HASHIMOTO Takeshi 橋本剛

Researcher Number	80380153
Other IDs
Affiliation (Current)	2025: 香川大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2013 – 2025: 香川大学, 医学部, 助教 2007 – 2011: Kagawa University, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Endocrinology / Eating habits Except Principal Investigator Basic Section 47040:Pharmacology-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 59040:Nutrition science and health science-related / Studies on the Super-Aging Society / Cardiovascular medicine / Circulatory organs internal medicine
Keywords	Principal Investigator PAR1欠損マウス / インスリン抵抗性 / トロンビン受容体 / 糖尿病 / 肥満 / 肥満症 / 脂肪肝 / グルココルチコイド / スフィンゴシンキナーゼ / 加齢性糖代謝異常 … More / インスリン分解酵素 / 加齢性インスリン抵抗性 / PAR1受容体 / 自発活動量 / 血液凝固因子 / 栄養学 / 薬理学 / 生理学 / PPARγ受容体 / 受容体遮断薬 / 肝非実質細胞 / 肝星状細胞 / ミフェプリストン / 非アルコール性脂肪性肝炎（NASH） / S1P / スフィンゴ脂質 / 脂肪細胞分化 / デキサメタゾン / 成熟脂肪細胞 / 前駆脂肪細胞 / Sphingosine Kinase (Sphk) / Sphingosine I-phosphate (SIP) / Sphingosine Kinase(SphK) / Sphingosine 1-phosphate(S1P) / ob マウス / ob / 3T3-L1細胞 / 脂肪組織 / 脂肪細胞 / Sphingosine Kinase (SphK) / Sphingosine 1-phosphate (S1P) / スフィンゴシン1リン酸 … More Except Principal Investigator プロテイナーゼ活性化型受容体１ / インスリン分解酵素 / 受容体 / 凝固因子 / 老化 / インスリン抵抗性 / プロテイナーゼ活性化型受容体 / サイトカイン / 線維化狭窄 / クローン病 / 認知症 / 血液凝固系 / カルシウム / 細胞間接着 / 血管内皮細胞 / RNA干渉法 / マイクロアレイ解析 / 貯蔵部作動性カルシウム流入 / 遺伝子発現 / 廊下 / 血液凝固 / 高齢者 / 糖尿病 / DNAマイクロアレイ解析 / 血液凝固因子 / 成長因子 / 内皮細胞 / 血管新生 / caveolin-1 / 受容体シグナリング / 細胞内情報伝達機構 / スフィンゴ脂質 / 脂質メディエーター / 心筋虚血 Less

Development of a novel therapeutic strategy targeting proteinase-activated receptor 1 for Crohn's disease fibrosis
- Principal Investigator
  
  倉原琳
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kagawa University
Elucidation of novel aspect of relationship between blood coagulation system and dementia and development of its regulation
- Principal Investigator
  
  平野勝也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kagawa University
加齢に伴うインスリン抵抗性発症におけるトロンビン受容体ＰＡＲ１の役割解明Principal Investigator
- Principal Investigator
  
  橋本剛
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kagawa University
Elucidation and regulation of the senescence-accelerating function of coagulation system
- Principal Investigator
  
  平野勝也
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kagawa University
Development of strategies for improvement of insulin resistance of the aged by targeting the blood coagulation system
- Principal Investigator
  
  Hirano Katsuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  Kagawa University
Novel development of Improvement Insulin Resistance by Thrombin ReceptorsPrincipal Investigator
- Principal Investigator
  
  Hashimoto Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kagawa University
New development of animal model of non-obese nonalcoholic steatohepatitis and its corrective establishmentPrincipal Investigator
- Principal Investigator
  
  Hashimoto Takeshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Kagawa University
Vessel maturation by a cytokine TGFbeta1 and crosstalk with VEGFR2 signaling
- Principal Investigator
  
  Igarashi Junsuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kagawa University
Mifepristone improved Diet-induced insulin resistance by increasing blood level of adiponectin.Principal Investigator
- Principal Investigator
  
  HASHIMOTO Takeshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Kagawa University
Exploring the roles of sphingosine 1-phosphate(S1P), a lipid mediator, in ischemic heart
- Principal Investigator
  
  IGARASHI Junsuke
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kagawa University
Elucidation of physiological roles of sphingosine 1-phosphate and its receptors in adipose tissuePrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  Kagawa University

[Journal Article] Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells2024
- Author(s)
  Hashimoto Takeshi、Hirano Katsuya
- Journal Title
  
  Cellular & Molecular Biology Letters
  
  Volume: 29 Issue: 1 Pages: 45-45
- DOI
  10.1186/s11658-024-00559-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K10890, KAKENHI-PROJECT-23K24793
[Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts.2016
- Author(s)
  Igarashi J, Okamoto R, Yamashita T, Hashimoto T, Karita S, Nakai K, Kubota Y, Takata M, Yamaguchi F, Tokuda M, Sakakibara N, Tsukamoto I, Konishi R, Hirano K.
- Journal Title
  
  Physiological Reports
  
  Volume: 4 Issue: 6 Pages: e12742-e12742
- DOI
  10.14814/phy2.12742
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461132
[Journal Article] Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes.2015
- Author(s)
  Hasan AU, Ohmori K, Konishi K, Igarashi J, Hashimoto T, Kamitori K, Yamaguchi
- Journal Title
  
  Mol Cell Endocrinol.
  
  Volume: 406 Pages: 10-18
- DOI
  10.1016/j.mce.2015.02.012
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591057, KAKENHI-PROJECT-25461132
[Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells2014
- Author(s)
  Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, TakuwaY, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I.
- Journal Title
  
  Pharmacology Research & Perspectives
  
  Volume: 2 Issue: 5 Pages: 68-68
- DOI
  10.1002/prp2.68
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390051, KAKENHI-PROJECT-24591654, KAKENHI-PROJECT-24790123, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25461132, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26220203
[Journal Article] Valsartan ameliorates the constitutive adipokine expression pattern in mature adipocytes: a role for inverse agonism of the angiotensin II type 1 receptor in obesity2014
- Author(s)
  Hasan AU, Ohmori K, Hashimoto T., Kamitori K, Yamaguchi F, Ishihara Y, Ishihara N, Noma T, Tokuda M, Kohno M,
- Journal Title
  
  Hypertens Res
  
  Volume: 37(7) Pages: 621-628
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860770
[Journal Article] Reaction mechanism of single subunit NADH-ubiquinone oxidoreductase(Ndi1) from Saccharomyces cerevisiae : evidence for a ternary complex mechanism2011
- Author(s)
  Yang Y, Yamashita T, Nakamaru-Ogiso E, Hashimoto T, Murai M, Igarashi J, Miyoshi H, Mori N, Matsuno-Yagi A, Yagi T and Kosaka H
- Journal Title
  
  J Biol Chem
  
  Volume: 286(11) Pages: 9287-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis2009
- Author(s)
  Hashimoto T, Igarashi J, Kosaka H
- Journal Title
  
  Journal of lipid research 50(4)
  
  Pages: 602-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790650
[Journal Article] Transforming Growth Factor-{ beta} 1 Down-Regulates Caveolin-1 Expression And Enhances Sphingosine 1-Phosphate Signaling In Cultured Vascular Endothelial Cells2009
- Author(s)
  Igarashi J, Shoji K, Hashimoto T, Moriue T, Yoneda K, Takamura T, Yamashita T, Kubota Y, and Kosaka H
- Journal Title
  
  Am. J. Physiol.(Cell Physiology)
  
  Volume: 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis2009
- Author(s)
  橋本剛
- Journal Title
  
  Journal of Lipid Research 50
  
  Pages: 602-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis2009
- Author(s)
  Hashimoto T, Igarashi J, Kosaka H.
- Journal Title
  
  Journal of lipid research 50(4)
  
  Pages: 602-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790650
[Presentation] Role of proteinase-activated receptor 1 in the development of age-related insulin resistance2024
- Author(s)
  Takeshi Hashimoto, Natsuko Tsurudome, Katsuya Hirano
- Organizer
  The Annual Meeting of the Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-23K10890
[Presentation] Role of proteinase-activated receptor 1 in the development of age-related insulin resistance2024
- Author(s)
  Hashimoto T, Tsurudome N, Hirano K
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K24793
[Presentation] Characteristics of the adipocytes differentiated by a glucocorticoid receptor antagonist RU4862022
- Author(s)
  Hirano K, Hashimoto T
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K20663
[Presentation] グルココルチコイド受容体拮抗薬（RU486）単独処理による脂肪細胞分化に伴う遺伝子発現特性2022
- Author(s)
  橋本剛、平野勝也
- Organizer
  第141回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K20663
[Presentation] グルココルチコイド受容体拮抗薬（RU486）単独処理による脂肪細胞分化に伴う遺伝子発現特性2022
- Author(s)
  橋本剛、平野勝也
- Organizer
  第141回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-23K24793
[Presentation] 糖質コルチコイド受容体拮抗薬ミフェプリストンの新たな脂肪細胞分化誘導剤としての可能性2021
- Author(s)
  橋本剛、平野勝也
- Organizer
  第73回日本生理学会中国四国地方会
- Data Source
  KAKENHI-PROJECT-20K20663
[Presentation] 糖質コルチコイド受容体拮抗薬ミフェプリストン単独の脂肪細胞分化促進作用2020
- Author(s)
  橋本剛、平野勝也
- Organizer
  第72回日本生理学会中国四国地方会
- Data Source
  KAKENHI-PROJECT-20K20663
[Presentation] Mifepristone, a steroid hormone receptor antagonist, upregulates vimentin expression in human hepatic stellate cells.2019
- Author(s)
  Takeshi Hashimoto, Katsuya Hirano
- Organizer
  9th FAOPS: Federation of the Asian and Oceanian Physiological Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K00852
[Presentation] ミフェプリストンが引き起こす非肥満非アルコール性脂肪性肝炎におけるビメンチンの発現亢進には肝星状細胞が関与する2018
- Author(s)
  橋本　剛、平野勝也
- Organizer
  第70回日本生理学会中国四国地方会
- Data Source
  KAKENHI-PROJECT-16K00852
[Presentation] ミフェプリストンは肝星状細胞においてビメンチンタンパク質の発現を増加させる2018
- Author(s)
  橋本　剛、平野勝也
- Organizer
  第３９回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K00852
[Presentation] Mifepristone, a steroid receptor antagonist, induces hepatic steatosis in association with upregulation of resistin expression in liver2017
- Author(s)
  Hashimoto T; Igarashi J; Yamashita T; Hirano K
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  静岡県浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K00852
[Presentation] NAD(P)H and low ionic strength suppresses dissociation of apoptosis-inducing factor from the E. coli membrane2017
- Author(s)
  Yamashita T; Matsumoto K; Hashimoto T; Igarashi J; Kosaka H; Hirano K
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  静岡県浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K00852
[Presentation] A novel angiogenic agent COA-Cl promotes VEGF secretion from mouse C2C12 skeletal myocytes via the activation of cAMP/PKA/CREB/PGC-1alpha signaling axis2017
- Author(s)
  Igarashi J; Okamoto R; Hashimoto T; Yamashita T; Kubota Y; Tsukamoto I; Sakakibara N; Konishi R; Hirano K
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  静岡県浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K00852
[Presentation] Coagulation factor XIa induces Ca2+ influx via L-type Ca2+ channel in vascular smooth muscle cells2017
- Author(s)
  Lui W; Hashimoto T; Yamashita T; Igarashi J; Hirano K
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  静岡県浜松市
- Data Source
  KAKENHI-PROJECT-16K00852
[Presentation] Apoptosis-inducing factorと大腸菌膜との相互作用の解析（Analysis of interaction of apoptosis-inducing factor with E. coli membrane）2016
- Author(s)
  松本感; 山下哲生; 橋本剛; 五十嵐淳介; 小坂博昭; 平野勝也
- Organizer
  第68回日本生理学会中国四国地方会
- Place of Presentation
  岡山県
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-16K00852
[Presentation] A key role of a second messenger cAMP in the induction of a transcriptional coactivator PGC-1α by a novel proangiogenic adenosine analogue COA-Cl in human fibroblasts2016
- Author(s)
  五十嵐淳介; 岡本隆司; 橋本剛; 山下哲生; Takata M; 窪田泰夫; Sakakibara N; 塚本郁子; 小西良士; 平野勝也
- Organizer
  The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
- Place of Presentation
  宮城県仙台市
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-16K00852
[Presentation] Coagulation factor XIa induces Ca2+ response in rat aorta smooth muscle cells via proteinase-activated receptor 12016
- Author(s)
  劉文華; 橋本剛; 山下哲生; 五十嵐淳介; 平野勝也
- Organizer
  第68回日本生理学会中国四国地方会
- Place of Presentation
  岡山県
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-16K00852
[Presentation] 新規アデノシン類似化合物COA-Cl（コアクロル）はcAMP/CREB/PGC-1αの経路を介して血管内皮成長因子（VEGF）の産生を促進する2015
- Author(s)
  岡本隆司、五十嵐淳介、橋本剛、山下哲生、苅田咲子、窪田泰夫、高田麻紀、小西良士、塚本郁子、平野勝也
- Organizer
  第67回日本生理学会中国四国地方会
- Place of Presentation
  鳥取県米子市
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] Activation of cAMP/CREB/PGC-1α Pathway Plays a Key Role for a Novel Adenosine-like Angiogenic Agent COA-Cl to Induce Production of Vascular Endothelial Growth Gactor (VEGF) in Cultured Human Fibroblasts.2015
- Author(s)
  Okamoto R, Igarashi J, Hashimoto T, Yamashita T, Shoji K, Kubota Y, Sakakibara N, Tsukamoto I, Konishi R, Hirano K.
- Organizer
  Scientific Sessions 2015, American Heart Association
- Place of Presentation
  アメリカ合衆国フロリダ州オーランド市
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] A Key Role of PGC-1α Co-transcription Factor, but not HIF1α Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic Agent COA-Cl in Cultured Human Fibroblasts.2015
- Author(s)
  Okamoto R, Igarashi J, Yamashita T, Takeshi Hashimoto T, Karita S, Shoji K, Kubota Y, Takata M, Yamaguchi F, Tokuda M, Sakakibara N, Tsukamoto I, Konishi R, Hirano K.
- Organizer
  Scientific Sessions 2015, American Heart Association
- Place of Presentation
  アメリカ合衆国フロリダ州オーランド市
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] 新規核酸類似物質COA-Clによる血管新生反応におけるS1P1受容体の役割2014
- Author(s)
  五十嵐淳介、窪田泰夫、小路和代、榊原紀和、丸山徳見、高田真紀、小坂博昭、多久和陽、橋本剛、山下哲生、小西良二、塚本郁子
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] TGFβ1 down-regulates VEGFR-2 and attenuates VEGF-induced activation of protein kinase Akt in cultured endothelial cells2012
- Author(s)
  Igarashi J, Shoji K, Hashimoto T, Tsukamoto I, Yoneda K, Kubota Y, and Kosaka H
- Organizer
  日本生理学会
- Place of Presentation
  長野県松本市
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] Glucocorticoid(GC) up-regulates expression of caveolin-1(cav-1) and attenuates VEGF responses in endothelial cells(EC)2011
- Author(s)
  Igarashi J, Shoji K, Hashimoto T, Yoneda K, Moriue T, Tsukamoto I, Kubota Y, and Kosaka H
- Organizer
  日本生理学会
- Place of Presentation
  誌上開催
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] ステロイド受容体アゴニストはcaveolin-1(cav-1)発現を増加させることで血管内皮のVEGF反応を抑制する2011
- Author(s)
  五十嵐淳介、小路和代、橋本剛、米田耕造、森上徹也、塚本郁子、窪田泰夫、小坂博昭
- Organizer
  日本心脈管作動物質学会
- Place of Presentation
  香川県高松市
- Year and Date
  2011-02-04
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] Steroid Hormones Induce Caveolin-1(cav-1) And Attenuate vascular endothelial growth factor(VEGF) Responses In Cultured Vascular Endothelial Cells(EC)2010
- Author(s)
  Igarashi J, Hashimoto T, Shoji K, Yoneda K, Kubota Y, and Kosaka H
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  アメリカ合衆国イリノイ州シカゴ市
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] Sphingosine Kinase-1, an S1P-producing enzyme, promotes adipogenesis2008
- Author(s)
  橋本剛;五十嵐淳介;小坂博昭
- Organizer
  第81回日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2008-03-17
- Data Source
  KAKENHI-PROJECT-19790650
[Presentation] Sphingosine Kinase 1,an SIP producing enzyme,promotes adipogenesis2008
- Author(s)
  橋本剛、五十嵐淳介、小坂博昭
- Organizer
  日本薬理学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-03-17
- Data Source
  KAKENHI-PROJECT-19790650
[Presentation] 3T3-L1前駆脂肪細胞におけるSphingosine Kinase-1の脂肪細胞分化への関与2007
- Author(s)
  橋本剛;五十嵐淳介;小坂博昭
- Organizer
  第84回日本生理学会
- Place of Presentation
  大阪
- Year and Date
  2007-03-20
- Data Source
  KAKENHI-PROJECT-19790650
[Presentation] COA-Cl-induced adipogenesis is associated with an increased cell cycle progression and down-regulation of p27Kip1 in mouse pre-adipocyte 3T3-L1 cells
- Author(s)
  Takeshi Hashimoto、Junsuke Igarashi、Ikuko Tsukamoto, Tetsuo Yamashita, Katsuya Hirano
- Organizer
  第９２回日本生理学会
- Place of Presentation
  兵庫
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25860770
[Presentation] アデノシン類似化合物COA-ClによるVEGF分泌促進機序の検討
- Author(s)
  岡本隆司五十嵐淳介山下哲生橋本剛平野勝也高田麻紀小西良士塚本郁子小路和代窪田泰夫
- Organizer
  第66回日本生理学会中国四国地方会
- Place of Presentation
  香川県高松市
- Year and Date
  2014-11-01 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] HUVECにおけるCOA-Clの血管新生作用に対するS1Pレセプターの関与
- Author(s)
  塚本郁子、五十嵐淳介、橋本剛、山下哲生、小路和代、榊原紀和、丸山徳見、高田麻紀、窪田泰夫、平野勝也、小西良士
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25860770
[Presentation] A novel angiogenic agent COA-Cl induced PGC-1α-mediated VEGF production in cultured human fibroblasts.
- Author(s)
  Okamoto R, Igarashi J, Yamashita T, Hashimoto T, Shoji K, Kubota Y, Takata M, Tsukamoto I, Konishi R, Hirano K
- Organizer
  第92回日本生理学会総会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-03-22 – 2015-03-24
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] 血管新生化合物COA-ClのVEGF分泌作用機序の検討
- Author(s)
  岡本隆司, 五十嵐淳介, 山下哲生, 橋本剛, 平野勝也, 高田麻紀, 小西良士, 塚本郁子, 小路和代, 窪田泰夫
- Organizer
  第66回日本生理学会中国四国地方会
- Place of Presentation
  香川
- Year and Date
  2014-11-01 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25860770
[Presentation] 新規アデノシンアナログCOA-Clの血管新生作用
- Author(s)
  塚本郁子、五十嵐淳介、橋本剛、山下哲生、榊原紀和、丸山徳見、高田麻紀、窪田泰夫、平野勝也、小西良士
- Organizer
  第66回日本皮膚科学会西部支部学術大会
- Place of Presentation
  香川
- Year and Date
  2014-11-08 – 2014-11-09
- Data Source
  KAKENHI-PROJECT-25860770
[Presentation] A novel angiogenic agent COA-Cl induced PGC-1α-mediated VEGF production in cultured human fibroblasts
- Author(s)
  Ryuji Okamoto, Junsuke Igarashi, Tetsuo Yamashita, Takeshi Hashimoto, Katsuya Hirano, Maki Takada, Ryoji Konishi, Ikuko Tsukamoto, Kazuyo Shoji, Yasuo Kubota
- Organizer
  第９２回日本生理学会
- Place of Presentation
  兵庫
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25860770

1. Hirano Katsuya (80291516)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. IGARASHI Junsuke (20346638)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. KOSAKA Hiroaki (60158897)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. 倉原琳 (00341438)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 山下哲生 (80444727)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 石川亮 (60863743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HASAN Ul arif

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 多久和典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 岡本安雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 多久和陽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 大森浩二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASHIMOTO Takeshi 橋本 剛

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Development of a novel therapeutic strategy targeting proteinase-activated receptor 1 for Crohn's disease fibrosis

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Elucidation of novel aspect of relationship between blood coagulation system and dementia and development of its regulation

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加齢に伴うインスリン抵抗性発症におけるトロンビン受容体ＰＡＲ１の役割解明Principal Investigator

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Elucidation and regulation of the senescence-accelerating function of coagulation system

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Development of strategies for improvement of insulin resistance of the aged by targeting the blood coagulation system

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Novel development of Improvement Insulin Resistance by Thrombin ReceptorsPrincipal Investigator

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New development of animal model of non-obese nonalcoholic steatohepatitis and its corrective establishmentPrincipal Investigator

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Vessel maturation by a cytokine TGFbeta1 and crosstalk with VEGFR2 signaling

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Mifepristone improved Diet-induced insulin resistance by increasing blood level of adiponectin.Principal Investigator

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Exploring the roles of sphingosine 1-phosphate(S1P), a lipid mediator, in ischemic heart

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Elucidation of physiological roles of sphingosine 1-phosphate and its receptors in adipose tissuePrincipal Investigator

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[Journal Article] Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells2024

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[Journal Article] A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts.2016

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HASHIMOTO Takeshi 橋本剛