Yoshino Jun 吉野純

… Alternative Names

YOSHINO Jun 吉野純

吉野純ヨシノジユン

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Researcher Number	80383777
Other IDs
Affiliation (Current)	2026: 島根大学, 学術研究院医学・看護学系, 准教授
Affiliation (based on the past Project Information) *help	2024: 島根大学, 学術研究院医学・看護学系, 准教授 2024: 慶應義塾大学, 医学部(信濃町), 客員講師 2023: 慶應義塾大学, 医学部(信濃町), 非常勤講師 2021 – 2023: 慶應義塾大学, 医学部(信濃町), 特任准教授 2007: Keio University, 医学部, 助教 2006: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Medicine, Dentistry, and Pharmacy / Kidney internal medicine Except Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 56060:Ophthalmology-related
Keywords	Principal Investigator 代謝 / インスリン抵抗性 / 肥満 / 老化 / ミトコンドリア / NAD / 脂肪 / 慢性腎臓病 / トランスレーショナル型研究 / 臨床研究 … More / 脂肪細胞 / NMN / エネルギー代謝 / 心血管病変 / NFκB / 血管内皮細胞 / 遺伝子操作動物 / 進行性腎障害 / 賢繊維化 / Cre-loxPシステム / NF〓B / 進行性賢障害 / 遺伝子改変動物 … More Except Principal Investigator ニコチンアミドアデニンジヌクレオチド / 心停止蘇生後症候群 / ニコチンアミドモノヌクレオチド(NMN) / ニコチンアミドアデニンジヌクレオチド(NAD＋) / 心停止後症候群 / 環境 / 角膜移植 / 虹彩萎縮 / 治療薬 / 前房環境 / 前房関連角膜内皮症 / 角膜内皮細胞 / 細胞老化 / ニコチナミドモノヌクレオチド / 難治性水疱性角膜症 Less

Establishment of experimental basis to improve the prognosis of corneal transplantation in treating bullous keratoplasty due to pathological aqueous humor.
- Principal Investigator
  
  山口剛史
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tokyo Dental College
Development of a Novel Treatment Targeting the NAD Synthesis Pathway for Post-Cardiac Arrest Syndrome and Elucidation of Its Role in Severe Disease States
- Principal Investigator
  
  本間康一郎
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Keio University
新規ミトコンドリアNAD輸送体SLC25A51の脂肪細胞機能制御および臨床的意義の解明Principal Investigator
- Principal Investigator
  
  吉野純
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Shimane University
Pathophysiological significance and clinical implication of adipocyte NAD biologyPrincipal Investigator
- Principal Investigator
  
  YOSHINO Jun
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
- Review Section
  
  Medicine, Dentistry, and Pharmacy
- Research Institution
  Keio University
Tie2-Creマウスを用いた腎内皮細胞傷害・修復機構におけるNFκBの機能解析Principal Investigator
- Principal Investigator
  
  吉野純
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Keio University

All 2025 2024 2023 2022 2021 2007

All Journal Article Presentation

[Journal Article] Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring2025
- Author(s)
  Yao Na、Nomura Seitaro et al.
- Journal Title
  
  Cell Metabolism
  
  Volume: 37 Issue: 2 Pages: 395-412.e6
- DOI
  10.1016/j.cmet.2024.12.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05045, KAKENHI-PROJECT-24H00633, KAKENHI-PROJECT-23K24789, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-23K23798, KAKENHI-PROJECT-24K02452, KAKENHI-PROJECT-24K02506, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-24K22126, KAKENHI-PROJECT-24K23940
[Journal Article] DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages.2025
- Author(s)
  Nishimura ES, Hishikawa A, Nakamichi R, Akashio R, Chikuma S, Hashiguchi A, Yoshimoto N, Hama EY, Maruki T, Itoh W, Yamaguchi S, Yoshino J, Itoh H, Hayashi K
- Journal Title
  
  Nat Commun
  
  Volume: 16 Issue: 1 Pages: 3958-3958
- DOI
  10.1038/s41467-025-59297-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23H04789, KAKENHI-PROJECT-23K24114, KAKENHI-PROJECT-23K24351, KAKENHI-PROJECT-22K19511, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-24K02506
[Journal Article] Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model2025
- Author(s)
  Akhter Arju、Md. Sheikh Abdullah、Yoshino Jun、Kanda Takeshi、Nagai Atsushi、Matsuo Masafumi、Yano Shozo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 26 Issue: 7 Pages: 3098-3098
- DOI
  10.3390/ijms26073098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24K02506
[Journal Article] Intracellular dark endothelial spots detected using specular microscopy are associated with graft failure after Descemet’s membrane endothelial keratoplasty2025
- Author(s)
  Igarashi Ami、Takeda Masato、Mashiko Naoko、Shimizu Toshiki、Yuda Kentaro、Oie Yoshinori、Okumura Naoki、Yamaguchi Takefumi、Yamagami Satoru、Hayashi Takahiko
- Journal Title
  
  Graefe's Archive for Clinical and Experimental Ophthalmology
  
  Volume: 1 Issue: 5 Pages: 1373-1382
- DOI
  10.1007/s00417-025-06745-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27754
[Journal Article] Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men2024
- Author(s)
  Yamaguchi Shintaro、Irie Junichiro、Mitsuishi Masanori、Uchino Yuichi、Nakaya Hideaki、Takemura Ryo、Inagaki Emi、Kosugi Shotaro、Okano Hideyuki、Yasui Masato、Tsubota Kazuo、Hayashi Kaori、Yoshino Jun、Itoh Hiroshi
- Journal Title
  
  Endocr J
  
  Volume: 71 Issue: 2 Pages: 153-169
- DOI
  10.1507/endocrj.EJ23-0431
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-21K08584
[Journal Article] Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity2024
- Author(s)
  Petersen Max C.、Smith Gordon I.、Palacios Hector H.、Farabi Sarah S.、Yoshino Mihoko、Yoshino Jun、Cho Kevin、Davila-Roman Victor G.、Shankaran Mahalakshmi、Barve Ruteja A.、Yu Jinsheng、Stern Jennifer H.、Patterson Bruce W.、Hellerstein Marc K.、Shulman Gerald I.、Patti Gary J.、Klein Samuel
- Journal Title
  
  Cell Metabolism
  
  Volume: 36 Issue: 4 Pages: 745-761.e5
- DOI
  10.1016/j.cmet.2024.03.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-24K02506
[Journal Article] Renal sinus fat is associated with intrarenal hemodynamic abnormalities independent of visceral fat in patients with chronic kidney disease2024
- Author(s)
  Kaneko K, Mitsuno R, Kojima D, Azegami T, Kosugi S, Nakamura T, Hashiguchi A, Yamada Y, Jinzaki M, Yamaguchi S, Itoh H, Yoshino J, Hayashi K.
- Journal Title
  
  Obes Res Clin Pract
  
  Volume: in press Issue: 2 Pages: 118-123
- DOI
  10.1016/j.orcp.2024.03.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-24K02506
[Journal Article] Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging2024
- Author(s)
  Qi Nathan、Franczyk Michael P.、Yamaguchi Shintaro、Kojima Daiki、Hayashi Kaori、Satoh Akiko、Ogiso Noboru、Kanda Takeshi、Sasaki Yo、Finck Brian N.、DeBosch Brian J.、Yoshino Jun
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: 327 Issue: 1 Pages: E81-E88
- DOI
  10.1152/ajpendo.00313.2023
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23H03848, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-24K02506
[Journal Article] 肥満関連代謝疾患の新規治療標的としてのNAD＋生物学の可能性2024
- Author(s)
  児島大輝, 吉野純
- Journal Title
  
  カレントテラピー
  
  Volume: 42 Pages: 133-138
- Data Source
  KAKENHI-PROJECT-20K23382
[Journal Article] Intracellular dark spots are associated with endothelial cell loss after Descemet’s stripping automated endothelial keratoplasty2024
- Author(s)
  Mori-Ogiwara Yurina、Yagi-Yaguchi Yukari、Ibrahim Osama、Higa Kazunari、Kasamatsu Hirotsugu、Kanda Takahiro、Tomida Daisuke、Oie Yoshinori、Hayashi Takahiko、Shimazaki Jun、Yamaguchi Takefumi
- Journal Title
  
  British Journal of Ophthalmology
  
  Volume: in press Issue: 7 Pages: 837-839
- DOI
  10.1136/bjo-2024-325702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27754
[Journal Article] Hepatocyte MMP14 mediates liver and inter-organ inflammatory responses to diet-induced liver injury2024
- Author(s)
  Kelly Shannon C、Higgins Cassandra B、Sun Jiameng、Adams Joshua A、Zhang Yiming、Ballentine Samuel、Miao Yong、Cui XiaoXia、Milewska Ma?gorzata、Wandzik Ilona、Yoshino Jun、Swarts Benjamin M、Wada Shun-ichi、DeBosch Brian J
- Journal Title
  
  PNAS Nexus
  
  Volume: 3 Issue: 9 Pages: 357-357
- DOI
  10.1093/pnasnexus/pgae357
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-24K02506, KAKENHI-PROJECT-24K08695
[Journal Article] Very-low-density lipoprotein triglyceride and free fatty acid plasma kinetics in women with high or low brown adipose tissue volume and overweight/obesity2024
- Author(s)
  Chondronikola Maria、Yoshino Jun、Ramaswamy Raja、Giardina Joseph Daniel、Laforest Richard、Wahl Richard L.、Patterson Bruce W.、Mittendorfer Bettina、Klein Samuel
- Journal Title
  
  Cell Reports Medicine
  
  Volume: 5 Issue: 1 Pages: 101370-101370
- DOI
  10.1016/j.xcrm.2023.101370
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Journal Article] Adipose Tissue Biology and Effect of Weight Loss in Women With Lipedema2024
- Author(s)
  Cifarelli Vincenza、Smith Gordon I.、Gonzalez-Nieves Silvia、Samovski Dmitri、Palacios Hector H.、Yoshino Jun、Stein Richard I.、Fuchs Anja、Wright Thomas F.、Klein Samuel
- Journal Title
  
  Diabetes
  
  Volume: 74 Issue: 3 Pages: 308-319
- DOI
  10.2337/db24-0890
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-24K02506
[Journal Article] Nicotinamide mononucleotide, a potential future treatment in ocular diseases2024
- Author(s)
  Deokho Lee, Yohei Tomita, Ari Shinojima, Norimitsu Ban, Shintaro Yamaguchi, Ken Nishioka, Kazuno Negishi, Jun Yoshino, Toshihide Kurihara
- Journal Title
  
  Graefes Arch Clin Exp Ophthalmol
  
  Volume: 262(3) Issue: 3 Pages: 689-700
- DOI
  10.1007/s00417-023-06118-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K15938, KAKENHI-PROJECT-20K23382
[Journal Article] Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice2024
- Author(s)
  LaPoint Andrew、Singer Jason M.、Ferguson Daniel、Shew Trevor M.、Renkemeyer M. Katie、Palacios Hector H.、Field Rachael L.、Yerrathota Sireesha、Kumari Roshan、Shankaran Mahalakshmi、Smith Gordon I.、Yoshino Jun、et al
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 134 Issue: 23
- DOI
  10.1172/jci169722
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-24K02506
[Journal Article] Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism2023
- Author(s)
  Yamaguchi Shintaro、Kojima Daiki、Iqbal Tooba、Kosugi Shotaro、Franczyk Michael P.、Qi Nathan、Sasaki Yo、Yaku Keisuke、Kaneko Kenji、Kinouchi Kenichiro、Itoh Hiroshi、Hayashi Kaori、Nakagawa Takashi、Yoshino Jun
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 674 Pages: 162-169
- DOI
  10.1016/j.bbrc.2023.07.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-21K11593, KAKENHI-PROJECT-23K24762
[Journal Article] Heterogeneity in the effect of marked weight loss on metabolic function in women with obesity2023
- Author(s)
  Mittendorfer Bettina、Kayser Brandon D.、Yoshino Mihoko、Yoshino Jun、Watrous Jeramie D.、Jain Mohit、Eagon J. Christopher、Patterson Bruce W.、Klein Samuel
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 12
- DOI
  10.1172/jci.insight.169541
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Journal Article] NMN(Nicotinamide Mononucleotide)の臨床応用の現状2023
- Author(s)
  吉野美保子, 吉野純
- Journal Title
  
  糖尿病・内分泌代謝科
  
  Volume: 57 Pages: 111-116
- Data Source
  KAKENHI-PROJECT-20K23382
[Journal Article] Risk factors of neonatal hypoglycemia in neonates born to mothers with gestational diabetes2023
- Author(s)
  Arimitsu T, Kasuga Y, Ikenoue S, Saisho Y, Hida M, Yoshino J, Itoh H, Tanaka M, Ochiai D.
- Journal Title
  
  Endocr J
  
  Volume: 70 Issue: 5 Pages: 511-517
- DOI
  10.1507/endocrj.EJ22-0521
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12734, KAKENHI-PROJECT-20K23382
[Journal Article] Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes2023
- Author(s)
  Beals Joseph W.、Kayser Brandon D.、Smith Gordon I.、Schweitzer George G.、Kirbach Kyleigh、Kearney Monica L.、Yoshino Jun、Rahman Gibraan、Knight Rob、Patterson Bruce W.、Klein Samuel
- Journal Title
  
  Nature Metabolism
  
  Volume: 5 Issue: 7 Pages: 1221-1235
- DOI
  10.1038/s42255-023-00829-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Journal Article] Association Between Renal Sinus Fat and Cardiometabolic and Renin-Angiotensin System Parameters in Primary Aldosteronism2023
- Author(s)
  Mitsuno Ryunosuke、Kaneko Kenji、Nakamura Toshifumi、Kojima Daiki、Mizutani Yosuke、Azegami Tatsuhiko、Yamaguchi Shintaro、Yamada Yoshitake、Jinzaki Masahiro、Kinouchi Kenichiro、Yoshino Jun、Hayashi Kaori
- Journal Title
  
  Journal of the Endocrine Society
  
  Volume: 8 Issue: 1
- DOI
  10.1210/jendso/bvad154
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-24K19135
[Journal Article] NAD+ and mtRNA sensing drive human kidney diseases2023
- Author(s)
  Itoh Hiroshi、Yoshino Jun
- Journal Title
  
  Nature Metabolism
  
  Volume: 5 Issue: 3 Pages: 357-359
- DOI
  10.1038/s42255-023-00762-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-20K23382
[Journal Article] Intestinal epithelial NAD(+) biosynthesis regulates GLP-1 production and postprandial glucose metabolism in mice2022
- Author(s)
  Nagahisa Taichi, Yamaguchi Shintaro, Kosugi Shotaro, Homma Koichiro, Miyashita Kazutoshi, Irie Junichiro, Yoshino Jun, Itoh Hiroshi
- Journal Title
  
  Endocrinology
  
  Volume: 163 Issue: 4 Pages: 1-12
- DOI
  10.1210/endocr/bqac023
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-21K08584, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-20H00535
[Journal Article] Nicotinamide mononucleotide prevents retinal dysfunction in a mouse model of retinal ischemia/reperfusion injury.2022
- Author(s)
  Lee D, Tomita Y, Miwa Y, Shinojima A, Ban N, Yamaguchi S, Nishioka K, Negishi K, Yoshino J, Kurihara T
- Journal Title
  
  International Journal of Molecular Sciences.
  
  Volume: 23 Issue: 19 Pages: 11228-11228
- DOI
  10.3390/ijms231911228
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-20K18393
[Journal Article] Circadian transcription factor NPAS2 and the NAD(+)‐dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward2022
- Author(s)
  Becker‐Krail Darius D., Parekh Puja K., Ketchesin Kyle D., Yamaguchi Shintaro, Yoshino Jun, Hildebrand Mariah A., Dunham Brandan, Ganapathiraju Madhavi K., Logan Ryan W., McClung Colleen A.
- Journal Title
  
  European Journal of Neuroscience
  
  Volume: 55 Issue: 3 Pages: 675-693
- DOI
  10.1111/ejn.15596
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-20K23382
[Journal Article] SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase2022
- Author(s)
  Cassandra B Higgins, Allyson L Mayer, Yiming Zhang, Michael Franczyk, Samuel Ballentine, Jun Yoshino, Brian J DeBosch
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 1-17
- DOI
  10.1038/s41467-022-28717-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K23382
[Journal Article] Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes2022
- Author(s)
  Yoshino Mihoko、Yoshino Jun、Smith Gordon I.、Stein Richard I.、Bittel Adam J.、Bittel Daniel C.、Reeds Dominic N.、Sinacore David R.、Cade W. Todd、Patterson Bruce W.、Cho Kevin、Patti Gary J.、Mittendorfer Bettina、Klein Samuel
- Journal Title
  
  Cell Metabolism
  
  Volume: 34 Issue: 10 Pages: 1431-1441.e5
- DOI
  10.1016/j.cmet.2022.08.012
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Journal Article] Nicotinamide Mononucleotide Protects against Retinal Dysfunction in a Murine Model of Carotid Artery Occlusion.2022
- Author(s)
  Lee D, Tomita Y, Miwa Y, Jeong H, Shinojima A, Ban N, Yamaguchi S, Nishioka K, Negishi K, Yoshino J, Kurihara T.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 23 Pages: 14711-14711
- DOI
  10.3390/ijms232314711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07377, KAKENHI-PROJECT-20K23382, KAKENHI-PROJECT-20K18393
[Journal Article] NMN・NAD 生物学研究のブレークスルー：最新の二重盲検無作為化比較試験の結果より2021
- Author(s)
  吉野美保子、吉野純、今井眞一郎、Samuel Klein
- Journal Title
  
  Geriatric Medicine
  
  Volume: 59 Pages: 693-698
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Journal Article] Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility2021
- Author(s)
  Franczyk Michael P、Qi Nathan、Stromsdorfer Kelly L、Li Chengcheng、Yamaguchi Shintaro、Itoh Hiroshi、Yoshino Mihoko、Sasaki Yo、Brookheart Rita T、Finck Brian N、DeBosch Brian J、Klein Samuel、Yoshino Jun
- Journal Title
  
  Endocrinology
  
  Volume: 162 Issue: 3 Pages: 1-12
- DOI
  10.1210/endocr/bqab006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00535, KAKENHI-PROJECT-18K15399, KAKENHI-PROJECT-20K23382
[Journal Article] Snaill is involved in the renal epithelial-mesenchymal transition.2007
- Author(s)
  吉野純
- Journal Title
  
  Biochem Biophys Res Commun. 362 (1)
  
  Pages: 63-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790575
[Presentation] Intracellular dark endothelial spots after endothelial keratoplasty in Fuchs’ endothelial corneal dystrophy2024
- Author(s)
  Takefumi Yamaguchi, Takahiro Kanda, Rie Sakata, Yurina Mori-Ogiwara, Hirotsugu Kasamatsu, Yukari Yagi-Yaguchi, Yuki Kusano, Chifune Kai Chifune, Sayo Maeno, Yoshinori Oie, Naoki Okumura, Takahiko Hayashi, Masahito Yoshihara, Kohji Nishida
- Organizer
  ARVO2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27754
[Presentation] Associations between renal sinus fat volume and cardiometabolic and renin-angiotensin system parameters in patients with primary aldosteronism2024
- Author(s)
  Mitsuno R, Kaneko K, Nakamura T, Kojima D, Mizutani Y, Azegami T, Yamaguchi S, Yamada Y, Jinzaki M, Kinouchi K, Yoshino J, Hayashi K
- Organizer
  Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT and WDA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 糖・エネルギー代謝制御における脂肪細胞ミトコンドリアNAD+生物学の重要性2024
- Author(s)
  児島大輝, 夜久圭介, 金子賢司, 満野竜ノ介, 小杉将太郎, 山口慎太郎, 佐藤亜希子, 豊國伸哉, 伊藤裕, 神田武志, 中川崇, 林香, 吉野純
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-24K02506
[Presentation] Associations between renal sinus fat volume and cardiometabolic and renin-angiotensin system parameters in patients with primary aldosteronism2024
- Author(s)
  Mitsuno R, Kaneko K, Nakamura T, Kojima D, Mizutani Y, Azegami T, Yamaguchi S, Yamada Y, Jinzaki M, Kinouchi K, Yoshino J, Hayashi K
- Organizer
  Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT and WDA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02506
[Presentation] 糖・エネルギー代謝制御における脂肪細胞ミトコンドリアNAD+代謝の重要性2024
- Author(s)
  児島大輝, 夜久圭介, 林香, 吉野純
- Organizer
  第28回日本肥満学会アディポサイエンスシンポジウム
- Data Source
  KAKENHI-PROJECT-24K02506
[Presentation] 糖・エネルギー代謝制御における脂肪細胞ミトコンドリアNAD+代謝の意義の検証2024
- Author(s)
  児島大輝, 夜久圭介, 小杉将太郎, 金子賢司, 満野竜ノ介, 山口慎太郎, 佐藤亜希子, 豊國伸哉, 伊藤裕, 中川崇, 林香, 吉野純
- Organizer
  第23回日本ミトコンドリア学会
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] フレイル・サルコペニアの新規治療標的としてのNAD生物学の可能性2024
- Author(s)
  吉野純
- Organizer
  第11 回日本サルコペニア・フレイル学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-24K02506
[Presentation] Renal sinus fat is associated with renal resistive index in patients with chronic kidney disease2024
- Author(s)
  Kaneko K, Mitsuno R, Kojima D, Azegami T, Kosugi S, Nakamura T, Hashiguchi A, Yamada Y, Jinzaki M, Yamaguchi S, Itoh H, Yoshino J, Hayashi K
- Organizer
  Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT and WDA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] フレイル・サルコペニアの新規治療標的としてのNAD生物学の可能性2024
- Author(s)
  吉野純
- Organizer
  第11 回日本サルコペニア・フレイル学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic enzyme, causes a metabolically-unhealthy lean phenotype during aging2024
- Author(s)
  Kojima D, Qi N, Franczyk MP, Yamaguchi S, Kaneko K, Mitsuno R, Sasaki Y, Finck BN, DeBosch BJ,Hayashi K, Yoshino J
- Organizer
  Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT and WDA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] Renal sinus fat is associated with renal resistive index in patients with chronic kidney disease2024
- Author(s)
  Kaneko K, Mitsuno R, Kojima D, Azegami T, Kosugi S, Nakamura T, Hashiguchi A, Yamada Y, Jinzaki M, Yamaguchi S, Itoh H, Yoshino J, Hayashi K
- Organizer
  Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT and WDA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02506
[Presentation] Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic enzyme, causes a metabolically-unhealthy lean phenotype during aging2024
- Author(s)
  Kojima D, Qi N, Franczyk MP, Yamaguchi S, Kaneko K, Mitsuno R, Sasaki Y, Finck BN, DeBosch BJ,Hayashi K, Yoshino J
- Organizer
  Kidney Health In Aging and Aged Societies: JSN/ERA Symposium Collaboration with JSDT and WDA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02506
[Presentation] Importance of adipocyte mitochondrial NAD+ biology in glucose and energy metabolism2024
- Author(s)
  児島大輝, 夜久圭介, 林香, 吉野純
- Organizer
  アディポサイエンスシンポジウム
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 糖・エネルギー代謝制御における脂肪細胞ミトコンドリアNAD+代謝の重要性2024
- Author(s)
  児島大輝, 夜久圭介, 林香, 吉野純
- Organizer
  第28回日本肥満学会アディポサイエンスシンポジウム
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 糖・エネルギー代謝制御における脂肪細胞ミトコンドリアNAD+生物学の重要性2024
- Author(s)
  児島大輝, 夜久圭介, 金子賢司, 満野竜ノ介, 小杉将太郎, 山口慎太郎, 佐藤亜希子, 豊國伸哉, 伊藤裕, 神田武志, 中川崇, 林香, 吉野純
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 原発性アルドステロン症における腎洞脂肪蓄積の臨床的意義の検証2024
- Author(s)
  満野竜ノ介, 金子賢司, 中村俊文, 児島大輝, 水谷洋佑, 畔上達彦, 山口慎太郎, 山田祥岳, 陣崎雅弘, 木内謙一郎, 吉野純, 林香
- Organizer
  第97回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-24K02506
[Presentation] 糖・エネルギー代謝制御における脂肪細胞ミトコンドリアNAD+代謝の意義の検証2024
- Author(s)
  児島大輝, 夜久圭介, 小杉将太郎, 金子賢司, 満野竜ノ介, 山口慎太郎, 佐藤亜希子, 豊國伸哉, 伊藤裕, 中川崇, 林香, 吉野純
- Organizer
  第23回日本ミトコンドリア学会
- Data Source
  KAKENHI-PROJECT-24K02506
[Presentation] 原発性アルドステロン症における腎洞脂肪蓄積の臨床的意義の検証2024
- Author(s)
  満野竜ノ介, 金子賢司, 中村俊文, 児島大輝, 水谷洋佑, 畔上達彦, 山口慎太郎, 山田祥岳, 陣崎雅弘, 木内謙一郎, 吉野純, 林香
- Organizer
  第97回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] インスリン抵抗性におけるNAD+生物学の重要性,2023
- Author(s)
  吉野純
- Organizer
  第55回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 生活習慣病の新規予防・治療標的としてのNAD+生物学の可能性2023
- Author(s)
  吉野純
- Organizer
  第56回日本成人病（生活習慣病）学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 糖尿病領域におけるNAD生物学の進捗2023
- Author(s)
  吉野純
- Organizer
  第61回総会日本糖尿病学会中国四国地方会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 糖・エネルギー代謝制御における脂肪細胞NAD+生物学の重要性2023
- Author(s)
  吉野純
- Organizer
  第42回日本トリプトファン研究会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] NAD+ biology as a new therapeutic target for obesity and diabetes2023
- Author(s)
  吉野純
- Organizer
  第26回アディポサイエンスシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] Cellular Insights into Metabolically Healthy and Unhealthy Obesity2023
- Author(s)
  Max C. Petersen, Gordon I. Smith, Ruteja A. Barve, Jinsheng Yu, Jun Yoshino, Gerald I. Shulman, Samuel Klein
- Organizer
  ENDO 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] Cellular Insights into Metabolically Healthy and Unhealthy Obesity2023
- Author(s)
  Petersen MC, Smith GI, Barve RA, Yu J, Yoshino J, Shulman GI, Klein S
- Organizer
  The Endocrine Society Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 肥満・糖尿病におけるNAD生物学トランスレーショナル研究の新展開2022
- Author(s)
  吉野純
- Organizer
  第65回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 肥満・インスリン抵抗性における脂肪細胞NAD+生物学の重要性2022
- Author(s)
  吉野純
- Organizer
  第42回日本肥満学会　メインシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 糖尿病性神経障害の新規治療標的としてのNAD生物学の可能性2022
- Author(s)
  吉野純
- Organizer
  日本末梢神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 肥満・インスリン抵抗性におけるNAD+生物学トランスレーショナル型研究の進捗2022
- Author(s)
  吉野純
- Organizer
  第95回日本内分泌学学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] The association between insulin resistance and decline in organ function in non-obese Japanese individuals2022
- Author(s)
  Kaneko K, Shimizu-Hirota R, Makino K, Nagasaka T, Kojima D, Takaishi H, Yoshino J, Itoh H.
- Organizer
  The 29th Scientific Meeting of the International Society of Hypertension
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] NAD biology as a potent therapeutic target for diabetes and hypertension2022
- Author(s)
  Jun Yoshino
- Organizer
  The 29th Scientific Meeting of the International Society of Hypertension
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 肥満・インスリン抵抗性における脂肪細胞NAD生物学の重要性2022
- Author(s)
  吉野純
- Organizer
  第43回日本肥満学会・第40回日本肥満治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] NAD+生物学が与える抗肥満・抗老化法の可能性2022
- Author(s)
  吉野純
- Organizer
  第43回日本肥満学会・第40回日本肥満治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 肥満・インスリン抵抗性における脂肪細胞NAD+生物学の意義と治療標的としての可能性2022
- Author(s)
  吉野純
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 肥満・インスリン抵抗性におけるNAD生物学トランスレーショナル型研究の進捗2021
- Author(s)
  吉野純
- Organizer
  第7回日本筋学会学術集会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 肥満・インスリン抵抗性におけるNAD+生物学トランスレーショナル型研究の進捗2021
- Author(s)
  吉野純
- Organizer
  第44回日本分子生物学会年会　ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 肥満・インスリン抵抗性におけるNAD生物学トランスレーショナル型研究の進捗2021
- Author(s)
  吉野純
- Organizer
  第19回日本機能性食品医用学会総会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] 糖尿病性腎臓病治療のパラダイムシフト2021
- Author(s)
  吉野純
- Organizer
  第32回日本糖尿病性腎症研究会スポンサードセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20K23382
[Presentation] Effect of Intense Lifestyle Therapy in People with Obesity and Type Diabetes2021
- Author(s)
  Yoshino M, Yoshino J, Bittel AJ, Bittle D, Reeds D, Stein R, Sinacore DR, Cade WT, Okunade AL, Patterson BW, Klein S
- Organizer
  American Diabetes Association 81st Scientific Sessions (ADA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K23382

1. 山口剛史 (20383771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 石垣和慶 (00790338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 金蔵孝介 (10508568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 植田幸嗣 (10509110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 比嘉一成 (60398782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 野間久史 (70633486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 本間康一郎 (10383762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 中川崇 (40610374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. YAMAGUCHI Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
10. 木内謙一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 伊藤裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 佐藤亜希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 竹馬俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 富田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshino Jun 吉野 純

YOSHINO Jun 吉野 純

吉野 純 ヨシノ ジユン

Research Projects

Research Products

Co-Researchers

Establishment of experimental basis to improve the prognosis of corneal transplantation in treating bullous keratoplasty due to pathological aqueous humor.

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Development of a Novel Treatment Targeting the NAD Synthesis Pathway for Post-Cardiac Arrest Syndrome and Elucidation of Its Role in Severe Disease States

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新規ミトコンドリアNAD輸送体SLC25A51の脂肪細胞機能制御および臨床的意義の解明Principal Investigator

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Pathophysiological significance and clinical implication of adipocyte NAD biologyPrincipal Investigator

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Tie2-Creマウスを用いた腎内皮細胞傷害・修復機構におけるNFκBの機能解析Principal Investigator

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[Journal Article] Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring2025

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[Journal Article] DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages.2025

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[Journal Article] Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model2025

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[Journal Article] Intracellular dark endothelial spots detected using specular microscopy are associated with graft failure after Descemet’s membrane endothelial keratoplasty2025

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[Journal Article] Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men2024

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[Journal Article] Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity2024

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[Journal Article] Renal sinus fat is associated with intrarenal hemodynamic abnormalities independent of visceral fat in patients with chronic kidney disease2024

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[Journal Article] Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging2024

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[Journal Article] 肥満関連代謝疾患の新規治療標的 としてのNAD＋生物学の可能性2024

Author(s)

Yoshino Jun 吉野純

YOSHINO Jun 吉野純

吉野純ヨシノジユン

[Journal Article] 肥満関連代謝疾患の新規治療標的としてのNAD＋生物学の可能性2024