincipal Investigator
- Principal Investigator
  
  KOJIMA Misaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Agrobiological Sciences

All 2022 2021 2019 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Sex, Organ, and Breed Differences in the mRNA Expression of Drug Transporters in the Liver and Kidney of Pigs2022
- Author(s)
  Kojima Misaki、Degawa Masakuni
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 4 Pages: 508-516
- DOI
  10.1248/bpb.b21-01033
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-04-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06463
[Journal Article] Androgen-Dependent Differences in the Amounts of <i>CYP</i> mRNAs in the Pig Kidney2021
- Author(s)
  Kojima Misaki、Degawa Masakuni
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 8 Pages: 1120-1128
- DOI
  10.1248/bpb.b21-00333
- NAID
  130008070578
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06463
[Journal Article] Serum androgen level is determined by autosomal dominant inheritance and regulates sexrelated CYP genes in pigs2013
- Author(s)
  M. Kojima and M. Degawa
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 430 Issue: 2 Pages: 833-838
- DOI
  10.1016/j.bbrc.2012.11.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590166
[Journal Article] Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice2012
- Author(s)
  M.Kojima
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 35 Issue: 2 Pages: 246-250
- DOI
  10.1248/bpb.35.246
- NAID
  130001872300
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009, KAKENHI-PROJECT-22590166
[Journal Article] Interleukin-1 Controls the Constitutive Expression of the Cyp7a1 Gene by Regulating the Expression of Cyp7a1 Transcriptional Regulators in the Mouse Liver2011
- Author(s)
  M.Kojima
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 34 Issue: 10 Pages: 1644-1647
- DOI
  10.1248/bpb.34.1644
- NAID
  130001086603
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009, KAKENHI-PROJECT-22590166
[Journal Article] Androgn-mediated down-regulation of CYP1A subfamily genes in the pig liver2010
- Author(s)
  M. Kojima, M. Sekimoto and M. Degawa
- Journal Title
  
  J. Endocrinol
  
  Volume: 207 Pages: 203-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590166
[Journal Article] Androgen-mediated down-regulation of CYP1A subfamily genes in the pig liver2010
- Author(s)
  M.Kojima, M.Sekimoto, M.Degawa
- Journal Title
  
  J.Endocrinol
  
  Volume: 207 Pages: 203-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590166
[Presentation] ブタの肝臓と腎臓における薬物輸送体発現の性差とテストステロンの関与2022
- Author(s)
  小島美咲、出川雅邦
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K06463
[Presentation] 2型糖尿病モデルとして新規に樹立したDDD.Cg-Ay マウスの特性解析：飼育条件が病態に及ぼす影響2019
- Author(s)
  小島美咲、須藤淳一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16H05048
[Presentation] マウス肝でのcholesterol 7α-hydroxylaseおよびその転写因子の構成的遺伝子発現におけるInterleulin-1の寄与2012
- Author(s)
  小島美咲、芦野隆、吉田武美、岩倉洋一郎、関本征史、出川雅邦
- Organizer
  フォーラム2012:衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Year and Date
  2012-10-25
- Data Source
  KAKENHI-PROJECT-22590166
[Presentation] Sex-differences in the constitutive gene expression levels of CYPs in the pig liver2012
- Author(s)
  Misaki Kojima, Masashi Sekimoto, Masakuni Degawa
- Organizer
  Androgen-mediated downregulation. 50th Anniversary Symposium on Cytochrome
- Place of Presentation
  福岡
- Year and Date
  2012-12-03
- Data Source
  KAKENHI-PROJECT-22590166
[Presentation] ブタにおける血清中アンドロゲン濃度は遺伝的に規定され、肝CYP1A酵素遺伝子の発現に影響を与える2011
- Author(s)
  小島美咲、出川雅邦
- Organizer
  第84回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22590166
[Presentation] ブタの肝臓における構成的CYP2およびCYP3ファミリー酵素の遺伝子発現に及ぼすアンドロゲンの影響2011
- Author(s)
  小島美咲、出川雅邦
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22590166
[Presentation] マウス肝でのcholetserol 7α-hydroxylaseおよびその転写因子の構成的遺伝子発現におけるInterleulin-1の寄与
- Author(s)
  小島美咲、芦野隆、吉田武美、岩倉洋一郎、関本征史、出川雅邦
- Organizer
  フォーラム2012：衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590166

1. DEGAWA Masakuni (50134002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. Aiura Koichi (00184010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Itano Osamu (90265827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Kitago Minoru (70296599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Matsuda Sachiko (90534537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Onishi Akira (30414890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Tanigichi Yoshihito (00324616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Yoshiura Yasushi (90372052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Suto Jun-ichi (60355740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 淵本大一郎 (10343998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kojima Misaki 小島 美咲

KOJIMA Misaki 小島 美咲

Research Projects

Research Products

Co-Researchers

Analysis of androgen-dependent gene expression of drug metabolizing enzymes using GHR-KO pigsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genetic and pathophysiologic analyses of type 2 diabetes mellitus in newly established mouse model DDD-Ay

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel animal model of hepatocellular carcinoma with nonalcoholic steatohepatitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibitory effect of androgen on the constitutive gene expression of hepatic drug metabolizing enzymes and its mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sex, Organ, and Breed Differences in the mRNA Expression of Drug Transporters in the Liver and Kidney of Pigs2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Androgen-Dependent Differences in the Amounts of <i>CYP</i> mRNAs in the Pig Kidney2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Serum androgen level is determined by autosomal dominant inheritance and regulates sexrelated CYP genes in pigs2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice2012

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Interleukin-1 Controls the Constitutive Expression of the Cyp7a1 Gene by Regulating the Expression of Cyp7a1 Transcriptional Regulators in the Mouse Liver2011

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Androgn-mediated down-regulation of CYP1A subfamily genes in the pig liver2010

Author(s)

Journal Title

Data Source

[Journal Article] Androgen-mediated down-regulation of CYP1A subfamily genes in the pig liver2010

Author(s)

Journal Title

Data Source

[Presentation] ブタの肝臓と腎臓における薬物輸送体発現の性差とテストステロンの関与2022

Author(s)

Organizer

Data Source

[Presentation] 2型糖尿病モデルとして新規に樹立したDDD.Cg-Ay マウスの特性解析：飼育条件が病態に及ぼす影響2019

Kojima Misaki 小島美咲

KOJIMA Misaki 小島美咲